Erschienen in:
Open Access
01.12.2012 | Oral presentation
Abnormal osteogenesis in osteoarthritis: gone with the Wnt?
verfasst von:
Daniel Lajeunesse, Thomas F Chan, Aline Delalandre, Jean-Pierre Pelletier, Johanne Martel-Pelletier, Élie Abed
Erschienen in:
Arthritis Research & Therapy
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Sonderheft 1/2012
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Excerpt
Clinical and in vitro studies suggest that subchondral bone sclerosis due to abnormal osteoblast (Ob) functions, is involved in the progression and/or onset of osteoarthritis (OA). Human OA subchondral Ob show a differentiated phenotype, however they fail to mineralize normally. The canonical Wnt/b-catenin signaling pathway (cWnt) plays a key role in osteogenesis by promoting the differentiation and mineralization of Ob. Dickkopfs (DKKs) are potent antagonists whereas R-spondins (Rspo) are newly described agonists that play key roles in cWnt signalling. However, the regulation of DKKs and Rspos in OA Ob remains unknown. …