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International Journal of Clinical Oncology

Erschienen in:

01.12.2015 | Original Article

Amyloidosis and the risk of cancer: a nationwide population-based study

verfasst von: Vincent Yi-Fong Su, Chia-Jen Liu, Yu-Wen Hu, Wei-Juin Su, Yuh-Min Chen, Shinn-Liang Lai, Tzeng-Ji Chen, Diahn-Warng Perng, Yu-Chin Lee, Cheng-Hwai Tzeng, Kun-Ta Chou

Erschienen in: International Journal of Clinical Oncology | Ausgabe 6/2015

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Abstract

Background

The association between amyloidosis and cancer remains unclear.

Participants and methods

Using the Taiwan National Health Insurance Research Database we conducted a population-based cohort study. Patients newly diagnosed with amyloidosis between 1997 and 2009 were enrolled. Patients with antecedent cancer were excluded. Standardized incidence ratios (SIR) of cancers were calculated for the study cohort and compared with cancer incidence among the general population. We used a multivariate Cox regression model to evaluate the predictors of cancer development for patients with amyloidosis.

Results

The study included 1,693 subjects with median follow-up of 5.63 years. A total of 68 patients developed cancer. The incidence of kidney cancer (SIR 3.42; 95 % CI 1.11–7.97; p = 0.034) and hematologic malignancies (SIR 3.88; 95 % CI 1.86–7.14; p < 0.001) were significantly higher for patients with amyloidosis.

Conclusion

This is currently the largest study to evaluate cancer risk among patients with amyloidosis. The results indicate that amyloidosis may be associated with an increased risk of kidney cancer and hematologic malignancies.

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Titel: Amyloidosis and the risk of cancer: a nationwide population-based study
verfasst von: Vincent Yi-Fong Su
Chia-Jen Liu
Yu-Wen Hu
Wei-Juin Su
Yuh-Min Chen
Shinn-Liang Lai
Tzeng-Ji Chen
Diahn-Warng Perng
Yu-Chin Lee
Cheng-Hwai Tzeng
Kun-Ta Chou
Publikationsdatum: 01.12.2015
Verlag: Springer Japan
Erschienen in: International Journal of Clinical Oncology / Ausgabe 6/2015
Print ISSN: 1341-9625
Elektronische ISSN: 1437-7772
DOI: https://doi.org/10.1007/s10147-015-0849-9

Springer Medizin

Amyloidosis and the risk of cancer: a nationwide population-based study