Skip to main content

2023 | OriginalPaper | Buchkapitel

6. Antipsychotika

verfasst von : Prof. Dr. med. Claudia Mehler-Wex, Prof. Dr. med. Timo D. Vloet, Prof. Dr. rer. nat. Manfred Gerlach

Erschienen in: Neuro-/Psychopharmaka im Kindes- und Jugendalter

Verlag: Springer Berlin Heidelberg

Zusammenfassung

Antipsychotika (früherer Begriff Neuroleptika) sind Neuro‑/Psychopharmaka, die vorrangig zur symptomatischen Behandlung von Erkrankungen aus dem schizophrenen Formenkreis eingesetzt werden sowie bei psychotischen Symptomen im Rahmen anderer Störungen (u. a. affektive oder organisch bedingte Störungen) und bei Manie. Einige werden in der Kinder- und Jugendpsychiatrie aber auch als Stimmungsstabilisatoren, bei Tic-Störungen und zudem symptomatisch bei Reizbarkeit, Agitiertheit und aggressiven Verhaltensweisen sowie Anspannung, Einschlafstörungen oder gedanklicher Einengung angewandt.
In diesem Kapitel werden die Klassifikation und Wirk(ungs)mechanismen der Antipsychotika, die in der Kinder- und Jugendpsychiatrie eingesetzt werden, besprochen und schwerpunktmäßig diejenigen pharmakologischen Aspekte von Antipsychotika dargestellt, die für klinisch tätige ärztliche Kollegen für den therapeutischen Einsatz dieser Substanzen relevant sind. Dabei wird u. a. auf Anwendungsgebiete, die klinische Wirksamkeit und die Studienlage eingegangen. Es werden Dosierungsempfehlungen gegeben und mögliche unerwünschte Arzneimittelwirkungen und -wechselwirkungen behandelt. Das Kapitel schließt mit Empfehlungen zur Behandlungsdauer sowie zu notwendigen Kontrolluntersuchungen im Rahmen der Pharmakotherapie mit Antipsychotika.
Literatur
Zurück zum Zitat AACAP Official Action (2001) Practice parameter for the assessment and treatment of children and adolescents with schizophrenia. J Am Acad Child Psy 40(Suppl):4–S23 AACAP Official Action (2001) Practice parameter for the assessment and treatment of children and adolescents with schizophrenia. J Am Acad Child Psy 40(Suppl):4–S23
Zurück zum Zitat Al-Dhaher Z, Kapoor S, Saito E et al. (2016) Activating and tranquilizing effects of first-time treatment with aripiprazole, olanzapine, quetiapine, and risperidone in youth. J Child Adolesc Psychopharmacology 26:458–470CrossRef Al-Dhaher Z, Kapoor S, Saito E et al. (2016) Activating and tranquilizing effects of first-time treatment with aripiprazole, olanzapine, quetiapine, and risperidone in youth. J Child Adolesc Psychopharmacology 26:458–470CrossRef
Zurück zum Zitat Aman MG, Mcdougle CJ, Scahill L et al. (2009) Medication and parent training in children with pervasive developmental disorders and serious behavior problems: Results from a randomized clinical trial. J Am Acad Child Psy 48:1143–1154 (for the Research Units on Pediatric Psychopharmacology Autism Network)CrossRef Aman MG, Mcdougle CJ, Scahill L et al. (2009) Medication and parent training in children with pervasive developmental disorders and serious behavior problems: Results from a randomized clinical trial. J Am Acad Child Psy 48:1143–1154 (for the Research Units on Pediatric Psychopharmacology Autism Network)CrossRef
Zurück zum Zitat Amato D, Canneva F, Cumming P et al. (2020) A dopaminergic mechanism of antipsychotic drug efficacy, failure, and failure reversal: the role of the dopamine transporter. Mol Psychiatry 25:2101–2118PubMedCrossRef Amato D, Canneva F, Cumming P et al. (2020) A dopaminergic mechanism of antipsychotic drug efficacy, failure, and failure reversal: the role of the dopamine transporter. Mol Psychiatry 25:2101–2118PubMedCrossRef
Zurück zum Zitat Amor LB (2012) Antipsychotics in pediatric and adolescent patients: a review of comparative safety data. J Affect Disorders 138:22–S30CrossRef Amor LB (2012) Antipsychotics in pediatric and adolescent patients: a review of comparative safety data. J Affect Disorders 138:22–S30CrossRef
Zurück zum Zitat Ayanthi AR, Hickman IJ, Wang AYH et al. (2006) Olanzapine treatment is associated with reduced high molecular weight adiponectin in serum. J Clin Psychopharm 26:232–237CrossRef Ayanthi AR, Hickman IJ, Wang AYH et al. (2006) Olanzapine treatment is associated with reduced high molecular weight adiponectin in serum. J Clin Psychopharm 26:232–237CrossRef
Zurück zum Zitat Bai YH, Liu TB, Xu AH, Yang HC, Gao KM (2019) Comparison of common side effects from mood stabilizers and antipsychotics between pediatric and adult patients with bipolar disorder: a systematic review of randomized, double-blind, placebo-controlled trials. Expert Opin Drug Safety 18:703–717CrossRef Bai YH, Liu TB, Xu AH, Yang HC, Gao KM (2019) Comparison of common side effects from mood stabilizers and antipsychotics between pediatric and adult patients with bipolar disorder: a systematic review of randomized, double-blind, placebo-controlled trials. Expert Opin Drug Safety 18:703–717CrossRef
Zurück zum Zitat Baptista T, Kin Y, Beaulieu S, de Baptista EA (2002) Obesity and related metabolic abnormalities during antipsychotic drug administration: mechanisms, management and research perspectives. Pharmacopsychiatry 35:205–219PubMedCrossRef Baptista T, Kin Y, Beaulieu S, de Baptista EA (2002) Obesity and related metabolic abnormalities during antipsychotic drug administration: mechanisms, management and research perspectives. Pharmacopsychiatry 35:205–219PubMedCrossRef
Zurück zum Zitat Benes FM (2009) Neural circuitry models of schizophrenia: Is it dopamine, GABA, glutamate, or something else? Biol Psychiat 65:1003–1005PubMedCrossRef Benes FM (2009) Neural circuitry models of schizophrenia: Is it dopamine, GABA, glutamate, or something else? Biol Psychiat 65:1003–1005PubMedCrossRef
Zurück zum Zitat Bernagie C, Danckaerts M, Wampers M, De Hert M (2016) Aripiprazole and acute extrapyramidal symptoms in children and adolescents: a meta-analysis. CNS Drugs 30:807–818PubMedPubMedCentralCrossRef Bernagie C, Danckaerts M, Wampers M, De Hert M (2016) Aripiprazole and acute extrapyramidal symptoms in children and adolescents: a meta-analysis. CNS Drugs 30:807–818PubMedPubMedCentralCrossRef
Zurück zum Zitat Brannan SK, Sawchak S, Miller AC et al. (2021) Muscarinic cholinergic receptor agonist and peripheral antagonist for schizophrenia. New Engl J Med 384:717–726PubMedCrossRef Brannan SK, Sawchak S, Miller AC et al. (2021) Muscarinic cholinergic receptor agonist and peripheral antagonist for schizophrenia. New Engl J Med 384:717–726PubMedCrossRef
Zurück zum Zitat Brown AS (2011) The environment and susceptibility to schizophrenia. Prog Neurobiol 93:23–58PubMedCrossRef Brown AS (2011) The environment and susceptibility to schizophrenia. Prog Neurobiol 93:23–58PubMedCrossRef
Zurück zum Zitat Calarge CA, Burns TL, Schlechte JA, Zemel BS (2015) Longitudinal examination of the scelettal effects of selective serotonin reuptake inhibitors an risperidone in boys. J Clin Psychiatry 76:607–613PubMedPubMedCentralCrossRef Calarge CA, Burns TL, Schlechte JA, Zemel BS (2015) Longitudinal examination of the scelettal effects of selective serotonin reuptake inhibitors an risperidone in boys. J Clin Psychiatry 76:607–613PubMedPubMedCentralCrossRef
Zurück zum Zitat Campbell M, Small AM, Green WH et al. (1984) A comparison of haloperidol and lithium in hospitalized aggressive conduct disordered children. Arch Gen Psychiat 41:650–656PubMedCrossRef Campbell M, Small AM, Green WH et al. (1984) A comparison of haloperidol and lithium in hospitalized aggressive conduct disordered children. Arch Gen Psychiat 41:650–656PubMedCrossRef
Zurück zum Zitat Carlsson A, Lindqvist M (1963) Effect of chlorpromazine or haloperidol on formation of 3-methoxytyramine and normetanephrine in mouse brain. Acta Pharmacol Toxicol 20:140–144CrossRef Carlsson A, Lindqvist M (1963) Effect of chlorpromazine or haloperidol on formation of 3-methoxytyramine and normetanephrine in mouse brain. Acta Pharmacol Toxicol 20:140–144CrossRef
Zurück zum Zitat Carpenter WT, Davis JM (2012) Perspective. Another view of the history of antipsychotic drug discovery and development. Mol Psychiatr 17:1168–1173CrossRef Carpenter WT, Davis JM (2012) Perspective. Another view of the history of antipsychotic drug discovery and development. Mol Psychiatr 17:1168–1173CrossRef
Zurück zum Zitat Ceraso A, Lin JJ, Schneider-Thoma J et al. (2020) Maintenance treatment with antipsychotic drugs for schizophrenia. Cochrane Database Syst Rev 11:Cd8016 Ceraso A, Lin JJ, Schneider-Thoma J et al. (2020) Maintenance treatment with antipsychotic drugs for schizophrenia. Cochrane Database Syst Rev 11:Cd8016
Zurück zum Zitat Cohen D, Huinink S (2007) Atypical antipsychotic-induced diabetes mellitus in child and adolescent psychiatry. CNS Drugs 21:1035–1038PubMedCrossRef Cohen D, Huinink S (2007) Atypical antipsychotic-induced diabetes mellitus in child and adolescent psychiatry. CNS Drugs 21:1035–1038PubMedCrossRef
Zurück zum Zitat Comai S, Tau M, Pavlovic Z, Gobbi G (2012) The psychopharmacology of aggressive behavior: a translational approach. Part 2: Clinical studies using atypical antipsychotics, anticonvulsants, and lithium. J Clin Psychopharm 32:237–260CrossRef Comai S, Tau M, Pavlovic Z, Gobbi G (2012) The psychopharmacology of aggressive behavior: a translational approach. Part 2: Clinical studies using atypical antipsychotics, anticonvulsants, and lithium. J Clin Psychopharm 32:237–260CrossRef
