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Erschienen in: Seminars in Immunopathology 2/2007

01.06.2007 | Review

UNK cells: their role in tissue re-modelling and preeclampsia

verfasst von: Jianhong Zhang, Zhigang Tian

Erschienen in: Seminars in Immunopathology | Ausgabe 2/2007

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Abstract

In different species of mammal, uterine natural killer (uNK) cells are massively recruited and presented at the fetal maternal interface with a spatio-temporal pattern, and regarded as a constructive element to support reproductive development. Recent insights highlight the uNK cells activation, function and interaction with local compartments, which all contribute to the initiation of vascular structural changes. New trends of uNK cells research will benefit the diagnosis, management and test treatment strategy of preeclampsia. Furthermore, we suggest that more efforts and specific studies are needed to further explore the role of uNK cells at the unique micro-environment.
Literatur
1.
Zurück zum Zitat Lanier LL (2006) Natural killer cells: roundup. Immunol Rev 214:5–8PubMed Lanier LL (2006) Natural killer cells: roundup. Immunol Rev 214:5–8PubMed
2.
Zurück zum Zitat Seaman WE (2000) Natural killer cells and natural killer T cells. Arthritis Rheum 43:1204–1217PubMed Seaman WE (2000) Natural killer cells and natural killer T cells. Arthritis Rheum 43:1204–1217PubMed
3.
Zurück zum Zitat King A (2000) Uterine leukocytes and decidualization. Hum Reprod Updat 6:28–36 King A (2000) Uterine leukocytes and decidualization. Hum Reprod Updat 6:28–36
4.
Zurück zum Zitat Peel S (1989) Granulated metrial gland cells. Adv Anat Embryol Cell Biol 115:1–112PubMed Peel S (1989) Granulated metrial gland cells. Adv Anat Embryol Cell Biol 115:1–112PubMed
5.
Zurück zum Zitat Anne Croy B, van den Heuvel MJ, Borzychowski AM, Tayade C (2006) Uterine natural killer cells: a specialized differentiation regulated by ovarian hormones. Immunol Rev 214:161–185PubMed Anne Croy B, van den Heuvel MJ, Borzychowski AM, Tayade C (2006) Uterine natural killer cells: a specialized differentiation regulated by ovarian hormones. Immunol Rev 214:161–185PubMed
6.
Zurück zum Zitat Moffett-King A (2002) Natural killer cells and pregnancy. Nat Rev Immunol 2:656–663PubMed Moffett-King A (2002) Natural killer cells and pregnancy. Nat Rev Immunol 2:656–663PubMed
7.
Zurück zum Zitat Head JR (1996) Uterine natural killer cells during pregnancy in rodents. Nat Immun 15:7–21PubMed Head JR (1996) Uterine natural killer cells during pregnancy in rodents. Nat Immun 15:7–21PubMed
8.
Zurück zum Zitat Zhang J, Croy BA, Tian Z (2005) Uterine natural killer cells: their choices, their missions. Cell Mol Immunol 2:123–129PubMed Zhang J, Croy BA, Tian Z (2005) Uterine natural killer cells: their choices, their missions. Cell Mol Immunol 2:123–129PubMed
9.
Zurück zum Zitat Koopman LA, Kopcow HD, Rybalov B, Boyson JE, Orange JS, Schatz F, Masch R, Lockwood CJ, Schachter AD, Park PJ, Strominger JL (2003) Human decidual natural killer cells are a unique NK cell subset with immunomodulatory potential. J Exp Med 198:1201–1212PubMed Koopman LA, Kopcow HD, Rybalov B, Boyson JE, Orange JS, Schatz F, Masch R, Lockwood CJ, Schachter AD, Park PJ, Strominger JL (2003) Human decidual natural killer cells are a unique NK cell subset with immunomodulatory potential. J Exp Med 198:1201–1212PubMed
10.
Zurück zum Zitat Cooper MA, Fehniger TA, Caligiuri MA (2001) The biology of human natural killer-cell subsets. Trends Immunol 22:633–640PubMed Cooper MA, Fehniger TA, Caligiuri MA (2001) The biology of human natural killer-cell subsets. Trends Immunol 22:633–640PubMed
11.
Zurück zum Zitat Cooper MA, Fehniger TA, Turner SC, Chen KS, Ghaheri BA, Ghayur T, Carson WE, Caligiuri MA (2001) Human natural killer cells: a unique innate immunoregulatory role for the CD56bright subset. Blood 97:3146–3151PubMed Cooper MA, Fehniger TA, Turner SC, Chen KS, Ghaheri BA, Ghayur T, Carson WE, Caligiuri MA (2001) Human natural killer cells: a unique innate immunoregulatory role for the CD56bright subset. Blood 97:3146–3151PubMed
12.
Zurück zum Zitat Kopcow HD, Allan DSJ, Chen X, Rybalov B, Andzelm MM, Ge B, Strominger JL (2005) Human decidual NK cells form immature activating synapses and are not cytotoxic. PNAS 102:15563–15568PubMed Kopcow HD, Allan DSJ, Chen X, Rybalov B, Andzelm MM, Ge B, Strominger JL (2005) Human decidual NK cells form immature activating synapses and are not cytotoxic. PNAS 102:15563–15568PubMed
13.
