nach oben

Erschienen in:

19.08.2019 | Original Article

Absolute and relative estimates of genetic and environmental variance in brain structure volumes

verfasst von: Lachlan T. Strike, Narelle K. Hansell, Paul M. Thompson, Greig I. de Zubicaray, Katie L. McMahon, Brendan P. Zietsch, Margaret J. Wright

Erschienen in: Brain Structure and Function | Ausgabe 8/2019

Einloggen, um Zugang zu erhalten

Abstract

Comparing estimates of the amount of genetic and environmental variance for different brain structures may elucidate differences in the genetic architecture or developmental constraints of individual brain structures. However, most studies compare estimates of relative genetic (heritability) and environmental variance in brain structure, which do not reflect differences in absolute variance between brain regions. Here we used a population sample of young adult twins and singleton siblings of twins (n = 791; M = 23 years, Queensland Twin IMaging study) to estimate the absolute genetic and environmental variance, standardised by the phenotypic mean, in the size of cortical, subcortical, and ventricular brain structures. Mean-standardised genetic variance differed widely across structures [23.5-fold range 0.52% (hippocampus) to 12.28% (lateral ventricles)], but the range of estimates within cortical, subcortical, or ventricular structures was more moderate (two to fivefold range). There was no association between mean-standardised and relative measures of genetic variance (i.e., heritability) in brain structure volumes. We found similar results in an independent sample (n = 1075, M = 29 years, Human Connectome Project). These findings open important new lines of enquiry: namely, understanding the bases of these variance patterns, and their implications regarding the genetic architecture, evolution, and development of the human brain.

Nur mit Berechtigung zugänglich

Allen JS, Damasio H, Grabowski TJ (2002) Normal neuroanatomical variation in the human brain: an MRI-volumetric study. Am J Phys Anthropol 118(4):341–358. https://doi.org/10.1002/ajpa.10092 CrossRefPubMed

Apostolova LG, Green AE, Babakchanian S, Hwang KS, Chou YY, Toga AW, Thompson PM (2012) Hippocampal atrophy and ventricular enlargement in normal aging, mild cognitive impairment (MCI), and Alzheimer Disease. Alzheimer Dis Assoc Disord 26(1):17–27. https://doi.org/10.1097/WAD.0b013e3182163b62 CrossRefPubMedPubMedCentral

Barton NH, Keightley PD (2002) Understanding quantitative genetic variation. Nat Rev Genet 3(1):11–21. https://doi.org/10.1038/nrg700 CrossRefPubMed

Blokland GA, McMahon KL, Thompson PM, Hickie IB, Martin NG, de Zubicaray GI, Wright MJ (2014) Genetic effects on the cerebellar role in working memory: same brain, different genes? Neuroimage 86(C):392–403. https://doi.org/10.1016/j.neuroimage.2013.10.006 CrossRefPubMed

Carmichael OT, Kuller LH, Lopez OL, Thompson PM, Dutton RA, Lu A, Lee SE, Lee JY, Aizenstein HJ, Meltzer CC, Liu Y, Toga AW, Becker JT (2007) Ventricular volume and dementia progression in the Cardiovascular Health Study. Neurobiol Aging 28(3):389–397. https://doi.org/10.1016/j.neurobiolaging.2006.01.006 CrossRefPubMed

Carpenter EM (2016) Development of brain ventricles and choroid plexus. In: Chen TC (ed) The choroid plexus and cerebrospinal fluid. Academic Press, San Diego, pp 15–27. https://doi.org/10.1016/b978-0-12-801740-1.00002-0 CrossRef

Charlesworth B (1984) The evolutionary genetics of life histories. In: Shorrocks B (ed) Evolutionary ecology. Blackwell Publishers, Oxford

Charlesworth B (1987) The heritability of fitness. In: Bradbury JW, Andersson MB (eds) Sexual selection: testing the alternatives. Wiley, New York, pp 21–40

Chiang MC, McMahon KL, de Zubicaray GI, Martin NG, Hickie I, Toga AW, Wright MJ, Thompson PM (2011) Genetics of white matter development: a DTI study of 705 twins and their siblings aged 12–29. Neuroimage 54(3):2308–2317. https://doi.org/10.1016/j.neuroimage.2010.10.015 CrossRefPubMed

Coltman DW, O’Donoghue P, Hogg JT, Festa-Bianchet M (2005) Selection and genetic (co)variance in bighorn sheep. Evolution 59(6):1372–1382. https://doi.org/10.1111/j.0014-3820.2005.tb01786.x CrossRefPubMed

Core Team R (2019) R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna

de Leeuw J (1992) Introduction to Akaike (1973) information theory and an extension of the maximum likelihood principle. In: Kotz S, Johnson NL (eds) Breakthroughs in statistics. Springer series in statistics. Springer, New York, pp 599–609. https://doi.org/10.1007/978-1-4612-0919-5_37 CrossRef

de Zubicaray GI, Chiang MC, McMahon KL, Shattuck DW, Toga AW, Martin NG, Wright MJ, Thompson PM (2008) Meeting the challenges of neuroimaging genetics. Brain Imaging Behav 2(4):258–263. https://doi.org/10.1007/s11682-008-9029-0 CrossRefPubMedPubMedCentral