Zurück zum Zitat Correll CU (2008) Antipsychotic use in children and adolescents: minimizing adverse effects to maximize outcomes. J Am Acad Child Psy 47:9–20CrossRef Correll CU (2008) Antipsychotic use in children and adolescents: minimizing adverse effects to maximize outcomes. J Am Acad Child Psy 47:9–20CrossRef
Zurück zum Zitat Correll CU (2011) Antipsychotic agents: traditional and atypical. In: Martin A, Scahill L, Kratochvil (Hrsg) Pediatric psychopharmacology. Principles and practise, 2. Aufl. University Press, Oxford New York, S 312–337 Correll CU (2011) Antipsychotic agents: traditional and atypical. In: Martin A, Scahill L, Kratochvil (Hrsg) Pediatric psychopharmacology. Principles and practise, 2. Aufl. University Press, Oxford New York, S 312–337
Zurück zum Zitat Correll Ch, Carlson HE (2006) Endocrine and metabolic adverse effects of psychotropic medications in children and adolescents. J Am Acad Child Psy 45:771–791CrossRef Correll Ch, Carlson HE (2006) Endocrine and metabolic adverse effects of psychotropic medications in children and adolescents. J Am Acad Child Psy 45:771–791CrossRef
Zurück zum Zitat Correll CU, Kane JM (2007) One-year incidence rates of tardive dyskinesia in children and adolescents treated with second-generation antipsychotics: a systematic review. J Child Adolesc Psychopharmacol 17:647–655PubMedCrossRef Correll CU, Kane JM (2007) One-year incidence rates of tardive dyskinesia in children and adolescents treated with second-generation antipsychotics: a systematic review. J Child Adolesc Psychopharmacol 17:647–655PubMedCrossRef
Zurück zum Zitat Correll CU, Sheridan EM, DelBello MP (2010) Antipsychotic and mood stabilizer efficacy and tolerability in pediatric and adult patients with bipolar I mania: a comparative analysis of acute, randomized, placebo-controlled trials. Bipolar Disord 12:116–141PubMedCrossRef Correll CU, Sheridan EM, DelBello MP (2010) Antipsychotic and mood stabilizer efficacy and tolerability in pediatric and adult patients with bipolar I mania: a comparative analysis of acute, randomized, placebo-controlled trials. Bipolar Disord 12:116–141PubMedCrossRef
Zurück zum Zitat Correll CU, Kratochvil CJ, March JS (2011) Development in pediatric psychopharmacology: focus on stimulants, antidepressants, and antipsychotics. J Clin Psychiat 72:655–670CrossRef Correll CU, Kratochvil CJ, March JS (2011) Development in pediatric psychopharmacology: focus on stimulants, antidepressants, and antipsychotics. J Clin Psychiat 72:655–670CrossRef
Zurück zum Zitat Correll CU, Kohegy E, Zhao C (2017) Oral aripiprazole as maintenance treatment in adolsescent schizophrenia: results from a 52-week, randomized, placebo-controlles withdrawal study. J Am Acad Child Adolesc Psychiatry 56:784–792PubMedCrossRef Correll CU, Kohegy E, Zhao C (2017) Oral aripiprazole as maintenance treatment in adolsescent schizophrenia: results from a 52-week, randomized, placebo-controlles withdrawal study. J Am Acad Child Adolesc Psychiatry 56:784–792PubMedCrossRef
Zurück zum Zitat Correll CU, Litman RE, Filts Y et al. (2020a) Efficacy and safety of once monthly Risperidone ISM in schizophrenic patients with acute exacerbation. Schizophrenia 6:37PubMedPubMedCentralCrossRef Correll CU, Litman RE, Filts Y et al. (2020a) Efficacy and safety of once monthly Risperidone ISM in schizophrenic patients with acute exacerbation. Schizophrenia 6:37PubMedPubMedCentralCrossRef
Zurück zum Zitat Correll CU, Sikich L, Reeves G et al. (2020b) Metformin add-on vs. Antipsychotic switch vs. Continued antipsychotic treatment plus healthy lifestyle education in overweight or obese youth with severe mental illness: results from the IMPACT trial. World Psychiatry 19:69–80PubMedPubMedCentralCrossRef Correll CU, Sikich L, Reeves G et al. (2020b) Metformin add-on vs. Antipsychotic switch vs. Continued antipsychotic treatment plus healthy lifestyle education in overweight or obese youth with severe mental illness: results from the IMPACT trial. World Psychiatry 19:69–80PubMedPubMedCentralCrossRef
Zurück zum Zitat Coustals N, Ménard ML, Cohen D (2020) Aripiprazole in children and adolescents. J Child Adolesc Psychopharmacol 20:1–29 Coustals N, Ménard ML, Cohen D (2020) Aripiprazole in children and adolescents. J Child Adolesc Psychopharmacol 20:1–29
Zurück zum Zitat Creese I, Burt DR, Snyder SH (1976) Dopamine receptors binding predicts clinical potencies of antischizophrenic drugs. Science 192:481–483PubMedCrossRef Creese I, Burt DR, Snyder SH (1976) Dopamine receptors binding predicts clinical potencies of antischizophrenic drugs. Science 192:481–483PubMedCrossRef
Zurück zum Zitat DeNayer A, DeHert M, Scheen A, Van Gaal L, Peuskens J (2007) Belgian consensus on metabolic problems associated with atypical antipsychotics. Encephale 33:197–202CrossRef DeNayer A, DeHert M, Scheen A, Van Gaal L, Peuskens J (2007) Belgian consensus on metabolic problems associated with atypical antipsychotics. Encephale 33:197–202CrossRef
Zurück zum Zitat DelBello MP, Goldman R, Philips D et al. (2017) Efficacy and safety of lurasidone in children and adolescents with bipolar I depression: a double-blind, placebo controlled study. J Am Acad Child Adolesc Psychiatry 56:1015–1025PubMedCrossRef DelBello MP, Goldman R, Philips D et al. (2017) Efficacy and safety of lurasidone in children and adolescents with bipolar I depression: a double-blind, placebo controlled study. J Am Acad Child Adolesc Psychiatry 56:1015–1025PubMedCrossRef
Zurück zum Zitat Dietmaier O, Laux G (2020) Weiterbildungs-Curriculum Pschopharmakologie/Pharmakotherapie. Teil 15: Kombinationstherapien, Interaktionen. Psychopharmakotherapie 27:295–305 Dietmaier O, Laux G (2020) Weiterbildungs-Curriculum Pschopharmakologie/Pharmakotherapie. Teil 15: Kombinationstherapien, Interaktionen. Psychopharmakotherapie 27:295–305
Zurück zum Zitat Ebdrup BH, Knop FK (2021) Weight gain on antipsychotics - A perfect storm of complex pathophysiology and psychopharmacology. Acta Psychiatr Scand 144:521–523PubMedCrossRef Ebdrup BH, Knop FK (2021) Weight gain on antipsychotics - A perfect storm of complex pathophysiology and psychopharmacology. Acta Psychiatr Scand 144:521–523PubMedCrossRef
Zurück zum Zitat Egberts K, Mehler-Wex C, Gerlach M (2011) Therapeutic drug monitoring in child and adolescent psychiatry. Pharmacopsychiatry 44:249–253PubMedCrossRef Egberts K, Mehler-Wex C, Gerlach M (2011) Therapeutic drug monitoring in child and adolescent psychiatry. Pharmacopsychiatry 44:249–253PubMedCrossRef
Zurück zum Zitat Eggers C, Roepcke B (2007) Schizophrenie, schizotype und wahnhafte Störungen (F2). In: Deutsche Gesellschaft für Kinder- und Jugendpsychiatrie und Psychotherapie, Bundesarbeitsgemeinschaft Leitender Klinikärzte für Kinder- und Jugendpsychiatrie, Psychotherapie und Bundesverband der Ärzte für Kinder- und Jugendpsychiatrie und Psychotherapie (Hrsg) Leitlinien zu Diagnostik und Therapie von psychischen Störungen im Säuglings-, Kindes- und Jugendalter, 3. Aufl. Deutscher Ärzte-Verlag, Köln, S 33–43 Eggers C, Roepcke B (2007) Schizophrenie, schizotype und wahnhafte Störungen (F2). In: Deutsche Gesellschaft für Kinder- und Jugendpsychiatrie und Psychotherapie, Bundesarbeitsgemeinschaft Leitender Klinikärzte für Kinder- und Jugendpsychiatrie, Psychotherapie und Bundesverband der Ärzte für Kinder- und Jugendpsychiatrie und Psychotherapie (Hrsg) Leitlinien zu Diagnostik und Therapie von psychischen Störungen im Säuglings-, Kindes- und Jugendalter, 3. Aufl. Deutscher Ärzte-Verlag, Köln, S 33–43
Zurück zum Zitat Eggers C, Rothenberger A, Berghaus U (1988) Clinical and neurobiological findings in children suffering from tic disease following treatment with tiapride. Eur Arch Psy Clin N 237:223–229 Eggers C, Rothenberger A, Berghaus U (1988) Clinical and neurobiological findings in children suffering from tic disease following treatment with tiapride. Eur Arch Psy Clin N 237:223–229
Zurück zum Zitat Ellul P, Delorme R, Cortese S (2018) Metformin for weight gain associated with second generation antipsychotics in children and adolescents: a systematic review and meta-analysis. CNS Drugs 32:1103–1112PubMedCrossRef Ellul P, Delorme R, Cortese S (2018) Metformin for weight gain associated with second generation antipsychotics in children and adolescents: a systematic review and meta-analysis. CNS Drugs 32:1103–1112PubMedCrossRef
Zurück zum Zitat Findling RK, Cavus I, Pappadopulos E et al.(2013) Ziprasidone in adolescents with schizophrenia: Results from a placebo-controlled efficacy and long-term open-extension study. J Child Adoles Psychopharmacol 23:531-544CrossRef Findling RK, Cavus I, Pappadopulos E et al.(2013) Ziprasidone in adolescents with schizophrenia: Results from a placebo-controlled efficacy and long-term open-extension study. J Child Adoles Psychopharmacol 23:531-544CrossRef
