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Erschienen in: Pathology & Oncology Research 2/2020

27.06.2019 | Original Article

A Single Nucleotide Polymorphism in GAS5 lncRNA is Associated with Risk of Bladder Cancer in Iranian Population

verfasst von: Azadeh Rakhshan, Mohammad Hossein Esmaeili, Mir Salar Kahaei, Mohammad Taheri, Mir Davood Omrani, Rezvan Noroozi, Soudeh Ghafouri-Fard

Erschienen in: Pathology & Oncology Research | Ausgabe 2/2020

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Abstract

Down-regulation of the long non-coding RNA (lncRNA) growth arrest-specific 5 (GAS5) has a pathogenic role in bladder cancer. Moreover, genomic variants of this lncRNA have been associated with risk of diverse cancers. In the present project, we genotyped two putative functional SNPs (rs2067079 and rs6790) in 122 bladder cancer patients and 150 age- and sex-matched healthy subjects. The rs2067079 was associated risk of bladder cancer in recessive inheritance model (TT vs.CC + CT: OR (95% Confidence interval (CI)) = 2.67 (1.27–5.62), adjusted P value = 0.02). The T G haplotype (rs2067079 and rs6790) increased the risk of bladder cancer in the assessed population (OR (95% CI) = 1.73 (1.18–2.56), adjusted P value = 0.02). Consequently, in the current project we introduced a novel risk locus for bladder cancer in Iranian population.
Literatur
1.
Zurück zum Zitat Rafiemanesh H, Lotfi Z, Bakhtazad S, Ghoncheh M, Salehiniya H (2018) The epidemiological and histological trend of bladder cancer in Iran. J Cancer Res Ther 14(3):532–536CrossRef Rafiemanesh H, Lotfi Z, Bakhtazad S, Ghoncheh M, Salehiniya H (2018) The epidemiological and histological trend of bladder cancer in Iran. J Cancer Res Ther 14(3):532–536CrossRef
2.
Zurück zum Zitat Gu J, Wu XF (2011) Genetic susceptibility to bladder cancer risk and outcome. Pers Med 8(3):365–374CrossRef Gu J, Wu XF (2011) Genetic susceptibility to bladder cancer risk and outcome. Pers Med 8(3):365–374CrossRef
3.
Zurück zum Zitat Taheri M, Omrani MD, Ghafouri-Fard S (2018) Long non-coding RNA expression in bladder cancer. Biophys Rev 10(4):1205–1213CrossRef Taheri M, Omrani MD, Ghafouri-Fard S (2018) Long non-coding RNA expression in bladder cancer. Biophys Rev 10(4):1205–1213CrossRef
4.
Zurück zum Zitat Minotti L, Agnoletto C, Baldassari F, Corra F, Volinia S (2018) SNPs and somatic mutation on long non-coding RNA: new frontier in the cancer studies? High-throughput. 7(4)CrossRef Minotti L, Agnoletto C, Baldassari F, Corra F, Volinia S (2018) SNPs and somatic mutation on long non-coding RNA: new frontier in the cancer studies? High-throughput. 7(4)CrossRef
5.
Zurück zum Zitat Zhang H, Guo Y, Song Y, Shang C (2017) Long noncoding RNA GAS5 inhibits malignant proliferation and chemotherapy resistance to doxorubicin in bladder transitional cell carcinoma. Cancer Chemother Pharmacol 79(1):49–55CrossRef Zhang H, Guo Y, Song Y, Shang C (2017) Long noncoding RNA GAS5 inhibits malignant proliferation and chemotherapy resistance to doxorubicin in bladder transitional cell carcinoma. Cancer Chemother Pharmacol 79(1):49–55CrossRef
6.
Zurück zum Zitat Mourtada-Maarabouni M, Pickard MR, Hedge VL, Farzaneh F, Williams GT (2009) GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer. Oncogene. 28(2):195–208CrossRef Mourtada-Maarabouni M, Pickard MR, Hedge VL, Farzaneh F, Williams GT (2009) GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer. Oncogene. 28(2):195–208CrossRef
7.
Zurück zum Zitat Mahdi Eftekharian M, Noroozi R, Komaki A, Mazdeh M, Taheri M, Ghafouri-Fard S (2019) GAS5 genomic variants and risk of multiple sclerosis. Neurosci Lett 701:54–57CrossRef Mahdi Eftekharian M, Noroozi R, Komaki A, Mazdeh M, Taheri M, Ghafouri-Fard S (2019) GAS5 genomic variants and risk of multiple sclerosis. Neurosci Lett 701:54–57CrossRef
8.
Zurück zum Zitat Smith CM, Steitz JA (1998) Classification of gas5 as a multi-small-nucleolar-RNA (snoRNA) host gene and a member of the 5′-terminal oligopyrimidine gene family reveals common features of snoRNA host genes. Mol Cell Biol 18(12):6897–6909CrossRef Smith CM, Steitz JA (1998) Classification of gas5 as a multi-small-nucleolar-RNA (snoRNA) host gene and a member of the 5′-terminal oligopyrimidine gene family reveals common features of snoRNA host genes. Mol Cell Biol 18(12):6897–6909CrossRef
9.
Zurück zum Zitat Ghaforui-Fard S, Taheri M (2019) Growth arrest specific transcript 5 in tumorigenesis process: An update on the expression pattern and genomic variants. Biomed Pharmacother 112 Ghaforui-Fard S, Taheri M (2019) Growth arrest specific transcript 5 in tumorigenesis process: An update on the expression pattern and genomic variants. Biomed Pharmacother 112
