Skip to main content
Erschienen in: Seminars in Immunopathology 2/2007

01.06.2007 | Review

Antisperm antibodies and conception

verfasst von: L. W. Chamley, G. N. Clarke

Erschienen in: Seminars in Immunopathology | Ausgabe 2/2007

Einloggen, um Zugang zu erhalten

Abstract

Sperm have been known to be antigenic for more than a century. There is a strong body of evidence that in humans and in other species at least some antibodies that bind to sperm antigens can cause infertility. Therefore, these antibodies are of interest today for two practical reasons. Firstly, the association of the antibodies with infertility means that they must be detected and then the couples treated appropriately. Secondly, because these antibodies can induce infertility they have the potential to be developed for contraceptive purposes in humans and also for the control of feral animal populations.
Literatur
1.
Zurück zum Zitat Abdel-Latif A, Mathur S, Rust PF, Fredericks CM, Abdel-Aal H, Williamson HO (1986) Cytotoxic sperm antibodies inhibit sperm penetration of zona-free hamster eggs. Fertil Steril 45:542–549PubMed Abdel-Latif A, Mathur S, Rust PF, Fredericks CM, Abdel-Aal H, Williamson HO (1986) Cytotoxic sperm antibodies inhibit sperm penetration of zona-free hamster eggs. Fertil Steril 45:542–549PubMed
2.
Zurück zum Zitat Acosta AA, van der Merwe JP, Doncel G, Kruger TF, Sayilgan A, Franken DR, Kolm P (1994) Fertilization efficiency of morphologically abnormal spermatozoa in assisted reproduction is further impaired by antisperm antibodies on the male partner’s sperm. Fertil Steril 62:826–833PubMed Acosta AA, van der Merwe JP, Doncel G, Kruger TF, Sayilgan A, Franken DR, Kolm P (1994) Fertilization efficiency of morphologically abnormal spermatozoa in assisted reproduction is further impaired by antisperm antibodies on the male partner’s sperm. Fertil Steril 62:826–833PubMed
3.
Zurück zum Zitat Agarwal A (1992) Treatment of immunological infertility by sperm washing and intrauterine insemination. Arch Androl 29:207–213PubMed Agarwal A (1992) Treatment of immunological infertility by sperm washing and intrauterine insemination. Arch Androl 29:207–213PubMed
4.
Zurück zum Zitat Aitken RJ, Parslow JM, Hargreave TB, Hendry WF (1988) Influence of antisperm antibodies on human sperm function. Br J Urol 62:367–373PubMed Aitken RJ, Parslow JM, Hargreave TB, Hendry WF (1988) Influence of antisperm antibodies on human sperm function. Br J Urol 62:367–373PubMed
5.
Zurück zum Zitat Alexander NJ, Schmidt SS (1977) Incidence of antisperm antibody levels and granulomas in men. Fertil Steril 28:655–657PubMed Alexander NJ, Schmidt SS (1977) Incidence of antisperm antibody levels and granulomas in men. Fertil Steril 28:655–657PubMed
6.
Zurück zum Zitat Ansbacher R (1971) Sperm-agglutinating and sperm-immobilizing antibodies in vasectomized men. Fertil Steril 22:629–632PubMed Ansbacher R (1971) Sperm-agglutinating and sperm-immobilizing antibodies in vasectomized men. Fertil Steril 22:629–632PubMed
7.
Zurück zum Zitat Ansbacher R, Keung-Yeung K, Wurster JC (1972) Sperm antibodies in vasectomized men. Fertil Steril 23:640–643PubMed Ansbacher R, Keung-Yeung K, Wurster JC (1972) Sperm antibodies in vasectomized men. Fertil Steril 23:640–643PubMed
8.
Zurück zum Zitat Auer J, Senechal H, De Almeida M (1997) Sperm-associated and circulating IgA and IgG classes of antibodies recognise different antigens on the human sperm plasma membrane. J Reprod Immunol 34:121–136PubMed Auer J, Senechal H, De Almeida M (1997) Sperm-associated and circulating IgA and IgG classes of antibodies recognise different antigens on the human sperm plasma membrane. J Reprod Immunol 34:121–136PubMed
9.
Zurück zum Zitat Auer J, Senechal H, Desvaux FX, Albert M, De Almeida M (2000) Isolation and characterisation of two sperm membrane proteins recognised by sperm-associated antibodies in infertile men. Mol Reprod Dev 57:393–405PubMed Auer J, Senechal H, Desvaux FX, Albert M, De Almeida M (2000) Isolation and characterisation of two sperm membrane proteins recognised by sperm-associated antibodies in infertile men. Mol Reprod Dev 57:393–405PubMed
10.
Zurück zum Zitat Auer J, Camoin L, Courtot AM, Hotellier F, De Almeida M (2004) Evidence that P36, a human sperm acrosomal antigen involved in the fertilization process is triosephosphate isomerase. Mol Reprod Dev 68:515–523PubMed Auer J, Camoin L, Courtot AM, Hotellier F, De Almeida M (2004) Evidence that P36, a human sperm acrosomal antigen involved in the fertilization process is triosephosphate isomerase. Mol Reprod Dev 68:515–523PubMed
11.
Zurück zum Zitat Ayvaliotis B, Bronson R, Rosenfeld D, Cooper G (1985) Conception rates in couples where autoimmunity to sperm is detected. Fertil Steril 43:739–742PubMed Ayvaliotis B, Bronson R, Rosenfeld D, Cooper G (1985) Conception rates in couples where autoimmunity to sperm is detected. Fertil Steril 43:739–742PubMed
12.
Zurück zum Zitat Baskin M (1932) Temporary sterilization by the injection of human spermatozoa. A preliminary report. Am J Obstet Gynecol 24:892–897 Baskin M (1932) Temporary sterilization by the injection of human spermatozoa. A preliminary report. Am J Obstet Gynecol 24:892–897
13.
Zurück zum Zitat Benoff S, Cooper GW, Hurley I, Mandel FS, Rosenfeld DL (1993) Antisperm antibody binding to human sperm inhibits capacitation induced changes in the levels of plasma membrane sterols. Am J Reprod Immunol 30:113–130PubMed Benoff S, Cooper GW, Hurley I, Mandel FS, Rosenfeld DL (1993) Antisperm antibody binding to human sperm inhibits capacitation induced changes in the levels of plasma membrane sterols. Am J Reprod Immunol 30:113–130PubMed
14.
Zurück zum Zitat Bhande S, Naz RK (2007) Molecular identities of human sperm proteins reactive with antibodies in sera of immunoinfertile women. Mol Reprod Dev 74:332–340PubMed Bhande S, Naz RK (2007) Molecular identities of human sperm proteins reactive with antibodies in sera of immunoinfertile women. Mol Reprod Dev 74:332–340PubMed
15.
Zurück zum Zitat Bohring C, Krause W (1999) The characterization of human spermatozoa membrane proteins—surface antigens and immunological infertility. Electrophoresis 20:971–976PubMed Bohring C, Krause W (1999) The characterization of human spermatozoa membrane proteins—surface antigens and immunological infertility. Electrophoresis 20:971–976PubMed
16.
Zurück zum Zitat Bohring C, Krause E, Habermann B, Krause W (2001) Isolation and identification of sperm membrane antigens recognized by antisperm antibodies, and their possible role in immunological infertility disease. Mol Hum Reprod 7:113–118PubMed Bohring C, Krause E, Habermann B, Krause W (2001) Isolation and identification of sperm membrane antigens recognized by antisperm antibodies, and their possible role in immunological infertility disease. Mol Hum Reprod 7:113–118PubMed
17.
Zurück zum Zitat Bohring C, Klepper L, Krause W (2004) Localization of binding sites of naturally occurring antisperm antibodies on human spermatozoa by immunofluorescence. Andrologia 36:286–290PubMed Bohring C, Klepper L, Krause W (2004) Localization of binding sites of naturally occurring antisperm antibodies on human spermatozoa by immunofluorescence. Andrologia 36:286–290PubMed
18.
Zurück zum Zitat Bonduelle M, Wennerholm UB, Loft A, Tarlatzis BC, Peters C, Henriet S, Mau C, Victorin-Cederquist A, Van Steirteghem A, Balaska A, Emberson JR, Sutcliffe AG (2005) A multi-centre cohort study of the physical health of 5-year-old children conceived after intracytoplasmic sperm injection, in vitro fertilization and natural conception. Hum Reprod 20:413–419PubMed Bonduelle M, Wennerholm UB, Loft A, Tarlatzis BC, Peters C, Henriet S, Mau C, Victorin-Cederquist A, Van Steirteghem A, Balaska A, Emberson JR, Sutcliffe AG (2005) A multi-centre cohort study of the physical health of 5-year-old children conceived after intracytoplasmic sperm injection, in vitro fertilization and natural conception. Hum Reprod 20:413–419PubMed
19.
Zurück zum Zitat Brewis IA, Van Gestel RA, Gadella BM, Jones R, Publicover SJ, Roldan ER, Frayne J, Barratt CL (2005) The spermatozoon at fertilisation: current understanding and future research directions. Hum Fertil (Camb) 8:241–251 Brewis IA, Van Gestel RA, Gadella BM, Jones R, Publicover SJ, Roldan ER, Frayne J, Barratt CL (2005) The spermatozoon at fertilisation: current understanding and future research directions. Hum Fertil (Camb) 8:241–251
20.
Zurück zum Zitat Bronson R, Cooper G, Rosenfeld D, Witkin SS (1984) Detection of spontaneously occurring sperm-directed antibodies in infertile couples by immunobead binding and enzyme-linked immunosorbent assay. Ann N Y Acad Sci 438:504–507PubMed Bronson R, Cooper G, Rosenfeld D, Witkin SS (1984) Detection of spontaneously occurring sperm-directed antibodies in infertile couples by immunobead binding and enzyme-linked immunosorbent assay. Ann N Y Acad Sci 438:504–507PubMed
21.
Zurück zum Zitat Bronson RA, Cooper GW, Rosenfeld DL (1982) Sperm-specific isoantibodies and autoantibodies inhibit the binding of human sperm to the human zona pellucida. Fertil Steril 38:724–729PubMed Bronson RA, Cooper GW, Rosenfeld DL (1982) Sperm-specific isoantibodies and autoantibodies inhibit the binding of human sperm to the human zona pellucida. Fertil Steril 38:724–729PubMed
22.
Zurück zum Zitat Bronson RA, Cooper GW, Rosenfeld DL (1983) Complement-mediated effects of sperm head-directed human antibodies on the ability of human spermatozoa to penetrate zona-free hamster eggs. Fertil Steril 40:91–95PubMed Bronson RA, Cooper GW, Rosenfeld DL (1983) Complement-mediated effects of sperm head-directed human antibodies on the ability of human spermatozoa to penetrate zona-free hamster eggs. Fertil Steril 40:91–95PubMed
23.
Zurück zum Zitat Bronson RA, Cooper GW, Rosenfeld DL (1984) Autoimmunity to spermatozoa: effect on sperm penetration of cervical mucus as reflected by postcoital testing. Fertil Steril 41:609–614PubMed Bronson RA, Cooper GW, Rosenfeld DL (1984) Autoimmunity to spermatozoa: effect on sperm penetration of cervical mucus as reflected by postcoital testing. Fertil Steril 41:609–614PubMed
24.
Zurück zum Zitat Bronson RA, Cooper GW, Rosenfeld DL, Gilbert JV, Plaut AG (1987) The effect of an IgA1 protease on immunoglobulins bound to the sperm surface and sperm cervical mucus penetrating ability. Fertil Steril 47:985–991PubMed Bronson RA, Cooper GW, Rosenfeld DL, Gilbert JV, Plaut AG (1987) The effect of an IgA1 protease on immunoglobulins bound to the sperm surface and sperm cervical mucus penetrating ability. Fertil Steril 47:985–991PubMed
25.
