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International Journal of Behavioral Medicine

Erschienen in:

09.02.2022 | Full length manuscript

Adiposity and Smoking Mediate the Relationship Between Depression History and Inflammation Among Young Adults

verfasst von: Xiao Yang, Rhobert W. Evans, Charles J. George, Karen A. Matthews, Maria Kovacs

Erschienen in: International Journal of Behavioral Medicine | Ausgabe 6/2022

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Abstract

Background

Depression is associated with inflammation, but the mechanisms underlying this association are unclear. We examined adiposity and smoking as potential pathways through which childhood depression may lead to an elevated inflammatory status among young adults.

Methods

The sample included 294 subjects with histories of depression (probands), 270 never-depressed siblings of probands (high-risk siblings), and 169 controls. C-reactive protein (CRP), interleukin-6 (IL-6), and soluble intercellular adhesion molecule-1 (sICAM-1) were assessed in serum samples. An adiposity score was computed from body mass index and waist circumference. Smoking behavior was evaluated during an interview. Mixed-effects models were used to test whether adiposity and smoking mediate the relationship between depression and inflammation.

Results

Probands (p = .004), but not siblings (p = .071), had higher levels of sICAM-1 compared to controls. However, depression history and risk status had no direct effects on CRP (ps > .13) or IL-6 (ps > .16). Importantly, adiposity indirectly mediated the effect of group (probands vs. controls; siblings vs. controls) on all three inflammatory markers. Smoking indirectly mediated the effect of group (probands vs. controls; siblings vs. controls) on sICAM-1 only.

Conclusions

Among young adults, the adverse inflammatory consequences of depression history are significant for sICAM-1. Adiposity and smoking are pathways through which depression can indirectly impact several inflammatory markers, suggesting possible preventive interventions to improve the immunologic and cardiovascular health of depression-prone individuals.

Howren M, Lamkin D, Suls J. Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis. Psychosom Med. 2009;71:171–86.PubMed

Kiecolt-Glaser J, Derry H, Fagundes C. Inflammation: depression fans the flames and feasts on the heat. Am J Psychiatry. 2015;172:1075–91.PubMedPubMedCentral

Serhan CN, Ward PA, Gilroy DW. Fundamentals of inflammation. Cambridge: Cambridge University Press; 2010.

Elovainio M, Keltikangas-Järvinen L, Pulkki-Råback L, Kivimäki M, Puttonen S, Viikari L, Räsänen L, Mansikkaniemi K, Viikari J, Raitakari O. Depressive symptoms and C-reactive protein: the cardiovascular risk in Young Finns study. Psychol Med. 2006;36:797–805.PubMed

Ford D, Erlinger T. Depression and C-reactive protein in US adults: data from the Third National Health and Nutrition Examination Survey. Arch Intern Med. 2004;164:1010–4.PubMed

Copeland W, Shanahan L, Worthman C, Angold A, Costello E. Cumulative depression episodes predict later C-reactive protein levels: a prospective analysis. Biol Psychiatry. 2012;71:15–21.PubMed

Deverts D, Cohen S, DiLillo V, Lewis C, Kiefe C, Whooley M, Matthews K. Depressive symptoms, race, and circulating C-reactive protein: the Coronary Artery Risk Development in Young Adults (CARDIA) study. Psychosom Med. 2010;72:734–41.PubMedPubMedCentral

Matthews K, Schott L, Bromberger J, Cyranowski J, Everson-Rose S, Sowers M. Are there bi-directional associations between depressive symptoms and C-reactive protein in mid-life women? Brain Behav Immun. 2010;24:96–101.PubMed

Motivala S, Sarfatti A, Olmos L, Irwin M. Inflammatory markers and sleep disturbance in major depression. Psychosom Med. 2005;67:187–94.PubMed

10.

O’Brien S, Scully P, Fitzgerald P, Scott L, Dinan T. Plasma cytokine profiles in depressed patients who fail to respond to selective serotonin reuptake inhibitor therapy. Psychiatry Res. 2007;41:326–31.

11.