10.
Zurück zum Zitat Li QJ, Ma G, Sun SH, Xu Y, Wang BJ (2018) Polymorphism in the promoter region of lncRNA GAS5 is functionally associated with the risk of gastric cancer. Clin Res Hepatol Gas 42(5):478–482CrossRef Li QJ, Ma G, Sun SH, Xu Y, Wang BJ (2018) Polymorphism in the promoter region of lncRNA GAS5 is functionally associated with the risk of gastric cancer. Clin Res Hepatol Gas 42(5):478–482CrossRef
11.
Zurück zum Zitat Li WH, Huang K, Wen FB, Cui GH, Guo HZ, Zhao S (2017) Genetic variation of lncRNA GAS5 contributes to the development of lung cancer. Oncotarget. 8(53):91025–91029CrossRef Li WH, Huang K, Wen FB, Cui GH, Guo HZ, Zhao S (2017) Genetic variation of lncRNA GAS5 contributes to the development of lung cancer. Oncotarget. 8(53):91025–91029CrossRef
12.
Zurück zum Zitat Zhu ZS, Xue YZ, Fu W, Li CY, Feng LJ, Xing YH et al (2016) Functional indel polymorphism within lncRNA GAS5 and colorectal carcinoma risk. Int J Clin Exp Pathol 9(11):11767–11773 Zhu ZS, Xue YZ, Fu W, Li CY, Feng LJ, Xing YH et al (2016) Functional indel polymorphism within lncRNA GAS5 and colorectal carcinoma risk. Int J Clin Exp Pathol 9(11):11767–11773
13.
Zurück zum Zitat Guo Z, Wang YH, Zhao Y, Jin Y, An L, Wu B et al (2017) Genetic polymorphisms of long non-coding RNA GAS5 predict platinum-based concurrent chemoradiotherapy response in nasopharyngeal carcinoma patients. Oncotarget. 8(37):62286–62297CrossRef Guo Z, Wang YH, Zhao Y, Jin Y, An L, Wu B et al (2017) Genetic polymorphisms of long non-coding RNA GAS5 predict platinum-based concurrent chemoradiotherapy response in nasopharyngeal carcinoma patients. Oncotarget. 8(37):62286–62297CrossRef
14.
Zurück zum Zitat Wang M, Guo C, Wang L, Luo G, Huang C, Li YW et al (2018) Long noncoding RNA GAS5 promotes bladder cancer cells apoptosis through inhibiting EZH2 transcription. Cell Death Dis 9 Wang M, Guo C, Wang L, Luo G, Huang C, Li YW et al (2018) Long noncoding RNA GAS5 promotes bladder cancer cells apoptosis through inhibiting EZH2 transcription. Cell Death Dis 9
15.
Zurück zum Zitat Yoo J, Lee Y, Kim Y, Rha SY, Kim Y (2008) SNPAnalyzer 2.0: a web-based integrated workbench for linkage disequilibrium analysis and association analysis. BMC Bioinf 9:290CrossRef Yoo J, Lee Y, Kim Y, Rha SY, Kim Y (2008) SNPAnalyzer 2.0: a web-based integrated workbench for linkage disequilibrium analysis and association analysis. BMC Bioinf 9:290CrossRef
16.
Zurück zum Zitat Liu ZH, Wang W, Jiang JT, Bao ED, Xu DL, Zeng YG et al (2013) Downregulation of GAS5 promotes bladder cancer cell proliferation, partly by regulating CDK6. PLoS One 8(9)CrossRef Liu ZH, Wang W, Jiang JT, Bao ED, Xu DL, Zeng YG et al (2013) Downregulation of GAS5 promotes bladder cancer cell proliferation, partly by regulating CDK6. PLoS One 8(9)CrossRef
17.
Zurück zum Zitat Ren C, An GL, Zhao CH, Ouyang ZY, Bo XC, Shu WJ (2018) Lnc2Catlas: an atlas of long noncoding RNAs associated with risk of cancers. Sci Rep-Uk 8 Ren C, An GL, Zhao CH, Ouyang ZY, Bo XC, Shu WJ (2018) Lnc2Catlas: an atlas of long noncoding RNAs associated with risk of cancers. Sci Rep-Uk 8
18.
Zurück zum Zitat Ward LD, Kellis M (2012) HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants. Nucleic Acids Res 40(D1):D930–D9D4CrossRef Ward LD, Kellis M (2012) HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants. Nucleic Acids Res 40(D1):D930–D9D4CrossRef
19.
Zurück zum Zitat Zhang Q, Stovall DB, Inoue K, Sui G (2011) The oncogenic role of Yin Yang 1. Crit Rev Oncog 16(3–4):163–197CrossRef Zhang Q, Stovall DB, Inoue K, Sui G (2011) The oncogenic role of Yin Yang 1. Crit Rev Oncog 16(3–4):163–197CrossRef
20.
Zurück zum Zitat Zaravinos A, Lambrou GI, Boulalas I, Delakas D, Spandidos DA (2011) Identification of common differentially expressed genes in urinary bladder cancer. PLoS One 6(4):e18135CrossRef Zaravinos A, Lambrou GI, Boulalas I, Delakas D, Spandidos DA (2011) Identification of common differentially expressed genes in urinary bladder cancer. PLoS One 6(4):e18135CrossRef
Metadaten
Titel
A Single Nucleotide Polymorphism in GAS5 lncRNA is Associated with Risk of Bladder Cancer in Iranian Population
verfasst von
Azadeh Rakhshan
Mohammad Hossein Esmaeili
Mir Salar Kahaei
Mohammad Taheri
Mir Davood Omrani
Rezvan Noroozi
Soudeh Ghafouri-Fard
Publikationsdatum
27.06.2019
Verlag
Springer Netherlands
Erschienen in
Pathology & Oncology Research / Ausgabe 2/2020
Print ISSN: 1219-4956
Elektronische ISSN: 1532-2807
DOI
https://doi.org/10.1007/s12253-019-00693-2

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