Zurück zum Zitat Bronson RA, Fleit HB, Fusi F (1990) Identification of an oolemmal IgG Fc receptor: its role in promoting binding of antibody-labelled human sperm to zona-free hamster eggs. Am J Reprod Immunol 23:87–92PubMed Bronson RA, Fleit HB, Fusi F (1990) Identification of an oolemmal IgG Fc receptor: its role in promoting binding of antibody-labelled human sperm to zona-free hamster eggs. Am J Reprod Immunol 23:87–92PubMed
26.
Zurück zum Zitat Bronson RA, Fusi F, Cooper GW, Phillips DM (1990) Antisperm antibodies induce polyspermy by promoting adherence of human sperm to zona-free hamster eggs. Hum Reprod 5:690–696PubMed Bronson RA, Fusi F, Cooper GW, Phillips DM (1990) Antisperm antibodies induce polyspermy by promoting adherence of human sperm to zona-free hamster eggs. Hum Reprod 5:690–696PubMed
27.
Zurück zum Zitat Buckingham KL, Stone PR, Smith JF, Chamley LW (2006) Antiphospholipid antibodies in serum and follicular fluid–is there a correlation with IVF implantation failure? Hum Reprod 21:728–734PubMed Buckingham KL, Stone PR, Smith JF, Chamley LW (2006) Antiphospholipid antibodies in serum and follicular fluid–is there a correlation with IVF implantation failure? Hum Reprod 21:728–734PubMed
28.
Zurück zum Zitat Busacca M, Fusi F, Brigante C, Doldi N, Smid M, Vigano P (1989) Evaluation of antisperm antibodies in infertile couples with immunobead test: prevalence and prognostic value. Acta Eur Fertil 20:77–82PubMed Busacca M, Fusi F, Brigante C, Doldi N, Smid M, Vigano P (1989) Evaluation of antisperm antibodies in infertile couples with immunobead test: prevalence and prognostic value. Acta Eur Fertil 20:77–82PubMed
29.
Zurück zum Zitat Cervoni F, Oglesby TJ, Adams EM, Milesifluet C, Nickells M, Fenichel P, Atkinson JP, Hsi BL (1992) Identification and characterization of membrane cofactor protein of human spermatozoa. J Immunol 148:1431–1437PubMed Cervoni F, Oglesby TJ, Adams EM, Milesifluet C, Nickells M, Fenichel P, Atkinson JP, Hsi BL (1992) Identification and characterization of membrane cofactor protein of human spermatozoa. J Immunol 148:1431–1437PubMed
30.
Zurück zum Zitat Chang JJ, Peng JP, Yang Y, Wang JL, Xu L (2006) Study on the antifertility effects of the plasmid DNA vaccine expressing partial brLDH-C4′. Reproduction 131:183–192PubMed Chang JJ, Peng JP, Yang Y, Wang JL, Xu L (2006) Study on the antifertility effects of the plasmid DNA vaccine expressing partial brLDH-C4′. Reproduction 131:183–192PubMed
31.
Zurück zum Zitat Chang TH, Jih MH, Wu TC (1993) Relationship of sperm antibodies in women and men to human in vitro fertilization, cleavage, and pregnancy rate. Am J Reprod Immunol 30:108–112PubMed Chang TH, Jih MH, Wu TC (1993) Relationship of sperm antibodies in women and men to human in vitro fertilization, cleavage, and pregnancy rate. Am J Reprod Immunol 30:108–112PubMed
32.
Zurück zum Zitat Check JH, Bollendorf A, Katsoff D, Kozak J (1994) The frequency of antisperm antibodies in the cervical mucus of women with poor postcoital tests and their effect on pregnancy rates. Am J Reprod Immunol 32:38–42PubMed Check JH, Bollendorf A, Katsoff D, Kozak J (1994) The frequency of antisperm antibodies in the cervical mucus of women with poor postcoital tests and their effect on pregnancy rates. Am J Reprod Immunol 32:38–42PubMed
33.
Zurück zum Zitat Cherr GN, Yudin AI, Overstreet JW (2001) The dual functions of GPI-anchored PH-20: hyaluronidase and intracellular signaling. Matrix Biol 20:515–525PubMed Cherr GN, Yudin AI, Overstreet JW (2001) The dual functions of GPI-anchored PH-20: hyaluronidase and intracellular signaling. Matrix Biol 20:515–525PubMed
34.
Zurück zum Zitat Chiu WW, Chamley LW (2002) Use of antisperm antibodies in differential display Western blotting to identify sperm proteins important in fertility. Hum Reprod 17:984–989PubMed Chiu WW, Chamley LW (2002) Use of antisperm antibodies in differential display Western blotting to identify sperm proteins important in fertility. Hum Reprod 17:984–989PubMed
35.
Zurück zum Zitat Chiu WW, Erikson EK, Sole CA, Shelling AN, Chamley LW (2004) SPRASA, a novel sperm protein involved in immune-mediated infertility. Hum Reprod 19:243–249PubMed Chiu WW, Erikson EK, Sole CA, Shelling AN, Chamley LW (2004) SPRASA, a novel sperm protein involved in immune-mediated infertility. Hum Reprod 19:243–249PubMed
36.
Zurück zum Zitat Clarke GN (1984) Detection of antispermatozoal antibodies of IgG, IgA, and IgM immunoglobulin classes in cervical mucus. Am J Reprod Immunol 6:195–197PubMed Clarke GN (1984) Detection of antispermatozoal antibodies of IgG, IgA, and IgM immunoglobulin classes in cervical mucus. Am J Reprod Immunol 6:195–197PubMed
37.
Zurück zum Zitat Clarke GN, Hsieh C, Koh SH, Cauchi MN (1984) Sperm antibodies, immunoglobulins, and complement in human follicular fluid. Am J Reprod Immunol 5:179–181PubMed Clarke GN, Hsieh C, Koh SH, Cauchi MN (1984) Sperm antibodies, immunoglobulins, and complement in human follicular fluid. Am J Reprod Immunol 5:179–181PubMed
38.
Zurück zum Zitat Clarke GN, Stojanoff A, Cauchi MN, McBain JC, Speirs AL, Johnston WI (1984) Detection of antispermatozoal antibodies of IgA class in cervical mucus. Am J Reprod Immunol 5:61–65PubMed Clarke GN, Stojanoff A, Cauchi MN, McBain JC, Speirs AL, Johnston WI (1984) Detection of antispermatozoal antibodies of IgA class in cervical mucus. Am J Reprod Immunol 5:61–65PubMed
39.
Zurück zum Zitat Clarke GN (1985) Induction of the shaking phenomenon by IgA class antispermatozoal antibodies from serum. Am J Reprod Immunol Microbiol 9:12–14PubMed Clarke GN (1985) Induction of the shaking phenomenon by IgA class antispermatozoal antibodies from serum. Am J Reprod Immunol Microbiol 9:12–14PubMed
40.
Zurück zum Zitat Clarke GN, Elliott PJ, Smaila C (1985) Detection of sperm antibodies in semen using the immunobead test: a survey of 813 consecutive patients. Am J Reprod Immunol Microbiol 7:118–123PubMed Clarke GN, Elliott PJ, Smaila C (1985) Detection of sperm antibodies in semen using the immunobead test: a survey of 813 consecutive patients. Am J Reprod Immunol Microbiol 7:118–123PubMed
41.
Zurück zum Zitat Clarke GN, Lopata A, McBain JC, Baker HW, Johnston WI (1985) Effect of sperm antibodies in males on human in vitro fertilization (IVF). Am J Reprod Immunol Microbiol 8:62–66PubMed Clarke GN, Lopata A, McBain JC, Baker HW, Johnston WI (1985) Effect of sperm antibodies in males on human in vitro fertilization (IVF). Am J Reprod Immunol Microbiol 8:62–66PubMed
42.
Zurück zum Zitat Clarke GN (1988) Immunoglobulin class and regional specificity of antispermatozoal autoantibodies blocking cervical mucus penetration by human spermatozoa. Am J Reprod Immunol Microbiol 16:135–138PubMed Clarke GN (1988) Immunoglobulin class and regional specificity of antispermatozoal autoantibodies blocking cervical mucus penetration by human spermatozoa. Am J Reprod Immunol Microbiol 16:135–138PubMed
43.
Zurück zum Zitat Clarke GN (1988) Sperm antibodies and human fertilization. Am J Reprod Immunol Microbiol 17:65–71PubMed Clarke GN (1988) Sperm antibodies and human fertilization. Am J Reprod Immunol Microbiol 17:65–71PubMed
44.
Zurück zum Zitat Clarke GN, Hyne RV, du Plessis Y, Johnston WI (1988) Sperm antibodies and human in vitro fertilization. Fertil Steril 49:1018–1025PubMed Clarke GN, Hyne RV, du Plessis Y, Johnston WI (1988) Sperm antibodies and human in vitro fertilization. Fertil Steril 49:1018–1025PubMed
45.
Zurück zum Zitat Clarke GN (1990) Detection of antisperm antibodies using immunobeads. In: Keel B, Webster B (eds) Handbook of diagnosis and treatments of infertility. CRC, Boca Raton, pp 177–192 Clarke GN (1990) Detection of antisperm antibodies using immunobeads. In: Keel B, Webster B (eds) Handbook of diagnosis and treatments of infertility. CRC, Boca Raton, pp 177–192
46.
Zurück zum Zitat Clarke GN, Baker HW (1993) Lack of association between sperm antibodies and recurrent spontaneous abortion. Fertil Steril 59:463–464PubMed Clarke GN, Baker HW (1993) Lack of association between sperm antibodies and recurrent spontaneous abortion. Fertil Steril 59:463–464PubMed
47.
Zurück zum Zitat Clarke GN, Bourne H, Baker HW (1997) Intracytoplasmic sperm injection for treating infertility associated with sperm autoimmunity. Fertil Steril 68:112–117PubMed Clarke GN, Bourne H, Baker HW (1997) Intracytoplasmic sperm injection for treating infertility associated with sperm autoimmunity. Fertil Steril 68:112–117PubMed
48.
Zurück zum Zitat Clarke GN (2006) Association between sperm autoantibodies and enhanced embryo implantation rates during in vitro fertilization. Fertil Steril 86:753–754PubMed Clarke GN (2006) Association between sperm autoantibodies and enhanced embryo implantation rates during in vitro fertilization. Fertil Steril 86:753–754PubMed
49.
Zurück zum Zitat Collins JA, Burrows EA, Yeo J, YoungLai EV (1993) Frequency and predictive value of antisperm antibodies among infertile couples. Hum Reprod 8:592–598PubMed Collins JA, Burrows EA, Yeo J, YoungLai EV (1993) Frequency and predictive value of antisperm antibodies among infertile couples. Hum Reprod 8:592–598PubMed
50.
Zurück zum Zitat D’Cruz OJ, Haas GG, Jr., Lambert H (1990) Evaluation of antisperm complement-dependent immune mediators in human ovarian follicular fluid. J Immunol 144:3841–3848PubMed D’Cruz OJ, Haas GG, Jr., Lambert H (1990) Evaluation of antisperm complement-dependent immune mediators in human ovarian follicular fluid. J Immunol 144:3841–3848PubMed
51.
Zurück zum Zitat D’Cruz OJ, Haas GG Jr, de La Rocha R, Lambert H (1991) Occurrence of serum antisperm antibodies in patients with cystic fibrosis. Fertil Steril 56:519–527PubMed D’Cruz OJ, Haas GG Jr, de La Rocha R, Lambert H (1991) Occurrence of serum antisperm antibodies in patients with cystic fibrosis. Fertil Steril 56:519–527PubMed
52.
Zurück zum Zitat D’Cruz OJ, Haas GG, Jr., Wang BL, DeBault LE (1991) Activation of human complement by IgG antisperm antibody and the demonstration of C3 and C5b-9-mediated immune injury to human sperm. J Immunol 146:611–620PubMed D’Cruz OJ, Haas GG, Jr., Wang BL, DeBault LE (1991) Activation of human complement by IgG antisperm antibody and the demonstration of C3 and C5b-9-mediated immune injury to human sperm. J Immunol 146:611–620PubMed
53.
Zurück zum Zitat D’Cruz OJ, Wang BL, Haas GG, Jr. (1992) Phagocytosis of immunoglobulin G and C3-bound human sperm by human polymorphonuclear leukocytes is not associated with the release of oxidative radicals. Biol Reprod 46:721–732PubMed D’Cruz OJ, Wang BL, Haas GG, Jr. (1992) Phagocytosis of immunoglobulin G and C3-bound human sperm by human polymorphonuclear leukocytes is not associated with the release of oxidative radicals. Biol Reprod 46:721–732PubMed
54.