Yang K, Xie G, Zhang Z, Wang C, Li W, Zhou W, Tang Y. Levels of serum interleukin (IL)-6, IL-1β, tumour necrosis factor-α and leptin and their correlation in depression. Aust N Z J Psychiatry. 2007;41:266–73.PubMed

12.

Miller G, Cole S. Clustering of depression and inflammation in adolescents previously exposed to childhood adversity. Biol Psychiatry. 2012;72:34–40.PubMedPubMedCentral

13.

Ng A, Tam WW, Zhang MW, Ho CS, Husain SF, McIntyre RS, Ho RC. IL-1β, IL-6, TNF-α and CRP in elderly patients with depression or Alzheimer’s disease: systematic review and meta-analysis. Sci Rep. 2018;8:1–12.

14.

Schnoor M, Alcaide P, Voisin M, van Buul J. Crossing the vascular wall: common and unique mechanisms exploited by different leukocyte subsets during extravasation. Mediators Inflamm. 2015;2015:946509.PubMedPubMedCentral

15.

Jones DP, True HD, Patel J. Leukocyte trafficking in cardiovascular disease: insights from experimental models. Mediators Inflamm. 2017;2017:9746169.PubMedPubMedCentral

16.

Müller N. The role of intercellular adhesion molecule-1 in the pathogenesis of psychiatric disorders. Front Pharmacol. 2019;10:1–9.

17.

van Agtmaal M, Houben A, Pouwer F, Stehouwer C, Schram MT. Association of microvascular dysfunction with late-life depression: a systematic review and meta-analysis. JAMA Psychiat. 2017;74:729–39.

18.

Miller G, Freedland K, Carney R, Stetler C, Banks W. Pathways linking depression, adiposity, and inflammatory markers in healthy young adults. Brain Behav Immun. 2003;17:276–85.PubMed

19.

Chaiton M, Cohen J, O’Loughlin J, Rehm J. A systematic review of longitudinal studies on the association between depression and smoking in adolescents. BMC Public Health. 2009;9:356–66.PubMedPubMedCentral

20.

Luppino F, de Wit L, Bouvy P, Stijnen T, Cuijpers P, Penninx B, Zitman F. Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies. Arch Gen Psychiatry. 2010;67:220–9.PubMed

21.

Rocha V, Libby P. Obesity, inflammation, and atherosclerosis. Nat Rev Cardiol. 2009;6:399–409.PubMed

22.

Thakore JH, Richards PJ, Reznek RH, Martin A, Dinan TG. Increased intra-abdominal fat deposition in patients with major depressive illness as measured by computed tomography. Biol Psychiatry. 1997;41:1140–2.PubMed

23.

Jequier E. Leptin signaling, adiposity, and energy balance. Ann N Y Acad Sci. 2002;967:379–88.PubMed

24.

Strzelak A, Ratajczak A, Adamiec A, Feleszko W. Tobacco smoke induces and alters immune responses in the lung triggering inflammation, allergy, asthma and other lung diseases: a mechanistic review. Int J Environ Res Public Health. 2018;15:1033–67.PubMedPubMedCentral

25.

Lee J, Taneja V, Vassallo R. Cigarette smoking and inflammation: cellular and molecular mechanisms. J Dent Res. 2012;91:142–9.PubMedPubMedCentral

26.

Fontes J, Yamamoto J, Larson M, Wang N, Dallmeier D, Rienstra M, Schnabel R, Vasan R, Keaney J Jr, Benjamin E. Clinical correlates of change in inflammatory biomarkers: the Framingham Heart Study. Atherosclerosis. 2013;228:217–23.PubMedPubMedCentral

27.

Rottenberg J, Yaroslavsky I, Carney R, Freedland K, George C, Baji I, Dochnal R, Gádoros J, Halas K, Kapornai K, Kiss E. The association between major depressive disorder in childhood and risk factors for cardiovascular disease in adolescence. Psychosom Med. 2014;76:122–7.PubMedPubMedCentral

28.

Liechty J, Lee M. Longitudinal predictors of dieting and disordered eating among young adults in the US. Int J Eat Disord. 2013;46:790–800.PubMed

29.

Matthews K, Jennings J, Lee L, Pardini D. Depressive symptoms during childhood and cardiovascular risk factors in black and white men. Psychosom Med. 2019;81:176–83.PubMedPubMedCentral

30.