Zurück zum Zitat Findling RL, Landbloom RP, Mackle M et al. (2015a) Safety and efficacy from an 8 week double-blind trial and a 26 week open label extension of asenapine in children and adolescents with schizophrenia. J Child Adolesc Psychopharmacol 25:384–396PubMedPubMedCentralCrossRef Findling RL, Landbloom RP, Mackle M et al. (2015a) Safety and efficacy from an 8 week double-blind trial and a 26 week open label extension of asenapine in children and adolescents with schizophrenia. J Child Adolesc Psychopharmacol 25:384–396PubMedPubMedCentralCrossRef
Zurück zum Zitat Findling RL, Landbloom RL, Szegedi et al. (2015b) Asenapine for the acute treatment of pediatric manic or mixed episode of bipolar I disorder. J Am Acad Child Adolesc Psychiatry 54:1032–1041PubMedCrossRef Findling RL, Landbloom RL, Szegedi et al. (2015b) Asenapine for the acute treatment of pediatric manic or mixed episode of bipolar I disorder. J Am Acad Child Adolesc Psychiatry 54:1032–1041PubMedCrossRef
Zurück zum Zitat Fleischhaker Ch, Heiser P, Hennighausen K et al. (2008) Weight gain in children and adolescents during 45 weeks treatment with clozapine, olanzapine and risperidone. J Neural Transm 115:1599–1608PubMedCrossRef Fleischhaker Ch, Heiser P, Hennighausen K et al. (2008) Weight gain in children and adolescents during 45 weeks treatment with clozapine, olanzapine and risperidone. J Neural Transm 115:1599–1608PubMedCrossRef
Zurück zum Zitat Fountoulakis KN, Moeller HJ, Kasper S et al. (2021) The report of the joint WPA/CINP workgroup on the use and usefulness of antipsychotic medication in the treatment of schizophrenia. CNS Spectr 26:562–586CrossRef Fountoulakis KN, Moeller HJ, Kasper S et al. (2021) The report of the joint WPA/CINP workgroup on the use and usefulness of antipsychotic medication in the treatment of schizophrenia. CNS Spectr 26:562–586CrossRef
Zurück zum Zitat Fraguas D, Correll CU, Merchán-Naranjo J et al. (2011) Efficacy and safety of second-generation antipsychotics in children and adolescents with psychotic and bipolar spectrum disorders: comprehensive review of prospective head-to-head and placebo-controlled comparisons. Eur Neuropsychopharm 21:621–645CrossRef Fraguas D, Correll CU, Merchán-Naranjo J et al. (2011) Efficacy and safety of second-generation antipsychotics in children and adolescents with psychotic and bipolar spectrum disorders: comprehensive review of prospective head-to-head and placebo-controlled comparisons. Eur Neuropsychopharm 21:621–645CrossRef
Zurück zum Zitat Friedrich ME, Winkler D, Konstantinidis A et al. (2020) Cardiovascular adverse reactions during antipsychotic treatment: results of AMSP, a drug surveillance program between 1993 and 2013. Int J Psychopharmacol 23:67–75 Friedrich ME, Winkler D, Konstantinidis A et al. (2020) Cardiovascular adverse reactions during antipsychotic treatment: results of AMSP, a drug surveillance program between 1993 and 2013. Int J Psychopharmacol 23:67–75
Zurück zum Zitat Galling B, Roldán A, Nielsen RE et al. (2016) Type 2 diabetes mellitus in youth exposed to antipsychotics: a systematic review and meta-analysis. JAMA Psychiatry 73:247–259PubMedCrossRef Galling B, Roldán A, Nielsen RE et al. (2016) Type 2 diabetes mellitus in youth exposed to antipsychotics: a systematic review and meta-analysis. JAMA Psychiatry 73:247–259PubMedCrossRef
Zurück zum Zitat Galling B, Roldán A, Hagi K et al. (2017) Antipsychotic augementation versus monotherapy in schiziphrenia: a systematic review, meta-analysis und meta-regression analysis. World Psychiatry 16:77–89PubMedPubMedCentralCrossRef Galling B, Roldán A, Hagi K et al. (2017) Antipsychotic augementation versus monotherapy in schiziphrenia: a systematic review, meta-analysis und meta-regression analysis. World Psychiatry 16:77–89PubMedPubMedCentralCrossRef
Zurück zum Zitat Gebicke-Haerter PJ (2012) Epigenetics of schizophrenia. Pharmacopsychiatry 45(Suppl 1):S42–S48PubMed Gebicke-Haerter PJ (2012) Epigenetics of schizophrenia. Pharmacopsychiatry 45(Suppl 1):S42–S48PubMed
Zurück zum Zitat Gerlach M (2021) Pharmakologische und rechtliche Grundkenntnisse der Psychopharmakotherapie. Psych Up2date 15:71–84CrossRef Gerlach M (2021) Pharmakologische und rechtliche Grundkenntnisse der Psychopharmakotherapie. Psych Up2date 15:71–84CrossRef
Zurück zum Zitat Gerlach M, Hünnerkopf R, Rothenhöfer S et al. (2007) Therapeutic drug monitoring of quetiapine in adolescents with psychotic disorders. Pharmacopsychiatry 40:72–76PubMedCrossRef Gerlach M, Hünnerkopf R, Rothenhöfer S et al. (2007) Therapeutic drug monitoring of quetiapine in adolescents with psychotic disorders. Pharmacopsychiatry 40:72–76PubMedCrossRef
Zurück zum Zitat Giessing Jensen K, Juul K, Fink-Jensen A, Correll CU (2015) Corrected QT changes during antipsychotic treatment of children and adolescents: a systematic review and meta-analysis of clinical trials. J Am Acad Child Adolesc Psychaitry 54:25–36CrossRef Giessing Jensen K, Juul K, Fink-Jensen A, Correll CU (2015) Corrected QT changes during antipsychotic treatment of children and adolescents: a systematic review and meta-analysis of clinical trials. J Am Acad Child Adolesc Psychaitry 54:25–36CrossRef
Zurück zum Zitat Glassman AH, Bigger Th (2001) Antipsychotic drugs: Prolonged QTc interval, torsade de pointes and sudden death. Am J Psychiat 158:1774–1782PubMedCrossRef Glassman AH, Bigger Th (2001) Antipsychotic drugs: Prolonged QTc interval, torsade de pointes and sudden death. Am J Psychiat 158:1774–1782PubMedCrossRef
Zurück zum Zitat Goedhard LE, Stolker JJ, Herrdink ER et al. (2006) Pharmacotherapy of aggressive behavior in general adult psychiatry: A systematic review. J Clin Psychiat 67:1013–1024CrossRef Goedhard LE, Stolker JJ, Herrdink ER et al. (2006) Pharmacotherapy of aggressive behavior in general adult psychiatry: A systematic review. J Clin Psychiat 67:1013–1024CrossRef
Zurück zum Zitat Goldman R, Loebel A, Cucchiaro J (2017) Efficacy and safety of lurasidone in adolescents with schizophrenia: a six-week, randomized placebo controlled study. J Child Adolesc Psychopharmacol 27:516–525PubMedPubMedCentralCrossRef Goldman R, Loebel A, Cucchiaro J (2017) Efficacy and safety of lurasidone in adolescents with schizophrenia: a six-week, randomized placebo controlled study. J Child Adolesc Psychopharmacol 27:516–525PubMedPubMedCentralCrossRef
Zurück zum Zitat Goldstein BI, Sassi R, Diler RS (2012) Pharmacological treatment of bipolar disorder in children and adolescents. Child Adolesc Psychiatr Clin N 21:911–939CrossRef Goldstein BI, Sassi R, Diler RS (2012) Pharmacological treatment of bipolar disorder in children and adolescents. Child Adolesc Psychiatr Clin N 21:911–939CrossRef
Zurück zum Zitat Grohmann R, Hippius H, Rüther R (2001) Extrapyramidal motor side-effects and blood profile changes. Stumbling blocks in psychiatric pharmacotherapy. MMW Fortschr Med 77(Suppl 2):76–77 Grohmann R, Hippius H, Rüther R (2001) Extrapyramidal motor side-effects and blood profile changes. Stumbling blocks in psychiatric pharmacotherapy. MMW Fortschr Med 77(Suppl 2):76–77
Zurück zum Zitat Guinart D, Taipale H, Rubio JM et al. (2021) Risk Factors, incidence, and outcomes of neuroleptic malignant syndrome on long-acting injectable vs oral antipsychotics in a nationwide schizophrenia cohort. Schizophr Bull 476:1621–1623CrossRef Guinart D, Taipale H, Rubio JM et al. (2021) Risk Factors, incidence, and outcomes of neuroleptic malignant syndrome on long-acting injectable vs oral antipsychotics in a nationwide schizophrenia cohort. Schizophr Bull 476:1621–1623CrossRef
Zurück zum Zitat Haase HJ (1954) About prevalence and interpretation of the psychomotor Parkinson syndrome in megaphen or largactil treatment duration. Nervenarzt 25:486–492PubMed Haase HJ (1954) About prevalence and interpretation of the psychomotor Parkinson syndrome in megaphen or largactil treatment duration. Nervenarzt 25:486–492PubMed
Zurück zum Zitat Haase HJ, Janssen PAJ (1965) The action of neuroleptic drugs. Year Book Medical, Chicago Haase HJ, Janssen PAJ (1965) The action of neuroleptic drugs. Year Book Medical, Chicago
Zurück zum Zitat Hasan A, Falkai P, Wobrock T et al. (2015) World Federation of Societis of Biological Psychiatry (WFSBP) guidelines for biological treatment of schizophrenia. Part 3: update 2015 management of special circumstances: depression, suicidality, substance use disorders and pregnancy and lactation. World J Biol Psychiatry 16:142–170 (on behalf of the WFSBP Task Force on Treatment Guidelines for Schizophrenia)PubMedCrossRef Hasan A, Falkai P, Wobrock T et al. (2015) World Federation of Societis of Biological Psychiatry (WFSBP) guidelines for biological treatment of schizophrenia. Part 3: update 2015 management of special circumstances: depression, suicidality, substance use disorders and pregnancy and lactation. World J Biol Psychiatry 16:142–170 (on behalf of the WFSBP Task Force on Treatment Guidelines for Schizophrenia)PubMedCrossRef
Zurück zum Zitat Häßler F, Dück A, Jung M, Reis O (2014) treatment of aggressive behavior problems in boys with intellectual disabilities using zuclopenthixol. J Child Adolesc Psychopharmacol 24:579–581PubMedCrossRef Häßler F, Dück A, Jung M, Reis O (2014) treatment of aggressive behavior problems in boys with intellectual disabilities using zuclopenthixol. J Child Adolesc Psychopharmacol 24:579–581PubMedCrossRef