Zurück zum Zitat Daitoh T, Kamada M, Yamano S, Murayama S, Kobayashi T, Maegawa M, Aono T (1995) High implantation rate and consequently high pregnancy rate by in vitro fertilization-embryo transfer treatment in infertile women with antisperm antibody. Fertil Steril 63:87–91PubMed Daitoh T, Kamada M, Yamano S, Murayama S, Kobayashi T, Maegawa M, Aono T (1995) High implantation rate and consequently high pregnancy rate by in vitro fertilization-embryo transfer treatment in infertile women with antisperm antibody. Fertil Steril 63:87–91PubMed
55.
Zurück zum Zitat Dandekar P, Aggeler J, Talbot P (1992) Structure, distribution and composition of the extracellular matrix of human oocytes and cumulus masses. Hum Reprod 7:391–398PubMed Dandekar P, Aggeler J, Talbot P (1992) Structure, distribution and composition of the extracellular matrix of human oocytes and cumulus masses. Hum Reprod 7:391–398PubMed
56.
Zurück zum Zitat de Almeida M, Gazagne I, Jeulin C, Herry M, Belaisch-Allart J, Frydman R, Jouannet P, Testart J (1989) In-vitro processing of sperm with autoantibodies and in-vitro fertilization results. Hum Reprod 4:49–53PubMed de Almeida M, Gazagne I, Jeulin C, Herry M, Belaisch-Allart J, Frydman R, Jouannet P, Testart J (1989) In-vitro processing of sperm with autoantibodies and in-vitro fertilization results. Hum Reprod 4:49–53PubMed
57.
Zurück zum Zitat de Lamirande E, Leclerc P, Gagnon C (1997) Capacitation as a regulatory event that primes spermatozoa for the acrosome reaction and fertilization. Mol Hum Reprod 3:175–194PubMed de Lamirande E, Leclerc P, Gagnon C (1997) Capacitation as a regulatory event that primes spermatozoa for the acrosome reaction and fertilization. Mol Hum Reprod 3:175–194PubMed
58.
Zurück zum Zitat Delves PJ, Lund T, Roitt IM (2002) Antifertility vaccines. Trends Immunol 23:213–219PubMed Delves PJ, Lund T, Roitt IM (2002) Antifertility vaccines. Trends Immunol 23:213–219PubMed
59.
Zurück zum Zitat Diekman AB, Herr JC (1997) Sperm antigens and their use in the development of an immunocontraceptive. Am J Reprod Immunol 37:111–117PubMed Diekman AB, Herr JC (1997) Sperm antigens and their use in the development of an immunocontraceptive. Am J Reprod Immunol 37:111–117PubMed
60.
Zurück zum Zitat Diekman AB, Westbrook-Case VA, Naaby-Hansen S, Klotz KL, Flickinger CJ, Herr JC (1997) Biochemical characterization of sperm agglutination antigen-1, a human sperm surface antigen implicated in gamete interactions. Biol Reprod 57:1136–1144PubMed Diekman AB, Westbrook-Case VA, Naaby-Hansen S, Klotz KL, Flickinger CJ, Herr JC (1997) Biochemical characterization of sperm agglutination antigen-1, a human sperm surface antigen implicated in gamete interactions. Biol Reprod 57:1136–1144PubMed
61.
Zurück zum Zitat Diekman AB, Norton EJ, Westbrook VA, Klotz KL, Naaby-Hansen S, Herr JC (2000) Anti-sperm antibodies from infertile patients and their cognate sperm antigens: a review. Identity between SAGA-1, the H6-3C4 antigen, and CD52. Am J Reprod Immunol 43:134–143PubMed Diekman AB, Norton EJ, Westbrook VA, Klotz KL, Naaby-Hansen S, Herr JC (2000) Anti-sperm antibodies from infertile patients and their cognate sperm antigens: a review. Identity between SAGA-1, the H6-3C4 antigen, and CD52. Am J Reprod Immunol 43:134–143PubMed
62.
Zurück zum Zitat Duckworth JA, Wilson K, Cui X, Molinia FC, Cowan PE (2007) Immunogenicity and contraceptive potential of three infertility-relevant zona pellucida 2 epitopes in the marsupial brushtail possum (Trichosurus vulpecula). Reproduction 133:177–186PubMed Duckworth JA, Wilson K, Cui X, Molinia FC, Cowan PE (2007) Immunogenicity and contraceptive potential of three infertility-relevant zona pellucida 2 epitopes in the marsupial brushtail possum (Trichosurus vulpecula). Reproduction 133:177–186PubMed
63.
Zurück zum Zitat Eggert-Kruse W, Hofsass A, Haury E, Tilgen W, Gerhard I, Runnebaum B (1991) Relationship between local anti-sperm antibodies and sperm–mucus interaction in vitro and in vivo. Hum Reprod 6:267–276PubMed Eggert-Kruse W, Hofsass A, Haury E, Tilgen W, Gerhard I, Runnebaum B (1991) Relationship between local anti-sperm antibodies and sperm–mucus interaction in vitro and in vivo. Hum Reprod 6:267–276PubMed
64.
Zurück zum Zitat Eggert-Kruse W, Bockem-Hellwig S, Doll A, Rohr G, Tilgen W, Runnebaum B (1993) Antisperm antibodies in cervical mucus in an unselected subfertile population. Hum Reprod 8:1025–1031PubMed Eggert-Kruse W, Bockem-Hellwig S, Doll A, Rohr G, Tilgen W, Runnebaum B (1993) Antisperm antibodies in cervical mucus in an unselected subfertile population. Hum Reprod 8:1025–1031PubMed
65.
Zurück zum Zitat el-Roeiy A, Valesini G, Friberg J, Shoenfeld Y, Kennedy RC, Tincani A, Balestrieri G, Gleicher N (1988) Autoantibodies and common idiotypes in men and women with sperm antibodies. Am J Obstet Gynecol 158:596–603PubMed el-Roeiy A, Valesini G, Friberg J, Shoenfeld Y, Kennedy RC, Tincani A, Balestrieri G, Gleicher N (1988) Autoantibodies and common idiotypes in men and women with sperm antibodies. Am J Obstet Gynecol 158:596–603PubMed
66.
Zurück zum Zitat Fichorova R, Nakov L, Baleva M, Nikolov K, Gegova I (1996) Sperm, nuclear, phospholipid, and red blood cell antibodies and isotype RF in infertile couples and patients with autoimmune rheumatic diseases. Am J Reprod Immunol 36:309–316PubMed Fichorova R, Nakov L, Baleva M, Nikolov K, Gegova I (1996) Sperm, nuclear, phospholipid, and red blood cell antibodies and isotype RF in infertile couples and patients with autoimmune rheumatic diseases. Am J Reprod Immunol 36:309–316PubMed
67.
Zurück zum Zitat Flesch FM, Gadella BM (2000) Dynamics of the mammalian sperm plasma membrane in the process of fertilization. Biochim Biophys Acta 1469:197–235PubMed Flesch FM, Gadella BM (2000) Dynamics of the mammalian sperm plasma membrane in the process of fertilization. Biochim Biophys Acta 1469:197–235PubMed
68.
Zurück zum Zitat Flickinger CJ, Bush LA, Howards SS, Herr JC (1997) Distribution of leukocytes in the epithelium and interstitium of four regions of the Lewis rat epididymis. Anat Rec 248:380–390PubMed Flickinger CJ, Bush LA, Howards SS, Herr JC (1997) Distribution of leukocytes in the epithelium and interstitium of four regions of the Lewis rat epididymis. Anat Rec 248:380–390PubMed
69.
Zurück zum Zitat Ford WC, Williams KM, McLaughlin EA, Harrison S, Ray B, Hull MG (1996) The indirect immunobead test for seminal antisperm antibodies and fertilization rates at in-vitro fertilization. Hum Reprod 11:1418–1422PubMed Ford WC, Williams KM, McLaughlin EA, Harrison S, Ray B, Hull MG (1996) The indirect immunobead test for seminal antisperm antibodies and fertilization rates at in-vitro fertilization. Hum Reprod 11:1418–1422PubMed
70.
Zurück zum Zitat Francavilla F, Romano R, Santucci R (1991) Effect of sperm-antibodies on acrosome reaction of human sperm used for the hamster egg penetration assay. Am J Reprod Immunol 25:77–80PubMed Francavilla F, Romano R, Santucci R (1991) Effect of sperm-antibodies on acrosome reaction of human sperm used for the hamster egg penetration assay. Am J Reprod Immunol 25:77–80PubMed
71.
Zurück zum Zitat Francavilla F, Romano R, Santucci R, Marrone V, Corraa G (1992) Failure of intrauterine insemination in male immunological infertility in cases in which all spermatozoa are antibody-coated. Fertil Steril 58:587–592PubMed Francavilla F, Romano R, Santucci R, Marrone V, Corraa G (1992) Failure of intrauterine insemination in male immunological infertility in cases in which all spermatozoa are antibody-coated. Fertil Steril 58:587–592PubMed
72.
Zurück zum Zitat Francavilla F, Romano R, Santucci R, Marrone V, Properzi G, Ruvolo G (1997) Occurrence of the interference of sperm-associated antibodies on sperm fertilizing ability as evaluated by the sperm-zona pellucida binding test and by the TEST-yolk buffer enhanced sperm penetration assay. Am J Reprod Immunol 37:267–274PubMed Francavilla F, Romano R, Santucci R, Marrone V, Properzi G, Ruvolo G (1997) Occurrence of the interference of sperm-associated antibodies on sperm fertilizing ability as evaluated by the sperm-zona pellucida binding test and by the TEST-yolk buffer enhanced sperm penetration assay. Am J Reprod Immunol 37:267–274PubMed
73.
Zurück zum Zitat Francavilla F, Romano R, Santucci R, Marrone V, Properzi G, Ruvolo G (1997) Interference of antisperm antibodies with the induction of the acrosome reaction by zona pellucida (ZP) and its relationship with the inhibition of ZP binding. Fertil Steril 67:1128–1133PubMed Francavilla F, Romano R, Santucci R, Marrone V, Properzi G, Ruvolo G (1997) Interference of antisperm antibodies with the induction of the acrosome reaction by zona pellucida (ZP) and its relationship with the inhibition of ZP binding. Fertil Steril 67:1128–1133PubMed
74.
Zurück zum Zitat Franklin RR, Dukes CD (1964) Antispermatozoal antibody and unexplained infertility. Am J Obstet Gynecol 89:6–9PubMed Franklin RR, Dukes CD (1964) Antispermatozoal antibody and unexplained infertility. Am J Obstet Gynecol 89:6–9PubMed
75.
Zurück zum Zitat Franklin RR, Dukes CD (1964) Further studies on sperm-agglutinating antibody and unexplained infertility. JAMA 190:682–683PubMed Franklin RR, Dukes CD (1964) Further studies on sperm-agglutinating antibody and unexplained infertility. JAMA 190:682–683PubMed
76.
Zurück zum Zitat Fusi F, Bronson RA (1990) Effects of incubation time in serum and capacitation on spermatozoal reactivity with antisperm antibodies. Fertil Steril 54:887–893PubMed Fusi F, Bronson RA (1990) Effects of incubation time in serum and capacitation on spermatozoal reactivity with antisperm antibodies. Fertil Steril 54:887–893PubMed
77.
Zurück zum Zitat Galle PC, McRae MA, Colliver JA, Alexander JS (1990) Sperm washing and intrauterine insemination for cervical factor, oligospermia, immunologic infertility and unexplained infertility. J Reprod Med 35:116–122PubMed Galle PC, McRae MA, Colliver JA, Alexander JS (1990) Sperm washing and intrauterine insemination for cervical factor, oligospermia, immunologic infertility and unexplained infertility. J Reprod Med 35:116–122PubMed
78.
Zurück zum Zitat Georgiou I, Syrrou M, Pardalidis N, Karakitsios K, Mantzavinos T, Giotitsas N, Loutradis D, Dimitriadis F, Saito M, Miyagawa I, Tzoumis P, Sylakos A, Kanakas N, Moustakareas T, Baltogiannis D, Touloupides S, Giannakis D, Fatouros M, Sofikitis N (2006) Genetic and epigenetic risks of intracytoplasmic sperm injection method. Asian J Androl 8:643–673PubMed Georgiou I, Syrrou M, Pardalidis N, Karakitsios K, Mantzavinos T, Giotitsas N, Loutradis D, Dimitriadis F, Saito M, Miyagawa I, Tzoumis P, Sylakos A, Kanakas N, Moustakareas T, Baltogiannis D, Touloupides S, Giannakis D, Fatouros M, Sofikitis N (2006) Genetic and epigenetic risks of intracytoplasmic sperm injection method. Asian J Androl 8:643–673PubMed
79.
