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Journal of Natural Medicines

Erschienen in:

01.04.2016 | Original Paper

Acylated neo-clerodane type diterpenoids from the aerial parts of Scutellaria coleifolia Levl. (Lamiaceae)

verfasst von: Shin-ichiro Kurimoto, Jian-Xin Pu, Han-Dong Sun, Hirofumi Shibata, Yoshihisa Takaishi, Yoshiki Kashiwada

Erschienen in: Journal of Natural Medicines | Ausgabe 2/2016

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Abstract

Twenty new neo-clerodane type diterpenoids, scutefolides G₁-S (1–20), were isolated from the 70 % aqueous acetone extract of the aerial parts of Scutellaria coleifolia. Their structures were elucidated by extensive spectroscopic analyses. The absolute configurations of 1, 2, 7, 8, 14 and 15 were determined by means of the CD exciton chirality method. Compounds 1, 2, 5, 7, 8, 12, 14, 15, 18 and 19 were evaluated for their cytotoxic activities against four human cancer cell lines, and anti-bacterial activities against methicillin-resistant Staphylococcus aureus.

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Titel: Acylated neo-clerodane type diterpenoids from the aerial parts of Scutellaria coleifolia Levl. (Lamiaceae)
verfasst von: Shin-ichiro Kurimoto
Jian-Xin Pu
Han-Dong Sun
Hirofumi Shibata
Yoshihisa Takaishi
Yoshiki Kashiwada
Publikationsdatum: 01.04.2016
Verlag: Springer Japan
Erschienen in: Journal of Natural Medicines / Ausgabe 2/2016
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-016-0967-3

Springer Medizin

Abstract

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