Zurück zum Zitat Heuvel MJ, Xie X, Tayade C, Peralta C, Fang Y, Leonard S, Paffaro VA, Sheikhi AK, Murrant C, Anne Croy B (2005) A review of trafficking and activation of uterine natural killer cells. Am J Reprod Immunol 54:322–331PubMed Heuvel MJ, Xie X, Tayade C, Peralta C, Fang Y, Leonard S, Paffaro VA, Sheikhi AK, Murrant C, Anne Croy B (2005) A review of trafficking and activation of uterine natural killer cells. Am J Reprod Immunol 54:322–331PubMed
14.
Zurück zum Zitat van den Heuvel M, Peralta C, Bashar S, Taylor S, Horrocks J, Croy BA (2005) Trafficking of peripheral blood CD56(bright) cells to the decidualizing uterus—new tricks for old dogmas? J Reprod Immunol 67:21–34PubMed van den Heuvel M, Peralta C, Bashar S, Taylor S, Horrocks J, Croy BA (2005) Trafficking of peripheral blood CD56(bright) cells to the decidualizing uterus—new tricks for old dogmas? J Reprod Immunol 67:21–34PubMed
15.
Zurück zum Zitat Herington JL, Bany BM (2007) Effect of the Conceptus on uterine natural killer cell numbers and function in the mouse uterus during decidualization. Biol Reprod 76:579–588PubMed Herington JL, Bany BM (2007) Effect of the Conceptus on uterine natural killer cell numbers and function in the mouse uterus during decidualization. Biol Reprod 76:579–588PubMed
16.
Zurück zum Zitat King A, Burrows T, Loke YW (1996) Human uterine natural killer cells. Nat Immun 15:41–52PubMed King A, Burrows T, Loke YW (1996) Human uterine natural killer cells. Nat Immun 15:41–52PubMed
17.
Zurück zum Zitat Hanna J, Goldman-Wohl D, Hamani Y, Avraham I, Greenfield C, Natanson-Yaron S, Prus D, Cohen-Daniel L, Arnon TI, Manaster I, Gazit R, Yutkin V, Benharroch D, Porgador A, Keshet E, Yagel S, Mandelboim O (2006) Decidual NK cells regulate key developmental processes at the human fetal-maternal interface. Nat Med 12:1065–1074PubMed Hanna J, Goldman-Wohl D, Hamani Y, Avraham I, Greenfield C, Natanson-Yaron S, Prus D, Cohen-Daniel L, Arnon TI, Manaster I, Gazit R, Yutkin V, Benharroch D, Porgador A, Keshet E, Yagel S, Mandelboim O (2006) Decidual NK cells regulate key developmental processes at the human fetal-maternal interface. Nat Med 12:1065–1074PubMed
18.
Zurück zum Zitat Leonard S, Murrant C, Tayade C, van den Heuvel M, Watering R, Croy BA (2006) Mechanisms regulating immune cell contributions to spiral artery modification—facts and hypotheses—a review. Placenta 27(Suppl A):S40–S46PubMed Leonard S, Murrant C, Tayade C, van den Heuvel M, Watering R, Croy BA (2006) Mechanisms regulating immune cell contributions to spiral artery modification—facts and hypotheses—a review. Placenta 27(Suppl A):S40–S46PubMed
19.
Zurück zum Zitat Ashkar AA, Croy BA (2001) Functions of uterine natural killer cells are mediated by interferon gamma production during murine pregnancy. Semin Immunol 13:235–241PubMed Ashkar AA, Croy BA (2001) Functions of uterine natural killer cells are mediated by interferon gamma production during murine pregnancy. Semin Immunol 13:235–241PubMed
20.
Zurück zum Zitat Eriksson M, Meadows SK, Basu S, Mselle TF, Wira CR, Sentman CL (2006) TLRs Mediate IFN-{gamma} Production by Human Uterine NK Cells in Endometrium. J Immunol 176:6219–6224PubMed Eriksson M, Meadows SK, Basu S, Mselle TF, Wira CR, Sentman CL (2006) TLRs Mediate IFN-{gamma} Production by Human Uterine NK Cells in Endometrium. J Immunol 176:6219–6224PubMed
21.
Zurück zum Zitat Sargent IL, Borzychowski AM, Redman CWG (2006) NK cells and human pregnancy—an inflammatory view. Trends Immunol 27:399–404PubMed Sargent IL, Borzychowski AM, Redman CWG (2006) NK cells and human pregnancy—an inflammatory view. Trends Immunol 27:399–404PubMed
22.
Zurück zum Zitat Moffett A, Regan L, Braude P (2004) Natural killer cells, miscarriage, and infertility. BMJ 329:1283–1285PubMed Moffett A, Regan L, Braude P (2004) Natural killer cells, miscarriage, and infertility. BMJ 329:1283–1285PubMed
23.
Zurück zum Zitat Tabiasco J, Rabot M, Aguerre-Girr M, El Costa H, Berrebi A, Parant O, Laskarin G, Juretic K, Bensussan A, Rukavina D, Le Bouteiller P (2006) Human decidual NK cells: unique phenotype and functional properties—a review. Placenta 27(Suppl A):S34–S39PubMed Tabiasco J, Rabot M, Aguerre-Girr M, El Costa H, Berrebi A, Parant O, Laskarin G, Juretic K, Bensussan A, Rukavina D, Le Bouteiller P (2006) Human decidual NK cells: unique phenotype and functional properties—a review. Placenta 27(Suppl A):S34–S39PubMed
24.