Zurück zum Zitat Goldberg E, Wheat TE, Powell JE, Stevens VC (1981) Reduction of fertility in female baboons immunized with lactate dehydrogenase C4. Fertil Steril 35:214–217PubMed Goldberg E, Wheat TE, Powell JE, Stevens VC (1981) Reduction of fertility in female baboons immunized with lactate dehydrogenase C4. Fertil Steril 35:214–217PubMed
80.
Zurück zum Zitat Goldberg E, VandeBerg JL, Mahony MC, Doncel GF (2001) Immune response of male baboons to testis-specific LDH-C(4). Contraception 64:93–98PubMed Goldberg E, VandeBerg JL, Mahony MC, Doncel GF (2001) Immune response of male baboons to testis-specific LDH-C(4). Contraception 64:93–98PubMed
81.
Zurück zum Zitat Grigoriou O, Konidaris S, Antonaki V, Papadias C, Antoniou G, Gargaropoulos A (1996) Corticosteroid treatment does not improve the results of intrauterine insemination in male subfertility caused by antisperm antibodies. Eur J Obstet Gynecol Reprod Biol 65:227–230PubMed Grigoriou O, Konidaris S, Antonaki V, Papadias C, Antoniou G, Gargaropoulos A (1996) Corticosteroid treatment does not improve the results of intrauterine insemination in male subfertility caused by antisperm antibodies. Eur J Obstet Gynecol Reprod Biol 65:227–230PubMed
82.
Zurück zum Zitat Gupta SK, Srivastava N, Choudhury S, Rath A, Sivapurapu N, Gahlay GK, Batra D (2004) Update on zona pellucida glycoproteins based contraceptive vaccine. J Reprod Immunol 62:79–89PubMed Gupta SK, Srivastava N, Choudhury S, Rath A, Sivapurapu N, Gahlay GK, Batra D (2004) Update on zona pellucida glycoproteins based contraceptive vaccine. J Reprod Immunol 62:79–89PubMed
83.
Zurück zum Zitat Haas GG Jr, Ausmanus M, Culp L, Tureck RW, Blasco L (1985) The effect of immunoglobulin occurring on human sperm in vivo on the human sperm/hamster ova penetration assay. Am J Reprod Immunol Microbiol 7:109–112PubMed Haas GG Jr, Ausmanus M, Culp L, Tureck RW, Blasco L (1985) The effect of immunoglobulin occurring on human sperm in vivo on the human sperm/hamster ova penetration assay. Am J Reprod Immunol Microbiol 7:109–112PubMed
84.
Zurück zum Zitat Haas GG Jr, Kubota K, Quebbeman JF, Jijon A, Menge AC, Beer AE (1986) Circulating antisperm antibodies in recurrently aborting women. Fertil Steril 45:209–215PubMed Haas GG Jr, Kubota K, Quebbeman JF, Jijon A, Menge AC, Beer AE (1986) Circulating antisperm antibodies in recurrently aborting women. Fertil Steril 45:209–215PubMed
85.
Zurück zum Zitat Hammitt DG, Muench MM, Williamson RA (1988) Antibody binding to greater than 50% of sperm at the tail tip does not impair male fertility. Fertil Steril 49:174–177PubMed Hammitt DG, Muench MM, Williamson RA (1988) Antibody binding to greater than 50% of sperm at the tail tip does not impair male fertility. Fertil Steril 49:174–177PubMed
86.
Zurück zum Zitat Hardy CM, Clydesdale G, Mobbs KJ (2004) Development of mouse-specific contraceptive vaccines: infertility in mice immunized with peptide and polyepitope antigens. Reproduction 128:395–407PubMed Hardy CM, Clydesdale G, Mobbs KJ (2004) Development of mouse-specific contraceptive vaccines: infertility in mice immunized with peptide and polyepitope antigens. Reproduction 128:395–407PubMed
87.
Zurück zum Zitat Hardy CM, Clydesdale G, Mobbs KJ, Pekin J, Lloyd ML, Sweet C, Shellam GR, Lawson MA (2004) Assessment of contraceptive vaccines based on recombinant mouse sperm protein PH20. Reproduction 127:325–334PubMed Hardy CM, Clydesdale G, Mobbs KJ, Pekin J, Lloyd ML, Sweet C, Shellam GR, Lawson MA (2004) Assessment of contraceptive vaccines based on recombinant mouse sperm protein PH20. Reproduction 127:325–334PubMed
88.
Zurück zum Zitat Heidenreich A, Bonfig R, Wilbert DM, Strohmaier WL, Engelmann UH (1994) Risk factors for antisperm antibodies in infertile men. Am J Reprod Immunol 31:69–76PubMed Heidenreich A, Bonfig R, Wilbert DM, Strohmaier WL, Engelmann UH (1994) Risk factors for antisperm antibodies in infertile men. Am J Reprod Immunol 31:69–76PubMed
89.
Zurück zum Zitat Hirano M, Kamada M, Maegawa M, Gima H, Aono T (1999) Binding of human secretory leukocyte protease inhibitor in uterine cervical mucus to immunoglobulins: pathophysiology in immunologic infertility and local immune defense. Fertil Steril 71:1108–1114PubMed Hirano M, Kamada M, Maegawa M, Gima H, Aono T (1999) Binding of human secretory leukocyte protease inhibitor in uterine cervical mucus to immunoglobulins: pathophysiology in immunologic infertility and local immune defense. Fertil Steril 71:1108–1114PubMed
90.
Zurück zum Zitat Homyk M, Herr JC (1992) Light and electron microscopic immunolocalization of sperm proteins identified by monoclonal antibodies from the World Health Organization Task Force on Sperm Antigens. J Reprod Immunol 22:237–256PubMed Homyk M, Herr JC (1992) Light and electron microscopic immunolocalization of sperm proteins identified by monoclonal antibodies from the World Health Organization Task Force on Sperm Antigens. J Reprod Immunol 22:237–256PubMed
91.
Zurück zum Zitat Howe SE, Grider SL, Lynch DM, Fink LM (1991) Antisperm antibody binding to human acrosin: a study of patients with unexplained infertility. Fertil Steril 55:1176–1182PubMed Howe SE, Grider SL, Lynch DM, Fink LM (1991) Antisperm antibody binding to human acrosin: a study of patients with unexplained infertility. Fertil Steril 55:1176–1182PubMed
92.
Zurück zum Zitat Imade GE, Baker HW, de Kretser DM, Hedger MP (1997) Immunosuppressive activities in the seminal plasma of infertile men: Relationship to sperm antibodies and autoimmunity. Hum Reprod 12:256–262PubMed Imade GE, Baker HW, de Kretser DM, Hedger MP (1997) Immunosuppressive activities in the seminal plasma of infertile men: Relationship to sperm antibodies and autoimmunity. Hum Reprod 12:256–262PubMed
93.
Zurück zum Zitat Ingerslev HJ, Ingerslev M (1980) Clinical findings in infertile women with circulating antibodies against spermatozoa. Fertil Steril 33:514–520PubMed Ingerslev HJ, Ingerslev M (1980) Clinical findings in infertile women with circulating antibodies against spermatozoa. Fertil Steril 33:514–520PubMed
94.
Zurück zum Zitat Ingerslev HJ, Moller NP, Jager S, Kremer J (1982) Immunoglobulin class of sperm antibodies in cervical mucus from infertile women. Am J Reprod Immunol 2:296–300PubMed Ingerslev HJ, Moller NP, Jager S, Kremer J (1982) Immunoglobulin class of sperm antibodies in cervical mucus from infertile women. Am J Reprod Immunol 2:296–300PubMed
95.
Zurück zum Zitat Jager S, Kremer J, van Slochteren-Draaisma T (1978) A simple method of screening for antisperm antibodies in the human male. Detection of spermatozoal surface IgG with the direct mixed antiglobulin reaction carried out on untreated fresh human semen. Int J Fertil 23:12–21PubMed Jager S, Kremer J, van Slochteren-Draaisma T (1978) A simple method of screening for antisperm antibodies in the human male. Detection of spermatozoal surface IgG with the direct mixed antiglobulin reaction carried out on untreated fresh human semen. Int J Fertil 23:12–21PubMed
96.
Zurück zum Zitat Jager S, Kremer J, Kuiken J, Mulder I (1981) The significance of the Fc part of antispermatozoal antibodies for the shaking phenomenon in the sperm–cervical mucus contact test. Fertil Steril 36:792–797PubMed Jager S, Kremer J, Kuiken J, Mulder I (1981) The significance of the Fc part of antispermatozoal antibodies for the shaking phenomenon in the sperm–cervical mucus contact test. Fertil Steril 36:792–797PubMed
97.
Zurück zum Zitat Jager S, Kremer J, Kuiken J, van Slochteren-Draaisma T, Mulder I, de Wilde-Janssen IW (1981) Induction of the shaking phenomenon by pretreatment of spermatozoa with sera containing antispermatozoal antibodies. Fertil Steril 36:784–791PubMed Jager S, Kremer J, Kuiken J, van Slochteren-Draaisma T, Mulder I, de Wilde-Janssen IW (1981) Induction of the shaking phenomenon by pretreatment of spermatozoa with sera containing antispermatozoal antibodies. Fertil Steril 36:784–791PubMed
98.
Zurück zum Zitat Janssen HJ, Bastiaans BA, Goverde HJ, Hollanders HM, Wetzels AA, Schellekens LA (1992) Antisperm antibodies and in vitro fertilization. J Assist Reprod Genet 9:345–349PubMed Janssen HJ, Bastiaans BA, Goverde HJ, Hollanders HM, Wetzels AA, Schellekens LA (1992) Antisperm antibodies and in vitro fertilization. J Assist Reprod Genet 9:345–349PubMed
99.
Zurück zum Zitat Jones W (ed) (1976) Immunological aspects of infertility. Academic, London Jones W (ed) (1976) Immunological aspects of infertility. Academic, London
100.
Zurück zum Zitat Junk SM, Matson PL, Yovich JM, Bootsma B, Yovich JL (1986) The fertilization of human oocytes by spermatozoa from men with antispermatozoal antibodies in semen. J In Vitro Fert Embryo Transf 3:350–352PubMed Junk SM, Matson PL, Yovich JM, Bootsma B, Yovich JL (1986) The fertilization of human oocytes by spermatozoa from men with antispermatozoal antibodies in semen. J In Vitro Fert Embryo Transf 3:350–352PubMed
101.
Zurück zum Zitat Kadam AL, Fateh M, Naz RK (1995) Fertilization antigen (FA-1) completely blocks human sperm binding to human zona pellucida: FA-1 antigen may be a sperm receptor for zona pellucida in humans. J Reprod Immunol 29:19–30PubMed Kadam AL, Fateh M, Naz RK (1995) Fertilization antigen (FA-1) completely blocks human sperm binding to human zona pellucida: FA-1 antigen may be a sperm receptor for zona pellucida in humans. J Reprod Immunol 29:19–30PubMed
102.
Zurück zum Zitat Kamada M, Daitoh T, Hasebe H, Irahara M, Yamano S, Mori T (1985) Blocking of human fertilization in vitro by sera with sperm-immobilizing antibodies. Am J Obstet Gynecol 153:328–331PubMed Kamada M, Daitoh T, Hasebe H, Irahara M, Yamano S, Mori T (1985) Blocking of human fertilization in vitro by sera with sperm-immobilizing antibodies. Am J Obstet Gynecol 153:328–331PubMed
103.
Zurück zum Zitat Katsh S (1959) Immunology, fertility and infertiliy: a historical survey. Am J Obstet Gynecol 77:946–956PubMed Katsh S (1959) Immunology, fertility and infertiliy: a historical survey. Am J Obstet Gynecol 77:946–956PubMed
104.
Zurück zum Zitat Katz DF, Mills RN, Pritchett TR (1978) The movement of human spermatozoa in cervical mucus. J Reprod Fertil 53:259–265PubMed Katz DF, Mills RN, Pritchett TR (1978) The movement of human spermatozoa in cervical mucus. J Reprod Fertil 53:259–265PubMed
105.
Zurück zum Zitat Krapez JA, Hayden CJ, Rutherford AJ, Balen AH (1998) Survey of the diagnosis and management of antisperm antibodies. Hum Reprod 13:3363–3367PubMed Krapez JA, Hayden CJ, Rutherford AJ, Balen AH (1998) Survey of the diagnosis and management of antisperm antibodies. Hum Reprod 13:3363–3367PubMed
106.
