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Journal of Mammary Gland Biology and Neoplasia

Erschienen in:

01.06.2008

Amphiregulin as a Novel Target for Breast Cancer Therapy

verfasst von: Nicole E. Willmarth, Stephen P. Ethier

Erschienen in: Journal of Mammary Gland Biology and Neoplasia | Ausgabe 2/2008

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Abstract

Amphiregulin, an EGF family growth factor, binds and activates the epidermal growth factor receptor (EGFR or ErbB1). Activation of the EGFR by amphiregulin can occur through autocrine, paracrine and juxtacrine mechanisms. Amphiregulin plays a role in several biological processes including nerve regeneration, blastocyst implantation, and bone formation. Amphiregulin also plays an important role in mammary duct formation as well as the outgrowth and branching of several other human tissues such as the lung, kidney and prostate. This effect is most likely due to the induction of genes involved in invasion and migration such as cytokines and matrix metalloproteases. Clinical studies have suggested that amphiregulin also plays a role in human breast cancer progression and its expression has been associated with aggressive disease. Therefore, amphiregulin may be a novel and effective target for the treatment of breast cancer and could represent an alternative to targeting the EGFR.

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Titel: Amphiregulin as a Novel Target for Breast Cancer Therapy
verfasst von: Nicole E. Willmarth
Stephen P. Ethier
Publikationsdatum: 01.06.2008
Verlag: Springer US
Erschienen in: Journal of Mammary Gland Biology and Neoplasia / Ausgabe 2/2008
Print ISSN: 1083-3021
Elektronische ISSN: 1573-7039
DOI: https://doi.org/10.1007/s10911-008-9081-9

Springer Medizin

Amphiregulin as a Novel Target for Breast Cancer Therapy

Abstract

Neu im Fachgebiet Onkologie

Labor, CT-Anthropometrie zeigen Risiko für Pankreaskrebs

Viel pflanzliche Nahrung, seltener Prostata-Ca.-Progression

Alter verschlechtert Prognose bei Endometriumkarzinom

Darf man die Behandlung eines Neonazis ablehnen?

Update Onkologie

Springer Medizin

Abstract

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