Desikan RS, Segonne F, Fischl B, Quinn BT, Dickerson BC, Blacker D, Buckner RL, Dale AM, Maguire RP, Hyman BT, Albert MS, Killiany RJ (2006) An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest. Neuroimage 31(3):968–980. https://doi.org/10.1016/j.neuroimage.2006.01.021 CrossRefPubMed

Eyler LT, Prom-Wormley E, Fennema-Notestine C, Panizzon MS, Neale MC, Jernigan TL, Fischl B, Franz CE, Lyons MJ, Stevens A, Pacheco J, Perry ME, Schmitt JE, Spitzer NC, Seidman LJ, Thermenos HW, Tsuang MT, Dale AM, Kremen WS (2011) Genetic patterns of correlation among subcortical volumes in humans: results from a magnetic resonance imaging twin study. Hum Brain Mapp 32(4):641–653. https://doi.org/10.1002/hbm.21054 CrossRefPubMed

Fischl B (2012) FreeSurfer. Neuroimage 62(2):774–781. https://doi.org/10.1016/j.neuroimage.2012.01.021 CrossRefPubMed

Fujii T, Youssefzadeh J, Novel M, Neman J (2016) Introduction to the ventricular system and choroid plexus. In: Neman J, Chen TC (eds) The choroid plexus and cerebrospinal fluid, 1st edn. Academic Press, San Diego, pp 1–13. https://doi.org/10.1016/b978-0-12-801740-1.00001-9 CrossRef

Garcia-Gonzalez F, Simmons LW, Tomkins JL, Kotiaho JS, Evans JP (2012) Comparing evolvabilities: common errors surrounding the calculation and use of coefficients of additive genetic variation. Evolution 66(8):2341–2349. https://doi.org/10.1111/j.1558-5646.2011.01565.x CrossRefPubMed

Glasser MF, Coalson TS, Robinson EC, Hacker CD, Harwell J, Yacoub E, Ugurbil K, Andersson J, Beckmann CF, Jenkinson M, Smith SM, Van Essen DC (2016) A multi-modal parcellation of human cerebral cortex. Nature 536(7615):171–178. https://doi.org/10.1038/nature18933 CrossRefPubMedPubMedCentral

Gu J, Kanai R (2014) What contributes to individual differences in brain structure? Front Hum Neurosci 8:262. https://doi.org/10.3389/fnhum.2014.00262 CrossRefPubMedPubMedCentral

Hansen TF, Pelabon C, Armbruster WS, Carlson ML (2003) Evolvability and genetic constraint in Dalechampia blossoms: components of variance and measures of evolvability. J Evol Biol 16(4):754–766CrossRefPubMed

Hansen TF, Pélabon C, Houle D (2011) Heritability is not evolvability. Evol Biol 38(3):258–277CrossRef

Hibar DP, Westlye LT, van Erp TG, Rasmussen J, Leonardo CD, Faskowitz J, Haukvik UK, Hartberg CB, Doan NT, Agartz I, Dale AM, Gruber O, Kramer B, Trost S, Liberg B, Abe C, Ekman CJ, Ingvar M, Landen M, Fears SC, Freimer NB, Bearden CE, Costa Rica/Colombia Consortium for Genetic Investigation of Bipolar E, Sprooten E, Glahn DC, Pearlson GD, Emsell L, Kenney J, Scanlon C, McDonald C, Cannon DM, Almeida J, Versace A, Caseras X, Lawrence NS, Phillips ML, Dima D, Delvecchio G, Frangou S, Satterthwaite TD, Wolf D, Houenou J, Henry C, Malt UF, Boen E, Elvsashagen T, Young AH, Lloyd AJ, Goodwin GM, Mackay CE, Bourne C, Bilderbeck A, Abramovic L, Boks MP, van Haren NE, Ophoff RA, Kahn RS, Bauer M, Pfennig A, Alda M, Hajek T, Mwangi B, Soares JC, Nickson T, Dimitrova R, Sussmann JE, Hagenaars S, Whalley HC, McIntosh AM, Thompson PM, Andreassen OA (2016) Subcortical volumetric abnormalities in bipolar disorder. Mol Psychiatry 21(12):1710–1716. https://doi.org/10.1038/mp.2015.227 CrossRefPubMedPubMedCentral

