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01.12.2005

Activatory Properties of Lysophosphatidic Acid on Human THP-1 Cells

verfasst von: F. D’Aquilio, M. Procaccini, V. Izzi, V. Chiurchiu’, V. Giambra, F. Carotenuto, P. Di Nardo, P. M. Baldini

Erschienen in: Inflammation | Ausgabe 4-6/2005

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Abstract

Excessive leukocyte proliferation and proinflammatory mediators release represent common phenomena in several chronic inflammatory diseases. Multiple evidences identify lysophosphatidic acid (LPA), a small lipid endowed with pleiotropic activities, as an important modulator of both proliferation and activation of different cell types involved in several inflammation-associated pathologies. However, its possible role on monocyte proinflammatory activation is not fully understood yet. Aim of the present study was to investigate LPA effects on THP-1 cells in terms of proliferation, reactive oxygen intermediates (ROI) production and release of arachidonic acid-derived inflammatory mediators. Actually, LPA significantly increased both DNA synthesis and ROI production as well as prostaglandin E₂ release and the upregulation of LPA₃ receptor expression. These findings identified LPA as both a growth factor and a triggering mediator of proinflammatory response in THP-1 cells.

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Titel: Activatory Properties of Lysophosphatidic Acid on Human THP-1 Cells
verfasst von: F. D’Aquilio
M. Procaccini
V. Izzi
V. Chiurchiu’
V. Giambra
F. Carotenuto
P. Di Nardo
P. M. Baldini
Publikationsdatum: 01.12.2005
Verlag: Kluwer Academic Publishers-Plenum Publishers
Erschienen in: Inflammation / Ausgabe 4-6/2005
Print ISSN: 0360-3997
Elektronische ISSN: 1573-2576
DOI: https://doi.org/10.1007/s10753-006-9008-9

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