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01.09.2009 | Original Article

Amyloid precursor-like protein 2 association with HLA class I molecules

verfasst von: Amit Tuli, Mahak Sharma, Xiaojian Wang, Laura C. Simone, Haley L. Capek, Steven Cate, William H. Hildebrand, Naava Naslavsky, Steve Caplan, Joyce C. Solheim

Erschienen in: Cancer Immunology, Immunotherapy | Ausgabe 9/2009

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Abstract

Amyloid precursor-like protein 2 (APLP2) is a ubiquitously expressed protein. The previously demonstrated functions for APLP2 include binding to the mouse major histocompatibility complex (MHC) class I molecule H-2K^d and down regulating its cell surface expression. In this study, we have investigated the interaction of APLP2 with the human leukocyte antigen (HLA) class I molecule in human tumor cell lines. APLP2 was readily detected in pancreatic, breast, and prostate tumor lines, although it was found only in very low amounts in lymphoma cell lines. In a pancreatic tumor cell line, HLA class I was extensively co-localized with APLP2 in vesicular compartments following endocytosis of HLA class I molecules. In pancreatic, breast, and prostate tumor lines, APLP2 was bound to the HLA class I molecule. APLP2 was found to bind to HLA-A24, and more strongly to HLA-A2. Increased expression of APLP2 resulted in reduced surface expression of HLA-A2 and HLA-A24. Overall, these studies demonstrate that APLP2 binds to the HLA class I molecule, co-localizes with it in intracellular vesicles, and reduces the level of HLA class I molecule cell surface expression.

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Titel: Amyloid precursor-like protein 2 association with HLA class I molecules
verfasst von: Amit Tuli
Mahak Sharma
Xiaojian Wang
Laura C. Simone
Haley L. Capek
Steven Cate
William H. Hildebrand
Naava Naslavsky
Steve Caplan
Joyce C. Solheim
Publikationsdatum: 01.09.2009
Verlag: Springer-Verlag
Erschienen in: Cancer Immunology, Immunotherapy / Ausgabe 9/2009
Print ISSN: 0340-7004
Elektronische ISSN: 1432-0851
DOI: https://doi.org/10.1007/s00262-009-0657-z

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