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Pediatric Nephrology
Erschienen in: Pediatric Nephrology 9/2022

30.11.2021 | Educational Review

Acute kidney injury in pediatrics: an overview focusing on pathophysiology

verfasst von: Ana Flávia Lima Ruas, Gabriel Malheiros Lébeis, Nicholas Bianco de Castro, Vitória Andrade Palmeira, Larissa Braga Costa, Katharina Lanza, Ana Cristina Simões e Silva

Erschienen in: Pediatric Nephrology | Ausgabe 9/2022

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Abstract

Acute kidney injury (AKI) is defined as an abrupt decline in glomerular filtration rate, with increased serum creatinine and nitrogenous waste products due to several possible etiologies. Incidence in the pediatric population is estimated to be 3.9 per 1,000 hospitalizations, and prevalence among children admitted to intensive care units is 26.9%. Despite being a condition with important incidence and morbimortality, further evidence on pathophysiology and management among the pediatric population is still lacking. This narrative review aimed to summarize and discuss current data on AKI pathophysiology in the pediatric population, considering all the physiological particularities of this age range and common etiologies. Additionally, we reported current diagnostic tools, novel biomarkers, and newly proposed medications that have been studied with the aim of early diagnosis and appropriate treatment of AKI in the future.
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Metadaten
Titel
Acute kidney injury in pediatrics: an overview focusing on pathophysiology
verfasst von
Ana Flávia Lima Ruas
Gabriel Malheiros Lébeis
Nicholas Bianco de Castro
Vitória Andrade Palmeira
Larissa Braga Costa
Katharina Lanza
Ana Cristina Simões e Silva
Publikationsdatum
30.11.2021
Verlag
Springer Berlin Heidelberg
Erschienen in
Pediatric Nephrology / Ausgabe 9/2022
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-021-05346-8

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