Erschienen in:
22.05.2019 | Correspondence
ALK-positive histiocytosis with KIF5B-ALK fusion in the central nervous system
verfasst von:
Calixto-Hope G. Lucas, Ahmed Gilani, David A. Solomon, Xiayuan Liang, Ossama M. Maher, Gabriel Chamyan, Bette K. Kleinschmidt-Demasters, Arie Perry
Erschienen in:
Acta Neuropathologica
|
Ausgabe 2/2019
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Excerpt
Histiocytic disorders are uncommon and often affect multiple organ systems. They pose diagnostic challenges because of their rarity and the fact that the nosology of these lesions is still being decided. ALK-positive histiocytosis is one of the newest subtypes and was originally described about 10 years ago, wherein there was a predilection for neonates and infants with multi-organ involvement [
1]. Since then, ten additional cases have been reported, with only one having exclusive intracranial disease, along with involvement of the cavernous sinus [
2,
3]. Here, we report two additional cases with exclusive involvement of the central nervous system. …