Introduction
Materials and methods
Organism collection
Antimicrobial susceptibility testing
Results
Organism (no. of isolates) | No. and cumulative % of isolates inhibited at dalbavancin MIC (mg/L) of: | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
≤ 0.004 | 0.008 | 0.015 | 0.03 | 0.06 | 0.12 | 0.25 | 0.5 | 1 | 2 | > 2 | MIC50 | MIC90 | ||
S. aureus (3908) | 4 0.1 | 31 0.9 | 970 25.7 | 2,840 98.4 | 62 > 99.9 | 1 100.0 | 0.03 | 0.03 | ||||||
MSSA (2607) | 3 0.1 | 25 1.1 | 661 26.4 | 1882 98.6 | 35 > 99.9 | 1 100.0 | 0.03 | 0.03 | ||||||
MRSA (1301) | 1 0.1 | 6 0.5 | 309 24.3 | 958 97.9 | 27 100.0 | 0.03 | 0.03 | |||||||
E. faecalis (1053) | 159 15.1 | 752 86.5 | 117 97.6 | 6 98.2 | 1 98.3 | 0 98.3 | 0 98.3 | 1 98.4 | 17 100.0 | 0.03 | 0.06 | |||
VAN-S (≤ 4 mg/L) (1030) | 159 15.4 | 752 88.4 | 112 99.3 | 6 99.9 | 1 100.0 | 0.03 | 0.06 | |||||||
S. epidermidis (765) | 3 0.4 | 17 2.6 | 201 28.9 | 436 85.9 | 90 97.6 | 17 99.9 | 1 100.0 | 0.03 | 0.06 | |||||
β-hemolytic streptococci (735) | 130 17.7 | 213 46.7 | 307 88.4 | 66 97.4 | 17 99.7 | 2 100.0 | 0.015 | 0.03 | ||||||
E. faecium (659) | 71 10.8 | 155 34.3 | 138 55.2 | 52 63.1 | 15 65.4 | 6 66.3 | 3 66.8 | 11 68.4 | 208 100.0 | 0.06 | > 2 | |||
VAN-S (≤ 4 mg/L) (397) | 68 17.1 | 143 53.1 | 133 86.6 | 47 98.5 | 6 100.0 | 0.03 | 0.12 | |||||||
Viridans group streptococci (508) | 116 22.8 | 126 47.6 | 140 75.2 | 100 94.9 | 20 98.8 | 6 100.0 | 0.015 | 0.03 | ||||||
S. pneumoniae (461) | 12 2.6 | 245 55.7 | 187 96.3 | 16 99.8 | 1 100.0 | 0.008 | 0.015 | |||||||
S. hominis (175) | 1 0.6 | 4 2.9 | 52 32.6 | 95 86.9 | 19 97.7 | 4 100.0 | 0.03 | 0.06 | ||||||
S. haemolyticus (104) | 3 2.9 | 16 18.3 | 51 67.3 | 29 95.2 | 4 99.0 | 1 100.0 | 0.06 | 0.12 |
Organism/antimicrobial (no. tested) | MIC50 a | MIC90 a | % Susceptible per US FDA and CLSI (no. tested) | ||
---|---|---|---|---|---|
US | W-EU | E-EU | |||
S. aureus (3908) | (2,235) | (1,343) | (330) | ||
Dalbavancin | 0.03 | 0.03 | 100.0 | 100.0 | 100.0 |
Daptomycin | 0.25 | 0.5 | > 99.9 | 100.0 | 100.0 |
Vancomycin | 1 | 1 | 100.0 | 100.0 | 100.0 |
Teicoplanin | 0.5 | 0.5 | 100.0 | 100.0 | 100.0 |
