Skip to main content
Erschienen in: Journal of Neurology 11/2006

01.11.2006

Age-related psychomotor slowing as an important component of verbal fluency

Evidence from healthy individuals and Alzheimer’s patients

verfasst von: Claudia Rodríguez-Aranda, Knut Waterloo, Sigurd Sparr, Kjetil Sundet

Erschienen in: Journal of Neurology | Ausgabe 11/2006

Einloggen, um Zugang zu erhalten

Abstract

Generalized psychomotor slowing is a characteristic of normal aging, and there is evidence suggesting that this feature is also central in dementia. The present article aims to evaluate the importance of psychomotor slowing as a factor underlying changes in the performance of verbal fluency tasks in normal and pathological aging. In study 1 reading and handwriting speed were used to predict performance on written and oral verbal fluency tasks (VFTs) in healthy elderly subjects (n = 20) and in patients of the Alzheimer type disease (n = 20). In study 2, spectrographic techniques were used to obtain reaction times, average of voice intensity and duration of single word production in young individuals (n = 20), healthy elderly subjects (n = 20), and in patients of the Alzheimer type disease (n = 7). Additionally, duration of single word production were also obtained. The results suggest that age-related psychomotor decline in word production speed is an important determinant of VFT.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Zurück zum Zitat Baken RJ, Orlikoff RF (2000) Clinical measurement of speech and voice. Singular Thompson Learning, San Diego Baken RJ, Orlikoff RF (2000) Clinical measurement of speech and voice. Singular Thompson Learning, San Diego
2.
Zurück zum Zitat Barnes DE, Tager IB, Satariano WA, Yaffe K (2004) The relationship between literacy and cognition in well-educated elders. Journal of Gerontology: Medical Sciences 59A:390–395 Barnes DE, Tager IB, Satariano WA, Yaffe K (2004) The relationship between literacy and cognition in well-educated elders. Journal of Gerontology: Medical Sciences 59A:390–395
3.
Zurück zum Zitat Bayles KA, Tomoeda CK (1983) Confrontation naming impairment in dementia. Brain Language 19:98–114CrossRef Bayles KA, Tomoeda CK (1983) Confrontation naming impairment in dementia. Brain Language 19:98–114CrossRef
4.
Zurück zum Zitat Beck AT, Erbaugh J, Ward Ch, Mock J, Mendelsohn M (1961) An inventory for measuring depression. Arch Gen Psychiatry 4:561PubMed Beck AT, Erbaugh J, Ward Ch, Mock J, Mendelsohn M (1961) An inventory for measuring depression. Arch Gen Psychiatry 4:561PubMed
5.
Zurück zum Zitat Benson DF (1979) Neurologic correlates of anomia. In: Whitaker H, Whitaker HA (eds) Studies in neurolinguistics. Academic Press, New York, pp 293–328 Benson DF (1979) Neurologic correlates of anomia. In: Whitaker H, Whitaker HA (eds) Studies in neurolinguistics. Academic Press, New York, pp 293–328
6.
Zurück zum Zitat Benton AL (1967) Problems of test construction in the field of aphasia. Cortex 3:32–58 Benton AL (1967) Problems of test construction in the field of aphasia. Cortex 3:32–58
7.
Zurück zum Zitat Binetti G, Magni E, Padovani A, Cappa SF, Bianchetti A, Trabucchi M (1996) Executive dysfunction in early Alzheimer’s disease. J Neurol Neurosurg psychiatry 60:91–93PubMed Binetti G, Magni E, Padovani A, Cappa SF, Bianchetti A, Trabucchi M (1996) Executive dysfunction in early Alzheimer’s disease. J Neurol Neurosurg psychiatry 60:91–93PubMed
8.
Zurück zum Zitat Birren JE (1965) Age changes in speed of behavior: its central nature and physiological correlates. In: Welford AT, Birren JE (eds) Behavior, aging, and the nervous system. Thomas, Springfield: IL, pp 191–216 Birren JE (1965) Age changes in speed of behavior: its central nature and physiological correlates. In: Welford AT, Birren JE (eds) Behavior, aging, and the nervous system. Thomas, Springfield: IL, pp 191–216
9.
Zurück zum Zitat Broverman DM (1960) Cognitive style and intra-individual variation in abilities. J Personality 28:240–256CrossRefPubMed Broverman DM (1960) Cognitive style and intra-individual variation in abilities. J Personality 28:240–256CrossRefPubMed
10.
Zurück zum Zitat Bryan J, Luszcz MA (2000) Measurement of executive function: considerations for detecting adult age differences. J Clin Exp Neuropsychol 22:40–55PubMed Bryan J, Luszcz MA (2000) Measurement of executive function: considerations for detecting adult age differences. J Clin Exp Neuropsychol 22:40–55PubMed
11.
Zurück zum Zitat Chan AS, Salmon DP, DeLaPena J (1999) Conceptual and perceptual contributions to the acquisition and retention of text-specific reading skill in Alzheimer’s disease. J ClinExp Neuropsychol 21:325–340 Chan AS, Salmon DP, DeLaPena J (1999) Conceptual and perceptual contributions to the acquisition and retention of text-specific reading skill in Alzheimer’s disease. J ClinExp Neuropsychol 21:325–340