McKenzie M, Olsson C, Jorm A, Romaniuk H, Patton G. Association of adolescent symptoms of depression and anxiety with daily smoking and nicotine dependence in young adulthood: findings from a 10-year longitudinal study. Addiction. 2010;105:1652–9.PubMed

31.

Ehrlich K, Chen E, Yu T, Miller G, Brody G. Exposure to parental depression in adolescence and risk for metabolic syndrome in adulthood. Child Dev. 2019;90:1272–85.PubMed

32.

Farmer A, Harris T, Redman K, Sadler S, Mahmood A, McGuffin P. Cardiff Depression Study: a sib-pair study of life events and family in major depression. Br J Psychiatry. 2000;176:150–5.PubMed

33.

Ryan N, Williamson D, Iyengar S, Orvaschel H, Reich T, Dahl R, Puig-Antich J. A secular increase in child and adolescent onset affective disorder. J Am Acad Child Adolesc Psychiatry. 1992;31:600–5.PubMed

34.

Goldstein B, Carnethon M, Matthews K, McIntyre R, Miller G, Raghuveer G, Stoney C, Wasiak H, McCrindle B. Major depressive disorder and bipolar disorder predispose youth to accelerated atherosclerosis and early cardiovascular disease: a scientific statement from the American Heart Association. Circulation. 2015;132:965–86.PubMed

35.

Nicholson A, Kuper H, Hemingway H. Depression as an aetiologic and prognostic factor in coronary heart disease: a meta-analysis of 6362 events among 146 538 participants in 54 observational studies. Eur Heart J. 2006;27:2763–74.PubMed

36.

Lowe GD. The relationship between infection, inflammation, and cardiovascular disease: an overview. Ann Periodontol. 2001;6:1–8.PubMed

37.

Berg A, Scherer P. Adipose tissue, inflammation, and cardiovascular disease. Circ Res. 2005;96:939–49.PubMed

38.

Lopez-Candales A, Burgos P, Hernandez-Suarez D, Harris D. Linking chronic inflammation with cardiovascular disease: from normal aging to the metabolic syndrome. J Nat Sci. 2017;3:e341–62.PubMedPubMedCentral

39.

Pearson T, Mensah G, Alexander R, Anderson J, Cannon R III, Criqui M, Fadl Y, Fortmann S, Hong Y, Myers G, Rifai N. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation. 2003;107:499–511.PubMed

40.

Gooding HC, Gidding SS, Moran AE, Redmond N, Allen NB, Bacha F, Burns TL, Catov JM, Grandner MA, Harris KM, Johnson HM, Kiernan M, Lewis TT, Matthews KA, Monaghan M, Robinson JG, Tate T, Bibbins-Domingo K, Spring G. Challenges and opportunities for the prevention and treatment of cardiovascular disease among young adults: report from a National Heart, Lung, and Blood Institute working group. JAHA. 2020;9:1–20.

41.

Lloyd-Jones DM, Hon GY, Labarthe D, Mozaffarian D, Appel LJ, Van Horm L, Greenlund K, Daniels S, Nichol G, Tomaselli GH, et al. Defining and setting national goals for cardiovascular health promotion and disease reduction: The American Heart Association’s strategic impact goals through 2020 and beyond. Circulation. 2010;121:586–613.PubMed

42.

Galobardes B, Lynch JW, Smith GD. Is the association between childhood socioeconomic circumstances and cause-specific mortality established? Update of a systematic review. J Epidemiol Community Health. 2008;62:387–90.PubMed

43.

Gidding SS, Fana JS, Predergast C, McGill H, Carr JJ, Liu K, Colangelo LA, Loria CM, Lima J, Terry JG, et al. Pathobiological determinants of atherosclerosis in youth (PDAY) risk score in young adults predicts coronary artery and abdominal aorta calcium in middle age: the CARIDA study. Circulation. 2016;133:130–46.

44.

