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2018 | OriginalPaper | Buchkapitel

11. Anal- und Rektumtumoren

verfasst von : Prof. Dr. Dr. h.c. P. Hermanek, Prof. Dr. med. S. Merkel, Dr. med. J. Jongen, Dr. med. A. Ommer, Dr. med. J. Baral, Msc, EMBA HSG, Prof. Dr. med. M. Adamina

Erschienen in: Chirurgische Proktologie

Verlag: Springer Berlin Heidelberg

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Zusammenfassung

Anorektale Tumoren sind nicht selten. Neben seltenen Entitäten finden sich in der klinischen Praxis in erster Linie das Analkarzinom und das Rektumkarzinom. In diesem Kapitel werden pathologische Grundlagen und Therapieoptionen vorgestellt. Während bei den benignen Erkrankungen des Rektums in der Regel minimalinvasive endokopische oder transanale Verfahren zur Anwendung kommen, ist bei den Rektumkarzinomen und Analkarzinomen meist ein gemeinsames Vorgehen von Onkologen, Strahlentherapeuten und Koloproktologen indiziert.

Bosman FT, Carneiro F, Hruban RH, Theise ND (eds) (2010) WHO Classification of Tumours of the Digestive System, 4th ed. IARC, Lyon

Boyle P (1998) Some recent developments in the epidemiology of colorectal cancer. In: Bleiberg H, Rougier P, Wilke HJ (eds) Managment of colorectal cancer. Martin Dunitz, London

Brady MS, Kavolius JP, Quan SHQ (1995) Anorectal melanoma: a 64-year experience at Memorial Sloan-Kettering Cancer Center. Dis Colon Rectum 38: 146–151

Chiao EY, Krwon SE, Stier EA, Schrag D (2005) A populations-based analysis of temporal trends in the incidence of squamous anal canal cancer in relation to the HIV epidemic. J Acquir Immun Defic Syndr 40: 451–455

Clark MA, Hartley A, Ian Geh J (2004) Cancer of the anal canal. Lancet Oncology 5: 149–157

Cummings BJ, Swallow CJ, Ajani JA (2005) Cancer of the anal region. In: De Vita jr VT, Hellman S, Rosenberg SA (eds) Cancer. Principles and practice of oncology, 7th ed. Lippincott, Williams & Wilkins, Philadelphia, pp 1125–1137

Fritz A, Percy C, Jack A, Shanmugaratnam K, Sobin L, Parkin DM, Whelan S (eds) (2000) International classification of diseases for oncology, 3rd ed. WHO, Geneva

Hermanek P, Wittekind C (1996) Präkanzeröse Bedingungen und Läsionen des Gastrointestinaltraktes. In: Hahn EG, Riemann JF (Hrsg) Klinische Gastroenterologie, 3. Aufl. Thieme, Stuttgart New York

Hermanek P (2006) Current tumour classification. In: Herold A, Lehur P-A, Matzel KE, O’Connell PR (eds) European Manual of Medicin – Coloproctology. Springer, Berlin Heidelberg New York, pp 225–233

Le Boit PE, Burg G, Weedon D, Sarasia A (eds) (2006) Pathology and genetics of skin tumours. WHO classification of tumours. IARC Press, Lyon

Merkel S, Hohenberger W, Hermanek P (2010) Intraoperative lokale Tumorzelldissemination in der Rektumkarzinomchirurgie. Einfluss von Operationsprinzipien und neoadjuvanter Therapie. Chirurgie 81: 719–927

Nagtegaal ID, van de Velde CJH, Marijnen CA, van Krieken JH, Quirke P (2005) Low rectal cancer: a call for a change of approach in abdominoperineal resection. J Clin Oncol 23: 9257–9267

Raptis D, Schneider I, Matzel KE, Ott O, Fietkau R, Hohenberger W (2015) The differential diagnosis and interdisciplinary treatment of anal carcinoma. Dtsch Arztebl Int. 112: 243–249

Sarmiento JM, Wolff BG, Burgart LJ, Frizelle FA, Ilstrup DM (1997) Perianal Bowen’s disease: associated tumors, human papillomavirus, surgery, and other controversies. Dis Colon Rectum 40: 912–918

