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Journal of Neuro-Oncology

Erschienen in:

08.03.2018 | Laboratory Investigation

AnnexinA5 promote glioma cell invasion and migration via the PI3K/Akt/NF-κB signaling pathway

verfasst von: Chenxing Ji, Hua Guo, Pei Zhang, Wei Kuang, Yanghua Fan, Lei Wu

Erschienen in: Journal of Neuro-Oncology | Ausgabe 3/2018

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Abstract

As an important member of the Annexins, AnnexinA5 has been attributed important functions in trophoblast membrane repair, anticoagulation and cellular signal transduction. Accumulated studies show that AnnexinA5 is closely associated with various types of carcinomas. However, the potential contribution of AnnexinA5 to glioma cancer progression remains unclear. In this study, we report that AnnexinA5 is significantly upregulated in both high-grade glioma samples and glioma cell lines. Moreover, overexpression of AnnexinA5 promotes cell migration and invasion in vitro and tumorigenicity of glioma cells in nude mice, while knockdown of AnnexinA5 manifests a repressive function during these cellular processes. Importantly, mechanistic studies further reveal that AnnexinA5 is an essential transcriptional target of Snail via activating the PI3K/Akt/NF-κB signaling pathway. Taken together, these findings suggest that AnnexinA5 or the PI3K/Akt/NF-κB pathway may be promising therapeutic molecules to eradicate glioma metastases.

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Titel: AnnexinA5 promote glioma cell invasion and migration via the PI3K/Akt/NF-κB signaling pathway
verfasst von: Chenxing Ji
Hua Guo
Pei Zhang
Wei Kuang
Yanghua Fan
Lei Wu
Publikationsdatum: 08.03.2018
Verlag: Springer US
Erschienen in: Journal of Neuro-Oncology / Ausgabe 3/2018
Print ISSN: 0167-594X
Elektronische ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-018-2818-4

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