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Journal of Cancer Research and Clinical Oncology
Erschienen in: Journal of Cancer Research and Clinical Oncology 6/2021

17.04.2021 | Review – Cancer Research

A review: hippo signaling pathway promotes tumor invasion and metastasis by regulating target gene expression

verfasst von: Hong-Li Li, Qian-Yu Li, Min-Jie Jin, Chao-Fan Lu, Zhao-Yang Mu, Wei-Yi Xu, Jian Song, Yan Zhang, Sai-Yang Zhang

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 6/2021

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Abstract

Background

The Hippo pathway is widely considered to inhibit cell growth and play an important role in regulating the size of organs. However, recent studies have shown that abnormal regulation of the Hippo pathway can also affect tumor invasion and metastasis. Therefore, finding out how the Hippo pathway promotes tumor development by regulating the expression of target genes provides new ideas for future research on targeted drugs that inhibit tumor progression.

Methods

PubMed, Embase, Web of Science, and the Cochrane Library were systematically searched.

Results

The search strategy identified 1892 hits and 196 publications were finally included in this review. As the core molecule of the Hippo pathway, YAP/TAZ are usually highly expressed in tumors that undergo invasion and migration and are accompanied by abnormally strong nuclear metastasis. Through its interaction with nuclear transcription factors TEADs, it directly or indirectly regulates and the expressions of target genes related to tumor metastasis and invasion. These target genes can induce the formation of invasive pseudopodia in tumor cells, reduce intercellular adhesion, degrade extracellular matrix (ECM), and cause epithelial-mesenchymal transition (EMT), or indirectly promote through other signaling pathways, such as mitogen-activated protein kinases (MAPK), TGF/Smad, etc, which facilitate the invasion and metastasis of tumors.

Conclusion

This article mainly introduces the research progress of YAP/TAZ which are the core molecules of the Hippo pathway regulating related target genes to promote tumor invasion and metastasis. Focus on the target genes that affect tumor invasion and metastasis, providing the possibility for the selection of clinical drug treatment targets, to provide some help for a more in-depth study of tumor invasion and migration mechanism and the development of clinical drugs.
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Metadaten
Titel
A review: hippo signaling pathway promotes tumor invasion and metastasis by regulating target gene expression
verfasst von
Hong-Li Li
Qian-Yu Li
Min-Jie Jin
Chao-Fan Lu
Zhao-Yang Mu
Wei-Yi Xu
Jian Song
Yan Zhang
Sai-Yang Zhang
Publikationsdatum
17.04.2021
Verlag
Springer Berlin Heidelberg
Erschienen in
Journal of Cancer Research and Clinical Oncology / Ausgabe 6/2021
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI
https://doi.org/10.1007/s00432-021-03604-8

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