Thomas RM, Sobin LH (1995) Gastrointestinal cancer. Cancer 75: 154–170

UICC, Wittekind C, Meyer H-J (Hrsg und Übersetzer) (2010) TNM-Klassifikation maligner Tumoren, 7. Aufl. Wiley, Weinheim

UICC, Wittekind C, Compton CC, Brierley J, Sobin LH (Hrsg) (2013) TNM-Supplement, 4.Aufl. Deutsche Übersetzung: Wittekind C. Wiley, Weinheim

UICC, Wittekind C, Asamura H, Sobin LH (Hrsg) (2015) TNM-Atlas, 6.Aufl. Deutsche Übersetzung: Wittekind C. Wiley, Weinheim

UICC, Wittekind C (Hrsg u. Übersetzer) (2017) TNM-Klassifikation maligner Tumoren, 8. Aufl. Wiley-VCH, Weinheim

Wittekind C, Compton C, Quirke P, Nagtegaal I, Merkel S, Hermanek P, Sobin LH (2009) A uniform residual tumor (R) classification: integration of the R classification and the circumferential margin status. Cancer 115: 3483–3488

Allaix ME, Arezzo A, Cassoni P, Famiglietti F, et al. (2012) Recurrence after transanal endoscopic microsurgery for large rectal adenomas. Surg Endosc 26: 2594–2600

Arezzo A, Passera R, Saito Y, Sakamoto T, et al. (2014) Systematic review and meta-analysis of endoscopic submucosal dissection versus transanal endoscopic microsurgery for large noninvasive rectal lesions. Surg Endosc 28: 427–438

Bach SP, Hill J, Monson JR, Simson JN, et al. (2009) A predictive model for local recurrence after transanal endoscopic microsurgery for rectal cancer. Br J Surg 96: 280–290

Baral JEM, Fender SK, Hanna W, Schon MR (2016) The waterjet supported submucosal transanal endoscopic microsurgical excision of giant rectal adenomas (ESD-TEM). Web Page online in the internet http://cine-med.com/index.php?id=ACS-3124 (Zugang 15.07.2016)

Barendse RM, van den Broek FJ, van Schooten J, Bemelman WA, et al. (2012) Endoscopic mucosal resection vs transanal endoscopic microsurgery for the treatment of large rectal adenomas. Colorectal Dis 14: e191–196

Buess G, Hutterer F, Theiss J, Bobel M, et al. (1984) A system for a transanal endoscopic rectum operation. Chirurg 55: 677–680

Chiniah M, Ganganah O, Cheng Y, Sah SK (2016) Transanal endoscopic microsurgery is an oncologically safe alternative to total mesorectal excision for stage I rectal cancer: results of a meta-analysis of randomized controlled trials. Int J Colorectal Dis 31: 1501–1504

Clancy C, Burke JP, Albert MR, O’Connell PR, et al. (2015) Transanal endoscopic microsurgery versus standard transanal excision for the removal of rectal neoplasms: a systematic review and meta-analysis. Dis Colon Rectum 58: 254–261

Girona J, Mölle B (2012) Therapieverfahren. In: In: Lange J, Mölle B, Girona J (Hrsg) Chirurgische Proktologie, 2. Aufl. Springer, Berlin Heidelberg

Hermanek P, Gall FP (1986) Early (microinvasive) colorectal carcinoma. Pathology, diagnosis, surgical treatment. Int J Colorectal Dis 1: 79–84

Hompes R, McDonald R, Buskens C, Lindsey I, et al. (2013) Completion surgery following transanal endoscopic microsurgery: assessment of quality and short- and long-term outcome. Colorectal Dis 15: e576–581

Knabe M, Pohl J, Gerges C, Ell C, et al. (2014) Standardized long-term follow-up after endoscopic resection of large, nonpedunculated colorectal lesions: a prospective two-center study. Am J Gastroenterol 109: 183–189

Kraske P (1887) Die sacrale Methode der Exstirpation von Mastdarmkrebsen und die Resectio recti. Berl Klin Wochenschrift 24