Zurück zum Zitat Le Bouteiller P, Tabiasco J (2006) Killers become builders during pregnancy. Nat Med 12:991–992PubMed Le Bouteiller P, Tabiasco J (2006) Killers become builders during pregnancy. Nat Med 12:991–992PubMed
25.
Zurück zum Zitat Pijnenborg R, Vercruysse L, Hanssens M (2006) The uterine spiral arteries in human pregnancy: facts and controversies. Placenta 27:939–958PubMed Pijnenborg R, Vercruysse L, Hanssens M (2006) The uterine spiral arteries in human pregnancy: facts and controversies. Placenta 27:939–958PubMed
26.
Zurück zum Zitat Sibai B, Dekker G, Kupferminc M (2005) Pre-eclampsia. Lancet 365:785–799PubMed Sibai B, Dekker G, Kupferminc M (2005) Pre-eclampsia. Lancet 365:785–799PubMed
27.
Zurück zum Zitat Dekker GA, Sibai BM (1998) Etiology and pathogenesis of preeclampsia: current concepts. Am J Obstet Gynecol 179:1359–1375PubMed Dekker GA, Sibai BM (1998) Etiology and pathogenesis of preeclampsia: current concepts. Am J Obstet Gynecol 179:1359–1375PubMed
28.
Zurück zum Zitat Noris M, Perico N, Remuzzi G (2005) Mechanisms of disease: pre-eclampsia. Nat Clin Pract Nephrol 1:98–114 (quiz 120)PubMed Noris M, Perico N, Remuzzi G (2005) Mechanisms of disease: pre-eclampsia. Nat Clin Pract Nephrol 1:98–114 (quiz 120)PubMed
29.
Zurück zum Zitat Chaouat G, Ledee-bataille N, Zourbas S, Dubanchet S, Sandra O, Martal J, Ostojojic S, Frydman R (2003) Implantation: can immunological parameters of implantation failure be of interest for pre-eclampsia? J Reprod Immunol 59:205–217PubMed Chaouat G, Ledee-bataille N, Zourbas S, Dubanchet S, Sandra O, Martal J, Ostojojic S, Frydman R (2003) Implantation: can immunological parameters of implantation failure be of interest for pre-eclampsia? J Reprod Immunol 59:205–217PubMed
30.
Zurück zum Zitat Moffett A, Loke C (2006) Immunology of placentation in eutherian mammals. Nat Rev Immunol 6:584–594PubMed Moffett A, Loke C (2006) Immunology of placentation in eutherian mammals. Nat Rev Immunol 6:584–594PubMed
31.
Zurück zum Zitat Craven CM, Morgan T, Ward K (1998) Decidual spiral artery remodelling begins before cellular interaction with cytotrophoblasts. Placenta 19:241–252PubMed Craven CM, Morgan T, Ward K (1998) Decidual spiral artery remodelling begins before cellular interaction with cytotrophoblasts. Placenta 19:241–252PubMed
32.
Zurück zum Zitat Aplin JD (1991) Implantation, trophoblast differentiation and haemochorial placentation: mechanistic evidence in vivo and in vitro. J Cell Sci 99:681–692PubMed Aplin JD (1991) Implantation, trophoblast differentiation and haemochorial placentation: mechanistic evidence in vivo and in vitro. J Cell Sci 99:681–692PubMed
33.
Zurück zum Zitat Berthold H, Louis LHP (2005) Vascular biology in implantation and placentation. Angiogenesis V8:157–167 Berthold H, Louis LHP (2005) Vascular biology in implantation and placentation. Angiogenesis V8:157–167
34.
Zurück zum Zitat Redman CW, Sargent IL (2005) Latest advances in understanding preeclampsia. Science 308:1592–1594PubMed Redman CW, Sargent IL (2005) Latest advances in understanding preeclampsia. Science 308:1592–1594PubMed
35.
Zurück zum Zitat Parham P (2004) NK cells and trophoblasts: partners in pregnancy. J Exp Med 200:951–955PubMed Parham P (2004) NK cells and trophoblasts: partners in pregnancy. J Exp Med 200:951–955PubMed
36.
Zurück zum Zitat Slukvin, II, Breburda EE, Golos TG (2004) Dynamic changes in primate endometrial leukocyte populations: differential distribution of macrophages and natural killer cells at the rhesus monkey implantation site and in early pregnancy. Placenta 25:297–307PubMed Slukvin, II, Breburda EE, Golos TG (2004) Dynamic changes in primate endometrial leukocyte populations: differential distribution of macrophages and natural killer cells at the rhesus monkey implantation site and in early pregnancy. Placenta 25:297–307PubMed
37.
Zurück zum Zitat Trundley A, Moffett A (2004) Human uterine leukocytes and pregnancy. Tissue Antigens 63:1–12PubMed Trundley A, Moffett A (2004) Human uterine leukocytes and pregnancy. Tissue Antigens 63:1–12PubMed
38.
