Erschienen in:
Open Access
01.12.2012 | Poster presentation
Combined depletion of interleukin-1 and interleukin-6 does not exceed single depletion of interleukin -1 in TNF-mediated arthritis
verfasst von:
Silvia Hayer, B Niederreiter, J Smolen, K Redlich
Erschienen in:
Arthritis Research & Therapy
|
Sonderheft 1/2012
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Excerpt
Previous studies demonstrated a regulatory role of interleukin 1 (IL-1) in inflammatory cartilage damage and bone destruction in human tumor necrosis factor transgenic (hTNFtg) mice, an animal model for Rheumatoid Arthritis (RA). Moreover, blocking of IL-6 has been shown to reduce local bone erosions in this model. Therefore we wanted to investigate the effect of a combined depletion of IL-1 and IL-6 on the development and severity of inflammatory, erosive arthritis. …