Kudo S, Tamegai Y, Yamano H, Imai Y, et al. (2001) Endoscopic mucosal resection of the colon: the Japanese technique. Gastrointest Endosc Clin N Am 11: 519–535

Mason AY (1976) President’s address. Rectal cancer: the spectrum of selective surgery. Proc R Soc Med 69: 237–244

Mentges B, Buess G, Schafer D, Manncke K, et al. (1996) Local therapy of rectal tumors. Dis Colon Rectum 39: 886–892

Morino M, Allaix ME, Arolfo S, Arezzo A (2013) Previous transanal endoscopic microsurgery for rectal cancer represents a risk factor for an increased abdominoperineal resection rate. Surg Endosc 27: 3315–3321

Parks AG (1968) A technique for excising extensive villous papillomatous change in the lower rectum. Proc R Soc Med 61: 441–442

Pohl H, Srivastava A, Bensen SP, Anderson P, et al. (2013) Incomplete polyp resection during colonoscopy-results of the complete adenoma resection (CARE) study. Gastroenterology 144: 74–80 e1

Pox C, Aretz S, Bischoff C, Graeven U, et al. (2014) S3-Leitlinie Kolorektales Karzinom. Version 1.1. www.awmf.org/uploads/tx_szleitlinien/021-007OLl_S3_KRK_2014-08-verlaengert.pdf

Robertson DJ, Lieberman DA, Winawer SJ, Ahnen DJ, et al. (2014) Colorectal cancers soon after colonoscopy: a pooled multicohort analysis. Gut 63: 949–956

Scholefield JH, Harris D, Radcliffe A (2011) Guidelines for management of anal intraepithelial neoplasia. Colorectal Dis 13 (Suppl 1): 3–10

Shinya H, Wolff WI (1975) Colonoscopic polypectomy: Technique and safety. Hosp Pract 24

Smith LE, Ko ST, Saclarides T, Caushaj P, et al. (1996) Transanal endoscopic microsurgery. Initial registry results. Dis Colon Rectum 39: S79–84

Steele SR, Varma MG, Melton GB, Ross HM, et al. (2012) Practice parameters for anal squamous neoplasms. Dis Colon Rectum 55: 735–749

Sylla P, Rattner DW, Delgado S, Lacy AM (2010) NOTES transanal rectal cancer resection using transanal endoscopic microsurgery and laparoscopic assistance. Surg Endosc 24: 1205–1210

Wada Y, Kashida H, Kudo SE, Misawa M, et al. (2010) Diagnostic accuracy of pit pattern and vascular pattern analyses in colorectal lesions. Dig Endosc 22: 192–199

Walsh RM, Ackroyd FW, Shellito PC (1992) Endoscopic resection of large sessile colorectal polyps. Gastrointest Endosc 38: 303–309

Winawer SJ, Zauber AG, Ho MN, O’Brien MJ, et al. (1993) Prevention of colorectal cancer by colonoscopic polypectomy. The National Polyp Study Workgroup. N Engl J Med 329: 1977–1981

Yamamoto H, Koiwai H, Yube T, Isoda N, et al. (1999) A successful single-step endoscopic resection of a 40 millimeter flat-elevated tumor in the rectum: endoscopic mucosal resection using sodium hyaluronate. Gastrointest Endosc 50: 701–704

Ajani JA, Winter KA, Gunderson LL, Pedersen J, Benson AB, III, Thomas CR Jr, Mayer RJ, Haddock MG, Rich TA, Willett C (2008) Fluorouracil, mitomycin, and radiotherapy vs fluorouracil, cisplatin, and radiotherapy for carcinoma of the anal canal: a randomized controlled trial. JAMA 299 16: 1914–1921

Alemany L, Saunier M, Alvarado-Cabrero I, Quiros B, Salmeron J, Shin HR, Pirog EC, Guimera N, Hernandez-Suarez G, Felix A, Clavero O, Lloveras B, Kasamatsu E, Goodman MT, Hernandez BY, Laco J, Tinoco L, Geraets DT, Lynch CF, Mandys V, Poljak M, Jach R, Verge J, Clavel C, Ndiaye C, Klaustermeier J, Cubilla A, Castellsague X, Bravo IG, Pawlita M, Quint WG, Munoz N, Bosch FX, de SS (2015) Human papillomavirus DNA prevalence and type distribution in anal carcinomas worldwide. Int J Cancer 136: 98–107

