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Annals of Hematology

Erschienen in:

01.09.2013 | Original Article

Aberrant expression of signaling proteins in essential thrombocythemia

verfasst von: Wuhan Hui, Fei Ye, Wei Zhang, Congyan Liu, Miao Cui, Wei Li, Juan Xu, David Y. Zhang

Erschienen in: Annals of Hematology | Ausgabe 9/2013

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Abstract

Dysregulated expression of signaling proteins may contribute to the pathophysiology of essential thrombocythemia (ET). This study aimed to characterize protein expression in ET and to correlate the dysregulated proteins with phenotypes and prognosis of ET patients. The expression of 128 proteins in peripheral blood neutrophils from 74 ET patients was assessed and compared with those from 29 healthy subjects and 35 polycythemia vera (PV) patients using protein pathway array. Fifteen proteins were differentially expressed between ET patients and normal controls. These dysregulated proteins were involved in the signaling pathways related with apoptosis and inflammation. Our results showed a significant overlap in protein expression between ET patients with JAK2V617F mutation and PV patients. In addition, nine proteins were associated with JAK2V617F mutation status in ET patients. Furthermore, estrogen receptor beta (ERβ) and Stat3 were independent risk factors for subsequent thrombosis during follow-up on multivariable analysis. Our study shows a broad dysregulation of signaling protein in ET patients, suggesting their roles in ET pathogenesis. The expression levels of ERβ and Stat3 could be promising predictors of subsequent thrombosis in ET patients.

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Titel: Aberrant expression of signaling proteins in essential thrombocythemia
verfasst von: Wuhan Hui
Fei Ye
Wei Zhang
Congyan Liu
Miao Cui
Wei Li
Juan Xu
David Y. Zhang
Publikationsdatum: 01.09.2013
Verlag: Springer Berlin Heidelberg
Erschienen in: Annals of Hematology / Ausgabe 9/2013
Print ISSN: 0939-5555
Elektronische ISSN: 1432-0584
DOI: https://doi.org/10.1007/s00277-013-1755-8

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