McMahan CA, Gidding SS, Vikari JSA, Juonala M, Kahonen M, Hutri-Kahonean J, Jokinen E, Taittonen L, Pietikainen M, McGill HC, et al. Association of pathobiological determinants of atherosclerosis in youth risk score and 15-year change in risk score with carotid artery intima-media thickness in young adults (from the Cardiovascular Risk in Young Finns Study). Am J Cardiol. 2007;100:1124–9.PubMedPubMedCentral

45.

Korczak DJ, Lipman E, Morrison K. Szatmari P Are children and adolescents with psychiatric illness at risk for increased future body weight? A systematic review. Dev Med Child Neurol. 2013;55:980–7.PubMed

46.

Cundiff JM, Matthews KA. Friends with health benefits: the long-term benefits of early peer social integration for blood pressure and obesity in midlife. Psychol Sci. 2018;29:814–23.PubMedPubMedCentral

47.

Danese A, Moffitt TE, Harrington H, Milner BJ, Polanczyk G, Pariante CM, Poulton R, Caspi A. Adverse childhood experiences and adult risk factors for age-related disease. Arch Pediatr Adolesc Med. 2009;163:1135–43.PubMedPubMedCentral

48.

Yang YC, Boen C, Gerken K, Li T, Schorpp K. Harris KM Social relationships and physiological determinants of longevity across the human life span. Proc Natl Acad Sci USA. 2016;113:578–83.PubMedPubMedCentral

49.

Jakubowski KP, Cundiff JM, Matthews KA. Cumulative childhood adversity and adult cardiometabolic disease: A meta-analysis. Health Psychol. 2018;37:701–15.PubMedPubMedCentral

50.

American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed. Washington, DC: Author; 2000.

51.

Kiss E, Gentzler A, George C, Kapornai K, Tamás Z, Kovacs M, Vetró Á. Factors influencing mother–child reports of depressive symptoms and agreement among clinically referred depressed youngsters in Hungary. J Affect Disord. 2007;100:143–51.PubMed

52.

Tamás Z, Kovacs M, Gentzler A, Tepper P, Gádoros J, Kiss E, Kapornai K, Vetró Á. The relations of temperament and emotion self-regulation with suicidal behaviors in a clinical sample of depressed children in Hungary. J Abnorm Child Psychol. 2007;35:640–52.PubMed

53.

Maziade M, Roy M, Fournier J, Cliche D, Merette C, Caron C, Garneau Y, Montgrain N, Shriqui C, Dion C, Nicole L, Potvin A, Lavallée J, Pires A, Raymond V. Reliability of best-estimate diagnosis in genetic linkage studies of major psychoses: results from the Quebec pedigree studies. Am J Psychiatry. 1992;149:1674–86.PubMed

54.

Barinas-Mitchell E, Yang X, Matthews KA, Columbus ML, George CJ, Dósa E, Kiss E, Kapornai K, Evans R, Kovacs M. Childhood-onset depression and arterial stiffness in young adulthood. J Psychosom Res. 2021;148:110551. https://doi.org/10.1016/j.jpsychores.2021.110551.

55.

Sherrill J, Kovacs M. Interview schedule for children and adolescents (ISCA). J Am Acad Child Adolesc Psychiatry. 2000;39:67–75.PubMed

56.

National Institutes of Health, National Heart, Lung, and Blood Institute Obesity Education Initiative Expert Panel. Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults. NOE Initiative, 1998;6:51S–209S.

57.

Iseki K, Tozawa M, Yoshi S, Fukiyama K. Serum C-reactive protein (CRP) and risk of death in chronic dialysis patients. Nephrol Dial Transplant. 1999;14:1956–60.PubMed

58.

Sanada F, Taniyama Y, Muratsu J, Otsu R, Shimizu H, Rakugi H, Morishita R. Source of chronic inflammation in aging. Front Cardiovasc Med. 2018;5:113–7.

59.

Lawes S, Demakakos P, Steptoe A, Lewis G, Carvalho LA. Combined influence of depressive symptoms and systemic inflammation on all-cause and cardiovascular mortality: evidence for differential effects by gender in the English Longitudinal Study of Ageing. Psychol Med. 2019;49:1521–31.PubMed

60.