Zurück zum Zitat Hirano H, Imai Y, Ito H (2002) Spiral artery of placenta: development and pathology-immunohistochemical, microscopical, and electron-microscopic study. Kobe J Med Sci 48:13–23PubMed Hirano H, Imai Y, Ito H (2002) Spiral artery of placenta: development and pathology-immunohistochemical, microscopical, and electron-microscopic study. Kobe J Med Sci 48:13–23PubMed
39.
Zurück zum Zitat Adamson SL, Lu Y, Whiteley KJ, Holmyard D, Hemberger M, Pfarrer C, Cross JC (2002) Interactions between trophoblast cells and the maternal and fetal circulation in the mouse placenta. Dev Biol 250:358–373PubMed Adamson SL, Lu Y, Whiteley KJ, Holmyard D, Hemberger M, Pfarrer C, Cross JC (2002) Interactions between trophoblast cells and the maternal and fetal circulation in the mouse placenta. Dev Biol 250:358–373PubMed
40.
Zurück zum Zitat Croy BA, He H, Esadeg S, Wei Q, McCartney D, Zhang J, Borzychowski A, Ashkar AA, Black GP, Evans SS, Chantakru S, van den Heuvel M, Paffaro VA Jr, Yamada AT (2003) Uterine natural killer cells: insights into their cellular and molecular biology from mouse modelling. Reproduction 126:149–160PubMed Croy BA, He H, Esadeg S, Wei Q, McCartney D, Zhang J, Borzychowski A, Ashkar AA, Black GP, Evans SS, Chantakru S, van den Heuvel M, Paffaro VA Jr, Yamada AT (2003) Uterine natural killer cells: insights into their cellular and molecular biology from mouse modelling. Reproduction 126:149–160PubMed
41.
Zurück zum Zitat Cross JC, Hemberger M, Lu Y, Nozaki T, Whiteley K, Masutani M, Adamson SL (2002) Trophoblast functions, angiogenesis and remodeling of the maternal vasculature in the placenta. Mol Cell Endocrinol 187:207–212PubMed Cross JC, Hemberger M, Lu Y, Nozaki T, Whiteley K, Masutani M, Adamson SL (2002) Trophoblast functions, angiogenesis and remodeling of the maternal vasculature in the placenta. Mol Cell Endocrinol 187:207–212PubMed
42.
Zurück zum Zitat Kanellopoulos-Langevin C, Caucheteux SM, Verbeke P, Ojcius DM (2003) Tolerance of the fetus by the maternal immune system: role of inflammatory mediators at the feto-maternal interface. Reprod Biol Endocrinol 1:121PubMed Kanellopoulos-Langevin C, Caucheteux SM, Verbeke P, Ojcius DM (2003) Tolerance of the fetus by the maternal immune system: role of inflammatory mediators at the feto-maternal interface. Reprod Biol Endocrinol 1:121PubMed
43.
Zurück zum Zitat Georgiades P, Ferguson-Smith AC, Burton GJ (2002) Comparative developmental anatomy of the murine and human definitive placentae. Placenta 23:3–19PubMed Georgiades P, Ferguson-Smith AC, Burton GJ (2002) Comparative developmental anatomy of the murine and human definitive placentae. Placenta 23:3–19PubMed
44.
Zurück zum Zitat Croy BA, Esadeg S, Chantakru S, van den Heuvel M, Paffaro VA, He H, Black GP, Ashkar AA, Kiso Y, Zhang J (2003) Update on pathways regulating the activation of uterine Natural Killer cells, their interactions with decidual spiral arteries and homing of their precursors to the uterus. J Reprod Immunol 59:175–191PubMed Croy BA, Esadeg S, Chantakru S, van den Heuvel M, Paffaro VA, He H, Black GP, Ashkar AA, Kiso Y, Zhang J (2003) Update on pathways regulating the activation of uterine Natural Killer cells, their interactions with decidual spiral arteries and homing of their precursors to the uterus. J Reprod Immunol 59:175–191PubMed
45.
Zurück zum Zitat Chantakru S, Kuziel WA, Maeda N, Croy BA (2001) A study on the density and distribution of uterine Natural Killer cells at mid pregnancy in mice genetically-ablated for CCR2, CCR 5 and the CCR5 receptor ligand, MIP-1 alpha. J Reprod Immunol 49:33–47PubMed Chantakru S, Kuziel WA, Maeda N, Croy BA (2001) A study on the density and distribution of uterine Natural Killer cells at mid pregnancy in mice genetically-ablated for CCR2, CCR 5 and the CCR5 receptor ligand, MIP-1 alpha. J Reprod Immunol 49:33–47PubMed
46.
Zurück zum Zitat Esadeg S, He H, Pijnenborg R, Van Leuven F, Croy BA (2003) Alpha-2 macroglobulin controls trophoblast positioning in mouse implantation sites. Placenta 24:912–921PubMed Esadeg S, He H, Pijnenborg R, Van Leuven F, Croy BA (2003) Alpha-2 macroglobulin controls trophoblast positioning in mouse implantation sites. Placenta 24:912–921PubMed
47.