Zurück zum Zitat Hibar DP, Adams HHH, Jahanshad N, Chauhan G, Stein JL, Hofer E, Renteria ME, Bis JC, Arias-Vasquez A, Ikram MK, Desrivieres S, Vernooij MW, Abramovic L, Alhusaini S, Amin N, Andersson M, Arfanakis K, Aribisala BS, Armstrong NJ, Athanasiu L, Axelsson T, Beecham AH, Beiser A, Bernard M, Blanton SH, Bohlken MM, Boks MP, Bralten J, Brickman AM, Carmichael O, Chakravarty MM, Chen Q, Ching CRK, Chouraki V, Cuellar-Partida G, Crivello F, Den Braber A, Doan NT, Ehrlich S, Giddaluru S, Goldman AL, Gottesman RF, Grimm O, Griswold ME, Guadalupe T, Gutman BA, Hass J, Haukvik UK, Hoehn D, Holmes AJ, Hoogman M, Janowitz D, Jia T, Jorgensen KN, Karbalai N, Kasperaviciute D, Kim S, Klein M, Kraemer B, Lee PH, Liewald DCM, Lopez LM, Luciano M, Macare C, Marquand AF, Matarin M, Mather KA, Mattheisen M, McKay DR, Milaneschi Y, Munoz Maniega S, Nho K, Nugent AC, Nyquist P, Loohuis LMO, Oosterlaan J, Papmeyer M, Pirpamer L, Putz B, Ramasamy A, Richards JS, Risacher SL, Roiz-Santianez R, Rommelse N, Ropele S, Rose EJ, Royle NA, Rundek T, Samann PG, Saremi A, Satizabal CL, Schmaal L, Schork AJ, Shen L, Shin J, Shumskaya E, Smith AV, Sprooten E, Strike LT, Teumer A, Tordesillas-Gutierrez D, Toro R, Trabzuni D, Trompet S, Vaidya D, Van der Grond J, Van der Lee SJ, Van der Meer D, Van Donkelaar MMJ, Van Eijk KR, Van Erp TGM, Van Rooij D, Walton E, Westlye LT, Whelan CD, Windham BG, Winkler AM, Wittfeld K, Woldehawariat G, Wolf C, Wolfers T, Yanek LR, Yang J, Zijdenbos A, Zwiers MP, Agartz I, Almasy L, Ames D, Amouyel P, Andreassen OA, Arepalli S, Assareh AA, Barral S, Bastin ME, Becker DM, Becker JT, Bennett DA, Blangero J, van Bokhoven H, Boomsma DI, Brodaty H, Brouwer RM, Brunner HG, Buckner RL, Buitelaar JK, Bulayeva KB, Cahn W, Calhoun VD, Cannon DM, Cavalleri GL, Cheng CY, Cichon S, Cookson MR, Corvin A, Crespo-Facorro B, Curran JE, Czisch M, Dale AM, Davies GE, De Craen AJM, De Geus EJC, De Jager PL, De Zubicaray GI, Deary IJ, Debette S, DeCarli C, Delanty N, Depondt C, DeStefano A, Dillman A, Djurovic S, Donohoe G, Drevets WC, Duggirala R, Dyer TD, Enzinger C, Erk S, Espeseth T, Fedko IO, Fernandez G, Ferrucci L, Fisher SE, Fleischman DA, Ford I, Fornage M, Foroud TM, Fox PT, Francks C, Fukunaga M, Gibbs JR, Glahn DC, Gollub RL, Goring HHH, Green RC, Gruber O, Gudnason V, Guelfi S, Haberg AK, Hansell NK, Hardy J, Hartman CA, Hashimoto R, Hegenscheid K, Heinz A, Le Hellard S, Hernandez DG, Heslenfeld DJ, Ho BC, Hoekstra PJ, Hoffmann W, Hofman A, Holsboer F, Homuth G, Hosten N, Hottenga JJ, Huentelman M, Hulshoff Pol HE, Ikeda M, Jack CR Jr, Jenkinson M, Johnson R, Jonsson EG, Jukema JW, Kahn RS, Kanai R, Kloszewska I, Knopman DS, Kochunov P, Kwok JB, Lawrie SM, Lemaitre H, Liu X, Longo DL, Lopez OL, Lovestone S, Martinez O, Martinot JL, Mattay VS, McDonald C, McIntosh AM, McMahon FJ, McMahon KL, Mecocci P, Melle I, Meyer-Lindenberg A, Mohnke S, Montgomery GW, Morris DW, Mosley TH, Muhleisen TW, Muller-Myhsok B, Nalls MA, Nauck M, Nichols TE, Niessen WJ, Nothen MM, Nyberg L, Ohi K, Olvera RL, Ophoff RA, Pandolfo M, Paus T, Pausova Z, Penninx B, Pike GB, Potkin SG, Psaty BM, Reppermund S, Rietschel M, Roffman JL, Romanczuk-Seiferth N, Rotter JI, Ryten M, Sacco RL, Sachdev PS, Saykin AJ, Schmidt R, Schmidt H, Schofield PR, Sigursson S, Simmons A, Singleton A, Sisodiya SM, Smith C, Smoller JW, Soininen H, Steen VM, Stott DJ, Sussmann JE, Thalamuthu A, Toga AW, Traynor BJ, Troncoso J, Tsolaki M, Tzourio C, Uitterlinden AG, Hernandez MCV, Van der Brug M, van der Lugt A, van der Wee NJA, Van Haren NEM, van’t Ent D, Van Tol MJ, Vardarajan BN, Vellas B, Veltman DJ, Volzke H, Walter H, Wardlaw JM, Wassink TH, Weale ME, Weinberger DR, Weiner MW, Wen W, Westman E, White T, Wong TY, Wright CB, Zielke RH, Zonderman AB, Martin NG, Van Duijn CM, Wright MJ, Longstreth WT, Schumann G, Grabe HJ, Franke B, Launer LJ, Medland SE, Seshadri S, Thompson PM, Ikram MA (2017) Novel genetic loci associated with hippocampal volume. Nat Commun 8:13624. https://doi.org/10.1038/ncomms13624 CrossRefPubMedPubMedCentral Hibar DP, Adams HHH, Jahanshad N, Chauhan G, Stein JL, Hofer E, Renteria ME, Bis JC, Arias-Vasquez A, Ikram MK, Desrivieres S, Vernooij MW, Abramovic L, Alhusaini S, Amin N, Andersson M, Arfanakis K, Aribisala BS, Armstrong NJ, Athanasiu L, Axelsson T, Beecham AH, Beiser A, Bernard M, Blanton SH, Bohlken MM, Boks MP, Bralten J, Brickman AM, Carmichael O, Chakravarty MM, Chen Q, Ching CRK, Chouraki V, Cuellar-Partida G, Crivello F, Den Braber A, Doan NT, Ehrlich S, Giddaluru S, Goldman AL, Gottesman RF, Grimm O, Griswold ME, Guadalupe T, Gutman BA, Hass J, Haukvik UK, Hoehn D, Holmes AJ, Hoogman M, Janowitz D, Jia T, Jorgensen KN, Karbalai N, Kasperaviciute D, Kim S, Klein M, Kraemer B, Lee PH, Liewald DCM, Lopez LM, Luciano M, Macare C, Marquand AF, Matarin M, Mather KA, Mattheisen M, McKay DR, Milaneschi Y, Munoz Maniega S, Nho K, Nugent AC, Nyquist P, Loohuis LMO, Oosterlaan J, Papmeyer M, Pirpamer L, Putz B, Ramasamy A, Richards JS, Risacher SL, Roiz-Santianez R, Rommelse N, Ropele S, Rose EJ, Royle NA, Rundek T, Samann PG, Saremi A, Satizabal CL, Schmaal L, Schork AJ, Shen L, Shin J, Shumskaya E, Smith AV, Sprooten E, Strike LT, Teumer A, Tordesillas-Gutierrez D, Toro R, Trabzuni D, Trompet S, Vaidya D, Van der Grond J, Van der Lee SJ, Van der Meer D, Van Donkelaar MMJ, Van Eijk KR, Van Erp TGM, Van Rooij D, Walton E, Westlye LT, Whelan CD, Windham BG, Winkler AM, Wittfeld K, Woldehawariat G, Wolf C, Wolfers T, Yanek LR, Yang J, Zijdenbos A, Zwiers MP, Agartz I, Almasy L, Ames D, Amouyel P, Andreassen OA, Arepalli S, Assareh AA, Barral S, Bastin ME, Becker DM, Becker JT, Bennett DA, Blangero J, van Bokhoven H, Boomsma DI, Brodaty H, Brouwer RM, Brunner HG, Buckner RL, Buitelaar JK, Bulayeva KB, Cahn W, Calhoun VD, Cannon DM, Cavalleri GL, Cheng CY, Cichon S, Cookson MR, Corvin A, Crespo-Facorro B, Curran JE, Czisch M, Dale AM, Davies GE, De Craen AJM, De Geus EJC, De Jager PL, De Zubicaray GI, Deary IJ, Debette S, DeCarli C, Delanty N, Depondt C, DeStefano A, Dillman A, Djurovic S, Donohoe G, Drevets WC, Duggirala R, Dyer TD, Enzinger C, Erk S, Espeseth T, Fedko IO, Fernandez G, Ferrucci L, Fisher SE, Fleischman DA, Ford I, Fornage M, Foroud TM, Fox PT, Francks C, Fukunaga M, Gibbs JR, Glahn DC, Gollub RL, Goring HHH, Green RC, Gruber O, Gudnason V, Guelfi S, Haberg AK, Hansell NK, Hardy J, Hartman CA, Hashimoto R, Hegenscheid K, Heinz A, Le Hellard S, Hernandez DG, Heslenfeld DJ, Ho BC, Hoekstra PJ, Hoffmann W, Hofman A, Holsboer F, Homuth G, Hosten N, Hottenga JJ, Huentelman M, Hulshoff Pol HE, Ikeda M, Jack CR Jr, Jenkinson M, Johnson R, Jonsson EG, Jukema JW, Kahn RS, Kanai R, Kloszewska I, Knopman DS, Kochunov P, Kwok JB, Lawrie SM, Lemaitre H, Liu X, Longo DL, Lopez OL, Lovestone S, Martinez O, Martinot JL, Mattay VS, McDonald C, McIntosh AM, McMahon FJ, McMahon KL, Mecocci P, Melle I, Meyer-Lindenberg A, Mohnke S, Montgomery GW, Morris DW, Mosley TH, Muhleisen TW, Muller-Myhsok B, Nalls MA, Nauck M, Nichols TE, Niessen WJ, Nothen MM, Nyberg L, Ohi K, Olvera RL, Ophoff RA, Pandolfo M, Paus T, Pausova Z, Penninx B, Pike GB, Potkin SG, Psaty BM, Reppermund S, Rietschel M, Roffman JL, Romanczuk-Seiferth N, Rotter JI, Ryten M, Sacco RL, Sachdev PS, Saykin AJ, Schmidt R, Schmidt H, Schofield PR, Sigursson S, Simmons A, Singleton A, Sisodiya SM, Smith C, Smoller JW, Soininen H, Steen VM, Stott DJ, Sussmann JE, Thalamuthu A, Toga AW, Traynor BJ, Troncoso J, Tsolaki M, Tzourio C, Uitterlinden AG, Hernandez MCV, Van der Brug M, van der Lugt A, van der Wee NJA, Van Haren NEM, van’t Ent D, Van Tol MJ, Vardarajan BN, Vellas B, Veltman DJ, Volzke H, Walter H, Wardlaw JM, Wassink TH, Weale ME, Weinberger DR, Weiner MW, Wen W, Westman E, White T, Wong TY, Wright CB, Zielke RH, Zonderman AB, Martin NG, Van Duijn CM, Wright MJ, Longstreth WT, Schumann G, Grabe HJ, Franke B, Launer LJ, Medland SE, Seshadri S, Thompson PM, Ikram MA (2017) Novel genetic loci associated with hippocampal volume. Nat Commun 8:13624. https://doi.org/10.1038/ncomms13624 CrossRefPubMedPubMedCentral