Zurück zum Zitat Kremer J, Jager S (1980) Characteristics of anti-spermatozoal antibodies responsible for the shaking phenomenon with special regard to immunoglobulin class and antigen-reactive sites. Int J Androl 3:143–152PubMed Kremer J, Jager S (1980) Characteristics of anti-spermatozoal antibodies responsible for the shaking phenomenon with special regard to immunoglobulin class and antigen-reactive sites. Int J Androl 3:143–152PubMed
107.
Zurück zum Zitat Kutteh WH, Kilian M, Ermel LD, Byrd EW, Mestecky J (1994) Antisperm antibodies (ASAs) in infertile males: subclass distribution of IgA antibodies and the effect of an IgA1 protease on sperm-bound antibodies. Am J Reprod Immunol 31:77–83PubMed Kutteh WH, Kilian M, Ermel LD, Byrd EW, Mestecky J (1994) Antisperm antibodies (ASAs) in infertile males: subclass distribution of IgA antibodies and the effect of an IgA1 protease on sperm-bound antibodies. Am J Reprod Immunol 31:77–83PubMed
108.
Zurück zum Zitat Lahteenmaki A (1993) In-vitro fertilization in the presence of antisperm antibodies detected by the mixed antiglobulin reaction (MAR) and the tray agglutination test (TAT). Hum Reprod 8:84–88PubMed Lahteenmaki A (1993) In-vitro fertilization in the presence of antisperm antibodies detected by the mixed antiglobulin reaction (MAR) and the tray agglutination test (TAT). Hum Reprod 8:84–88PubMed
109.
Zurück zum Zitat Lahteenmaki A, Reima I, Hovatta O (1995) Treatment of severe male immunological infertility by intracytoplasmic sperm injection. Hum Reprod 10:2824–2828PubMed Lahteenmaki A, Reima I, Hovatta O (1995) Treatment of severe male immunological infertility by intracytoplasmic sperm injection. Hum Reprod 10:2824–2828PubMed
110.
Zurück zum Zitat Lansford B, Haas GG Jr, DeBault LE, Wolf DP (1990) Effect of sperm-associated antibodies on the acrosomal status of human sperm. J Androl 11:532–538PubMed Lansford B, Haas GG Jr, DeBault LE, Wolf DP (1990) Effect of sperm-associated antibodies on the acrosomal status of human sperm. J Androl 11:532–538PubMed
111.
Zurück zum Zitat Liu DY, Clarke GN, Baker HW (1991) Inhibition of human sperm–zona pellucida and sperm–oolemma binding by antisperm antibodies. Fertil Steril 55:440–442PubMed Liu DY, Clarke GN, Baker HW (1991) Inhibition of human sperm–zona pellucida and sperm–oolemma binding by antisperm antibodies. Fertil Steril 55:440–442PubMed
112.
Zurück zum Zitat Mahony MC, Blackmore PF, Bronson RA, Alexander NJ (1991) Inhibition of human sperm-zona pellucida tight binding in the presence of antisperm antibody positive polyclonal patient sera. J Reprod Immunol 19:287–301PubMed Mahony MC, Blackmore PF, Bronson RA, Alexander NJ (1991) Inhibition of human sperm-zona pellucida tight binding in the presence of antisperm antibody positive polyclonal patient sera. J Reprod Immunol 19:287–301PubMed
113.
Zurück zum Zitat Mandal A, Klotz KL, Shetty J, Jayes FL, Wolkowicz MJ, Bolling LC, Coonrod SA, Black MB, Diekman AB, Haystead TA, Flickinger CJ, Herr JC (2003) SLLP1, a unique, intra-acrosomal, non-bacteriolytic, c lysozyme-like protein of human spermatozoa. Biol Reprod 68:1525–1537PubMed Mandal A, Klotz KL, Shetty J, Jayes FL, Wolkowicz MJ, Bolling LC, Coonrod SA, Black MB, Diekman AB, Haystead TA, Flickinger CJ, Herr JC (2003) SLLP1, a unique, intra-acrosomal, non-bacteriolytic, c lysozyme-like protein of human spermatozoa. Biol Reprod 68:1525–1537PubMed
114.
Zurück zum Zitat Mandelbaum SL, Diamond MP, DeCherney AH (1987) Relationship of antisperm antibodies to oocyte fertilization in in vitro fertilization-embryo transfer. Fertil Steril 47:644–651PubMed Mandelbaum SL, Diamond MP, DeCherney AH (1987) Relationship of antisperm antibodies to oocyte fertilization in in vitro fertilization-embryo transfer. Fertil Steril 47:644–651PubMed
115.
Zurück zum Zitat Marin-Briggiler CI, Vazquez-Levin MH, Gonzalez-Echeverria F, Blaquier JA, Miranda PV, Tezon JG (2003) Effect of antisperm antibodies present in human follicular fluid upon the acrosome reaction and sperm-zona pellucida interaction. Am J Reprod Immunol 50:209–219PubMed Marin-Briggiler CI, Vazquez-Levin MH, Gonzalez-Echeverria F, Blaquier JA, Miranda PV, Tezon JG (2003) Effect of antisperm antibodies present in human follicular fluid upon the acrosome reaction and sperm-zona pellucida interaction. Am J Reprod Immunol 50:209–219PubMed
116.
Zurück zum Zitat McDonald SW (2000) Cellular responses to vasectomy. Int Rev Cytol 199:295–339PubMed McDonald SW (2000) Cellular responses to vasectomy. Int Rev Cytol 199:295–339PubMed
117.
Zurück zum Zitat Meaker S (1922) Some aspects of the problem of sterility. Boston Med Surg J 187:535–539 Meaker S (1922) Some aspects of the problem of sterility. Boston Med Surg J 187:535–539
118.
Zurück zum Zitat Meinertz H, Linnet L, Fogh-Andersen P, Hjort T (1990) Antisperm antibodies and fertility after vasovasostomy: a follow-up study of 216 men. Fertil Steril 54:315–321PubMed Meinertz H, Linnet L, Fogh-Andersen P, Hjort T (1990) Antisperm antibodies and fertility after vasovasostomy: a follow-up study of 216 men. Fertil Steril 54:315–321PubMed
119.
Zurück zum Zitat Menge AC (1970) Immune reactions and infertility. J Reprod Fertil Suppl 10:171–186PubMed Menge AC (1970) Immune reactions and infertility. J Reprod Fertil Suppl 10:171–186PubMed
120.
Zurück zum Zitat Menge AC, Rosenberg A, Burkons DM (1974) Effects of uterine fluids, and immunoglobulins from semen-immunized rabbits on rabbit embryos cultured in vitro. Proc Soc Exp Biol Med 145:371–378PubMed Menge AC, Rosenberg A, Burkons DM (1974) Effects of uterine fluids, and immunoglobulins from semen-immunized rabbits on rabbit embryos cultured in vitro. Proc Soc Exp Biol Med 145:371–378PubMed
121.
Zurück zum Zitat Menge AC, Medley NE, Mangione CM, Dietrich JW (1982) The incidence and influence of antisperm antibodies in infertile human couples on sperm–cervical mucus interactions and subsequent fertility. Fertil Steril 38:439–446PubMed Menge AC, Medley NE, Mangione CM, Dietrich JW (1982) The incidence and influence of antisperm antibodies in infertile human couples on sperm–cervical mucus interactions and subsequent fertility. Fertil Steril 38:439–446PubMed
122.
Zurück zum Zitat Menge AC, Naz RK (1988) Immunologic reactions involving sperm cells and preimplantation embryos. Am J Reprod Immunol Microbiol 18:17–20PubMed Menge AC, Naz RK (1988) Immunologic reactions involving sperm cells and preimplantation embryos. Am J Reprod Immunol Microbiol 18:17–20PubMed
123.
Zurück zum Zitat Menge AC, Beitner O (1989) Interrelationships among semen characteristics, antisperm antibodies, and cervical mucus penetration assays in infertile human couples. Fertil Steril 51:486–492PubMed Menge AC, Beitner O (1989) Interrelationships among semen characteristics, antisperm antibodies, and cervical mucus penetration assays in infertile human couples. Fertil Steril 51:486–492PubMed
124.
Zurück zum Zitat Morgan H, Stedronska J, Hendry WF, Chamberlain GF, Dewhurst CJ (1977) Sperm/cervical-mucus crossed hostility testing and antisperm antibodies in the husband. Lancet 1:1228–1230PubMed Morgan H, Stedronska J, Hendry WF, Chamberlain GF, Dewhurst CJ (1977) Sperm/cervical-mucus crossed hostility testing and antisperm antibodies in the husband. Lancet 1:1228–1230PubMed
125.
Zurück zum Zitat Mruk DD, Cheng CY (2004) Sertoli–Sertoli and Sertoli–germ cell interactions and their significance in germ cell movement in the seminiferous epithelium during spermatogenesis. Endocr Rev 25:747–806PubMed Mruk DD, Cheng CY (2004) Sertoli–Sertoli and Sertoli–germ cell interactions and their significance in germ cell movement in the seminiferous epithelium during spermatogenesis. Endocr Rev 25:747–806PubMed
126.
Zurück zum Zitat Myogo K, Yamano S, Nakagawa K, Kamada M, Maegawa M, Irahara M, Aono T (2001) Sperm-immobilizing antibodies block capacitation in human spermatozoa. Arch Androl 47:135–142PubMed Myogo K, Yamano S, Nakagawa K, Kamada M, Maegawa M, Irahara M, Aono T (2001) Sperm-immobilizing antibodies block capacitation in human spermatozoa. Arch Androl 47:135–142PubMed
127.
Zurück zum Zitat Nagy ZP, Verheyen G, Liu J, Joris H, Janssenswillen C, Wisanto A, Devroey P, Van Steirteghem AC (1995) Results of 55 intracytoplasmic sperm injection cycles in the treatment of male-immunological infertility. Hum Reprod 10:1775–1780PubMed Nagy ZP, Verheyen G, Liu J, Joris H, Janssenswillen C, Wisanto A, Devroey P, Van Steirteghem AC (1995) Results of 55 intracytoplasmic sperm injection cycles in the treatment of male-immunological infertility. Hum Reprod 10:1775–1780PubMed
128.
Zurück zum Zitat Naz RK, Wolf DP (1994) Antibodies to sperm-specific human FA-1 inhibit in vitro fertilization in rhesus monkeys: development of a simian model for testing of anti-FA-1 contraceptive vaccine. J Reprod Immunol 27:111–121PubMed Naz RK, Wolf DP (1994) Antibodies to sperm-specific human FA-1 inhibit in vitro fertilization in rhesus monkeys: development of a simian model for testing of anti-FA-1 contraceptive vaccine. J Reprod Immunol 27:111–121PubMed
129.
Zurück zum Zitat Naz RK, Chauhan SC (2001) Presence of antibodies to sperm YLP(12) synthetic peptide in sera and seminal plasma of immunoinfertile men. Mol Hum Reprod 7:21–26PubMed Naz RK, Chauhan SC (2001) Presence of antibodies to sperm YLP(12) synthetic peptide in sera and seminal plasma of immunoinfertile men. Mol Hum Reprod 7:21–26PubMed
130.
Zurück zum Zitat Naz RK, Chauhan SC (2002) Human sperm-specific peptide vaccine that causes long-term reversible contraception. Biol Reprod 67:674–680PubMed Naz RK, Chauhan SC (2002) Human sperm-specific peptide vaccine that causes long-term reversible contraception. Biol Reprod 67:674–680PubMed
131.
Zurück zum Zitat Naz RK, Chauhan SC, Trivedi RN (2002) Monoclonal antibody against human sperm-specific YLP12 peptide sequence involved in oocyte binding. Arch Androl 48:169–175PubMed Naz RK, Chauhan SC, Trivedi RN (2002) Monoclonal antibody against human sperm-specific YLP12 peptide sequence involved in oocyte binding. Arch Androl 48:169–175PubMed
132.
Zurück zum Zitat Naz RK (2005) Antisperm vaccine for contraception. Am J Reprod Immunol 54:378–383PubMed Naz RK (2005) Antisperm vaccine for contraception. Am J Reprod Immunol 54:378–383PubMed
133.
Zurück zum Zitat Naz RK (2006) Effect of sperm DNA vaccine on fertility of female mice. Mol Reprod Dev 73:918–928PubMed Naz RK (2006) Effect of sperm DNA vaccine on fertility of female mice. Mol Reprod Dev 73:918–928PubMed
134.
Zurück zum Zitat Naz RK (2006) Effect of fertilization antigen (FA-1) DNA vaccine on fertility of female mice. Mol Reprod Dev 73:1473–1479PubMed Naz RK (2006) Effect of fertilization antigen (FA-1) DNA vaccine on fertility of female mice. Mol Reprod Dev 73:1473–1479PubMed
135.