Zurück zum Zitat Heck J, Krichewsky B, Krause O et al. (2021) Photosensibilisierung durch Psychopharmaka und andere Arzneimittel. Psychopharmakotherapie 28:94–101 Heck J, Krichewsky B, Krause O et al. (2021) Photosensibilisierung durch Psychopharmaka und andere Arzneimittel. Psychopharmakotherapie 28:94–101
Zurück zum Zitat Henderson DC, Cagliero E, Copeland PM et al. (2007) Elevated hemoglobin A1c as possible indicator of diabetes mellitus and diabetic ketoacidosis in schizophrenia patients receiving atipycal antipsychotics. J Clin Psychiat 68:533–541CrossRef Henderson DC, Cagliero E, Copeland PM et al. (2007) Elevated hemoglobin A1c as possible indicator of diabetes mellitus and diabetic ketoacidosis in schizophrenia patients receiving atipycal antipsychotics. J Clin Psychiat 68:533–541CrossRef
Zurück zum Zitat Hiemke C, Pfuhlmann B (2012) Interactions and monitoring of antipsychotic drugs. Handb Exp Pharmacol 212:241–265CrossRef Hiemke C, Pfuhlmann B (2012) Interactions and monitoring of antipsychotic drugs. Handb Exp Pharmacol 212:241–265CrossRef
Zurück zum Zitat Hiemke C, Bergemann N, Clement HW et al. (2018) Consensus guidelines for therapeutic drug monitoring in neuropsychopharmacology - Update 2017. Pharmacopsychiatry 51:9–62PubMedCrossRef Hiemke C, Bergemann N, Clement HW et al. (2018) Consensus guidelines for therapeutic drug monitoring in neuropsychopharmacology - Update 2017. Pharmacopsychiatry 51:9–62PubMedCrossRef
Zurück zum Zitat Højlund M, Kemp AF, Haddad PM et al. (2021) Standard versus reduced dose of antipsychotics for relapse prevention in multi-episode schizophrenia: a systematic review and meta-analysis of randomized controlled trials. Lancet Psychiatry 8:471–486PubMedCrossRef Højlund M, Kemp AF, Haddad PM et al. (2021) Standard versus reduced dose of antipsychotics for relapse prevention in multi-episode schizophrenia: a systematic review and meta-analysis of randomized controlled trials. Lancet Psychiatry 8:471–486PubMedCrossRef
Zurück zum Zitat Howes OD, McCutcheon R, Owen MJ, Murray RM (2017) The role of genes, stress, and dopamine in the development of schizophrenia. Biol Psychiatry 81:9–20PubMedCrossRef Howes OD, McCutcheon R, Owen MJ, Murray RM (2017) The role of genes, stress, and dopamine in the development of schizophrenia. Biol Psychiatry 81:9–20PubMedCrossRef
Zurück zum Zitat Huber M, Schlosser-Weber G, Paeschke N, Broich K (2015) Antipsychotika in der Schwangerschaft. Psychopharmakotherapie 22:278–285 Huber M, Schlosser-Weber G, Paeschke N, Broich K (2015) Antipsychotika in der Schwangerschaft. Psychopharmakotherapie 22:278–285
Zurück zum Zitat Huhn M, Nikolakopoulou A, Schneider-Thoma J et al. (2019) Comparative efficacy and tolerability of 32 oral antipsychotics for the acute treatment of adults with multi-episode schizophrenia: a systematic review and network meta-analysis. Lancet 394:939–951PubMedPubMedCentralCrossRef Huhn M, Nikolakopoulou A, Schneider-Thoma J et al. (2019) Comparative efficacy and tolerability of 32 oral antipsychotics for the acute treatment of adults with multi-episode schizophrenia: a systematic review and network meta-analysis. Lancet 394:939–951PubMedPubMedCentralCrossRef
Zurück zum Zitat Huybrechts KF, Hernandez-Diaz S, Patorno E et al. (2016) Antipsychotic use in pregnancy and the risk of congenital malformations. JAMA Psychiatry 73:938–946PubMedPubMedCentralCrossRef Huybrechts KF, Hernandez-Diaz S, Patorno E et al. (2016) Antipsychotic use in pregnancy and the risk of congenital malformations. JAMA Psychiatry 73:938–946PubMedPubMedCentralCrossRef
Zurück zum Zitat Jensen KG, Juul K, Fink-Jensen A, Correll CU, Pagsberg AK (2015) Corrected QT changes during antipsychotic treatment of children and adolescents: a systematic review and meta-analysis of clinical trials. J Am Acad Child Adolesc Psychiatry 54:25–36PubMedCrossRef Jensen KG, Juul K, Fink-Jensen A, Correll CU, Pagsberg AK (2015) Corrected QT changes during antipsychotic treatment of children and adolescents: a systematic review and meta-analysis of clinical trials. J Am Acad Child Adolesc Psychiatry 54:25–36PubMedCrossRef
Zurück zum Zitat Kapur S, Seeman P (2000) Antipsychotic agents differ in how fast they come off the dopamine D2 receptors. Implications for atypical antipsychotic action. J Psychiatr Neurosci 25:161–166 Kapur S, Seeman P (2000) Antipsychotic agents differ in how fast they come off the dopamine D2 receptors. Implications for atypical antipsychotic action. J Psychiatr Neurosci 25:161–166
Zurück zum Zitat Kapur S, Seeman P (2001) Does fast dissociation from the dopamine D2 receptor explaine the action of atypical antipsychotics? A new hypothesis. Am J Psychiat 158:360–369PubMedCrossRef Kapur S, Seeman P (2001) Does fast dissociation from the dopamine D2 receptor explaine the action of atypical antipsychotics? A new hypothesis. Am J Psychiat 158:360–369PubMedCrossRef
Zurück zum Zitat Keefe RSE, Bilder RM, Davis SM et al. (2007) Neurocognitive effects of antipsychotic medications in patients with chronic schizophrenia in the CATIE Trial. Arch Gen Psychiat 64:633–647 (CATIE investigators and the Neurocognitive Working Group)PubMedCrossRef Keefe RSE, Bilder RM, Davis SM et al. (2007) Neurocognitive effects of antipsychotic medications in patients with chronic schizophrenia in the CATIE Trial. Arch Gen Psychiat 64:633–647 (CATIE investigators and the Neurocognitive Working Group)PubMedCrossRef
Zurück zum Zitat Kegeles LS, Slifstein M, Frankle WG et al. (2008) Dose-occupancy study of striatal and extrastriatal dopamine D2 receptors by aripiprazole in schizophrenia with PET and [18F]fallypride. Neuropsychopharmacology 33:3111–3125PubMedCrossRef Kegeles LS, Slifstein M, Frankle WG et al. (2008) Dose-occupancy study of striatal and extrastriatal dopamine D2 receptors by aripiprazole in schizophrenia with PET and [18F]fallypride. Neuropsychopharmacology 33:3111–3125PubMedCrossRef
Zurück zum Zitat Keks N, Hope J, Schwartz D et al. (2020) Comparative tolerability of dopamine D2/3 receptor partial agonists for schizophrenia. CNS Drugs 34:473–450PubMedCrossRef Keks N, Hope J, Schwartz D et al. (2020) Comparative tolerability of dopamine D2/3 receptor partial agonists for schizophrenia. CNS Drugs 34:473–450PubMedCrossRef
Zurück zum Zitat Kennedy WK, Jann MW, Kutscher EC (2013) Clinically significant drug interactions with atypical antipsychotics. CNS Drugs 27:1021–1048PubMedCrossRef Kennedy WK, Jann MW, Kutscher EC (2013) Clinically significant drug interactions with atypical antipsychotics. CNS Drugs 27:1021–1048PubMedCrossRef
Zurück zum Zitat Khandaker GM, Zimbron J, Dalman C, Lewis G, Jones PB (2012) Childhood infection and adult schizophrenia: a meta-analysis of population-based studies. Schizophr Res 139:161–168PubMedPubMedCentralCrossRef Khandaker GM, Zimbron J, Dalman C, Lewis G, Jones PB (2012) Childhood infection and adult schizophrenia: a meta-analysis of population-based studies. Schizophr Res 139:161–168PubMedPubMedCentralCrossRef
Zurück zum Zitat Kishimoto T, Hagi K, Nitta M, Kane JM, Correll CU (2019) Long-term effectiveness of oral second-generation antipsychotics in patients with schizophrenia and related disorders: a systematic review and meta-analysis of direct head-tohead comparisons. World Psychiatry 18:208–224PubMedPubMedCentralCrossRef Kishimoto T, Hagi K, Nitta M, Kane JM, Correll CU (2019) Long-term effectiveness of oral second-generation antipsychotics in patients with schizophrenia and related disorders: a systematic review and meta-analysis of direct head-tohead comparisons. World Psychiatry 18:208–224PubMedPubMedCentralCrossRef
Zurück zum Zitat Klampfl K, Taurines R, Preuss A et al. (2010) Serum concentrations, therapeutic response and side effects in children and adolescents with impulsive-aggressive symptoms during risperidone therapy. Pharmacopsychiatry 43:58–65PubMedCrossRef Klampfl K, Taurines R, Preuss A et al. (2010) Serum concentrations, therapeutic response and side effects in children and adolescents with impulsive-aggressive symptoms during risperidone therapy. Pharmacopsychiatry 43:58–65PubMedCrossRef
Zurück zum Zitat Koblan KS, Kent J, Hopkins SC et al. (2020) A non-D2-receptor-binding drug for the treatment of schizophrenia. New Engl J Med 382:1497–1506PubMedCrossRef Koblan KS, Kent J, Hopkins SC et al. (2020) A non-D2-receptor-binding drug for the treatment of schizophrenia. New Engl J Med 382:1497–1506PubMedCrossRef
Zurück zum Zitat Köster L-S, Carbon M, Correll CU (2014) Emerging drugs for schizophrenia: an update. Expert Opin Emerg Drugs 19:511–531PubMedCrossRef Köster L-S, Carbon M, Correll CU (2014) Emerging drugs for schizophrenia: an update. Expert Opin Emerg Drugs 19:511–531PubMedCrossRef
Zurück zum Zitat Koller E, Schneider B, Bennett K, Dubitsky G (2001) Clozapine-associated diabetes. Am J Med 111:716–723PubMedCrossRef Koller E, Schneider B, Bennett K, Dubitsky G (2001) Clozapine-associated diabetes. Am J Med 111:716–723PubMedCrossRef