Hoogman M, Bralten J, Hibar DP, Mennes M, Zwiers MP, Schweren LSJ, van Hulzen KJE, Medland SE, Shumskaya E, Jahanshad N, Zeeuw P, Szekely E, Sudre G, Wolfers T, Onnink AMH, Dammers JT, Mostert JC, Vives-Gilabert Y, Kohls G, Oberwelland E, Seitz J, Schulte-Ruther M, Ambrosino S, Doyle AE, Hovik MF, Dramsdahl M, Tamm L, van Erp TGM, Dale A, Schork A, Conzelmann A, Zierhut K, Baur R, McCarthy H, Yoncheva YN, Cubillo A, Chantiluke K, Mehta MA, Paloyelis Y, Hohmann S, Baumeister S, Bramati I, Mattos P, Tovar-Moll F, Douglas P, Banaschewski T, Brandeis D, Kuntsi J, Asherson P, Rubia K, Kelly C, Martino AD, Milham MP, Castellanos FX, Frodl T, Zentis M, Lesch KP, Reif A, Pauli P, Jernigan TL, Haavik J, Plessen KJ, Lundervold AJ, Hugdahl K, Seidman LJ, Biederman J, Rommelse N, Heslenfeld DJ, Hartman CA, Hoekstra PJ, Oosterlaan J, Polier GV, Konrad K, Vilarroya O, Ramos-Quiroga JA, Soliva JC, Durston S, Buitelaar JK, Faraone SV, Shaw P, Thompson PM, Franke B (2017) Subcortical brain volume differences in participants with attention deficit hyperactivity disorder in children and adults: a cross-sectional mega-analysis. Lancet Psychiatry 4(4):310–319. https://doi.org/10.1016/S2215-0366(17)30049-4 CrossRefPubMedPubMedCentral

