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01.04.2013 | Original Article

Antioxidant Levels at Diagnosis in Childhood Acute Lymphoblastic Leukemia

verfasst von: Nita Radhakrishnan, Veronique Dinand, Spriha Rao, Priyanka Gupta, G. S. Toteja, Manas Kalra, Satya Prakash Yadav, Anupam Sachdeva

Erschienen in: Indian Journal of Pediatrics | Ausgabe 4/2013

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Abstract

Objective

To measure serum zinc, selenium, retinol and tocoferol levels at diagnosis of pediatric acute lymphoblastic leukemia (ALL) and to compare it to that of a control population. Correlation was made with episodes of febrile neutropenia during the first 8 wk of therapy.

Methods

Fasting levels of serum zinc, selenium, retinol and tocoferol were measured in 45 children diagnosed with acute lymphoblastic leukemia and in 20 healthy controls.

Results

Lower levels of baseline selenium and tocoferol were noted in patients who developed febrile neutropenia compared to the patients who did not (p = 0.022 and 0.026 respectively). Serum retinol was also lower in patients who developed sepsis when compared to those who did not.

Conclusions

Supplementation of antioxidants may be considered in clinical trials aiming at reducing infection related morbidity and mortality.

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Titel: Antioxidant Levels at Diagnosis in Childhood Acute Lymphoblastic Leukemia
verfasst von: Nita Radhakrishnan
Veronique Dinand
Spriha Rao
Priyanka Gupta
G. S. Toteja
Manas Kalra
Satya Prakash Yadav
Anupam Sachdeva
Publikationsdatum: 01.04.2013
Verlag: Springer-Verlag
Erschienen in: Indian Journal of Pediatrics / Ausgabe 4/2013
Print ISSN: 0019-5456
Elektronische ISSN: 0973-7693
DOI: https://doi.org/10.1007/s12098-012-0892-8

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Antioxidant Levels at Diagnosis in Childhood Acute Lymphoblastic Leukemia