12.
Zurück zum Zitat Colombo L, Fonti C, Cappa S (2004) The impact of lexical-semantic impairment and executive dysfunction on the word reading performance of patients with probable Alzheimer dementia. Neuropsychologia 42:1192–1202CrossRefPubMed Colombo L, Fonti C, Cappa S (2004) The impact of lexical-semantic impairment and executive dysfunction on the word reading performance of patients with probable Alzheimer dementia. Neuropsychologia 42:1192–1202CrossRefPubMed
13.
14.
Zurück zum Zitat Croisile B (1999) Agraphia in Alzheimer’s disease. Dementia and geriatric cognitive disorders 10:226–230CrossRefPubMed Croisile B (1999) Agraphia in Alzheimer’s disease. Dementia and geriatric cognitive disorders 10:226–230CrossRefPubMed
15.
Zurück zum Zitat Croot K, Hodges JR, Xuereb J, Patterson K (2000) Phonological and articulatory impairment in Alzheimer’s disease: A case series. Brain Language 75:277–309CrossRef Croot K, Hodges JR, Xuereb J, Patterson K (2000) Phonological and articulatory impairment in Alzheimer’s disease: A case series. Brain Language 75:277–309CrossRef
16.
Zurück zum Zitat Crossley M, D’Arcy C, Rawson NSB (1997) Letter and category fluency in community-dwelling Canadian seniors: a comparison of normal participants to those with dementia of the Alzheimer or vascular type. J Clini Exp Neuropsychol 19:52–62 Crossley M, D’Arcy C, Rawson NSB (1997) Letter and category fluency in community-dwelling Canadian seniors: a comparison of normal participants to those with dementia of the Alzheimer or vascular type. J Clini Exp Neuropsychol 19:52–62
17.
Zurück zum Zitat Cummings JL, Houlihan JP, Hill MA (1986) The pattern of reading deterioration in dementia of the Alzheimer type: Observations and implications. Brain Language 29:315–323CrossRef Cummings JL, Houlihan JP, Hill MA (1986) The pattern of reading deterioration in dementia of the Alzheimer type: Observations and implications. Brain Language 29:315–323CrossRef
18.
Zurück zum Zitat Davis GA (1984) Effects of aging on normal language. In: Holland A (eds), Language disorders in adults. College-Hill Press, San Diego, California, pp 79–111 Davis GA (1984) Effects of aging on normal language. In: Holland A (eds), Language disorders in adults. College-Hill Press, San Diego, California, pp 79–111
19.
Zurück zum Zitat Diesfeldt HFA (1985) Verbal fluency in senile dementia: An analysis of search and knowledge. Arch GerontolGeriatr 4:231–239CrossRef Diesfeldt HFA (1985) Verbal fluency in senile dementia: An analysis of search and knowledge. Arch GerontolGeriatr 4:231–239CrossRef
20.
Zurück zum Zitat Ericsson K, Forssell LG, Holmen K, Viitanen M, Winblad B (1996) Copying and handwriting ability in the screening of cognitive dysfunction in old age. pp 103–121 Ericsson K, Forssell LG, Holmen K, Viitanen M, Winblad B (1996) Copying and handwriting ability in the screening of cognitive dysfunction in old age. pp 103–121
21.
Zurück zum Zitat Folstein MF, Folstein SF, McHugh PR (1975) Mini Mental State: a practical method for grading the cognitive state of patients for the clinician. J Psychiatric Res 12:189–198CrossRef Folstein MF, Folstein SF, McHugh PR (1975) Mini Mental State: a practical method for grading the cognitive state of patients for the clinician. J Psychiatric Res 12:189–198CrossRef
22.
Zurück zum Zitat Gilmore GC, Groth KE, Thomas CW (2005) Stimulus contrast and word reading speed in Alzheimer’s disease. Expl Aging Res 31:15–33CrossRef Gilmore GC, Groth KE, Thomas CW (2005) Stimulus contrast and word reading speed in Alzheimer’s disease. Expl Aging Res 31:15–33CrossRef
23.
Zurück zum Zitat Golden CJ (1978) Stroop color and word test. A manual for clinical and experimental uses. Stoelting, Wood Dale, IL Golden CJ (1978) Stroop color and word test. A manual for clinical and experimental uses. Stoelting, Wood Dale, IL
24.
Zurück zum Zitat Graham N, (2000) Dysgraphia in dementia. Neurocase 6:365–376 Graham N, (2000) Dysgraphia in dementia. Neurocase 6:365–376
25.
Zurück zum Zitat Hart S, Smith CM, Swash M (1998) Word fluency in patients with early dementia of Alzheimer type. Br J Clin Psychol 27:115–124 Hart S, Smith CM, Swash M (1998) Word fluency in patients with early dementia of Alzheimer type. Br J Clin Psychol 27:115–124
26.
Zurück zum Zitat Helmes E, Østbye T (2002) Beyond memory impairment. Cognitive changes in Alzheimer’s disease. Arch Clinl Neuropsychol 17:179–193CrossRef Helmes E, Østbye T (2002) Beyond memory impairment. Cognitive changes in Alzheimer’s disease. Arch Clinl Neuropsychol 17:179–193CrossRef