Houle D (1992) Comparing evolvability and variability of quantitative traits. Genetics 130(1):195–204PubMedPubMedCentral

Jansen AG, Mous SE, White T, Posthuma D, Polderman TJ (2015) What twin studies tell us about the heritability of brain development, morphology, and function: a review. Neuropsychol Rev 25(1):27–46. https://doi.org/10.1007/s11065-015-9278-9 CrossRefPubMedPubMedCentral

Joshi AA, Lepore N, Joshi SH, Lee AD, Barysheva M, Stein JL, McMahon KL, Johnson K, de Zubicaray GI, Martin NG, Wright MJ, Toga AW, Thompson PM (2011) The contribution of genes to cortical thickness and volume. Neuroreport 22(3):101–105. https://doi.org/10.1097/WNR.0b013e3283424c84 CrossRefPubMedPubMedCentral

Kelly AJ, Dubbs SL, Barlow FK, Zietsch BP (2018) Male and female nipples as a test case for the assumption that functional features vary less than nonfunctional byproducts. Adapt Hum Behav Phys 4(4):344–353. https://doi.org/10.1007/s40750-018-0096-1 CrossRef

Kennedy DN, Lange N, Makris N, Bates J, Meyer J, Caviness VS Jr (1998) Gyri of the human neocortex: an MRI-based analysis of volume and variance. Cereb Cortex (New York, NY: 1991) 8(4):372–384. https://doi.org/10.1093/cercor/8.4.372 CrossRef

Kremen WS, Prom-Wormley E, Panizzon MS, Eyler LT, Fischl B, Neale MC, Franz CE, Lyons MJ, Pacheco J, Perry ME, Stevens A, Schmitt JE, Grant MD, Seidman LJ, Thermenos HW, Tsuang MT, Eisen SA, Dale AM, Fennema-Notestine C (2010) Genetic and environmental influences on the size of specific brain regions in midlife: the VETSA MRI study. Neuroimage 49(2):1213–1223. https://doi.org/10.1016/j.neuroimage.2009.09.043 CrossRefPubMed