Zurück zum Zitat Koller EA, Cross JT, Schneider B (2004a) Risperidone-associated diabetis mellitus in children. Pediatrics 113:421–422PubMedCrossRef Koller EA, Cross JT, Schneider B (2004a) Risperidone-associated diabetis mellitus in children. Pediatrics 113:421–422PubMedCrossRef
Zurück zum Zitat Koller EA, Weber J, Doraiswamy PM, Schneider BS (2004b) A survey of reports of quetiapine-associated hyperglycemia and diabetes mellitus. J Clin Psychiat 65:857–863CrossRef Koller EA, Weber J, Doraiswamy PM, Schneider BS (2004b) A survey of reports of quetiapine-associated hyperglycemia and diabetes mellitus. J Clin Psychiat 65:857–863CrossRef
Zurück zum Zitat Kornhuber J, Thome J, Riederer P (1998) Modellvorstellungen zur Ätiopathogenese der Schizphrenien. In: Riederer P, Laux G, Pöldinger W (Hrsg) Neuroleptika, 2. Aufl. Neuro-Psychopharmaka. Ein Therapie-Handbuch, Bd. 4. Springer, Wien, S 3–21 Kornhuber J, Thome J, Riederer P (1998) Modellvorstellungen zur Ätiopathogenese der Schizphrenien. In: Riederer P, Laux G, Pöldinger W (Hrsg) Neuroleptika, 2. Aufl. Neuro-Psychopharmaka. Ein Therapie-Handbuch, Bd. 4. Springer, Wien, S 3–21
Zurück zum Zitat Koskuvi M, Lehtonen S, Trontti K et al. (2022) Contribution of astrocytes and clinical manifestation of schizophrenia. Glia 70:650–660PubMedCrossRef Koskuvi M, Lehtonen S, Trontti K et al. (2022) Contribution of astrocytes and clinical manifestation of schizophrenia. Glia 70:650–660PubMedCrossRef
Zurück zum Zitat Kulkarni SK, Naidu PS (2003) Pathophysiology and drug therapy of tardive dyskinesia: current concepts and future perspectives. Drug Today 39:19–49CrossRef Kulkarni SK, Naidu PS (2003) Pathophysiology and drug therapy of tardive dyskinesia: current concepts and future perspectives. Drug Today 39:19–49CrossRef
Zurück zum Zitat Labad J, Montalvo I, Gonzalez-Rodriguez A et al. (2020) Pharmacological treatment strategies for lowering prolactin in people with a psychotic disorder and hyperprolactinemia: a systematic review and meta-analysis. Schizophr Res 222:88–96PubMedCrossRef Labad J, Montalvo I, Gonzalez-Rodriguez A et al. (2020) Pharmacological treatment strategies for lowering prolactin in people with a psychotic disorder and hyperprolactinemia: a systematic review and meta-analysis. Schizophr Res 222:88–96PubMedCrossRef
Zurück zum Zitat Laruelle M (2014) Schizophrenia: from dopaminergic to glutamatergic interventions. Curr Opin Pharmacol 14:97–102PubMedCrossRef Laruelle M (2014) Schizophrenia: from dopaminergic to glutamatergic interventions. Curr Opin Pharmacol 14:97–102PubMedCrossRef
Zurück zum Zitat Lee SE, Kronsberg H, Findling RL (2020) Psychopharmacologic treatment of schizophrenia in adolsecents and children. Child Adolesc Psychiatr Clin N Am 29:183–210PubMedCrossRef Lee SE, Kronsberg H, Findling RL (2020) Psychopharmacologic treatment of schizophrenia in adolsecents and children. Child Adolesc Psychiatr Clin N Am 29:183–210PubMedCrossRef
Zurück zum Zitat Lessig MC, Shapira NA, Murphy TK (2001) Topiramate reversing atypical antipsychotic weight gain. Letter J Am Acad Child Psy 40:1364CrossRef Lessig MC, Shapira NA, Murphy TK (2001) Topiramate reversing atypical antipsychotic weight gain. Letter J Am Acad Child Psy 40:1364CrossRef
Zurück zum Zitat Leucht S, Corves C, Arbter D et al. (2009) Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis. Lancet 373:31–41PubMedCrossRef Leucht S, Corves C, Arbter D et al. (2009) Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis. Lancet 373:31–41PubMedCrossRef
Zurück zum Zitat Li A, Zalesky A, Yue W et al. (2020) A neuroimaging biomarker for striatal dysfunction in schizophrenie. Nat Med 26:558-565PubMedCrossRef Li A, Zalesky A, Yue W et al. (2020) A neuroimaging biomarker for striatal dysfunction in schizophrenie. Nat Med 26:558-565PubMedCrossRef
Zurück zum Zitat Lieberman JA (2004) Dopamine partial agonists. A new class of antipsychotics. CNS Drugs 18:251–267PubMedCrossRef Lieberman JA (2004) Dopamine partial agonists. A new class of antipsychotics. CNS Drugs 18:251–267PubMedCrossRef
Zurück zum Zitat Liu HY, Potter MP, Woodworth KY et al. (2011) Pharmcologic treatments for pediatric bipolar disorder: a review and meta-analysis. J Am Acad Child Psy 50:749–762CrossRef Liu HY, Potter MP, Woodworth KY et al. (2011) Pharmcologic treatments for pediatric bipolar disorder: a review and meta-analysis. J Am Acad Child Psy 50:749–762CrossRef
Zurück zum Zitat Loebel A, Brams M, Goldman R et al. (2016) Lurasidone for the treatment of irritability associated with autistic disorder. J Autism Dev Disord 46:1153–1163PubMedCrossRef Loebel A, Brams M, Goldman R et al. (2016) Lurasidone for the treatment of irritability associated with autistic disorder. J Autism Dev Disord 46:1153–1163PubMedCrossRef
Zurück zum Zitat López-Muñoz F, Alamo C, Cuenca E et al. (2005) History of the discovery and clinical introduction of chlorpromazine. Ann Clin Psychiatry 17:113–135PubMedCrossRef López-Muñoz F, Alamo C, Cuenca E et al. (2005) History of the discovery and clinical introduction of chlorpromazine. Ann Clin Psychiatry 17:113–135PubMedCrossRef
Zurück zum Zitat Madaan V, Dvir Y, Wilson DR (2008) Child and adolescent schizophrenia: pharmacological approaches. Exp Opin Pharmacol 9:2053–2068CrossRef Madaan V, Dvir Y, Wilson DR (2008) Child and adolescent schizophrenia: pharmacological approaches. Exp Opin Pharmacol 9:2053–2068CrossRef
Zurück zum Zitat Marenco S, Weinberger DR (2000) The neurodevelopmental hypothesis of schizophrenia: following a trail of evidence from cradle to grave. Dev Psychopathol 12:501–527PubMedCrossRef Marenco S, Weinberger DR (2000) The neurodevelopmental hypothesis of schizophrenia: following a trail of evidence from cradle to grave. Dev Psychopathol 12:501–527PubMedCrossRef
Zurück zum Zitat Martin WF, Correll CU, Weiden PJ et al. (2019) Mitigation of olanzapine-induced weight gain with samidorphan, an opioid antagonist: a randomized double-blind phase 2 study in patients with schizophrenia. Am J Psychiatry 176:457–467PubMedCrossRef Martin WF, Correll CU, Weiden PJ et al. (2019) Mitigation of olanzapine-induced weight gain with samidorphan, an opioid antagonist: a randomized double-blind phase 2 study in patients with schizophrenia. Am J Psychiatry 176:457–467PubMedCrossRef
Zurück zum Zitat Masi G, Liboni F (2011) Management of schizophrenia in children and adolescents. Drugs 71:179–208PubMedCrossRef Masi G, Liboni F (2011) Management of schizophrenia in children and adolescents. Drugs 71:179–208PubMedCrossRef
Zurück zum Zitat Mishara AL, Goldberg TE (2004) A meta-analysis and critical review of the effects of conventional neuroleptic treatment on cognition in schizophrenia: Opening a closed book. Biol Psychiat 55:1013–1022PubMedCrossRef Mishara AL, Goldberg TE (2004) A meta-analysis and critical review of the effects of conventional neuroleptic treatment on cognition in schizophrenia: Opening a closed book. Biol Psychiat 55:1013–1022PubMedCrossRef
Zurück zum Zitat Miyamoto S, Duncan GE, Marx CE, Lieberman JA (2005) Treatments for schizophrenia: a critical review of pharmacology and mechanisms of action of antipsychotic drugs. Mol Psychiatry 10:79–104PubMedCrossRef Miyamoto S, Duncan GE, Marx CE, Lieberman JA (2005) Treatments for schizophrenia: a critical review of pharmacology and mechanisms of action of antipsychotic drugs. Mol Psychiatry 10:79–104PubMedCrossRef
Zurück zum Zitat Möller HJ, Müller WE, Bandelow B (2001) Neuroleptika. Pharmakologische Grundlagen, klinisches Wissen und therapeutisches Vorgehen. Wissenschaftliche Verlagsgesellschaft, Stuttgart, S 243 Möller HJ, Müller WE, Bandelow B (2001) Neuroleptika. Pharmakologische Grundlagen, klinisches Wissen und therapeutisches Vorgehen. Wissenschaftliche Verlagsgesellschaft, Stuttgart, S 243
Zurück zum Zitat Müller WE (2019) Vergleichende Betrachtung der pharmakologischen Eigenschaften von Dopamin-D2-Partialagonisten. Psychopharmakotherapie 26:192–204 Müller WE (2019) Vergleichende Betrachtung der pharmakologischen Eigenschaften von Dopamin-D2-Partialagonisten. Psychopharmakotherapie 26:192–204
Zurück zum Zitat Morrison JA, Cottingham EM, Barton BA (2002) Metformin for weight loss in pediatric patients taking psychotropic drugs. Am J Psychiat 159:655–657PubMedCrossRef Morrison JA, Cottingham EM, Barton BA (2002) Metformin for weight loss in pediatric patients taking psychotropic drugs. Am J Psychiat 159:655–657PubMedCrossRef
Zurück zum Zitat Naguy A, Adel T, Almazeedi I (2019) Paliperidone use in child psychiatry: evidence or diffidence? Pharmacology 104:67–70PubMedCrossRef Naguy A, Adel T, Almazeedi I (2019) Paliperidone use in child psychiatry: evidence or diffidence? Pharmacology 104:67–70PubMedCrossRef
Zurück zum Zitat Nevels RM, Dehon EE, Alexander K, Gontkovsky ST (2010) Psychopharmacology of aggression in children and adolescents with primary neuropsychiatric disorders: A review of current and potentially promising treatment options. Exp Clin Psychopharm 18:184–201CrossRef Nevels RM, Dehon EE, Alexander K, Gontkovsky ST (2010) Psychopharmacology of aggression in children and adolescents with primary neuropsychiatric disorders: A review of current and potentially promising treatment options. Exp Clin Psychopharm 18:184–201CrossRef
