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Current Osteoporosis Reports
Erschienen in: Current Osteoporosis Reports 3/2015

01.06.2015 | Bone and Diabetes (AV Schwartz and P Vestergaard, Section Editors)

An Overview of the Metabolic Functions of Osteocalcin

verfasst von: Jianwen Wei, Gerard Karsenty

Erschienen in: Current Osteoporosis Reports | Ausgabe 3/2015

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Abstract

A recent unexpected development of bone biology is that bone is an endocrine organ regulating a growing number of physiological processes. One of the functions regulated by bone through the hormone osteocalcin is glucose homeostasis. In this overview, we will explain why we hypothesized that bone mass and energy metabolism should be subjected to a coordinated endocrine regulation. We will then review the experiments that revealed the endocrine function of osteocalcin and the cell biology events that allow osteocalcin to become a hormone. We will also illustrate the importance of this regulation to understand whole-body glucose homeostasis in the physiological state and in pathological conditions. Lastly, we will mention epidemiological and genetic evidence demonstrating that this function of osteocalcin is conserved in humans.
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Metadaten
Titel
An Overview of the Metabolic Functions of Osteocalcin
verfasst von
Jianwen Wei
Gerard Karsenty
Publikationsdatum
01.06.2015
Verlag
Springer US
Erschienen in
Current Osteoporosis Reports / Ausgabe 3/2015
Print ISSN: 1544-1873
Elektronische ISSN: 1544-2241
DOI
https://doi.org/10.1007/s11914-015-0267-y

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