Kremen WS, Panizzon MS, Neale MC, Fennema-Notestine C, Prom-Wormley E, Eyler LT, Stevens A, Franz CE, Lyons MJ, Grant MD, Jak AJ, Jernigan TL, Xian H, Fischl B, Thermenos HW, Seidman LJ, Tsuang MT, Dale AM (2012) Heritability of brain ventricle volume: converging evidence from inconsistent results. Neurobiol Aging 33(1):1–8. https://doi.org/10.1016/j.neurobiolaging.2010.02.007 CrossRefPubMed

Lange N, Giedd JN, Castellanos FX, Vaituzis AC, Rapoport JL (1997) Variability of human brain structure size: ages 4–20 years. Psychiatry Res 74(1):1–12. https://doi.org/10.1016/S0925-4927(96)03054-5 CrossRefPubMed

Lowery LA, Sive H (2009) Totally tubular: the mystery behind function and origin of the brain ventricular system. Bioessays 31(4):446–458. https://doi.org/10.1002/bies.200800207 CrossRefPubMedPubMedCentral

Miller GF, Penke L (2007) The evolution of human intelligence and the coefficient of additive genetic variance in human brain size. Intelligence 35(2):97–114. https://doi.org/10.1016/j.intell.2006.08.008 CrossRef

Neale MC, Cardon LR (1992) Methodology for genetic studies of twins and families. Kluwer Academic Publishers, DordrechtCrossRef

Neale MC, Hunter MD, Pritikin JN, Zahery M, Brick TR, Kirkpatrick RM, Estabrook R, Bates TC, Maes HH, Boker SM (2016) OpenMx 2.0: extended structural equation and statistical modeling. Psychometrika 81(2):535–549. https://doi.org/10.1007/s11336-014-9435-8 CrossRefPubMed

Nestor SM, Rupsingh R, Borrie M, Smith M, Accomazzi V, Wells JL, Fogarty J, Bartha R, Alzheimer’s Disease Neuroimaging I (2008) Ventricular enlargement as a possible measure of Alzheimer’s disease progression validated using the Alzheimer’s disease neuroimaging initiative database. Brain 131(Pt 9):2443–2454. https://doi.org/10.1093/brain/awn146 CrossRefPubMedPubMedCentral

Noreikiene K, Herczeg G, Gonda A, Balazs G, Husby A, Merila J (2015) Quantitative genetic analysis of brain size variation in sticklebacks: support for the mosaic model of brain evolution. Proc Biol Sci. https://doi.org/10.1098/rspb.2015.1008 CrossRefPubMedPubMedCentral

Posthuma D, Boomsma DI (2000) A note on the statistical power in extended twin designs. Behav Genet 30(2):147–158. https://doi.org/10.1023/A:1001959306025 CrossRefPubMed

Renteria ME, Hansell NK, Strike LT, McMahon KL, de Zubicaray GI, Hickie IB, Thompson PM, Martin NG, Medland SE, Wright MJ (2014) Genetic architecture of subcortical brain regions: common and region-specific genetic contributions. Genes Brain Behav 13(8):821–830. https://doi.org/10.1111/gbb.12177 CrossRefPubMedPubMedCentral

Schmaal L, Veltman DJ, van Erp TG, Samann PG, Frodl T, Jahanshad N, Loehrer E, Tiemeier H, Hofman A, Niessen WJ, Vernooij MW, Ikram MA, Wittfeld K, Grabe HJ, Block A, Hegenscheid K, Volzke H, Hoehn D, Czisch M, Lagopoulos J, Hatton SN, Hickie IB, Goya-Maldonado R, Kramer B, Gruber O, Couvy-Duchesne B, Renteria ME, Strike LT, Mills NT, de Zubicaray GI, McMahon KL, Medland SE, Martin NG, Gillespie NA, Wright MJ, Hall GB, MacQueen GM, Frey EM, Carballedo A, van Velzen LS, van Tol MJ, van der Wee NJ, Veer IM, Walter H, Schnell K, Schramm E, Normann C, Schoepf D, Konrad C, Zurowski B, Nickson T, McIntosh AM, Papmeyer M, Whalley HC, Sussmann JE, Godlewska BR, Cowen PJ, Fischer FH, Rose M, Penninx BW, Thompson PM, Hibar DP (2016) Subcortical brain alterations in major depressive disorder: findings from the ENIGMA Major Depressive Disorder working group. Mol Psychiatry 21(6):806–812. https://doi.org/10.1038/mp.2015.69 CrossRefPubMed