Zurück zum Zitat Onishi Y, Mikami K, Kimoto K et al. (2021) Second-generation antipsychotic drugs for children and adolescents. Review. J Nippon Med Sch 88:10–16PubMedCrossRef Onishi Y, Mikami K, Kimoto K et al. (2021) Second-generation antipsychotic drugs for children and adolescents. Review. J Nippon Med Sch 88:10–16PubMedCrossRef
Zurück zum Zitat Pagsberg AK, Tarp S, Glintborg D et al. (2017) Acute antipsychotic treatment with schizophrenia spectrum disorders: a systematic review and network meta-analysis. J Am Acad Child Adolesc Psychiatry 56:191–202PubMedCrossRef Pagsberg AK, Tarp S, Glintborg D et al. (2017) Acute antipsychotic treatment with schizophrenia spectrum disorders: a systematic review and network meta-analysis. J Am Acad Child Adolesc Psychiatry 56:191–202PubMedCrossRef
Zurück zum Zitat Patteet L, Morrens M, Maudens KE et al. (2012) Therapeutic drug monitoring of common antipsychotics. Ther Drug Monit 34:629–651PubMedCrossRef Patteet L, Morrens M, Maudens KE et al. (2012) Therapeutic drug monitoring of common antipsychotics. Ther Drug Monit 34:629–651PubMedCrossRef
Zurück zum Zitat Pillay J, Boylan K, Newton A et al. (2018) Harms of antipsychotics in children and adolescents: a systematic review update. Can J Psychiatry 63:661–678PubMedPubMedCentralCrossRef Pillay J, Boylan K, Newton A et al. (2018) Harms of antipsychotics in children and adolescents: a systematic review update. Can J Psychiatry 63:661–678PubMedPubMedCentralCrossRef
Zurück zum Zitat Pringsheim T, Gorman D (2012) Second-generation antipsychotics for the treatment of disruptive behaviour disorders in children: a systematic review. Can J Psychiat 57:722–727CrossRef Pringsheim T, Gorman D (2012) Second-generation antipsychotics for the treatment of disruptive behaviour disorders in children: a systematic review. Can J Psychiat 57:722–727CrossRef
Zurück zum Zitat Pringsheim T, Lam D, Ching H, Patten S (2011) Metabolic and neurological complications of second-generation anti-psychotic use in children. Drug Saf 34:651–668PubMedCrossRef Pringsheim T, Lam D, Ching H, Patten S (2011) Metabolic and neurological complications of second-generation anti-psychotic use in children. Drug Saf 34:651–668PubMedCrossRef
Zurück zum Zitat Rahman T, Sahrmann JM, Olsen MA et al. (2022) Risk of breast cancer with prolactin elevating antipsychotic drugs: an observational study of US women (Ages 18-64 years). J Clin Psychopharmacol 42:7–16PubMedPubMedCentralCrossRef Rahman T, Sahrmann JM, Olsen MA et al. (2022) Risk of breast cancer with prolactin elevating antipsychotic drugs: an observational study of US women (Ages 18-64 years). J Clin Psychopharmacol 42:7–16PubMedPubMedCentralCrossRef
Zurück zum Zitat Razjouyan K, Danesh A, Khademi M, Davari-Ashtiani R, Noorbaksh S (2018) A comparative study of risperidone and aripiprazole in attention deficit hyperactivity disorder in children under six years old. A randomized double-blind study. Iran J Pediatr 28:e60087CrossRef Razjouyan K, Danesh A, Khademi M, Davari-Ashtiani R, Noorbaksh S (2018) A comparative study of risperidone and aripiprazole in attention deficit hyperactivity disorder in children under six years old. A randomized double-blind study. Iran J Pediatr 28:e60087CrossRef
Zurück zum Zitat Reyad AA, Mishriky R (2019) Asenapine: Pharmacological aspects and role in psychiatric disorders. Psychiatr Danube 31:157–161CrossRef Reyad AA, Mishriky R (2019) Asenapine: Pharmacological aspects and role in psychiatric disorders. Psychiatr Danube 31:157–161CrossRef
Zurück zum Zitat Reyes M, Buitelaar J, Toren P, Augustyns I, Eerdekens M (2006) A randomized, double-blind, placebo-controlled study of risperidone maintenance treatment in children and adolescents with disruptive behavior disorders. Am J Psychiat 163:402–410PubMedCrossRef Reyes M, Buitelaar J, Toren P, Augustyns I, Eerdekens M (2006) A randomized, double-blind, placebo-controlled study of risperidone maintenance treatment in children and adolescents with disruptive behavior disorders. Am J Psychiat 163:402–410PubMedCrossRef
Zurück zum Zitat Robb AS, Carson WH, Nyilas M et al. (2010) Changes in positive and negative syndrome scale-derived hostility factor in adolescents with schizophrenia treated with aripiprazole: Post-hoc analysis of randomized clinical trial data. J Child Adol Psychop 20:33–38CrossRef Robb AS, Carson WH, Nyilas M et al. (2010) Changes in positive and negative syndrome scale-derived hostility factor in adolescents with schizophrenia treated with aripiprazole: Post-hoc analysis of randomized clinical trial data. J Child Adol Psychop 20:33–38CrossRef
Zurück zum Zitat Sallee F, Kohegy E, Zhao J et al. (2017) Randomized, double-blind, placebo-controlled trial demonstrates the efficacy and safety of oral aripiprazole fort he treatment of Tourette’s disorder in children and adolescents. J Child Adolesc Psychopharmacol 27:771–781PubMedPubMedCentralCrossRef Sallee F, Kohegy E, Zhao J et al. (2017) Randomized, double-blind, placebo-controlled trial demonstrates the efficacy and safety of oral aripiprazole fort he treatment of Tourette’s disorder in children and adolescents. J Child Adolesc Psychopharmacol 27:771–781PubMedPubMedCentralCrossRef
Zurück zum Zitat Sallee FR, Kurlan R, Goetz CG et al. (2000) Ziprasidone treatment of children and adolescents with Tourette’s syndrome: a pilot study. J Am Acad Child Psy 39:292–299CrossRef Sallee FR, Kurlan R, Goetz CG et al. (2000) Ziprasidone treatment of children and adolescents with Tourette’s syndrome: a pilot study. J Am Acad Child Psy 39:292–299CrossRef
Zurück zum Zitat Scahill L, Lechman JF, Schultz RT, Katsovich L, Peterson BS (2003) A placebo-controlled trial of risperidone in Tourette syndrome. Neurology 60:1130–1135PubMedCrossRef Scahill L, Lechman JF, Schultz RT, Katsovich L, Peterson BS (2003) A placebo-controlled trial of risperidone in Tourette syndrome. Neurology 60:1130–1135PubMedCrossRef
Zurück zum Zitat Schatzberg AF, Cole JO, De Battista C (2003) Manual of clinical psychopharmacology, 4. Aufl. American Psychiatric Publishing, Washington Schatzberg AF, Cole JO, De Battista C (2003) Manual of clinical psychopharmacology, 4. Aufl. American Psychiatric Publishing, Washington
Zurück zum Zitat Schimmelmann BG, Schmidt SJ, Carbon M, Correll CU (2013) Treatment of adolescents with early-onset schizophrenia spectrum disorders: in search of a rational, evidence-informed approach. Curr Opin Psychiatr 26:219–230CrossRef Schimmelmann BG, Schmidt SJ, Carbon M, Correll CU (2013) Treatment of adolescents with early-onset schizophrenia spectrum disorders: in search of a rational, evidence-informed approach. Curr Opin Psychiatr 26:219–230CrossRef
Zurück zum Zitat Schizophrenia Working Group of the Psychiatric Genomics Consortium (2014) Biological insights from 108 schizophrenia-associated genetic loci. Nature 511:421–427PubMedCentralCrossRef Schizophrenia Working Group of the Psychiatric Genomics Consortium (2014) Biological insights from 108 schizophrenia-associated genetic loci. Nature 511:421–427PubMedCentralCrossRef
Zurück zum Zitat Seeman P (2002) Atypical antipsychotics: mechanism of action. Can J Psychiat 47:27–38CrossRef Seeman P (2002) Atypical antipsychotics: mechanism of action. Can J Psychiat 47:27–38CrossRef
Zurück zum Zitat Seeman P, Lee T (1975) Antipsychotic drugs: direct correlation between clinical potency and presynaptic action on dopamine neurons. Science 188:1217–1219PubMedCrossRef Seeman P, Lee T (1975) Antipsychotic drugs: direct correlation between clinical potency and presynaptic action on dopamine neurons. Science 188:1217–1219PubMedCrossRef
Zurück zum Zitat Seida JC, Schouten JR, Boylan K et al. (2012) Antipsychotics for children and youth adults: A comparative effectiveness review. Pediatrics 129:e771–e784PubMedCrossRef Seida JC, Schouten JR, Boylan K et al. (2012) Antipsychotics for children and youth adults: A comparative effectiveness review. Pediatrics 129:e771–e784PubMedCrossRef
Zurück zum Zitat Shao P, Ou JJ, Peng M et al. (2015) Effects of clozapine and other atypical antipsychotics on infants development who were exposed to as fetus: a post-hoc analysis. Plos One 10:4 (Article Nr. e0123373) Shao P, Ou JJ, Peng M et al. (2015) Effects of clozapine and other atypical antipsychotics on infants development who were exposed to as fetus: a post-hoc analysis. Plos One 10:4 (Article Nr. e0123373)
Zurück zum Zitat Shapiro M, Reid A, Olsen B (2016) Topiramate and zonisamide and weight loss in children and adolscents prescribed psychiatric medications. Int J Psychiatry Med 51:56–68PubMedCrossRef Shapiro M, Reid A, Olsen B (2016) Topiramate and zonisamide and weight loss in children and adolscents prescribed psychiatric medications. Int J Psychiatry Med 51:56–68PubMedCrossRef
Zurück zum Zitat Silva RR, Munoz DM, Alpert M, Perlmutter IR, Diaz J (1999) Neuroleptic malignant syndrome in children and adolescents. J Am Acad Child Psy 38:187–194CrossRef Silva RR, Munoz DM, Alpert M, Perlmutter IR, Diaz J (1999) Neuroleptic malignant syndrome in children and adolescents. J Am Acad Child Psy 38:187–194CrossRef