Zurück zum Zitat Naicker T, Khedun SM, Moodley J, Pijnenborg R (2003) Quantitative analysis of trophoblast invasion in preeclampsia. Acta Obstet Gynecol Scand 82:722–729PubMed Naicker T, Khedun SM, Moodley J, Pijnenborg R (2003) Quantitative analysis of trophoblast invasion in preeclampsia. Acta Obstet Gynecol Scand 82:722–729PubMed
48.
Zurück zum Zitat Ain R, Canham LN, Soares MJ (2003) Gestation stage-dependent intrauterine trophoblast cell invasion in the rat and mouse: novel endocrine phenotype and regulation. Dev Biol 260:176–190PubMed Ain R, Canham LN, Soares MJ (2003) Gestation stage-dependent intrauterine trophoblast cell invasion in the rat and mouse: novel endocrine phenotype and regulation. Dev Biol 260:176–190PubMed
49.
Zurück zum Zitat Guimond MJ, Wang B, Fujita J, Terhorst C, Croy BA (1996) Pregnancy-associated uterine granulated metrial gland cells in mutant and transgenic mice. Am J Reprod Immunol 35:501–509PubMed Guimond MJ, Wang B, Fujita J, Terhorst C, Croy BA (1996) Pregnancy-associated uterine granulated metrial gland cells in mutant and transgenic mice. Am J Reprod Immunol 35:501–509PubMed
50.
Zurück zum Zitat Barber EM, Pollard JW (2003) The uterine NK cell population requires IL-15 but these cells are not required for pregnancy nor the resolution of a Listeria monocytogenes infection. J Immunol 171:37–46PubMed Barber EM, Pollard JW (2003) The uterine NK cell population requires IL-15 but these cells are not required for pregnancy nor the resolution of a Listeria monocytogenes infection. J Immunol 171:37–46PubMed
51.
Zurück zum Zitat Ashkar AA, Croy BA (1999) Interferon-gamma contributes to the normalcy of murine pregnancy. Biol Reprod 61:493–502PubMed Ashkar AA, Croy BA (1999) Interferon-gamma contributes to the normalcy of murine pregnancy. Biol Reprod 61:493–502PubMed
52.
Zurück zum Zitat Croy BA, Ashkar AA, Foster RA, DiSanto JP, Magram J, Carson D, Gendler SJ, Grusby MJ, Wagner N, Muller W, Guimond MJ (1997) Histological studies of gene-ablated mice support important functional roles for natural killer cells in the uterus during pregnancy. J Reprod Immunol 35:111–133PubMed Croy BA, Ashkar AA, Foster RA, DiSanto JP, Magram J, Carson D, Gendler SJ, Grusby MJ, Wagner N, Muller W, Guimond MJ (1997) Histological studies of gene-ablated mice support important functional roles for natural killer cells in the uterus during pregnancy. J Reprod Immunol 35:111–133PubMed
53.
Zurück zum Zitat Guimond MJ, Luross JA, Wang B, Terhorst C, Danial S, Croy BA (1997) Absence of natural killer cells during murine pregnancy is associated with reproductive compromise in TgE26 mice. Biol Reprod 56:169–179PubMed Guimond MJ, Luross JA, Wang B, Terhorst C, Danial S, Croy BA (1997) Absence of natural killer cells during murine pregnancy is associated with reproductive compromise in TgE26 mice. Biol Reprod 56:169–179PubMed
54.
Zurück zum Zitat Greenwood JD, Minhas K, di Santo JP, Makita M, Kiso Y, Croy BA (2000) Ultrastructural studies of implantation sites from mice deficient in uterine natural killer cells. Placenta 21:693–702PubMed Greenwood JD, Minhas K, di Santo JP, Makita M, Kiso Y, Croy BA (2000) Ultrastructural studies of implantation sites from mice deficient in uterine natural killer cells. Placenta 21:693–702PubMed
55.
Zurück zum Zitat Croy BA, Chantakru S, Esadeg S, Ashkar AA, Wei Q (2002) Decidual natural killer cells: key regulators of placental development (a review). J Reprod Immunol 57:151–168PubMed Croy BA, Chantakru S, Esadeg S, Ashkar AA, Wei Q (2002) Decidual natural killer cells: key regulators of placental development (a review). J Reprod Immunol 57:151–168PubMed
56.
Zurück zum Zitat Guimond MJ, Wang B, Croy BA (1998) Engraftment of bone marrow from severe combined immunodeficient (SCID) mice reverses the reproductive deficits in natural killer cell-deficient tg epsilon 26 mice. J Exp Med 187:217–223PubMed Guimond MJ, Wang B, Croy BA (1998) Engraftment of bone marrow from severe combined immunodeficient (SCID) mice reverses the reproductive deficits in natural killer cell-deficient tg epsilon 26 mice. J Exp Med 187:217–223PubMed
57.
Zurück zum Zitat King A, Burrows T, Verma S, Hiby S, Loke YW (1998) Human uterine lymphocytes. Hum Reprod Updat 4:480–485 King A, Burrows T, Verma S, Hiby S, Loke YW (1998) Human uterine lymphocytes. Hum Reprod Updat 4:480–485
58.
