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01.04.2013 | Note

Ability of endophytic filamentous fungi associated with Cinchona ledgeriana to produce Cinchona alkaloids

verfasst von: Shoji Maehara, Partomuan Simanjuntak, Yoshihide Maetani, Chinami Kitamura, Kazuyoshi Ohashi, Hirotaka Shibuya

Erschienen in: Journal of Natural Medicines | Ausgabe 2/2013

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Abstract

We have investigated the ability of endophytic filamentous fungi associated with Cinchona ledgeriana (Rubiaceae) to produce Cinchona alkaloids on potato dextrose agar medium and in a synthetic liquid medium. It was found that all twenty-one endophytic fungi produce Cinchona alkaloids, despite their genetic differences.

Shibuya H, Kitamura C, Maehara S, Nagahata M, Winarno H, Simanjuntak P, Kim H-S, Wataya Y, Ohashi K (2003) Transformation of Cinchona alkaloids into 1-N-oxide derivatives by endophytic Xylaria sp. isolated from Cinchona pubescens. Chem Pharm Bull 51:71–74PubMedCrossRef

Shibuya H, Agusta A, Ohashi K, Maehara S, Simanjuntak P (2005) Biooxidation of (+)-catechin and (–)-epicatechin into 3,4-dihydroxyflavan derivatives by the endophytic fungus Diaporthe sp. isolated from a tea plant. Chem Pharm Bull 53:866–867PubMedCrossRef

Agusta A, Maehara S, Ohashi K, Simanjuntak P, Shibuya H (2005) Stereoselective oxidation at C-4 of flavans by the endophytic fungus Diaporthe sp. isolated from a tea plant. Chem Pharm Bull 53:1565–1569PubMedCrossRef

Agusta A, Ohashi K, Shibuya H (2006) Composition of the endophytic filamentous fungi isolated from the tea plant Camellia sinensis. J Nat Med 60:268–272CrossRef

Maehara S, Simanjuntak P, Ohashi K, Shibuya H (2010) Composition of endophytic fungi living in Cinchona ledgeriana (Rubiaceae). J Nat Med 64:227–230PubMedCrossRef

Maehara S, Simanjuntak P, Kitamura C, Ohashi K, Shibuya H (2011) Cinchona alkaloids are also produced by an endophytic filamentous fungus living in Cinchona plant. Chem Pharm Bull 59:1073–1074PubMedCrossRef

Trimen H (1881) Cinchona ledgeriana a distinct species. J Bot Br Foreign 19:321–325

Titel: Ability of endophytic filamentous fungi associated with Cinchona ledgeriana to produce Cinchona alkaloids
verfasst von: Shoji Maehara
Partomuan Simanjuntak
Yoshihide Maetani
Chinami Kitamura
Kazuyoshi Ohashi
Hirotaka Shibuya
Publikationsdatum: 01.04.2013
Verlag: Springer Japan
Erschienen in: Journal of Natural Medicines / Ausgabe 2/2013
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-012-0701-8

Springer Medizin

Abstract

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