Schmaal L, Hibar DP, Samann PG, Hall GB, Baune BT, Jahanshad N, Cheung JW, van Erp TGM, Bos D, Ikram MA, Vernooij MW, Niessen WJ, Tiemeier H, Hofman A, Wittfeld K, Grabe HJ, Janowitz D, Bulow R, Selonke M, Volzke H, Grotegerd D, Dannlowski U, Arolt V, Opel N, Heindel W, Kugel H, Hoehn D, Czisch M, Couvy-Duchesne B, Renteria ME, Strike LT, Wright MJ, Mills NT, de Zubicaray GI, McMahon KL, Medland SE, Martin NG, Gillespie NA, Goya-Maldonado R, Gruber O, Kramer B, Hatton SN, Lagopoulos J, Hickie IB, Frodl T, Carballedo A, Frey EM, van Velzen LS, Penninx B, van Tol MJ, van der Wee NJ, Davey CG, Harrison BJ, Mwangi B, Cao B, Soares JC, Veer IM, Walter H, Schoepf D, Zurowski B, Konrad C, Schramm E, Normann C, Schnell K, Sacchet MD, Gotlib IH, MacQueen GM, Godlewska BR, Nickson T, McIntosh AM, Papmeyer M, Whalley HC, Hall J, Sussmann JE, Li M, Walter M, Aftanas L, Brack I, Bokhan NA, Thompson PM, Veltman DJ (2017) Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group. Mol Psychiatry 22(6):900–909. https://doi.org/10.1038/mp.2016.60 CrossRefPubMed

Schmitt JE, Neale MC, Fassassi B, Perez J, Lenroot RK, Wells EM, Giedd JN (2014) The dynamic role of genetics on cortical patterning during childhood and adolescence. Proc Natl Acad Sci USA 111(18):6774–6779. https://doi.org/10.1073/pnas.1311630111 CrossRefPubMedPubMedCentral

Thompson PM, Dutton RA, Hayashi KM, Lu A, Lee SE, Lee JY, Lopez OL, Aizenstein HJ, Toga AW, Becker JT (2006) 3D mapping of ventricular and corpus callosum abnormalities in HIV/AIDS. Neuroimage 31(1):12–23. https://doi.org/10.1016/j.neuroimage.2005.11.043 CrossRefPubMed

Thompson PM, Andreassen OA, Arias-Vasquez A, Bearden CE, Boedhoe PS, Brouwer RM, Buckner RL, Buitelaar JK, Bulayeva KB, Cannon DM, Cohen RA, Conrod PJ, Dale AM, Deary IJ, Dennis EL, de Reus MA, Desrivieres S, Dima D, Donohoe G, Fisher SE, Fouche JP, Francks C, Frangou S, Franke B, Ganjgahi H, Garavan H, Glahn DC, Grabe HJ, Guadalupe T, Gutman BA, Hashimoto R, Hibar DP, Holland D, Hoogman M, Pol HEH, Hosten N, Jahanshad N, Kelly S, Kochunov P, Kremen WS, Lee PH, Mackey S, Martin NG, Mazoyer B, McDonald C, Medland SE, Morey RA, Nichols TE, Paus T, Pausova Z, Schmaal L, Schumann G, Shen L, Sisodiya SM, Smit DJA, Smoller JW, Stein DJ, Stein JL, Toro R, Turner JA, van den Heuvel MP, van den Heuvel OL, van Erp TGM, van Rooij D, Veltman DJ, Walter H, Wang Y, Wardlaw JM, Whelan CD, Wright MJ, Ye J, Consortium E (2017) ENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide. Neuroimage 145(Pt B):389–408. https://doi.org/10.1016/j.neuroimage.2015.11.057 CrossRefPubMed

van Erp TG, Hibar DP, Rasmussen JM, Glahn DC, Pearlson GD, Andreassen OA, Agartz I, Westlye LT, Haukvik UK, Dale AM, Melle I, Hartberg CB, Gruber O, Kraemer B, Zilles D, Donohoe G, Kelly S, McDonald C, Morris DW, Cannon DM, Corvin A, Machielsen MW, Koenders L, de Haan L, Veltman DJ, Satterthwaite TD, Wolf DH, Gur RC, Gur RE, Potkin SG, Mathalon DH, Mueller BA, Preda A, Macciardi F, Ehrlich S, Walton E, Hass J, Calhoun VD, Bockholt HJ, Sponheim SR, Shoemaker JM, van Haren NE, Hulshoff Pol HE, Ophoff RA, Kahn RS, Roiz-Santianez R, Crespo-Facorro B, Wang L, Alpert KI, Jonsson EG, Dimitrova R, Bois C, Whalley HC, McIntosh AM, Lawrie SM, Hashimoto R, Thompson PM, Turner JA (2016) Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium. Mol Psychiatry 21(4):547–553. https://doi.org/10.1038/mp.2015.63 CrossRefPubMed

Van Essen DC, Ugurbil K, Auerbach E, Barch D, Behrens TE, Bucholz R, Chang A, Chen L, Corbetta M, Curtiss SW, Della Penna S, Feinberg D, Glasser MF, Harel N, Heath AC, Larson-Prior L, Marcus D, Michalareas G, Moeller S, Oostenveld R, Petersen SE, Prior F, Schlaggar BL, Smith SM, Snyder AZ, Xu J, Yacoub E, Consortium WU-MH (2012) The Human Connectome Project: a data acquisition perspective. Neuroimage 62(4):2222–2231. https://doi.org/10.1016/j.neuroimage.2012.02.018 CrossRefPubMed