Zurück zum Zitat Norton EJ, Diekman AB, Westbrook VA, Mullins DW, Klotz KL, Gilmer LL, Thomas TS, Wright DC, Brisker J, Engelhard VH, Flickinger CJ, Herr JC (2002) A male genital tract-specific carbohydrate epitope on human CD52: implications for immunocontraception. Tissue Antigens 60:354–364PubMed Norton EJ, Diekman AB, Westbrook VA, Mullins DW, Klotz KL, Gilmer LL, Thomas TS, Wright DC, Brisker J, Engelhard VH, Flickinger CJ, Herr JC (2002) A male genital tract-specific carbohydrate epitope on human CD52: implications for immunocontraception. Tissue Antigens 60:354–364PubMed
136.
Zurück zum Zitat O’Leary S, Jasper MJ, Warnes GM, Armstrong DT, Robertson SA (2004) Seminal plasma regulates endometrial cytokine expression, leukocyte recruitment and embryo development in the pig. Reproduction 128:237–247PubMed O’Leary S, Jasper MJ, Warnes GM, Armstrong DT, Robertson SA (2004) Seminal plasma regulates endometrial cytokine expression, leukocyte recruitment and embryo development in the pig. Reproduction 128:237–247PubMed
137.
Zurück zum Zitat O’Leary S, Jasper MJ, Robertson SA, Armstrong DT (2006) Seminal plasma regulates ovarian progesterone production, leukocyte recruitment and follicular cell responses in the pig. Reproduction 132:147–158PubMed O’Leary S, Jasper MJ, Robertson SA, Armstrong DT (2006) Seminal plasma regulates ovarian progesterone production, leukocyte recruitment and follicular cell responses in the pig. Reproduction 132:147–158PubMed
138.
Zurück zum Zitat O’Rand MG (1977) The presence of sperm-specific surface isoantigens on the egg following fertilization. J Exp Zool 202:267–273PubMed O’Rand MG (1977) The presence of sperm-specific surface isoantigens on the egg following fertilization. J Exp Zool 202:267–273PubMed
139.
Zurück zum Zitat Ochsenkuhn R, O’Connor AE, Hirst JJ, Gordon Baker HW, de Kretser DM, Hedger MP (2006) The relationship between immunosuppressive activity and immunoregulatory cytokines in seminal plasma: influence of sperm autoimmunity and seminal leukocytes. J Reprod Immunol 71:57–74PubMed Ochsenkuhn R, O’Connor AE, Hirst JJ, Gordon Baker HW, de Kretser DM, Hedger MP (2006) The relationship between immunosuppressive activity and immunoregulatory cytokines in seminal plasma: influence of sperm autoimmunity and seminal leukocytes. J Reprod Immunol 71:57–74PubMed
140.
Zurück zum Zitat Olson CK, Keppler-Noreuil KM, Romitti PA, Budelier WT, Ryan G, Sparks AE, Van Voorhis BJ (2005) In vitro fertilization is associated with an increase in major birth defects. Fertil Steril 84:1308–1315PubMed Olson CK, Keppler-Noreuil KM, Romitti PA, Budelier WT, Ryan G, Sparks AE, Van Voorhis BJ (2005) In vitro fertilization is associated with an increase in major birth defects. Fertil Steril 84:1308–1315PubMed
141.
Zurück zum Zitat Omu AE, Makhseed M, Mohammed AT, Munim RA (1997) Characteristics of men and women with circulating antisperm antibodies in a combined infertility clinic in Kuwait. Arch Androl 39:55–64PubMed Omu AE, Makhseed M, Mohammed AT, Munim RA (1997) Characteristics of men and women with circulating antisperm antibodies in a combined infertility clinic in Kuwait. Arch Androl 39:55–64PubMed
142.
Zurück zum Zitat Pagidas K, Hemmings R, Falcone T, Miron P (1994) The effect of antisperm autoantibodies in male or female partners undergoing in vitro fertilization-embryo transfer. Fertil Steril 62:363–369PubMed Pagidas K, Hemmings R, Falcone T, Miron P (1994) The effect of antisperm autoantibodies in male or female partners undergoing in vitro fertilization-embryo transfer. Fertil Steril 62:363–369PubMed
143.
Zurück zum Zitat Palermo G, Devroey P, Camus M, Khan I, Wisanto A, Van Steirteghem AC (1989) Assisted procreation in the presence of a positive direct mixed antiglobulin reaction test. Fertil Steril 52:645–649PubMed Palermo G, Devroey P, Camus M, Khan I, Wisanto A, Van Steirteghem AC (1989) Assisted procreation in the presence of a positive direct mixed antiglobulin reaction test. Fertil Steril 52:645–649PubMed
144.
Zurück zum Zitat Paschke R, Schulze Bertelsbeck D, Heinecke A (1994) Significance of sperm antibodies detected by the mixed antiglobulin reaction and the tray agglutination test. Andrologia 26:263–269PubMed Paschke R, Schulze Bertelsbeck D, Heinecke A (1994) Significance of sperm antibodies detected by the mixed antiglobulin reaction and the tray agglutination test. Andrologia 26:263–269PubMed
145.
Zurück zum Zitat Patrizio P, Silber SJ, Ord T, Moretti-Rojas I, Asch RH (1992) Relationship of epididymal sperm antibodies to their in vitro fertilization capacity in men with congenital absence of the vas deferens. Fertil Steril 58:1006–1010PubMed Patrizio P, Silber SJ, Ord T, Moretti-Rojas I, Asch RH (1992) Relationship of epididymal sperm antibodies to their in vitro fertilization capacity in men with congenital absence of the vas deferens. Fertil Steril 58:1006–1010PubMed
146.
Zurück zum Zitat Pattinson HA, Mortimer D, Taylor PJ (1990) Treatment of spermagglutination with proteolytic enzymes. II. Sperm function after enzymatic disagglutination. Hum Reprod 5:174–178PubMed Pattinson HA, Mortimer D, Taylor PJ (1990) Treatment of spermagglutination with proteolytic enzymes. II. Sperm function after enzymatic disagglutination. Hum Reprod 5:174–178PubMed
147.
Zurück zum Zitat Perricone R, Pasetto N, De Carolis C, Vaquero E, Piccione E, Baschieri L, Fontana L (1992) Functionally active complement is present in human ovarian follicular fluid and can be activated by seminal plasma. Clin Exp Immunol 89:154–157PubMed Perricone R, Pasetto N, De Carolis C, Vaquero E, Piccione E, Baschieri L, Fontana L (1992) Functionally active complement is present in human ovarian follicular fluid and can be activated by seminal plasma. Clin Exp Immunol 89:154–157PubMed
148.
Zurück zum Zitat Perricone R, De Carolis C, Giacomello F, Giacomelli R, De Sanctis G, Fontana L (2000) Impaired human ovarian follicular fluid complement function in hereditary angioedema. Scand J Immunol 51:104–108PubMed Perricone R, De Carolis C, Giacomello F, Giacomelli R, De Sanctis G, Fontana L (2000) Impaired human ovarian follicular fluid complement function in hereditary angioedema. Scand J Immunol 51:104–108PubMed
149.
Zurück zum Zitat Ponjaert-Kristoffersen I, Bonduelle M, Barnes J, Nekkebroeck J, Loft A, Wennerholm UB, Tarlatzis BC, Peters C, Hagberg BS, Berner A, Sutcliffe AG (2005) International collaborative study of intracytoplasmic sperm injection-conceived, in vitro fertilization-conceived, and naturally conceived 5-year-old child outcomes: cognitive and motor assessments. Pediatrics 115:e283–e289PubMed Ponjaert-Kristoffersen I, Bonduelle M, Barnes J, Nekkebroeck J, Loft A, Wennerholm UB, Tarlatzis BC, Peters C, Hagberg BS, Berner A, Sutcliffe AG (2005) International collaborative study of intracytoplasmic sperm injection-conceived, in vitro fertilization-conceived, and naturally conceived 5-year-old child outcomes: cognitive and motor assessments. Pediatrics 115:e283–e289PubMed
150.
Zurück zum Zitat Pretorius E, Franken DR, Shulman S, Gloeb J (1986) Sperm cervical mucus contact test and immunobead test for sperm antibodies. Arch Androl 16:199–202PubMed Pretorius E, Franken DR, Shulman S, Gloeb J (1986) Sperm cervical mucus contact test and immunobead test for sperm antibodies. Arch Androl 16:199–202PubMed
151.
Zurück zum Zitat Pretorius E, Franken DR (1988) The immunobead technique: an indicator of disturbed sperm cervical mucus interaction. Andrologia 20:5–9PubMed Pretorius E, Franken DR (1988) The immunobead technique: an indicator of disturbed sperm cervical mucus interaction. Andrologia 20:5–9PubMed
152.
Zurück zum Zitat Price RJ, Boettcher B (1979) The presence of complement in human cervical mucus and its possible relevance to infertility in women with complement-dependent sperm-immobilizing antibodies. Fertil Steril 32:61–66PubMed Price RJ, Boettcher B (1979) The presence of complement in human cervical mucus and its possible relevance to infertility in women with complement-dependent sperm-immobilizing antibodies. Fertil Steril 32:61–66PubMed
153.
Zurück zum Zitat Primakoff P, Hyatt H (1986) An antisperm monoclonal antibody inhibits sperm fusion with zona-free hamster eggs but not homologous eggs. Fertil Steril 46:489–493PubMed Primakoff P, Hyatt H (1986) An antisperm monoclonal antibody inhibits sperm fusion with zona-free hamster eggs but not homologous eggs. Fertil Steril 46:489–493PubMed
154.
Zurück zum Zitat Primakoff P, Lathrop W, Woolman L, Cowan A, Myles D (1988) Fully effective contraception in male and female guinea pigs immunized with the sperm protein PH-20. Nature 335:543–546PubMed Primakoff P, Lathrop W, Woolman L, Cowan A, Myles D (1988) Fully effective contraception in male and female guinea pigs immunized with the sperm protein PH-20. Nature 335:543–546PubMed
155.
Zurück zum Zitat Rajah SV, Parslow JM, Howell RJ, Hendry WF (1993) The effects on in-vitro fertilization of autoantibodies to spermatozoa in subfertile men. Hum Reprod 8:1079–1082PubMed Rajah SV, Parslow JM, Howell RJ, Hendry WF (1993) The effects on in-vitro fertilization of autoantibodies to spermatozoa in subfertile men. Hum Reprod 8:1079–1082PubMed
156.
Zurück zum Zitat Riley-Vargas RC, Lanzendorf S, Atkinson JP (2005) Targeted and restricted complement activation on acrosome-reacted spermatozoa. J Clin Invest 115:1241–1249PubMed Riley-Vargas RC, Lanzendorf S, Atkinson JP (2005) Targeted and restricted complement activation on acrosome-reacted spermatozoa. J Clin Invest 115:1241–1249PubMed
157.
Zurück zum Zitat Robertson SA (2005) Seminal plasma and male factor signalling in the female reproductive tract. Cell Tissue Res 322:43–52PubMed Robertson SA (2005) Seminal plasma and male factor signalling in the female reproductive tract. Cell Tissue Res 322:43–52PubMed
158.
Zurück zum Zitat Romano R, Santucci R, Marrone V, Francavilla F (1993) Effect of ionophore challenge on hamster egg penetration and acrosome reaction of antibody-coated human sperm. Am J Reprod Immunol 29:56–61PubMed Romano R, Santucci R, Marrone V, Francavilla F (1993) Effect of ionophore challenge on hamster egg penetration and acrosome reaction of antibody-coated human sperm. Am J Reprod Immunol 29:56–61PubMed
159.
Zurück zum Zitat Rumke P (1954) The presence of sperm antibodies in the serum of two patients with oligospermia. Vox Sang 4:135–140 Rumke P (1954) The presence of sperm antibodies in the serum of two patients with oligospermia. Vox Sang 4:135–140
160.
Zurück zum Zitat Rumke P, Van Amstel N, Messer EN, Bezemer PD (1974) Prognosis of fertility of men with sperm agglutinins in the serum. Fertil Steril 25:393–398PubMed Rumke P, Van Amstel N, Messer EN, Bezemer PD (1974) Prognosis of fertility of men with sperm agglutinins in the serum. Fertil Steril 25:393–398PubMed
161.