Amini A, Jones BL, Ghosh D, Schefter TE, Goodman KA (2017) Impact of facility volume on outcomes in patients with squamous cell carcinoma of the anal canal: Analysis of the National Cancer Data Base. Cancer 123: 228–236

Anderson JS, Hoy J, Hillman R, Barnden M, Eu B, McKenzie A, Gittleson C (2009) A randomized, placebo-controlled, dose-escalation study to determine the safety, tolerability, and immunogenicity of an HPV-16 therapeutic vaccine in HIV-positive participants with oncogenic HPV infection of the anus. J Acquir Immune Defic Syndr 52: 371–381

Ballo MT, Gershenwald JE, Zagars GK, Lee JE, Mansfield PF, Strom EA, Bedikian AY, Kim KB, Papadopoulos NE, Prieto VG, Ross MI (2002) Sphincter-sparing local excision and adjuvant radiation for anal-rectal melanoma. J Clin Oncol 20: 4555–4558

Bartelink H, Roelofsen F, Eschwege F, Rougier P, Bosset JF, Gonzalez DG, Peiffert D, van GM, Pierart M (1997) Concomitant radiotherapy and chemotherapy is superior to radiotherapy alone in the treatment of locally advanced anal cancer: results of a phase III randomized trial of the European Organization for Research and Treatment of Cancer Radiotherapy and Gastrointestinal Cooperative Groups. J Clin Oncol 15: 2040–2049

Baxter NN, Habermann EB, Tepper JE, Durham SB, Virnig BA (2005) Risk of pelvic fractures in older women following pelvic irradiation. JAMA 294: 2587–2593

Bernick PE, Klimstra DS, Shia J, Minsky B, Saltz L, Shi W, Thaler H, Guillem J, Paty P, Cohen AM, Wong WD (2004) Neuroendocrine carcinomas of the colon and rectum. Dis Colon Rectum 47: 163–169

Bilimoria KY, Bentrem DJ, Rock CE, Stewart AK, Ko CY, Halverson A (2009) Outcomes and prognostic factors for squamous-cell carcinoma of the anal canal: analysis of patients from the National Cancer Data Base. Dis Colon Rectum 52: 624–631

Brady MS, Kavolius JP, Quan SH (1995) Anorectal melanoma. A 64-year experience at Memorial Sloan-Kettering Cancer Center. Dis Colon Rectum 38: 146–151

Cagir B, Whiteford MH, Topham A, Rakinic J, Fry RD (1999) Changing epidemiology of anorectal melanoma. Dis Colon Rectum 42: 1203–1208

Chapet O, Gerard JP, Mornex F, Goncalves-Tavan S, Ardiet JM, D’hombres A, Favrel V, Romestaing P (2007) Prognostic factors of squamous cell carcinoma of the anal margin treated by radiotherapy: the Lyon experience. Int J Colorectal Dis 22: 191–199

Chen H, Cai Y, Liu Y, He J, Hu Y, Xiao Q, Hu W, Ding K (2016) Incidence, Surgical Treatment, and Prognosis of Anorectal Melanoma From 1973 to 2011: A Population-Based SEER Analysis. Medicine (Baltimore) 95: e2770

Chin-Hong PV, Palefsky JM (2002) Natural history and clinical management of anal human papillomavirus disease in men and women infected with human immunodeficiency virus. Clin Infect Dis 35: 1127–1134

Christensen AF, Nielsen MB, Svendsen LB, Engelholm SA (2006) Three-dimensional anal endosonography may improve detection of recurrent anal cancer. Dis Colon Rectum 49: 1527–1532

Ciarrocchi A, Pietroletti R, Carlei F, Amicucci G (2017) Extensive surgery and lymphadenectomy do not improve survival in primary melanoma of the anorectum: results from analysis of a large database (SEER). Colorectal Dis 19: 158–164

Constantinou EC, Daly W, Fung CY, Willett CG, Kaufman DS, DeLaney TF (1997) Time-dose considerations in the treatment of anal cancer. Int J Radiat Oncol Biol Phys 39: 651–657