Zurück zum Zitat Arcuri F, Cintorino M, Carducci A, Papa S, Riparbelli MG, Mangioni S, Di Blasio AM, Tosi P, Vigano P (2006) Human decidual natural killer cells as a source and target of macrophage migration inhibitory factor. Reproduction 131:175–182PubMed Arcuri F, Cintorino M, Carducci A, Papa S, Riparbelli MG, Mangioni S, Di Blasio AM, Tosi P, Vigano P (2006) Human decidual natural killer cells as a source and target of macrophage migration inhibitory factor. Reproduction 131:175–182PubMed
59.
Zurück zum Zitat Lanier LL (2005) NK cell recognition. Annu Rev Immunol 23:225–274PubMed Lanier LL (2005) NK cell recognition. Annu Rev Immunol 23:225–274PubMed
60.
Zurück zum Zitat Chaouat G, Cayol V, Mairovitz V, Dubanchet S (1999) Localization of the Th2 cytokines IL-3, IL-4, IL-10 at the fetomaternal interface during human and murine pregnancy and lack of requirement for Fas/Fas ligand interaction for a successful allogeneic pregnancy. Am J Reprod Immunol 42:1–13PubMed Chaouat G, Cayol V, Mairovitz V, Dubanchet S (1999) Localization of the Th2 cytokines IL-3, IL-4, IL-10 at the fetomaternal interface during human and murine pregnancy and lack of requirement for Fas/Fas ligand interaction for a successful allogeneic pregnancy. Am J Reprod Immunol 42:1–13PubMed
61.
Zurück zum Zitat van den Heuvel MJ, Xie X, Tayade C, Peralta C, Fang Y, Leonard S, Paffaro VA Jr, Sheikhi AK, Murrant C, Croy BA (2005) A review of trafficking and activation of uterine natural killer cells. Am J Reprod Immunol 54:322–331PubMed van den Heuvel MJ, Xie X, Tayade C, Peralta C, Fang Y, Leonard S, Paffaro VA Jr, Sheikhi AK, Murrant C, Croy BA (2005) A review of trafficking and activation of uterine natural killer cells. Am J Reprod Immunol 54:322–331PubMed
62.
Zurück zum Zitat Murphy SP, Fast LD, Hanna NN, Sharma S (2005) Uterine NK Cells Mediate Inflammation-Induced Fetal Demise in IL-10-Null Mice. J Immunol 175:4084–4090PubMed Murphy SP, Fast LD, Hanna NN, Sharma S (2005) Uterine NK Cells Mediate Inflammation-Induced Fetal Demise in IL-10-Null Mice. J Immunol 175:4084–4090PubMed
63.
Zurück zum Zitat Zenclussen AC (2006) Regulatory T cells in pregnancy. Springer Semin Immunopathol 28:31–39PubMed Zenclussen AC (2006) Regulatory T cells in pregnancy. Springer Semin Immunopathol 28:31–39PubMed
64.
Zurück zum Zitat Tang Q, Bluestone JA (2006) Plasmacytoid DCs and Treg cells: casual acquaintance or monogamous relationship? Nat Immunol 7:551–553PubMed Tang Q, Bluestone JA (2006) Plasmacytoid DCs and Treg cells: casual acquaintance or monogamous relationship? Nat Immunol 7:551–553PubMed
65.
Zurück zum Zitat Abrahams VM, Mor G (2005) Toll-like receptors and their role in the trophoblast. Placenta 26:540–547PubMed Abrahams VM, Mor G (2005) Toll-like receptors and their role in the trophoblast. Placenta 26:540–547PubMed
66.
Zurück zum Zitat Mor G, Romero R, Aldo PB, Abrahams VM (2005) Is the trophoblast an immune regulator? The role of Toll-like receptors during pregnancy. Crit Rev Immunol 25:375–388PubMed Mor G, Romero R, Aldo PB, Abrahams VM (2005) Is the trophoblast an immune regulator? The role of Toll-like receptors during pregnancy. Crit Rev Immunol 25:375–388PubMed
67.
Zurück zum Zitat Zhang JH, He H, Borzychowski AM, Takeda K, Akira S, Croy BA (2003) Analysis of cytokine regulators inducing interferon production by mouse uterine natural killer cells. Biol Reprod 69:404–411PubMed Zhang JH, He H, Borzychowski AM, Takeda K, Akira S, Croy BA (2003) Analysis of cytokine regulators inducing interferon production by mouse uterine natural killer cells. Biol Reprod 69:404–411PubMed
68.
Zurück zum Zitat Xie X, Kang Z, Anderson LN, He H, Lu B, Anne Croy B (2005) Analysis of the contributions of L-selectin and CXCR3 in mediating leukocyte homing to pregnant mouse uterus. Am J Reprod Immunol 53:1–12PubMed Xie X, Kang Z, Anderson LN, He H, Lu B, Anne Croy B (2005) Analysis of the contributions of L-selectin and CXCR3 in mediating leukocyte homing to pregnant mouse uterus. Am J Reprod Immunol 53:1–12PubMed
69.
Zurück zum Zitat Xie X, He H, Colonna M, Seya T, Takai T, Croy BA (2005) Pathways participating in activation of mouse uterine natural killer cells during pregnancy. Biol Reprod 73:510–518PubMed Xie X, He H, Colonna M, Seya T, Takai T, Croy BA (2005) Pathways participating in activation of mouse uterine natural killer cells during pregnancy. Biol Reprod 73:510–518PubMed
70.