Zurück zum Zitat Singh J, Robb A, Vijapurkar U, Nuamah I, Hough D (2011) A randomized, double-blind study of paliperidone extended-release in treatment of acute schizophrenia in adolescents. Biol Psychiatry 70:1179–1188PubMedCrossRef Singh J, Robb A, Vijapurkar U, Nuamah I, Hough D (2011) A randomized, double-blind study of paliperidone extended-release in treatment of acute schizophrenia in adolescents. Biol Psychiatry 70:1179–1188PubMedCrossRef
Zurück zum Zitat Smith RC, Maayan L, Wu R et al. (2018) Betahistine effects on weight-related measures in patients treated with antipsychotic medications: a double-blind placebo-controlled study. Psychopharmacology 235:3545–3558PubMedCrossRef Smith RC, Maayan L, Wu R et al. (2018) Betahistine effects on weight-related measures in patients treated with antipsychotic medications: a double-blind placebo-controlled study. Psychopharmacology 235:3545–3558PubMedCrossRef
Zurück zum Zitat Solmi M, Pigato G, Kane JM, Correll CU (2018) Clinical risk factors for the development of tardive dyskinesia. J Neurol Sciences 389:21–27CrossRef Solmi M, Pigato G, Kane JM, Correll CU (2018) Clinical risk factors for the development of tardive dyskinesia. J Neurol Sciences 389:21–27CrossRef
Zurück zum Zitat Spencer EK, Kafantaris V, Padron-Gayol MV, Rosenberg CR (1992) Haloperidol in schizophrenic children: early findings from a study in progress. Psychopharmacol Bull 28:183–186PubMed Spencer EK, Kafantaris V, Padron-Gayol MV, Rosenberg CR (1992) Haloperidol in schizophrenic children: early findings from a study in progress. Psychopharmacol Bull 28:183–186PubMed
Zurück zum Zitat Stentjeberg-Olesen M, Ganocy S, Findling R et al. (2015) Early response or non-response at week 2 and week 3 predict ultimate response or non-response in adolescents with schizophrenia treated with olanzapine: results from a 6-week randomized, placebo-controlled trial. Eur Child Adolesc Psychiatry 24:1485–1496CrossRef Stentjeberg-Olesen M, Ganocy S, Findling R et al. (2015) Early response or non-response at week 2 and week 3 predict ultimate response or non-response in adolescents with schizophrenia treated with olanzapine: results from a 6-week randomized, placebo-controlled trial. Eur Child Adolesc Psychiatry 24:1485–1496CrossRef
Zurück zum Zitat Stigler KA, Potenza MN, Posey DJ, McDougle CJ (2004) Weight gain associated with atypical antipsychotic use in children and adolescents. Prevalence, clinical relevance, and management. Pediatr Drugs 6:33–44CrossRef Stigler KA, Potenza MN, Posey DJ, McDougle CJ (2004) Weight gain associated with atypical antipsychotic use in children and adolescents. Prevalence, clinical relevance, and management. Pediatr Drugs 6:33–44CrossRef
Zurück zum Zitat Tamminga CA (2006) Principles of pharmacology of schizophrenia. In: Charney DS, Nestler (Hrsg) Neurobiology of mental illnesses, 2. Aufl. Oxford University Press, Oxford, S 339–354 Tamminga CA (2006) Principles of pharmacology of schizophrenia. In: Charney DS, Nestler (Hrsg) Neurobiology of mental illnesses, 2. Aufl. Oxford University Press, Oxford, S 339–354
Zurück zum Zitat Tickell AM, Rohleder C, Ho NI et al. (2021) Identifying pathways to early-onset metabolic dysfunction, insulin resistance and inflammation in young adult inpatients with emerging affective and major mood disorders. Early Interv Psychiatry 16:1121–1129PubMedCrossRef Tickell AM, Rohleder C, Ho NI et al. (2021) Identifying pathways to early-onset metabolic dysfunction, insulin resistance and inflammation in young adult inpatients with emerging affective and major mood disorders. Early Interv Psychiatry 16:1121–1129PubMedCrossRef
Zurück zum Zitat Vancampfort D, Firth J, Correll CU et al. (2019) The impact of pharmacological and non-pharmacological interventions to improve physical health outcomes in people with schizophrenia: a meta-review of Metaanalyses of randomized controlled trials. World Psychiatry 18:53–66PubMedPubMedCentralCrossRef Vancampfort D, Firth J, Correll CU et al. (2019) The impact of pharmacological and non-pharmacological interventions to improve physical health outcomes in people with schizophrenia: a meta-review of Metaanalyses of randomized controlled trials. World Psychiatry 18:53–66PubMedPubMedCentralCrossRef
Zurück zum Zitat Vazquez-Bourgon J, Alario MI, Mayoral van Son J et al. (2020) A 3-year prospective study on the metabolic effect of aripiprazol, quetiapin and ziprasidone: a pragmatic clinical trial in first episode psychosis patients. Eur Neuropsychopharmacol 39:46–55PubMedCrossRef Vazquez-Bourgon J, Alario MI, Mayoral van Son J et al. (2020) A 3-year prospective study on the metabolic effect of aripiprazol, quetiapin and ziprasidone: a pragmatic clinical trial in first episode psychosis patients. Eur Neuropsychopharmacol 39:46–55PubMedCrossRef
Zurück zum Zitat Vieta E, Montes E (2018) A review of asenapine in the treatment of bipolar disorder. Clin Drug Invest 38:87–99CrossRef Vieta E, Montes E (2018) A review of asenapine in the treatment of bipolar disorder. Clin Drug Invest 38:87–99CrossRef
Zurück zum Zitat Wagner E, Hasan A (2018) Cariprazin – eine neue medikamentöse Therapieoption in der Schizophreniebehandlung. Psychopharmakotherapie 25:278–285 Wagner E, Hasan A (2018) Cariprazin – eine neue medikamentöse Therapieoption in der Schizophreniebehandlung. Psychopharmakotherapie 25:278–285
Zurück zum Zitat Weizman S, Shelef A, Bris EB, Stryjer R (2021) A double-blind, placebo-controlled trial of bupropion add-on to olanzapine in overweight individuals with schizophrenia. J Clin Psychopharmacology 41:629-631CrossRef Weizman S, Shelef A, Bris EB, Stryjer R (2021) A double-blind, placebo-controlled trial of bupropion add-on to olanzapine in overweight individuals with schizophrenia. J Clin Psychopharmacology 41:629-631CrossRef
Zurück zum Zitat Wolkin A, Barouche F, Wolf A et al. (1989) Dopamine blockade and clinical response for two biological subgroups of schizophrenia. Am J Psychiatry 146:905–908PubMedCrossRef Wolkin A, Barouche F, Wolf A et al. (1989) Dopamine blockade and clinical response for two biological subgroups of schizophrenia. Am J Psychiatry 146:905–908PubMedCrossRef
Zurück zum Zitat Yee CS, Bahji A, Lolich M, Vazquez GH, Baldessarini RJ (2022) Comparative efficacy and tolerability of antipsychotics for juvenile psychotic disorders: a systematic review and network meta-analysis. J Clin Psychopharmacol 42:198–208PubMedCrossRef Yee CS, Bahji A, Lolich M, Vazquez GH, Baldessarini RJ (2022) Comparative efficacy and tolerability of antipsychotics for juvenile psychotic disorders: a systematic review and network meta-analysis. J Clin Psychopharmacol 42:198–208PubMedCrossRef
Zurück zum Zitat Zhao MJ, Qin B, Wang JB et al. (2018) Efficacy and acceptibility of cariprazine in acute exacerbation schizophrenia meta-analysis of randomized placebo-controlled trials. J Clin Psychopharmacol 38:55-59PubMedCrossRef Zhao MJ, Qin B, Wang JB et al. (2018) Efficacy and acceptibility of cariprazine in acute exacerbation schizophrenia meta-analysis of randomized placebo-controlled trials. J Clin Psychopharmacol 38:55-59PubMedCrossRef
Zurück zum Zitat Zuddas A, Zanni R, Usala T (2011) Second generation antipsychotics (SGas) for non-psychotic disorders in children and adolescents: a review of the randomized controlled studies. Eur Neuropsychopharm 21:600–620CrossRef Zuddas A, Zanni R, Usala T (2011) Second generation antipsychotics (SGas) for non-psychotic disorders in children and adolescents: a review of the randomized controlled studies. Eur Neuropsychopharm 21:600–620CrossRef
Zurück zum Zitat Fountoulakis KN, Moeller HJ, Kasper S et al. (2021) The report of the joint WPA/CINP workgroup on the use and usefulness of antipsychotic medication in the treatment of schizophrenia. CNS Spectr 26:562–586CrossRef Fountoulakis KN, Moeller HJ, Kasper S et al. (2021) The report of the joint WPA/CINP workgroup on the use and usefulness of antipsychotic medication in the treatment of schizophrenia. CNS Spectr 26:562–586CrossRef
Zurück zum Zitat Howes OD, McCutcheon R, Owen MJ, Murray RM (2017) The role of genes, stress, and dopamine in the development of schizophrenia. Biol Psychiatry 81:9–20PubMedCrossRef Howes OD, McCutcheon R, Owen MJ, Murray RM (2017) The role of genes, stress, and dopamine in the development of schizophrenia. Biol Psychiatry 81:9–20PubMedCrossRef
Zurück zum Zitat Schimmelmann BG, Schmidt SJ, Carbon M, Correll CU (2013) Treatment of adolescents with early-onset schizophrenia spectrum disorders: in search of a rational, evidence-informed approach. Curr Opin Psychiatr 26:219–230CrossRef Schimmelmann BG, Schmidt SJ, Carbon M, Correll CU (2013) Treatment of adolescents with early-onset schizophrenia spectrum disorders: in search of a rational, evidence-informed approach. Curr Opin Psychiatr 26:219–230CrossRef
Metadaten
Titel
Antipsychotika
verfasst von
Prof. Dr. med. Claudia Mehler-Wex
Prof. Dr. med. Timo D. Vloet
Prof. Dr. rer. nat. Manfred Gerlach
Copyright-Jahr
2023
Verlag
Springer Berlin Heidelberg
DOI
https://doi.org/10.1007/978-3-662-65267-1_6