27.
Zurück zum Zitat Heun R, Papassotiropoulos A, Jennssen F (1998) The validity of psychometric instruments for detection of dementia in the elderly general population. Intl J GeriatrPsychiatry 13:368–380 Heun R, Papassotiropoulos A, Jennssen F (1998) The validity of psychometric instruments for detection of dementia in the elderly general population. Intl J GeriatrPsychiatry 13:368–380
28.
Zurück zum Zitat Hodge FS, Colton RH, Kelley RT (2001) Vocal intensity characteristics in normal and elderly speakers. J Voice 15:503–511CrossRefPubMed Hodge FS, Colton RH, Kelley RT (2001) Vocal intensity characteristics in normal and elderly speakers. J Voice 15:503–511CrossRefPubMed
29.
Zurück zum Zitat Kozora E, Munro Cullum C (1995) Generative naming in normal aging: Total output and qualitative changes using phonemic and semantic constraints. Clin Neuropsychologist 9:313–320 Kozora E, Munro Cullum C (1995) Generative naming in normal aging: Total output and qualitative changes using phonemic and semantic constraints. Clin Neuropsychologist 9:313–320
30.
Zurück zum Zitat MacDonald CJ, Meck WH (2004) Systems-level integration of interval timing and reaction time. Neurosci Biobehav Rev 28:747–769CrossRefPubMed MacDonald CJ, Meck WH (2004) Systems-level integration of interval timing and reaction time. Neurosci Biobehav Rev 28:747–769CrossRefPubMed
31.
Zurück zum Zitat Madden DJ (2001) Speed and timing of behavioral processes. In: Birren JE, Schaie KW (eds) Handbook of the psychology of aging. Academic Press, San Diego, pp 288–312 Madden DJ (2001) Speed and timing of behavioral processes. In: Birren JE, Schaie KW (eds) Handbook of the psychology of aging. Academic Press, San Diego, pp 288–312
32.
Zurück zum Zitat Madden DJ, Nebes RD, Allen PA (1992) Cognitive slowing in Alzheimer’s disease as a function of task type and response type. Dev Neuropsychol 8:459–471CrossRef Madden DJ, Nebes RD, Allen PA (1992) Cognitive slowing in Alzheimer’s disease as a function of task type and response type. Dev Neuropsychol 8:459–471CrossRef
33.
Zurück zum Zitat Martin A, Fedio P (1983) Word production and comprehension in Alzheimer’s disease: the breakdown of semantic knowledge. BrainLanguage 19:124–141 Martin A, Fedio P (1983) Word production and comprehension in Alzheimer’s disease: the breakdown of semantic knowledge. BrainLanguage 19:124–141
34.
Zurück zum Zitat Matute E, Rosselli M, Ardila A, Morales G (2004) Verbal and nonverbal fluency in Spanish-speaking children. Dev Neuropsychol 26:647–660CrossRefPubMed Matute E, Rosselli M, Ardila A, Morales G (2004) Verbal and nonverbal fluency in Spanish-speaking children. Dev Neuropsychol 26:647–660CrossRefPubMed
35.
Zurück zum Zitat Monsch AU, Bondi MW, Butters N, Salmon DP, Katzman R, Thal LJ (1992) Comparisons of verbal fluency tasks in the detection of dementia of the Alzheimer type. Arch Neurol 49:1253–1258PubMed Monsch AU, Bondi MW, Butters N, Salmon DP, Katzman R, Thal LJ (1992) Comparisons of verbal fluency tasks in the detection of dementia of the Alzheimer type. Arch Neurol 49:1253–1258PubMed
36.
Zurück zum Zitat Murdoch BE, Chenery HJ, Wilks V, Boyle RS (1987) Language disorders in dementia of the Alzheimer type. Brain Language 31:122–137CrossRef Murdoch BE, Chenery HJ, Wilks V, Boyle RS (1987) Language disorders in dementia of the Alzheimer type. Brain Language 31:122–137CrossRef
37.
Zurück zum Zitat Myerson J, Lawrence B, Hale S, Jenkins L, Chen J (1998) General slowing of lexical and nonlexical information processing in dementia of the Alzheimer’s type. Aging, Neuropsychol Cogn 5:182–193CrossRef Myerson J, Lawrence B, Hale S, Jenkins L, Chen J (1998) General slowing of lexical and nonlexical information processing in dementia of the Alzheimer’s type. Aging, Neuropsychol Cogn 5:182–193CrossRef
38.
Zurück zum Zitat Oyer HJ, Deal LV (1985) Temporal aspects of speech and aging process. Folia Phoniatrica 37:109–112PubMed Oyer HJ, Deal LV (1985) Temporal aspects of speech and aging process. Folia Phoniatrica 37:109–112PubMed
39.
Zurück zum Zitat Parasuraman R, Martin A (1994) Cognition in Alzheimer’s disease: Disorders of attention and semantic knowledge. Curr Opin Neurobiol 4:237–244CrossRefPubMed Parasuraman R, Martin A (1994) Cognition in Alzheimer’s disease: Disorders of attention and semantic knowledge. Curr Opin Neurobiol 4:237–244CrossRefPubMed
40.
Zurück zum Zitat Pasquier F, Lebert F, Grymonprez L, Petit H (1995) Verbal fluency in dementia of frontal lobe type and dementia of Alzheimer type. J Neurol, neurosurgery and psychiatry 58:81–84CrossRef Pasquier F, Lebert F, Grymonprez L, Petit H (1995) Verbal fluency in dementia of frontal lobe type and dementia of Alzheimer type. J Neurol, neurosurgery and psychiatry 58:81–84CrossRef