Zurück zum Zitat Ashkar AA, Black GP, Wei Q, He H, Liang L, Head JR, Croy BA (2003) Assessment of requirements for IL-15 and IFN regulatory factors in uterine NK cell differentiation and function during pregnancy. J Immunol 171:2937–2944PubMed Ashkar AA, Black GP, Wei Q, He H, Liang L, Head JR, Croy BA (2003) Assessment of requirements for IL-15 and IFN regulatory factors in uterine NK cell differentiation and function during pregnancy. J Immunol 171:2937–2944PubMed
71.
Zurück zum Zitat Ashkar AA, Di Santo JP, Croy BA (2000) Interferon gamma contributes to initiation of uterine vascular modification, decidual integrity, and uterine natural killer cell maturation during normal murine pregnancy. J Exp Med 192:259–270PubMed Ashkar AA, Di Santo JP, Croy BA (2000) Interferon gamma contributes to initiation of uterine vascular modification, decidual integrity, and uterine natural killer cell maturation during normal murine pregnancy. J Exp Med 192:259–270PubMed
72.
Zurück zum Zitat Bachmayer N, Rafik Hamad R, Liszka L, Bremme K, Sverremark-Ekstrom E (2006) Aberrant uterine natural killer (NK)-cell expression and altered placental and serum levels of the NK-cell promoting cytokine interleukin-12 in pre-eclampsia. Am J Reprod Immunol 56:292–301PubMed Bachmayer N, Rafik Hamad R, Liszka L, Bremme K, Sverremark-Ekstrom E (2006) Aberrant uterine natural killer (NK)-cell expression and altered placental and serum levels of the NK-cell promoting cytokine interleukin-12 in pre-eclampsia. Am J Reprod Immunol 56:292–301PubMed
73.
Zurück zum Zitat Kastelein RA, Hunter CA, Cua DJ (2007) Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation. Annu Rev Immunol 25 Kastelein RA, Hunter CA, Cua DJ (2007) Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation. Annu Rev Immunol 25
74.
Zurück zum Zitat Iwakura Y, Ishigame H (2006) The IL-23/IL-17 axis in inflammation. J Clin Invest 116:1218–1222PubMed Iwakura Y, Ishigame H (2006) The IL-23/IL-17 axis in inflammation. J Clin Invest 116:1218–1222PubMed
75.
Zurück zum Zitat Groothuis PG, Nap AW, Winterhager E, Grummer R (2005) Vascular development in endometriosis. Angiogenesis V8:147–156 Groothuis PG, Nap AW, Winterhager E, Grummer R (2005) Vascular development in endometriosis. Angiogenesis V8:147–156
76.
Zurück zum Zitat van der Meer A, Lukassen HGM, van Cranenbroek B, Weiss EH, Braat DDM, van Lierop MJ, Joosten I (2006) Soluble HLA-G promotes Th1-type cytokine production by cytokine-activated uterine and peripheral natural killer cells. Mol Hum Reprod 13:123–133PubMed van der Meer A, Lukassen HGM, van Cranenbroek B, Weiss EH, Braat DDM, van Lierop MJ, Joosten I (2006) Soluble HLA-G promotes Th1-type cytokine production by cytokine-activated uterine and peripheral natural killer cells. Mol Hum Reprod 13:123–133PubMed
77.
Zurück zum Zitat Frankenstein Z, Alon U, Cohen IR (2006) The immune-body cytokine network defines a social architecture of cell interactions. Biol Direct 1:32PubMed Frankenstein Z, Alon U, Cohen IR (2006) The immune-body cytokine network defines a social architecture of cell interactions. Biol Direct 1:32PubMed
78.
Zurück zum Zitat Goswami D, Tannetta DS, Magee LA, Fuchisawa A, Redman CWG, Sargent IL, von Dadelszen P (2006) Excess syncytiotrophoblast microparticle shedding is a feature of early-onset pre-eclampsia, but not normotensive intrauterine growth restriction. Placenta 27:56–61PubMed Goswami D, Tannetta DS, Magee LA, Fuchisawa A, Redman CWG, Sargent IL, von Dadelszen P (2006) Excess syncytiotrophoblast microparticle shedding is a feature of early-onset pre-eclampsia, but not normotensive intrauterine growth restriction. Placenta 27:56–61PubMed
79.
Zurück zum Zitat Parra M, Rodrigo R, Barja P, Bosco C, Fernandez V, Munoz H, Soto-Chacon E (2005) Screening test for preeclampsia through assessment of uteroplacental blood flow and biochemical markers of oxidative stress and endothelial dysfunction. Am J Obstet Gynecol 193:1486–1491PubMed Parra M, Rodrigo R, Barja P, Bosco C, Fernandez V, Munoz H, Soto-Chacon E (2005) Screening test for preeclampsia through assessment of uteroplacental blood flow and biochemical markers of oxidative stress and endothelial dysfunction. Am J Obstet Gynecol 193:1486–1491PubMed
80.