Cooper PH, Mills SE, Allen MS, Jr. (1982) Malignant melanoma of the anus: report of 12 patients and analysis of 255 additional cases. Dis Colon Rectum 25: 693–703

Cummings BJ, Keane TJ, O’Sullivan B, Wong CS, Catton CN (1991) Epidermoid anal cancer: treatment by radiation alone or by radiation and 5-fluorouracil with and without mitomycin C. Int J Radiat Oncol Biol Phys 21: 1115–1125

Cummings BJ, Ajani JA, Swallow CJ (2008) Cancer of the anal region. In Cancer: Principles & Practice of Oncology, DeVita VT, Lawrence TS, Rosenberg SA (eds) pp 1301–1314. Lippincott, Williams & Wilkins, Philadelphia, PA

Faivre C, Rougier P, Ducreux M, Mitry E, Lusinchi A, Lasser P, Elias D, Eschwege F (1999) 5-fluorouracile and cisplatinum combination chemotherapy for metastatic squamous-cell anal cancer. Bull Cancer 86: 861–865

Ferrigno R, Nakamura RA, Dos Santos Novaes PE, Pellizzon AC, Maia MA, Fogarolli RC, Salvajoli JV, Filho WJ, Lopes A (2005) Radiochemotherapy in the conservative treatment of anal canal carcinoma: retrospective analysis of results and radiation dose effectiveness. Int J Radiat Oncol Biol Phys 61: 1136–1142

Flam M, John M, Pajak TF, Petrelli N, Myerson R, Doggett S, Quivey J, Rotman M, Kerman H, Coia L, Murray K (1996) Role of mitomycin in combination with fluorouracil and radiotherapy, and of salvage chemoradiation in the definitive nonsurgical treatment of epidermoid carcinoma of the anal canal: results of a phase III randomized intergroup study. J Clin Oncol 14: 2527–2539

Fraunholz I, Weiss C, Eberlein K, Haberl A, Rodel C (2010) Concurrent Chemoradiotherapy with 5-Fluorouracil and Mitomycin C for Invasive Anal Carcinoma in Human Immunodeficiency Virus-Positive Patients Receiving Highly Active Antiretroviral Therapy. Int J Radiat Oncol Biol Phys 76: 1425–1432

Frisch M, Glimelius B, van den Brule AJ, Wohlfahrt J, Meijer CJ, Walboomers JM, Goldman S, Svensson C, Adami HO, Melbye M (1997) Sexually transmitted infection as a cause of anal cancer. N Engl J Med 337: 1350–1358

Fuchshuber PR, Rodriguez-Bigas M, Weber T, Petrelli NJ (1997) Anal canal and perianal epidermoid cancers. J Am Coll Surg 185: 494–505

Garland SM, Paavonen J, Jaisamrarn U, Naud P, Salmeron J, Chow SN, Apter D, Castellsague X, Teixeira JC, Skinner SR, Hedrick J, Limson G, Schwarz TF, Poppe WA, Bosch FX, de Carvalho NS, Germar MJ, Peters K, Del Rosario-Raymundo MR, Catteau G, Descamps D, Struyf F, Lehtinen M, Dubin G (2016) Prior human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccination prevents recurrent high grade cervical intraepithelial neoplasia after definitive surgical therapy: Post-hoc analysis from a randomised controlled trial. Int J Cancer 139: 2812–2826

Giovannini M, Bardou VJ, Barclay R, Palazzo L, Roseau G, Helbert T, Burtin P, Bouche O, Pujol B, Favre O (2001) Anal carcinoma: prognostic value of endorectal ultrasound (ERUS). Results of a prospective multicenter study. Endoscopy 33: 231–236

Glynne-Jones, R., James, R., Meadows, H. M., Begum, R., Cunningham, D., Northover, J., Ledermann, J. A., Beare, S., Kadalayil, L., and Sebag-Montefiore, D (2012) Optimum time to assess complete clinical response (CR) following chemoradiation (CRT) using mitomycin (MMC) or cisplatin (CisP), with or without maintenance CisP/5FU in squamous cell carcinoma of the anus: Results of ACT II. J Clin Oncol 30 (Suppl), Abstr 4004

