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12.10.2020 | Review Article

Advances in intervention methods and brain protection mechanisms of in situ and remote ischemic postconditioning

verfasst von: Chun-Yan Li, Wei Ma, Kuang-Pin Liu, Jin-Wei Yang, Xian-Bin Wang, Zhen Wu, Tong Zhang, Jia-Wei Wang, Wei Liu, Jie Liu, Yu Liang, Xing-Kui Zhang, Jun-Jun Li, Jian-Hui Guo, Li-Yan Li

Erschienen in: Metabolic Brain Disease | Ausgabe 1/2021

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Abstract

Ischemic postconditioning (PostC) conventionally refers to a series of brief blood vessel occlusions and reperfusions, which can induce an endogenous neuroprotective effect and reduce cerebral ischemia/reperfusion (I/R) injury. Depending on the site of adaptive ischemic intervention, PostC can be classified as in situ ischemic postconditioning (ISPostC) and remote ischemic postconditioning (RIPostC). Many studies have shown that ISPostC and RIPostC can reduce cerebral IS injury through protective mechanisms that increase cerebral blood flow after reperfusion, decrease antioxidant stress and anti-neuronal apoptosis, reduce brain edema, and regulate autophagy as well as Akt, MAPK, PKC, and KATP channel cell signaling pathways. However, few studies have compared the intervention methods, protective mechanisms, and cell signaling pathways of ISPostC and RIPostC interventions. Thus, in this article, we compare the history, common intervention methods, neuroprotective mechanisms, and cell signaling pathways of ISPostC and RIPostC.

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Titel: Advances in intervention methods and brain protection mechanisms of in situ and remote ischemic postconditioning
verfasst von: Chun-Yan Li
Wei Ma
Kuang-Pin Liu
Jin-Wei Yang
Xian-Bin Wang
Zhen Wu
Tong Zhang
Jia-Wei Wang
Wei Liu
Jie Liu
Yu Liang
Xing-Kui Zhang
Jun-Jun Li
Jian-Hui Guo
Li-Yan Li
Publikationsdatum: 12.10.2020
Verlag: Springer US
Erschienen in: Metabolic Brain Disease / Ausgabe 1/2021
Print ISSN: 0885-7490
Elektronische ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-020-00562-x

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Advances in intervention methods and brain protection mechanisms of in situ and remote ischemic postconditioning

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