nach oben

Archives of Gynecology and Obstetrics

Erschienen in:

01.03.2011 | Materno-Fetal Medicine

Adverse pregnancy outcomes and long-term morbidity after early fetal hypokinesia in maternal smoking pregnancies

verfasst von: Dubravko Habek, Melita Kovačević

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 3/2011

Einloggen, um Zugang zu erhalten

Abstract

Aim

The aim of this study is to evaluate perinatal outcome and subsequent morbidity and neurodevelopment in 10-year-old children with fetal hypokinesia intrauterinely verified by ultrasonography in early pregnancy as a pattern of abnormal fetal behavior due to maternal chronic smoking. This study revealed significant global fetal hypokinesia as well as head and arm hypokinesia in early pregnancy in mothers’ chronic smokers (group 3—more than 20 cigarettes a day).

Materials and methods

This retrospective study was performed in mothers and their 10-year-old children included in the study of the effect of cigarette smoking on fetal movements in early pregnancy. Perinatal outcome was assessed according to maternal data, course, and outcome of pregnancy and delivery. Data on the long-term (10 years) development and morbidity from infancy during childhood until age 10 years were obtained from the children’s medical histories and medical rehabilitation records, maternal, and paternal histories. The psycholinguistic development was estimated.

Results

In group 3, there was a poor overall perinatal outcome and high rate of the bronchoconstrictive syndrome and recurrent infections, while one case of the sudden infant death syndrome. Poor school performance was recorded in five children, attention-deficit/hyperactivity disorder in four, and autism, dystonia syndrome, social maladaptation, and minimally cerebral disfunction in one child each. Retarded psycholinguistic development was found in seven children, only three of them attending speech therapy (P < 0.05).

Conclusion

Fetal hypokinesia in early pregnancy related with maternal smoking was found to correlate with poor perinatal outcome, subsequent morbidity, and developmental impairments in 10-year-old children born to mothers smoking more than 20 cigarettes a day.

Kurz H, Frischer T, Huber WD, Gotz M (1994) Adverse health effects in children caused by passive smoking. Wien Med Wochenschr 144:531–534PubMed

Habek D, Čerkez Habek J, Ivanišević M, Đelmiš J (2002) Fetal tobacco syndrome and perinatal outcome. Fetal Diagn Ther 17:367–371CrossRefPubMed

Wertelecki W, Hoff C, Zansky S (1987) Maternal smoking: greater effect on males, fetal tobacco syndrome. Teratology 35:317–320CrossRefPubMed

Boog G (2004) Obstetrical complications and subsequent schizophrenia in adolescent and young adult offsprings: is there a relationship ? Eur J Obstet Gynecol Reprod Biol 114:130–136CrossRefPubMed

Habek D, Živko M, Kulaš T, Selthofer R (2005) Sudden infant death syndrome and perinatal risk. J Perinat Med 33(S1):261

Buka SL, Shenassa ED, Niaura R (2003) Elevated risk of tobacco dependence among offspring of mothers who smoked during pregnancy: a 30 year prospective study. Am J Psychiatry 160:1978–1984CrossRefPubMed

Kandel DB, Wu P, Davies M (1994) Maternal smoking during pregnancy and smoking by adolescent daughters. Am J Public Health 84:1407–1413CrossRefPubMed

Habek D (1998) Effect of smoking on fetoplacental unit. Liječ Vjesn 120:215–219PubMed

Fergusson DM, Horwood LJ, Lynskey MT (1993) Maternal smoking before and after pregnancy: effects on behavioral outcomes in mildlechildhood. Pediatrics 92:815–822PubMed

10.

Glover V, O’Connor TG, Heron J, Golding J (2004) Antenatal maternal anxiety is linked with atypical handedness in the child. Early Hum Dev 79:107–118CrossRefPubMed

11.

Barker DJ (1999) The long-term outcome of retarded fetal growth. Schweiz Med Wochenschr 129:189–196PubMed

12.

Habek D (1996) Effects of smoking for the fetal dynamics in early pregnancy. Master thesis. School of Medicine, University of Zagreb

13.

Spinillo A, Ommetto A, Stronati M, Piazzi G, Iasci A, Rondini G (1995) Epidemiologic association between maternal smoking during pregnancy and intracranial hemorrhage in preterm infants. J Pediatr 127:472–478CrossRefPubMed

14.

Abdul-Khaliq H, Segerer H, Luck W, Obladen M (1993) Increased cerebral blood flow velocities in newborn infants of smoking mothers. Eur J Pediatr 152:232–235CrossRefPubMed

15.

de la Grandmaison GL, Dorandeu A, Carton M, Patey A, Durigon M (1999) Increase of pulmonary density of macrophages in sudden infant death syndrome. Forensic Sci Int 104:179–187CrossRef

16.