Glynne-Jones R, Kadalayil L, Meadows HM, Cunningham D, Samuel L, Geh JI, Lowdell C, James R, Beare S, Begum R, Ledermann JA, Sebag-Montefiore D (2014a) Tumour- and treatment-related colostomy rates following mitomycin C or cisplatin chemoradiation with or without maintenance chemotherapy in squamous cell carcinoma of the anus in the ACT II trial. Ann Oncol 25: 1616–1622

Glynne-Jones R, Nilsson PJ, Aschele C, Goh V, Peiffert D, Cervantes A, Arnold D (2014b) Anal cancer: ESMO-ESSO-ESTRO clinical practice guidelines for diagnosis, treatment and follow-up. Eur J Surg Oncol 40: 1165–1176

Graf R, Wust P, Hildebrandt B, Gogler H, Ullrich R, Herrmann R, Riess H, Felix R (2003) Impact of overall treatment time on local control of anal cancer treated with radiochemotherapy. Oncology 65: 14–22

Herzog U, Boss M, Spichtin HP (1994) Endoanal ultrasonography in the follow-up of anal carcinoma. Surg Endosc 8: 1186–1189

Hoffman R, Welton ML, Klencke B, Weinberg V, Krieg R (1999) The significance of pretreatment CD4 count on the outcome and treatment tolerance of HIV-positive patients with anal cancer. Int J Radiat Oncol Biol Phys 44: 127–131

Homsi J, Garrett C (2007) Melanoma of the anal canal: a case series. Dis Colon Rectum 50: 1004–1010

James RD, Glynne-Jones R, Meadows HM, Cunningham D, Myint AS, Saunders MP, Maughan T, McDonald A, Essapen S, Leslie M, Falk S, Wilson C, Gollins S, Begum R, Ledermann J, Kadalayil L, Sebag-Montefiore D (2013) Mitomycin or cisplatin chemoradiation with or without maintenance chemotherapy for treatment of squamous-cell carcinoma of the anus (ACT II): a randomised, phase 3, open-label, 2 x 2 factorial trial. Lancet Oncol 14: 516–524

Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ (2009) Cancer statistics, 2009. CA Cancer J Clin 59: 225–249

Johnson LG, Madeleine MM, Newcomer LM, Schwartz SM, Daling JR (2004) Anal cancer incidence and survival: the surveillance, epidemiology, and end results experience, 1973–2000. Cancer 101: 281–288

Jones M, Hruby G, Solomon M, Rutherford N, Martin J (2015) The Role of FDG-PET in the Initial Staging and Response Assessment of Anal Cancer: A Systematic Review and Meta-analysis. Ann Surg Oncol 22: 3574–3581

Khanfir K, Ozsahin M, Bieri S, Cavuto C, Mirimanoff RO, Zouhair A (2008) Patterns of failure and outcome in patients with carcinoma of the anal margin. Ann Surg Oncol 15: 1092–1098

Kim KB, Sanguino AM, Hodges C, Papadopoulos NE, Eton O, Camacho LH, Broemeling LD, Johnson MM, Ballo MT, Ross MI, Gershenwald JE, Lee JE, Mansfield PF, Prieto VG, Bedikian AY (2004) Biochemotherapy in patients with metastatic anorectal mucosal melanoma. Cancer 100: 1478–1483

Kiran RP, Rottoli M, Pokala N, Fazio VW (2010) Long-term Outcomes After Local Excision and Radical Surgery for Anal Melanoma: Data From a Population Database. Dis Colon Rectum 53: 402–408

Knowles J, Lynch AC, Warrier SK, Henderson M, Heriot AG (2016) A case series of anal melanoma including the results of treatment with imatinib in selected patients. Colorectal Dis 18: 877–882

Leeds IL, Alturki H, Canner JK, Schneider EB, Efron JE, Wick EC, Gearhart SL, Safar B, Fang SH (2016) Outcomes of abdominoperineal resection for management of anal cancer in HIV-positive patients: a national case review. World J Surg Oncol 14: 208