Demenzkranke durch Antipsychotika vielfach gefährdet

23.04.2024 Demenz Nachrichten

Wenn Demenzkranke aufgrund von Symptomen wie Agitation oder Aggressivität mit Antipsychotika behandelt werden, sind damit offenbar noch mehr Risiken verbunden als bislang angenommen.

Weniger postpartale Depressionen nach Esketamin-Einmalgabe

Bislang gibt es kein Medikament zur Prävention von Wochenbettdepressionen. Das Injektionsanästhetikum Esketamin könnte womöglich diese Lücke füllen.

„Psychotherapie ist auch bei sehr alten Menschen hochwirksam!“

22.04.2024 DGIM 2024 Kongressbericht

Die Kombination aus Medikamenten und Psychotherapie gilt als effektivster Ansatz bei Depressionen. Das ist bei betagten Menschen nicht anders, trotz Besonderheiten.

Auf diese Krankheiten bei Geflüchteten sollten Sie vorbereitet sein

22.04.2024 DGIM 2024 Nachrichten

Um Menschen nach der Flucht aus einem Krisengebiet bestmöglich medizinisch betreuen zu können, ist es gut zu wissen, welche Erkrankungen im jeweiligen Herkunftsland häufig sind. Dabei hilft eine Internetseite der CDC (Centers for Disease Control and Prevention).