Zurück zum Zitat Rumke P, Renckens CN, Bezemer PD, van Amstel N (1984) Prognosis of fertility in women with unexplained infertility and sperm agglutinins in the serum. Fertil Steril 42:561–567PubMed Rumke P, Renckens CN, Bezemer PD, van Amstel N (1984) Prognosis of fertility in women with unexplained infertility and sperm agglutinins in the serum. Fertil Steril 42:561–567PubMed
162.
Zurück zum Zitat Russell DL, Salustri A (2006) Extracellular matrix of the cumulus–oocyte complex. Semin Reprod Med 24:217–227PubMed Russell DL, Salustri A (2006) Extracellular matrix of the cumulus–oocyte complex. Semin Reprod Med 24:217–227PubMed
163.
Zurück zum Zitat Saragueta P, Lanuza G, Miranda PV, Tezon JG, Baranao JL (1994) Immunoglobulins from human follicular fluid induce the acrosome reaction in human sperm. Mol Reprod Dev 39:280–288PubMed Saragueta P, Lanuza G, Miranda PV, Tezon JG, Baranao JL (1994) Immunoglobulins from human follicular fluid induce the acrosome reaction in human sperm. Mol Reprod Dev 39:280–288PubMed
164.
Zurück zum Zitat Shai S, Naot Y (1992) Identification of human sperm antigens reacting with antisperm antibodies from sera and genital tract secretions. Fertil Steril 58:593–598PubMed Shai S, Naot Y (1992) Identification of human sperm antigens reacting with antisperm antibodies from sera and genital tract secretions. Fertil Steril 58:593–598PubMed
165.
Zurück zum Zitat Shelton JA, Goldberg E (1986) Local reproductive tract immunity to sperm-specific lactate dehydrogenase-C4. Biol Reprod 35:873–876PubMed Shelton JA, Goldberg E (1986) Local reproductive tract immunity to sperm-specific lactate dehydrogenase-C4. Biol Reprod 35:873–876PubMed
166.
Zurück zum Zitat Shibahara H, Shigeta M, Toji H, Koyama K (1995) Sperm immobilizing antibodies interfere with sperm migration from the uterine cavity through the fallopian tubes. Am J Reprod Immunol 34:120–124PubMed Shibahara H, Shigeta M, Toji H, Koyama K (1995) Sperm immobilizing antibodies interfere with sperm migration from the uterine cavity through the fallopian tubes. Am J Reprod Immunol 34:120–124PubMed
167.
Zurück zum Zitat Shibahara H, Shigeta M, Inoue M, Hasegawa A, Koyama K, Alexander NJ, Isojima S (1996) Diversity of the blocking effects of antisperm antibodies on fertilization in human and mouse. Hum Reprod 11:2595–2599PubMed Shibahara H, Shigeta M, Inoue M, Hasegawa A, Koyama K, Alexander NJ, Isojima S (1996) Diversity of the blocking effects of antisperm antibodies on fertilization in human and mouse. Hum Reprod 11:2595–2599PubMed
168.
Zurück zum Zitat Shulman S, Harlin B, Davis P, Reyniak JV (1978) Immune infertility and new approaches to treatment. Fertil Steril 29:309–313PubMed Shulman S, Harlin B, Davis P, Reyniak JV (1978) Immune infertility and new approaches to treatment. Fertil Steril 29:309–313PubMed
169.
Zurück zum Zitat Sinisi AA, Di Finizio B, Pasquali D, Scurini C, D’Apuzzo A, Bellastella A (1993) Prevalence of antisperm antibodies by SpermMARtest in subjects undergoing a routine sperm analysis for infertility. Int J Androl 16:311–314PubMed Sinisi AA, Di Finizio B, Pasquali D, Scurini C, D’Apuzzo A, Bellastella A (1993) Prevalence of antisperm antibodies by SpermMARtest in subjects undergoing a routine sperm analysis for infertility. Int J Androl 16:311–314PubMed
170.
Zurück zum Zitat Stavnezer J (1995) Regulation of antibody production and class switching by TGF-beta. J Immunol 155:1647–1651PubMed Stavnezer J (1995) Regulation of antibody production and class switching by TGF-beta. J Immunol 155:1647–1651PubMed
171.
Zurück zum Zitat Talwar GP, Singh O, Pal R, Chatterjee N, Sahai P, Dhall K, Kaur J, Das SK, Suri S, Buckshee K, Saraya L, Saxena BN (1994) A vaccine that prevents pregnancy in women. Proc Natl Acad Sci USA 91:8532–8536PubMed Talwar GP, Singh O, Pal R, Chatterjee N, Sahai P, Dhall K, Kaur J, Das SK, Suri S, Buckshee K, Saraya L, Saxena BN (1994) A vaccine that prevents pregnancy in women. Proc Natl Acad Sci USA 91:8532–8536PubMed
172.
Zurück zum Zitat Tasdemir I, Tasdemir M, Fukuda J, Kodama H, Matsui T, Tanaka T (1996) Sperm immobilization antibodies in infertile male sera decrease the acrosome reaction: a possible mechanism for immunologic infertility. J Assist Reprod Genet 13:413–416PubMed Tasdemir I, Tasdemir M, Fukuda J, Kodama H, Matsui T, Tanaka T (1996) Sperm immobilization antibodies in infertile male sera decrease the acrosome reaction: a possible mechanism for immunologic infertility. J Assist Reprod Genet 13:413–416PubMed
173.
Zurück zum Zitat Taylor CT, Biljan MM, Kingsland CR, Johnson PM (1994) Inhibition of human spermatozoon–oocyte interaction in vitro by monoclonal antibodies to CD46 (membrane cofactor protein). Hum Reprod 9:907–911PubMed Taylor CT, Biljan MM, Kingsland CR, Johnson PM (1994) Inhibition of human spermatozoon–oocyte interaction in vitro by monoclonal antibodies to CD46 (membrane cofactor protein). Hum Reprod 9:907–911PubMed
174.
Zurück zum Zitat Tomlinson MJ, White A, Barratt CL, Bolton AE, Cooke ID (1992) The removal of morphologically abnormal sperm forms by phagocytes: a positive role for seminal leukocytes? Hum Reprod 7:517–522PubMed Tomlinson MJ, White A, Barratt CL, Bolton AE, Cooke ID (1992) The removal of morphologically abnormal sperm forms by phagocytes: a positive role for seminal leukocytes? Hum Reprod 7:517–522PubMed
175.
Zurück zum Zitat Tremellen KP, Valbuena D, Landeras J, Ballesteros A, Martinez J, Mendoza S, Norman RJ, Robertson SA, Simon C (2000) The effect of intercourse on pregnancy rates during assisted human reproduction. Hum Reprod 15:2653–2658PubMed Tremellen KP, Valbuena D, Landeras J, Ballesteros A, Martinez J, Mendoza S, Norman RJ, Robertson SA, Simon C (2000) The effect of intercourse on pregnancy rates during assisted human reproduction. Hum Reprod 15:2653–2658PubMed
176.
Zurück zum Zitat Tsukui S, Noda Y, Yano J, Fukuda A, Mori T (1986) Inhibition of sperm penetration through human zona pellucida by antisperm antibodies. Fertil Steril 46:92–96PubMed Tsukui S, Noda Y, Yano J, Fukuda A, Mori T (1986) Inhibition of sperm penetration through human zona pellucida by antisperm antibodies. Fertil Steril 46:92–96PubMed
177.
Zurück zum Zitat Ulcova-Gallova Z, Mraz L, Planickova E, Macku F, Ulc I (1990) Three years experience with local hydrocortisone treatment in women with immunological cause of infertility. Zentralbl Gynakol 112(867–872):872–863 Ulcova-Gallova Z, Mraz L, Planickova E, Macku F, Ulc I (1990) Three years experience with local hydrocortisone treatment in women with immunological cause of infertility. Zentralbl Gynakol 112(867–872):872–863
178.
Zurück zum Zitat Vazquez-Levin MH, Notrica JA, Polak de Fried E (1997) Male immunologic infertility: sperm performance on in vitro fertilization. Fertil Steril 68:675–681PubMed Vazquez-Levin MH, Notrica JA, Polak de Fried E (1997) Male immunologic infertility: sperm performance on in vitro fertilization. Fertil Steril 68:675–681PubMed
179.
Zurück zum Zitat Vujisic S, Lepej SZ, Jerkovic L, Emedi I, Sokolic B (2005) Antisperm antibodies in semen, sera and follicular fluids of infertile patients: relation to reproductive outcome after in vitro fertilization. Am J Reprod Immunol 54:13–20PubMed Vujisic S, Lepej SZ, Jerkovic L, Emedi I, Sokolic B (2005) Antisperm antibodies in semen, sera and follicular fluids of infertile patients: relation to reproductive outcome after in vitro fertilization. Am J Reprod Immunol 54:13–20PubMed
180.
Zurück zum Zitat Wang C, Baker HW, Jennings MG, Burger HG, Lutjen P (1985) Interaction between human cervical mucus and sperm surface antibodies. Fertil Steril 44:484–488PubMed Wang C, Baker HW, Jennings MG, Burger HG, Lutjen P (1985) Interaction between human cervical mucus and sperm surface antibodies. Fertil Steril 44:484–488PubMed
181.
Zurück zum Zitat Wei SG, Wang LF, Miao SY, Zong SD, Koide SS (1994) Fertility studies with antisperm antibodies. Arch Androl 32:251–262PubMed Wei SG, Wang LF, Miao SY, Zong SD, Koide SS (1994) Fertility studies with antisperm antibodies. Arch Androl 32:251–262PubMed
182.
Zurück zum Zitat WHO (1999) WHO laboratory manual for the examination of human semen and sperm–cervical mucus interaction, 4th edn. Cambridge University Press, Cambridge WHO (1999) WHO laboratory manual for the examination of human semen and sperm–cervical mucus interaction, 4th edn. Cambridge University Press, Cambridge
183.
Zurück zum Zitat Wilson L (1954) Sperm agglutinins in human semen and blood. Proc Soc Exp Biol Med 85:652–655PubMed Wilson L (1954) Sperm agglutinins in human semen and blood. Proc Soc Exp Biol Med 85:652–655PubMed
184.
Zurück zum Zitat Witkin SS, David SS (1988) Effect of sperm antibodies on pregnancy outcome in a subfertile population. Am J Obstet Gynecol 158:59–62PubMed Witkin SS, David SS (1988) Effect of sperm antibodies on pregnancy outcome in a subfertile population. Am J Obstet Gynecol 158:59–62PubMed
185.
Zurück zum Zitat Xu L, Shi SQ, Yang Y, Peng JP (2007) Immunogenicity of four complementary deoxyribonucleic acid fragments from rabbit zona pellucida 3 and their effects on fertility. Fertil Steril 87:381–390PubMed Xu L, Shi SQ, Yang Y, Peng JP (2007) Immunogenicity of four complementary deoxyribonucleic acid fragments from rabbit zona pellucida 3 and their effects on fertility. Fertil Steril 87:381–390PubMed
186.
Zurück zum Zitat Yakirevich E, Yanai O, Sova Y, Sabo E, Stein A, Hiss J, Resnick MB (2002) Cytotoxic phenotype of intra-epithelial lymphocytes in normal and cryptorchid human testicular excurrent ducts. Hum Reprod 17:275–283PubMed Yakirevich E, Yanai O, Sova Y, Sabo E, Stein A, Hiss J, Resnick MB (2002) Cytotoxic phenotype of intra-epithelial lymphocytes in normal and cryptorchid human testicular excurrent ducts. Hum Reprod 17:275–283PubMed
187.
Zurück zum Zitat Yanagimachi R, Yanagimachi H, Rogers BJ (1976) The use of zona-free animal ova as a test-system for the assessment of the fertilizing capacity of human spermatozoa. Biol Reprod 15:471–476PubMed Yanagimachi R, Yanagimachi H, Rogers BJ (1976) The use of zona-free animal ova as a test-system for the assessment of the fertilizing capacity of human spermatozoa. Biol Reprod 15:471–476PubMed
188.
Zurück zum Zitat Yeh WR, Acosta AA, Seltman HJ, Doncel G (1995) Impact of immunoglobulin isotype and sperm surface location of antisperm antibodies on fertilization in vitro in the human. Fertil Steril 63:1287–1292PubMed Yeh WR, Acosta AA, Seltman HJ, Doncel G (1995) Impact of immunoglobulin isotype and sperm surface location of antisperm antibodies on fertilization in vitro in the human. Fertil Steril 63:1287–1292PubMed
Metadaten
Titel
Antisperm antibodies and conception
verfasst von
L. W. Chamley
G. N. Clarke
Publikationsdatum
01.06.2007
Verlag
Springer-Verlag
Erschienen in
Seminars in Immunopathology / Ausgabe 2/2007
Print ISSN: 1863-2297
Elektronische ISSN: 1863-2300
DOI
https://doi.org/10.1007/s00281-007-0075-2

