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Erschienen in: Herz 6/2013

01.09.2013 | Schwerpunkt

Adipositas und kardiale Kachexie bei chronischer Herzinsuffizienz

verfasst von: M. Clauser, Dr. J. Altenberger

Erschienen in: Herz | Ausgabe 6/2013

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Zusammenfassung

Sowohl das Phänomen „obesity paradox“ als auch insbesondere die kardiale Kachexie bei Herzinsuffizienz sind bis heute Gegenstand intensiver Forschung hinsichtlich zugrunde liegender Pathomechanismen und möglicher Therapieansätze. Die Adipositas ist ein etablierter Risikofaktor in der Entwicklung kardiovaskulärer Erkrankungen und ist mit einer erhöhten Mortalität assoziiert. Im Gegensatz dazu scheint Übergewicht bei herzinsuffizienten Patienten im Vergleich zu Normalgewichtigen mit einem Überlebensvorteil einherzugehen – ein Phänomen, welches auch als „obesity paradox“ bekannt ist. In den letzten Jahren ist die Kachexie als Komorbidität chronischer Erkrankungen wie Herzinsuffizienz, COPD, Karzinomen oder Niereninsuffizienz in den Fokus wissenschaftlichen Interesses gerückt. Da Kachexie mit einer deutlich ungünstigeren Prognose assoziiert ist, sind eine frühe Diagnose und gut wirksame Behandlungskonzepte von enormer Wichtigkeit. Ziel dieses Reviews ist es, einen aktuellen Überblick über die Pathomechanismen und erfolgversprechende Behandlungsmöglichkeiten zu geben.
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Metadaten
Titel
Adipositas und kardiale Kachexie bei chronischer Herzinsuffizienz
verfasst von
M. Clauser
Dr. J. Altenberger
Publikationsdatum
01.09.2013
Verlag
Urban & Vogel
Erschienen in
Herz / Ausgabe 6/2013
Print ISSN: 0340-9937
Elektronische ISSN: 1615-6692
DOI
https://doi.org/10.1007/s00059-013-3885-0

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