Smaardijk VR, Maas AH, Lodder P, Kop WJ, Mommersteeg PM. Sex and gender-stratified risks of psychological factors for adverse clinical outcomes in patients with ischemic heart disease: A systematic review and meta-analysis. Int J Cardiol. 2020;302:21–9.PubMed

61.

Ahonen T, Kautiainen H, Keinänen-Kiukaanniemi S, Kumpusalo E, Vanhala M. Gender difference among smoking, adiponectin, and high-sensitivity C-reactive protein. Am J Prev Med. 2008;35:598–601.PubMed

62.

Thorand B, Baumert J, Döring A, Herder C, Kolb H, Rathmann W, Giani G, Koenig W, KORA Group. Sex differences in the relation of body composition to markers of inflammation. Atherosclerosis. 2006;184:216–24.

63.

Hayes A, Rockwood N. Regression-based statistical mediation and moderation analysis in clinical research: observations, recommendations, and implementation. Behav Cogn Psychother. 2017;98:39–57.

64.

Tofighi D, MacKinnon D, Yoon M. Covariances between regression coefficient estimates in a single mediator model. Br J Math Stat Psychol. 2009;62:457–84.PubMed

65.

Baron RM, Kenny DA. The moderator–mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. J Pers Soc Psychol. 1986;51:1173–82.PubMed

66.

Takeuchi O, Sato S, Horiuchi T, Hoshino K, Takeda K, Dong Z, Modlin R, Akira S. Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J Immunol. 2002;169:10–4.PubMed

67.

Ellulu MS, Patimah I, Khaza’ai H, Rahmat A, Abed Y. Obesity and inflammation: the linking mechanism and the complications. Arch Med Sci. 2017;13:851–63.PubMed

68.

Mohamed-Ali V, Goodrick S, Rawesh A, Katz DR, Miles JM, Yudkin JS, Klein S, Coppack SW. Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-α, in vivo. J Clin Endocrinol Metab. 1997;82:4196–200.PubMed

69.

Yudkin JS, Kumari M, Humphries SE, Mohamed-Ali V. Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link? Atherosclerosis. 2000;2000(148):209–14.

70.

Di Gregorio GB, Yao-Borengasser A, Rasouli N, Varma V, Lu T, Miles LM, Ranganathan G, Peterson CA, McGehee RE, Kern PA. Expression of CD68 and macrophage chemoattractant protein-1 genes in human adipose and muscle tissues: association with cytokine expression, insulin resistance, and reduction by pioglitazone. Diabetes. 2005;2005(54):2305–13.

71.

Guzik TJ, Mangalat D, Korbut R. Adipocytokines novel link between inflammation. J Physiol Pharmacol. 2006;2006(4):505–28.

72.

Valkanova V, Ebmeier K, Allan C. CRP, IL-6 and depression: a systematic review and meta-analysis of longitudinal studies. J Affect Disord. 2013;150:736–44.PubMed

73.

Gokulakrishnan K, Ranjani H, Weber MB, Pandey GK, Anjana RM, Balasubramanyam M, Prabhakaran D, Tandon N, Narayan KM, Mohan V. Effect of lifestyle improvement program on the biomarkers of adiposity, inflammation and gut hormones in overweight/obese Asian Indians with prediabetes. Acta Diabetol. 2017;54:843–52.PubMed

74.

Wannamethee SG, Lowe GD, Shaper AG, Rumley A, Lennon L, Whincup PH. Associations between cigarette smoking, pipe/cigar smoking, and smoking cessation, and haemostatic and inflammatory markers for cardiovascular disease. Eur Heart J. 2005;26:1765–73.PubMed

Titel: Adiposity and Smoking Mediate the Relationship Between Depression History and Inflammation Among Young Adults
verfasst von: Xiao Yang
Rhobert W. Evans
Charles J. George
Karen A. Matthews
Maria Kovacs
Publikationsdatum: 09.02.2022
Verlag: Springer US
Erschienen in: International Journal of Behavioral Medicine / Ausgabe 6/2022
Print ISSN: 1070-5503
Elektronische ISSN: 1532-7558
DOI: https://doi.org/10.1007/s12529-022-10060-2

Springer Medizin

Abstract

Background

Methods

Results

Conclusions

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