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Erschienen in:

10.03.2018 | Review Article

Anti-neutrophil cytoplasmic antibodies and their clinical significance

verfasst von: Supaporn Suwanchote, Muanpetch Rachayon, Pongsawat Rodsaward, Jongkonnee Wongpiyabovorn, Tawatchai Deekajorndech, Helen L. Wright, Steven W. Edwards, Michael W. Beresford, Pawinee Rerknimitr, Direkrit Chiewchengchol

Erschienen in: Clinical Rheumatology | Ausgabe 4/2018

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Abstract

Anti-neutrophil cytoplasmic antibodies (ANCA) are a group of autoantibodies that cause systemic vascular inflammation by binding to target antigens of neutrophils. These autoantibodies can be found in serum from patients with systemic small-vessel vasculitis and they are considered as a biomarker for ANCA-associated vasculitis (AAV). A conventional screening test to detect ANCA in the serum is indirect immunofluorescence study, and subsequently confirmed by enzyme-linked immunosorbent assay. A positive staining of ANCA can be classified into three main categories based on the staining patterns: cytoplasmic, perinuclear, and atypical. Patients with granulomatosis with polyangiitis (GPA) mostly have a positive cytoplasmic staining pattern (c-ANCA) whilst a perinuclear pattern (p-ANCA) is more common in microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA) patients. Atypical pattern (a-ANCA) is rarely seen in patients with systemic small-vessel vasculitis but it can be found in other conditions. Here, techniques for ANCA detection, ANCA staining patterns and their clinical significances are reviewed.

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Titel: Anti-neutrophil cytoplasmic antibodies and their clinical significance
verfasst von: Supaporn Suwanchote
Muanpetch Rachayon
Pongsawat Rodsaward
Jongkonnee Wongpiyabovorn
Tawatchai Deekajorndech
Helen L. Wright
Steven W. Edwards
Michael W. Beresford
Pawinee Rerknimitr
Direkrit Chiewchengchol
Publikationsdatum: 10.03.2018
Verlag: Springer London
Erschienen in: Clinical Rheumatology / Ausgabe 4/2018
Print ISSN: 0770-3198
Elektronische ISSN: 1434-9949
DOI: https://doi.org/10.1007/s10067-018-4062-x

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