Friedd PA, Watkinson B (2001) Differential effects on facets of attention in adolescents prenatally exposed to cigarettes and marihuana. Neurotoxicol Teratol 23:421–430CrossRef

17.

Storm H, Nylander G, Saugstad OD (1999) The amount of brainstem gliosis in sudden infant death syndrome victims correlates with maternal cigarette smoking during pregnancy. Acta Paediatr 1:13–18

18.

Schellscheidt J, Oyen N, Jorch G (1997) Interactions between maternal smoking and other prenatal risk factors for sudden infant death syndrome (SIDS). Acta Paediatr 86:857–863CrossRefPubMed

19.

Slotkin TA (1998) Fetal nicotine or cocaine exposure—which one is worse. J Pharm Exp Ther 285:931–945

20.

Tolcos M, McGregor H, Walker D, Rees S (2000) Chronic prenatal exposure to carbon monoxyde results in a reduction in tyrosine hydroxylase-immunoreactivity and an increase in choline acetyltransferase-immunoreactivity in the fetal medulla: implications for sudden infant death syndrome. J Neuropathol Exp Neurol 59:218–228PubMed

21.

Porath AJ, Fried PA (2005) Effects of prenatal cigarette and marijuana exposure on drug use among offspring. Neurotoxicol Teratol 27:267–277CrossRefPubMed

22.

Park MK, Loughlin SF, Leslie FM (2006) Gestational nicotine-induced changes in adolescent neuronal activity. Brain Res 1094(1):119–126

23.

Thapar A, Fowler T, Rice F, Scourfield J, van den Bree M, Thomas H, Hay HD (2003) Maternal smoking during pregnancy and attention deficit hyperactivity disorder symptom in offspring. Am J Psych 160:1985–1989CrossRef

24.

DiPietro JA, Hilton SC, Hawkins M, Costigan KA, Pressman EK (2002) Maternal stress and affect influence fetal neurobehavioral development. Dev Psychol 38:659–668CrossRefPubMed

25.

Roseboom TJ, van der Meulen JH, Osmond C, Barker DJ, Eavelli AC, Bleker OP (2001) Adult survival after prenatal exposure to the Dutch famine 1944–1945. Paediatr Perinat Epidemiol 15:220–225CrossRefPubMed

26.

Wahlbeck K, Forsen T, Osmond C, Barker DJ, Eriksson JG (2001) Association of schizophrenia with low maternal body mass index, small size at birth, and thinnes during childhood. Arch Gen Psychiatry 58:48–52CrossRefPubMed

27.

Syddall HE, Aihie Sayer A, Simmonds SJ, Osmond C, Cox V, Dennison EM, Barker DJP, Cooper C (2005) Birth weight, infant weight gain, and cause-specific mortality. Am J Epidemiol 161:1074–1080CrossRefPubMed

28.

Cnattingius S, Hultman CM, Dahl M, Sparen P (1999) Very preterm birth, birth trauma, and the risk of anorexia nervosa among girls. Arch Gen Psychiatry 56:634–638CrossRefPubMed

29.

Hultman CM, Sparen P, Cnattingius S (2002) Perinatal risk factors for infantile autism. Epidemiology 13:417–423CrossRefPubMed

30.

Jakobovits AA (2001) Fetal ethology and its relevance to perinatal medicine. Zentralbl Gynakol 123:375–382CrossRefPubMed

31.

Alati R, Al Mamun A, O’Callaghan M, Najman JM, Williams GM (2006) In utero and postnatal maternal smoking and asthma in adolescence. Epidemiology 17:138–144CrossRefPubMed

32.

Franco P, Groswasser J, Hassid S, Lanquart JP, Scaillet S, Kahn A (1999) Prenatal exposure to cigarette smoking is associated with a decrease in arousal in infants. J Pediatr 135:34–38CrossRefPubMed

33.

Olds DL, Henderson CR Jr, Tatelbaum R (1994) Intellectual impairment in children of women who smoke cigarettes during pregnancy. Pediatrics 93:221–227PubMed

Titel: Adverse pregnancy outcomes and long-term morbidity after early fetal hypokinesia in maternal smoking pregnancies
verfasst von: Dubravko Habek
Melita Kovačević
Publikationsdatum: 01.03.2011
Verlag: Springer-Verlag
Erschienen in: Archives of Gynecology and Obstetrics / Ausgabe 3/2011
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-010-1395-3

Update Gynäkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.

Newsletter bestellen

Springer Medizin

Adverse pregnancy outcomes and long-term morbidity after early fetal hypokinesia in maternal smoking pregnancies

Abstract