Linezolid | 1 | 2 | 100.0 | 100.0 | 100.0 |
Oxacillin | 0.5 | > 2 | 58.7 | 78.5 | 72.7 |
Ceftaroline | 0.25 | 1 | 96.6 | 95.4 | 96.4 |
Clindamycin | 0.06 | > 2 | 85.5 | 96.2 | 89.1 |
Levofloxacin | 0.25 | > 4 | 67.6 | 79.4 | 85.8 |
Tetracycline | ≤ 0.5 | ≤ 0.5 | 95.1 | 96.0 | 83.6 |
TMP-SMXb | ≤ 0.5 | ≤ 0.5 | 97.7 | 99.8 | 99.7 |
E. faecalis (1053) | (515) | (463) | (75) | ||
Dalbavancin | 0.03 | 0.06 | 97.9 c | 98.7 c | 98.7 c |
Daptomycin | 1 | 1 | 99.2 | 99.6 | 100.0 |
Vancomycin | 1 | 2 | 97.5 | 98.3 | 97.3 |
Teicoplanin | 0.5 | 0.5 | 97.9 | 98.7 | 98.7 |
Linezolid | 1 | 2 | 99.8 | 99.8 | 97.3 |
Ampicillin | 1 | 1 | 100.0 | 100.0 | 100.0 |
Levofloxacin | 1 | > 4 | 78.8 | 73.4 | 70.7 |
S. epidermidis (765) | (396) | (332) | (37) | ||
Dalbavancin | 0.03 | 0.06 | [100.0]d | [100.0]d | [100.0]d |
Daptomycin | 0.25 | 0.5 | 100.0 | 100.0 | 100.0 |
Vancomycin | 2 | 2 | 100.0 | 100.0 | 100.0 |
Teicoplanin | 2 | 8 | 99.2 | 99.4 | 97.3 |
Linezolid | 1 | 1 | 93.9 | 96.4 | 94.6 |
Oxacillin | > 2 | > 2 | 26.8 | 33.1 | 13.5 |
Clindamycin | 0.06 | > 2 | 52.5 | 66.6 | 70.3 |
Levofloxacin | 4 | > 4 | 40.9 | 44.6 | 24.3 |
Tetracycline | 1 | > 8 | 80.8 | 85.2 | 73.0 |
TMP-SMXb | 1 | 8 | 54.3 | 58.4 | 73.0 |
β-hemolytic streptococci (735) | (430) | (228) | (77) | ||
Dalbavancin | 0.015 | 0.03 | 100.0e | 100.0e | 100.0e |
Daptomycin | ≤ 0.06 | 0.25 | 100.0 | 100.0 | 100.0 |
Vancomycin | 0.5 | 0.5 | 100.0 | 100.0 | 100.0 |
Linezolid | 1 | 2 | 100.0 | 100.0 | 100.0 |
Ceftriaxone | 0.03 | 0.06 | 100.0 | 100.0 | 100.0 |
Ceftaroline | ≤ 0.008 | 0.015 | 100.0 | 100.0 | 100.0 |
Penicillin | 0.015 | 0.06 | 100.0 | 100.0 | 100.0 |
Clindamycin | ≤ 0.25 | > 2 | 79.8 | 87.7 | 85.7 |
Levofloxacin | 0.5 | 1 | 98.1 | 97.4 | 98.7 |
Tetracycline | > 4 | > 4 | 41.7 | 52.2 | 55.8 |
E. faecium (659) | (238) | (348) | (73) | ||
Dalbavancin | 0.06 | > 2 | [38.7]c | [81.9]c | [74.0]c |
Daptomycin | 1 | 2 | [96.2]f | [100.0]f | [100.0]f |
Vancomycin | 0.5 | > 16 | 36.6 | 76.1 | 61.6 |
Teicoplanin | 1 | > 16 | 39.9 | 82.2 | 67.1 |
Linezolid | 1 | 2 | 99.2 | 99.7 | 100.0 |
Ampicillin | > 16 | > 16 | 18.5 | 12.6 | 2.7 |
Levofloxacin | > 4 | > 4 | 14.7 | 10.1 | 2.7 |