42.
Zurück zum Zitat Ratcliff G, Ganguli M, Chandra V, Sharma S, Belle S, Seaberg E, Pandav R (1998) Effects of literacy and eductaion on measures of word fluency. Brain Language 61:115–122CrossRef Ratcliff G, Ganguli M, Chandra V, Sharma S, Belle S, Seaberg E, Pandav R (1998) Effects of literacy and eductaion on measures of word fluency. Brain Language 61:115–122CrossRef
43.
Zurück zum Zitat Robbins J, Levine R, Wood J, Roecker EB, Luschei E (1995) Age effects on lingual pressure generation as a risk factor for dysphagia. J Gerontol Biol Sci 50A:M257–M262 Robbins J, Levine R, Wood J, Roecker EB, Luschei E (1995) Age effects on lingual pressure generation as a risk factor for dysphagia. J Gerontol Biol Sci 50A:M257–M262
44.
Zurück zum Zitat Rodríguez-Aranda C (2003) Reduced writing and reading speed and age-related changes in verbal fluency tasks. Clin Neuropsychologist 17:203–215 Rodríguez-Aranda C (2003) Reduced writing and reading speed and age-related changes in verbal fluency tasks. Clin Neuropsychologist 17:203–215
45.
Zurück zum Zitat Rosen WG (1980) Verbal fluency in aging and dementia. J Clin Neuropsychol 2:135–146 Rosen WG (1980) Verbal fluency in aging and dementia. J Clin Neuropsychol 2:135–146
46.
Zurück zum Zitat Sailor K, Antoine M, Diaz M, Kuslansky G, Kluger A (2004) The effects of Alzheimer’s disease on item output in verbal fluency tasks. Neuropsychology 18:306–314CrossRefPubMed Sailor K, Antoine M, Diaz M, Kuslansky G, Kluger A (2004) The effects of Alzheimer’s disease on item output in verbal fluency tasks. Neuropsychology 18:306–314CrossRefPubMed
47.
Zurück zum Zitat Salmon DP, Butters N, Chan AS (1999) The deterioration of semantic memory in Alzheimer’s disease. CanJ Exp Psychol 53:108–116 Salmon DP, Butters N, Chan AS (1999) The deterioration of semantic memory in Alzheimer’s disease. CanJ Exp Psychol 53:108–116
48.
Zurück zum Zitat Schröter A, Mergl R, Bürger K, Hampel H, Möller HJ, Hegerl U (2003) Kinematic analysis of handwriting movements in patients with Alzheimer’s disease, mild cognitive impairment, depression and healthy subjects. Dementia Geri Cogn d Disord 15:132–142CrossRef Schröter A, Mergl R, Bürger K, Hampel H, Möller HJ, Hegerl U (2003) Kinematic analysis of handwriting movements in patients with Alzheimer’s disease, mild cognitive impairment, depression and healthy subjects. Dementia Geri Cogn d Disord 15:132–142CrossRef
49.
Zurück zum Zitat Storandt M, Beaudreau S (2004) Do reaction time measures enhance diagnosis of early-stage dementia of the Alzheimer type. Arch Clinical Neuropsych 19:119–124CrossRef Storandt M, Beaudreau S (2004) Do reaction time measures enhance diagnosis of early-stage dementia of the Alzheimer type. Arch Clinical Neuropsych 19:119–124CrossRef
50.
Zurück zum Zitat Stuart-Hamilton I (1994) The psychology of ageing. An introduction. Jessica Kingsley Publishers, London Stuart-Hamilton I (1994) The psychology of ageing. An introduction. Jessica Kingsley Publishers, London
51.
Zurück zum Zitat Tabachnick BG, Fidell LS (2001) Using multivariate statistics. Allyn and Bacon, Boston Tabachnick BG, Fidell LS (2001) Using multivariate statistics. Allyn and Bacon, Boston
52.
Zurück zum Zitat Thurstone LL (1938) Primary mental abilities. University Chicago Press, Chicago Thurstone LL (1938) Primary mental abilities. University Chicago Press, Chicago
53.
Zurück zum Zitat Tomer R, Levin BE (1993) Differential effects of aging on two verbal fluency tasks. Percept Motor Skills 76:465–466PubMed Tomer R, Levin BE (1993) Differential effects of aging on two verbal fluency tasks. Percept Motor Skills 76:465–466PubMed
54.
Zurück zum Zitat Wechsler D, (1981) Manual for the Wechsler Adult intelligence Scale-Revised. Psychological Corporation, New York Wechsler D, (1981) Manual for the Wechsler Adult intelligence Scale-Revised. Psychological Corporation, New York
55.
Zurück zum Zitat Winer BJ, Brown DR, Michels KM (1991) Statistical principles in experimental design. McGraw-Hill, New York Winer BJ, Brown DR, Michels KM (1991) Statistical principles in experimental design. McGraw-Hill, New York
56.
Zurück zum Zitat Woodruff-Pak DS, (1997) The neuropsychology of aging. Blackwell, Oxford Woodruff-Pak DS, (1997) The neuropsychology of aging. Blackwell, Oxford
Metadaten
Titel
Age-related psychomotor slowing as an important component of verbal fluency
Evidence from healthy individuals and Alzheimer’s patients
verfasst von
Claudia Rodríguez-Aranda
Knut Waterloo
Sigurd Sparr
Kjetil Sundet
Publikationsdatum
01.11.2006
Erschienen in
Journal of Neurology / Ausgabe 11/2006
Print ISSN: 0340-5354
Elektronische ISSN: 1432-1459
DOI
https://doi.org/10.1007/s00415-006-0225-9

