Erschienen in:
08.09.2021 | Lessons for the Clinical Nephrologist
An unusual case of acute kidney injury in a patient with IgA paraproteinemia. Lessons for the clinical nephrologist
verfasst von:
Charles Ronsin, Christine Kandel-aznar, Yannick Le Bris, Clément Deltombe, Nicolas Blin, Simon Ville
Erschienen in:
Journal of Nephrology
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Ausgabe 2/2022
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Excerpt
A 61-year-old man was admitted to our department with severe kidney function impairment (serum creatinine 11.4 mg/dL) which was detected on routine blood tests, requested due to recent general impairment and weight loss. Renal ultrasound revealed bilateral increase in kidney size without obstruction. Further blood tests showed; hemoglobin 8.7 g/dL, platelet count 100 × 103/μL, white blood cells 5.5 × 103/µL, serum calcium 6.7 mg/dL, total proteins 9.9 g/dL. Protein electrophoresis showed a monoclonal spike, identified as an IgA kappa M-protein (4.9 g/dL; kappa light chain 5797 mg/L, ratio K/L 454). Urinary protein-to-creatinine ratio was 0.22 g/mmol. Bone marrow biopsy revealed diffuse infiltrates by monoclonal lymphoplasmacytic cells (immunophenotyping CD20 + CD5-CD10-CD23-kappa + lambda-). …