Lefevre JH, Corte H, Tiret E, Boccara D, Chaouat M, Touboul E, Svrcek M, Lefrancois M, Shields C, Parc Y (2012) Abdominoperineal resection for squamous cell anal carcinoma: survival and risk factors for recurrence. Ann Surg Oncol 19: 4186–4192

Leon O, Guren M, Hagberg O, Glimelius B, Dahl O, Havsteen H, Naucler G, Svensson C, Tveit KM, Jakobsen A, Pfeiffer P, Wanderas E, Ekman T, Lindh B, Balteskard L, Frykholm G, Johnsson A (2014) Anal carcinoma - Survival and recurrence in a large cohort of patients treated according to Nordic guidelines. Radiother Oncol 113: 352–358

Longo WE, Vernava AM, III, Wade TP, Coplin MA, Virgo KS, Johnson FE (1994) Recurrent squamous cell carcinoma of the anal canal. Predictors of initial treatment failure and results of salvage therapy. Ann Surg 220: 40–49

Lund JA, Wibe A, Sundstrom SH, Haaverstad R, Kaasa S, Myrvold HE (2007) Anal carcinoma in mid-Norway 1970–2000. Acta Oncol 46: 1019–1026

McDermott VG, Low VH, Keogan MT, Lawrence JA, Paulson EK (1996) Malignant melanoma metastatic to the gastrointestinal tract. AJR Am J Roentgenol 166: 809–813

Melbye M, Cote TR, Kessler L, Gail M, Biggar RJ (1994) High incidence of anal cancer among AIDS patients. The AIDS/Cancer Working Group. Lancet 343: 636–639

Mensah FA, Mehta MR, Lewis JS, Jr., Lockhart AC (2016) The Human Papillomavirus Vaccine: Current Perspective and Future Role in Prevention and Treatment of Anal Intraepithelial Neoplasia and Anal Cancer. Oncologist 21: 453–460

Metildi C, McLemore EC, Tran T, Chang D, Cosman B, Ramamoorthy SL, Saltzstein SL, Sadler GR (2013) Incidence and survival patterns of rare anal canal neoplasms using the surveillance epidemiology and end results registry. Am Surg 79: 1068–1074

Mullen JT, Rodriguez-Bigas MA, Chang GJ, Barcenas CH, Crane CH, Skibber JM, Feig BW (2007) Results of surgical salvage after failed chemoradiation therapy for epidermoid carcinoma of the anal canal. Ann Surg Oncol 14: 478–483

National Comprehensive Cancer Network. Accessed Sept 2, 2017

Nigro ND, Vaitkevicius VK, Considine B, Jr. (1974) Combined therapy for cancer of the anal canal: a preliminary report. Dis Colon Rectum 17: 354–356

Oehler-Janne C, Huguet F, Provencher S, Seifert B, Negretti L, Riener MO, Bonet M, Allal AS, Ciernik IF (2008) HIV-specific differences in outcome of squamous cell carcinoma of the anal canal: a multicentric cohort study of HIV-positive patients receiving highly active antiretroviral therapy. J Clin Oncol 26: 2550–2557

Palefsky JM, Giuliano AR, Goldstone S, Moreira ED, Jr., Aranda C, Jessen H, Hillman R, Ferris D, Coutlee F, Stoler MH, Marshall JB, Radley D, Vuocolo S, Haupt RM, Guris D, Garner EI (2011) HPV vaccine against anal HPV infection and anal intraepithelial neoplasia. N Engl J Med 365: 1576–1585

Papaconstantinou HT, Bullard KM, Rothenberger DA, Madoff RD (2006) Salvage abdominoperineal resection after failed Nigro protocol: modest success, major morbidity. Colorectal Dis 8: 124–129

Renehan AG, Saunders MP, Schofield PF, O’Dwyer ST (2005) Patterns of local disease failure and outcome after salvage surgery in patients with anal cancer. Br J Surg 92: 605–614

Roohipour R, Patil S, Goodman KA, Minsky BD, Wong WD, Guillem JG, Paty PB, Weiser MR, Neuman HB, Shia J, Schrag D, Temple LK (2008) Squamous-cell carcinoma of the anal canal: predictors of treatment outcome. Dis Colon Rectum 51 2: 147–153