Weitere Artikel der Ausgabe 11/2006

Journal of Neurology 11/2006 Zur Ausgabe

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Akuter Schwindel: Wann lohnt sich eine MRT?

28.04.2024 Schwindel Nachrichten

Akuter Schwindel stellt oft eine diagnostische Herausforderung dar. Wie nützlich dabei eine MRT ist, hat eine Studie aus Finnland untersucht. Immerhin einer von sechs Patienten wurde mit akutem ischämischem Schlaganfall diagnostiziert.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Frühe Alzheimertherapie lohnt sich

25.04.2024 AAN-Jahrestagung 2024 Nachrichten

Ist die Tau-Last noch gering, scheint der Vorteil von Lecanemab besonders groß zu sein. Und beginnen Erkrankte verzögert mit der Behandlung, erreichen sie nicht mehr die kognitive Leistung wie bei einem früheren Start. Darauf deuten neue Analysen der Phase-3-Studie Clarity AD.

Viel Bewegung in der Parkinsonforschung

25.04.2024 Parkinson-Krankheit Nachrichten

Neue arznei- und zellbasierte Ansätze, Frühdiagnose mit Bewegungssensoren, Rückenmarkstimulation gegen Gehblockaden – in der Parkinsonforschung tut sich einiges. Auf dem Deutschen Parkinsonkongress ging es auch viel um technische Innovationen.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.