Van Essen DC, Smith SM, Barch DM, Behrens TE, Yacoub E, Ugurbil K, Consortium WU-MH (2013) The WU-Minn Human Connectome Project: an overview. Neuroimage 80:62–79. https://doi.org/10.1016/j.neuroimage.2013.05.041 CrossRefPubMed

Waddington CH (1942) Canalization of development and the inheritance of acquired characters. Nature 150(3811):563–565. https://doi.org/10.1038/150563a0 CrossRef

Wagner DR, Heyward VH (2000) Measures of body composition in blacks and whites: a comparative review. Am J Clin Nutr 71(6):1392–1402. https://doi.org/10.1093/ajcn/71.6.1392 CrossRefPubMed

Wen W, Thalamuthu A, Mather KA, Zhu W, Jiang J, de Micheaux PL, Wright MJ, Ames D, Sachdev PS (2016) Distinct genetic influences on cortical and subcortical brain structures. Sci Rep 6:32760. https://doi.org/10.1038/srep32760 CrossRefPubMedPubMedCentral

Whelan CD, Hibar DP, van Velzen LS, Zannas AS, Carrillo-Roa T, McMahon K, Prasad G, Kelly S, Faskowitz J, deZubiracay G, Iglesias JE, van Erp TGM, Frodl T, Martin NG, Wright MJ, Jahanshad N, Schmaal L, Samann PG, Thompson PM, Alzheimer’s Disease Neuroimaging I (2016) Heritability and reliability of automatically segmented human hippocampal formation subregions. Neuroimage 128:125–137. https://doi.org/10.1016/j.neuroimage.2015.12.039 CrossRefPubMed

Winkler AM, Kochunov P, Blangero J, Almasy L, Zilles K, Fox PT, Duggirala R, Glahn DC (2010) Cortical thickness or grey matter volume? The importance of selecting the phenotype for imaging genetics studies. Neuroimage 53(3):1135–1146. https://doi.org/10.1016/j.neuroimage.2009.12.028 CrossRefPubMed

Woodley Of Menie MA, Fernandes HBF, Hopkins WD (2015) The more g-loaded, the more heritable, evolvable, and phenotypically variable: homology with humans in chimpanzee cognitive abilities. Intelligence 50:159–163. https://doi.org/10.1016/j.intell.2015.04.002 CrossRefPubMedPubMedCentral

Titel: Absolute and relative estimates of genetic and environmental variance in brain structure volumes
verfasst von: Lachlan T. Strike
Narelle K. Hansell
Paul M. Thompson
Greig I. de Zubicaray
Katie L. McMahon
Brendan P. Zietsch
Margaret J. Wright
Publikationsdatum: 19.08.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Brain Structure and Function / Ausgabe 8/2019
Print ISSN: 1863-2653
Elektronische ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-019-01931-8

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Neurologie

Schützt Olivenöl vor dem Tod durch Demenz?

10.05.2024 Morbus Alzheimer Nachrichten

Konsumieren Menschen täglich 7 Gramm Olivenöl, ist ihr Risiko, an einer Demenz zu sterben, um mehr als ein Vierten reduziert – und dies weitgehend unabhängig von ihrer sonstigen Ernährung. Dafür sprechen Auswertungen zweier großer US-Studien.

Bluttest erkennt Parkinson schon zehn Jahre vor der Diagnose

10.05.2024 Parkinson-Krankheit Nachrichten

Ein Bluttest kann abnorm aggregiertes Alpha-Synuclein bei einigen Menschen schon zehn Jahre vor Beginn der motorischen Parkinsonsymptome nachweisen. Mit einem solchen Test lassen sich möglicherweise Prodromalstadien erfassen und die Betroffenen früher behandeln.

Darf man die Behandlung eines Neonazis ablehnen?

08.05.2024 Gesellschaft Nachrichten

In einer Leseranfrage in der Zeitschrift Journal of the American Academy of Dermatology möchte ein anonymer Dermatologe bzw. eine anonyme Dermatologin wissen, ob er oder sie einen Patienten behandeln muss, der eine rassistische Tätowierung trägt.

Wartezeit nicht kürzer, aber Arbeit flexibler

Psychotherapie Medizin aktuell

Fünf Jahren nach der Neugestaltung der Psychotherapie-Richtlinie wurden jetzt die Effekte der vorgenommenen Änderungen ausgewertet. Das Hauptziel der Novellierung war eine kürzere Wartezeit auf Therapieplätze. Dieses Ziel wurde nicht erreicht, es gab jedoch positive Auswirkungen auf andere Bereiche.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Klimawandel und Gesundheit: Was Sie in der Hausarztpraxis wissen müssen und tun können

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 8/2019

Impact of COMT haplotypes on functional connectivity density and its association with the gene expression of dopamine receptors

The expression of DARPP-32 in adult male zebra finches (Taenopygia guttata)

Imaging the pituitary in psychopathologies: a review of in vivo magnetic resonance imaging studies

Acute and long-term treadmill running differentially induce c-Fos expression in region- and time-dependent manners in mouse brain

Functional neuroanatomy of the human eye movement network: a review and atlas