Roumen RM (1996) Anorectal melanoma in The Netherlands: a report of 63 patients. Eur J Surg Oncol 22: 598–601

Ryan DP, Compton CC, Mayer RJ (2000) Carcinoma of the anal canal. N Engl J Med 342: 792–800

Salama JK, Mell LK, Schomas DA, Miller RC, Devisetty K, Jani AB, Mundt AJ, Roeske JC, Liauw SL, Chmura SJ (2007) Concurrent chemotherapy and intensity-modulated radiation therapy for anal canal cancer patients: a multicenter experience. J Clin Oncol 25: 4581–4586

Schraut WH, Wang CH, Dawson PJ, Block GE (1983) Depth of invasion, location, and size of cancer of the anus dictate operative treatment. Cancer 51: 1291–1296

Skinner SR, Wheeler CM, Romanowski B, Castellsague X, Lazcano-Ponce E, Del Rosario-Raymundo MR, Vallejos C, Minkina G, Pereira Da SD, McNeil S, Prilepskaya V, Gogotadze I, Money D, Garland SM, Romanenko V, Harper DM, Levin MJ, Chatterjee A, Geeraerts B, Struyf F, Dubin G, Bozonnat MC, Rosillon D, Baril L (2016) Progression of HPV infection to detectable cervical lesions or clearance in adult women: Analysis of the control arm of the VIVIANE study. Int J Cancer 138: 2428–2438

Sobin LH, Brierley J (2009) Anal canal. In: Sobin LH, Gospodarowicz MK, Wittekind Ch (eds) TNM Classification of Malignant Tumours. Wiley-Blackwell, Chichester, pp 106–109

Steele SR, Varma MG, Melton GB, Ross HM, Rafferty JF, Buie WD (2012) Practice parameters for anal squamous neoplasms. Dis Colon Rectum 55: 735–749

Tang T, Eldabaje R, Yang L (2016) Current Status of Biological Therapies for the Treatment of Metastatic Melanoma. Anticancer Res 36: 3229–3241

Thomas RM, Sobin LH (1995) Gastrointestinal cancer. Cancer 75 (1 Suppl): 154–170

Touboul E, Schlienger M, Buffat L, Lefkopoulos D, Pene F, Parc R, Tiret E, Gallot D, Malafosse M, Laugier A (1994) Epidermoid carcinoma of the anal canal. Results of curative-intent radiation therapy in a series of 270 patients. Cancer 73: 1569–1579

UKCCCR Anal Cancer Trial Working Party, UK Co-ordinating Committee on Cancer Research (eds) Epidermoid anal cancer: results from the UKCCCR randomised trial of radiotherapy alone versus radiotherapy, 5-fluorouracil, and mitomycin. Lancet 348: 1049–1054

van Zeijl MC, van den Eertwegh AJ, Haanen JB, Wouters MW (2017) (Neo)adjuvant systemic therapy for melanoma. Eur J Surg Oncol 43: 534–543

Wilkinson JR, Morris EJ, Downing A, Finan PJ, Aravani A, Thomas JD, Sebag-Montefiore D (2014) The rising incidence of anal cancer in England 1990–2010: a population-based study. Colorectal Dis 16: O234-O239

Yeh JJ, Shia J, Hwu WJ, Busam KJ, Paty PB, Guillem JG, Coit DG, Wong WD, Weiser MR (2006) The role of abdominoperineal resection as surgical therapy for anorectal melanoma. Ann Surg 244: 1012–1017

Titel: Anal- und Rektumtumoren
verfasst von: Prof. Dr. Dr. h.c. P. Hermanek
Prof. Dr. med. S. Merkel
Dr. med. J. Jongen
Dr. med. A. Ommer
Dr. med. J. Baral
Msc, EMBA HSG, Prof. Dr. med. M. Adamina
Verlag: Springer Berlin Heidelberg
Buch: Chirurgische Proktologie
Print ISBN: 978-3-662-54681-9

Electronic ISBN: 978-3-662-54682-6

Copyright-Jahr: 2018
DOI: https://doi.org/10.1007/978-3-662-54682-6_11

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Zusammenfassung

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Neu im Fachgebiet Chirurgie

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