Weitere Artikel der Ausgabe 2/2007

Seminars in Immunopathology 2/2007 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Echinokokkose medikamentös behandeln oder operieren?

06.05.2024 DCK 2024 Kongressbericht

Die Therapie von Echinokokkosen sollte immer in spezialisierten Zentren erfolgen. Eine symptomlose Echinokokkose kann – egal ob von Hunde- oder Fuchsbandwurm ausgelöst – konservativ erfolgen. Wenn eine Op. nötig ist, kann es sinnvoll sein, vorher Zysten zu leeren und zu desinfizieren. 

Umsetzung der POMGAT-Leitlinie läuft

03.05.2024 DCK 2024 Kongressbericht

Seit November 2023 gibt es evidenzbasierte Empfehlungen zum perioperativen Management bei gastrointestinalen Tumoren (POMGAT) auf S3-Niveau. Vieles wird schon entsprechend der Empfehlungen durchgeführt. Wo es im Alltag noch hapert, zeigt eine Umfrage in einem Klinikverbund.

Proximale Humerusfraktur: Auch 100-Jährige operieren?

01.05.2024 DCK 2024 Kongressbericht

Mit dem demographischen Wandel versorgt auch die Chirurgie immer mehr betagte Menschen. Von Entwicklungen wie Fast-Track können auch ältere Menschen profitieren und bei proximaler Humerusfraktur können selbst manche 100-Jährige noch sicher operiert werden.

Die „Zehn Gebote“ des Endokarditis-Managements

30.04.2024 Endokarditis Leitlinie kompakt

Worauf kommt es beim Management von Personen mit infektiöser Endokarditis an? Eine Kardiologin und ein Kardiologe fassen die zehn wichtigsten Punkte der neuen ESC-Leitlinie zusammen.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.