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01.05.2007 | Original Paper

Alcohol intake and breast cancer risk: the European Prospective Investigation into Cancer and Nutrition (EPIC)

verfasst von: Anne Tjønneland, Jane Christensen, Anja Olsen, Connie Stripp, Birthe L. Thomsen, Kim Overvad, Petra H. M. Peeters, Carla H. van Gils, H. Bas Bueno-de-Mesquita, Marga C. Ocké, Anne Thiebaut, Agnès Fournier, Françoise Clavel-Chapelon, Franco Berrino, Domenico Palli, Rosario Tumino, Salvatore Panico, Paolo Vineis, Antonio Agudo, Eva Ardanaz, Carmen Martinez-Garcia, Pilar Amiano, Carmen Navarro, José R. Quirós, Tim J. Key, Gillian Reeves, Kay-Tee Khaw, Sheila Bingham, Antonia Trichopoulou, Dimitrios Trichopoulos, Androniki Naska, Gabriele Nagel, Jenny Chang-Claude, Heiner Boeing, Petra H. Lahmann, Jonas Manjer, Elisabet Wirfält, Göran Hallmans, Ingegerd Johansson, Eiliv Lund, Guri Skeie, Anette Hjartåker, Pietro Ferrari, Nadia Slimani, Rudolf Kaaks, Elio Riboli

Erschienen in: Cancer Causes & Control | Ausgabe 4/2007

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Abstract

Objective

Most epidemiologic studies have suggested an increased risk of breast cancer with increasing alcohol intake. Using data from 274,688 women participating in the European Prospective Investigation into Cancer and Nutrition study (EPIC), we investigated the relation between alcohol intake and the risk of breast cancer.

Methods

Incidence rate ratios (IRRs) based on Cox proportional hazard models were calculated using reported intake of alcohol, recent (at baseline) and lifetime exposure. We adjusted for known risk factors and stratified according to study center as well as potentially modifying host factors.

Results

During 6.4 years of follow up, 4,285 invasive cases of breast cancer within the age group 35–75 years were identified. For all countries together the IRR per 10 g/day higher recent alcohol intake (continuous) was 1.03 (95% confidence interval (CI): 1.01–1.05). When adjusted, no association was seen between lifetime alcohol intake and risk of breast cancer. No difference in risk was shown between users and non-users of HRT, and there was no significant interaction between alcohol intake and BMI, HRT or dietary folate.

Conclusion

This large European study supports previous findings that recent alcohol intake increases the risk of breast cancer.

Cancer Incidence in Five Continents No. 155 (2002) IARC Scientific Publication. Lyon

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Titel: Alcohol intake and breast cancer risk: the European Prospective Investigation into Cancer and Nutrition (EPIC)
verfasst von: Anne Tjønneland
Jane Christensen
Anja Olsen
Connie Stripp
Birthe L. Thomsen
Kim Overvad
Petra H. M. Peeters
Carla H. van Gils
H. Bas Bueno-de-Mesquita
Marga C. Ocké
Anne Thiebaut
Agnès Fournier
Françoise Clavel-Chapelon
Franco Berrino
Domenico Palli
Rosario Tumino
Salvatore Panico
Paolo Vineis
Antonio Agudo
Eva Ardanaz
Carmen Martinez-Garcia
Pilar Amiano
Carmen Navarro
José R. Quirós
Tim J. Key
Gillian Reeves
Kay-Tee Khaw
Sheila Bingham
Antonia Trichopoulou
Dimitrios Trichopoulos
Androniki Naska
Gabriele Nagel
Jenny Chang-Claude
Heiner Boeing
Petra H. Lahmann
Jonas Manjer
Elisabet Wirfält
Göran Hallmans
Ingegerd Johansson
Eiliv Lund
Guri Skeie
Anette Hjartåker
Pietro Ferrari
Nadia Slimani
Rudolf Kaaks
Elio Riboli
Publikationsdatum: 01.05.2007
Verlag: Kluwer Academic Publishers
Erschienen in: Cancer Causes & Control / Ausgabe 4/2007
Print ISSN: 0957-5243
Elektronische ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-006-0112-9

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Alcohol intake and breast cancer risk: the European Prospective Investigation into Cancer and Nutrition (EPIC)