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Cancer Chemotherapy and Pharmacology

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01.07.2014 | Review Article

Anti-EGFR MoAb treatment in colorectal cancer: limitations, controversies, and contradictories

verfasst von: Lei Cheng, Wei Ren, Li Xie, Ming Li, Jiang Liu, Jing Hu, Bao-Rui Liu, Xiao-Ping Qian

Erschienen in: Cancer Chemotherapy and Pharmacology | Ausgabe 1/2014

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Abstract

Anti-epidermal growth-factor receptor (EGFR) monoclonal antibody (MoAb) treatment for chemotherapy refractory or metastatic colorectal cancer has obtained great achievement. However, not every colorectal patient responds to such molecular-targeted agent well. Biomarkers associated with anti-EGFR resistance are not limited to KRAS mutation up to now. It was recently reported that cross-talking molecular effectors interacted with EGFR-related pathway were also negative predictor for anti-EGFR treatment. However, the limited data, controversial results, and contradictories between in vitro and clinical studies restrict the clinical application of these new biomarkers. Although the current theory of tumor microenvironment supported the application of multi-target treatment, the results from the clinical studies were less than expected. Moreover, WHO or RECIST guideline for response assessment in anti-EGFR MoAb treatment was also queried by recent AIO KRK-0306 trial. This review focuses on these controversies, contradictories, and limitations, in order to uncover the unmet needs in current status of anti-EGFR MoAb treatment in colorectal cancer.

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Titel: Anti-EGFR MoAb treatment in colorectal cancer: limitations, controversies, and contradictories
verfasst von: Lei Cheng
Wei Ren
Li Xie
Ming Li
Jiang Liu
Jing Hu
Bao-Rui Liu
Xiao-Ping Qian
Publikationsdatum: 01.07.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: Cancer Chemotherapy and Pharmacology / Ausgabe 1/2014
Print ISSN: 0344-5704
Elektronische ISSN: 1432-0843
DOI: https://doi.org/10.1007/s00280-014-2489-6

Springer Medizin

Anti-EGFR MoAb treatment in colorectal cancer: limitations, controversies, and contradictories

Abstract

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Springer Medizin

Abstract

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