Zurück zum Zitat Eriksson M, Meadows SK, Wira CR, Sentman CL (2006) Endogenous transforming growth factor-beta inhibits toll-like receptor mediated activation of human uterine natural killer cells. Am J Reprod Immunol 56:321–328PubMed Eriksson M, Meadows SK, Wira CR, Sentman CL (2006) Endogenous transforming growth factor-beta inhibits toll-like receptor mediated activation of human uterine natural killer cells. Am J Reprod Immunol 56:321–328PubMed
81.
Zurück zum Zitat Jianhong Zhang, Haiming Wei, Dongmei Wu, Tian Z (2006) Toll-like receptor 3 agonist induces impairment of uterine vascular remodeling and fetal losses in CBA×DBA/2 mice. J Reprod Immunol (in press). DOI 10.1016/j.jri.2006.10.005 Jianhong Zhang, Haiming Wei, Dongmei Wu, Tian Z (2006) Toll-like receptor 3 agonist induces impairment of uterine vascular remodeling and fetal losses in CBA×DBA/2 mice. J Reprod Immunol (in press). DOI 10.​1016/​j.​jri.​2006.​10.​005
82.
Zurück zum Zitat Ligam P, Manuelpillai U, Wallace EM, Walker D (2005) Localisation of indoleamine 2,3-dioxygenase and kynurenine hydroxylase in the human placenta and decidua: implications for role of the kynurenine pathway in pregnancy. Placenta 26:498–504PubMed Ligam P, Manuelpillai U, Wallace EM, Walker D (2005) Localisation of indoleamine 2,3-dioxygenase and kynurenine hydroxylase in the human placenta and decidua: implications for role of the kynurenine pathway in pregnancy. Placenta 26:498–504PubMed
83.
Zurück zum Zitat Wu X, Jin LP, Yuan MM, Zhu Y, Wang MY, Li DJ (2005) Human first-trimester trophoblast cells recruit CD56brightCD16- NK cells into decidua by way of expressing and secreting of CXCL12/stromal cell-derived factor 1. J Immunol 175:61–68PubMed Wu X, Jin LP, Yuan MM, Zhu Y, Wang MY, Li DJ (2005) Human first-trimester trophoblast cells recruit CD56brightCD16- NK cells into decidua by way of expressing and secreting of CXCL12/stromal cell-derived factor 1. J Immunol 175:61–68PubMed
84.
Zurück zum Zitat Bulmer JN, Lash GE (2005) Human uterine natural killer cells: a reappraisal. Mol Immunol 42:511–521PubMed Bulmer JN, Lash GE (2005) Human uterine natural killer cells: a reappraisal. Mol Immunol 42:511–521PubMed
85.
Zurück zum Zitat Lash GE, Schiessl B, Kirkley M, Innes BA, Cooper A, Searle RF, Robson SC, Bulmer JN (2006) Expression of angiogenic growth factors by uterine natural killer cells during early pregnancy. J Leukoc Biol 80:572–580PubMed Lash GE, Schiessl B, Kirkley M, Innes BA, Cooper A, Searle RF, Robson SC, Bulmer JN (2006) Expression of angiogenic growth factors by uterine natural killer cells during early pregnancy. J Leukoc Biol 80:572–580PubMed
86.
Zurück zum Zitat Li XF, Charnock-Jones DS, Zhang E, Hiby S, Malik S, Day K, Licence D, Bowen JM, Gardner L, King A, Loke YW, Smith SK (2001) Angiogenic growth factor messenger ribonucleic acids in uterine natural killer cells. J Clin Endocrinol Metab 86:1823–1834PubMed Li XF, Charnock-Jones DS, Zhang E, Hiby S, Malik S, Day K, Licence D, Bowen JM, Gardner L, King A, Loke YW, Smith SK (2001) Angiogenic growth factor messenger ribonucleic acids in uterine natural killer cells. J Clin Endocrinol Metab 86:1823–1834PubMed
87.
Zurück zum Zitat Hiby SE, Walker JJ, O’Shaughnessy K M, Redman CW, Carrington M, Trowsdale J, Moffett A (2004) Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success. J Exp Med 200:957–965PubMed Hiby SE, Walker JJ, O’Shaughnessy K M, Redman CW, Carrington M, Trowsdale J, Moffett A (2004) Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success. J Exp Med 200:957–965PubMed
88.
Zurück zum Zitat King A, Hiby SE, Gardner L, Joseph S, Bowen JM, Verma S, Burrows TD, Loke YW (2000) Recognition of trophoblast HLA class I molecules by decidual NK cell receptors—a review. Placenta 21(Suppl A):S81–S85PubMed King A, Hiby SE, Gardner L, Joseph S, Bowen JM, Verma S, Burrows TD, Loke YW (2000) Recognition of trophoblast HLA class I molecules by decidual NK cell receptors—a review. Placenta 21(Suppl A):S81–S85PubMed
89.
Zurück zum Zitat Chaouat G, Ledee-Bataille N, Dubanchet S (2005) Immunological similarities between implantation and pre-eclampsia. Am J Reprod Immunol 53:222–229PubMed Chaouat G, Ledee-Bataille N, Dubanchet S (2005) Immunological similarities between implantation and pre-eclampsia. Am J Reprod Immunol 53:222–229PubMed
90.
Zurück zum Zitat Le Bouteiller P, Pizzato N, Barakonyi A, Solier C (2003) HLA-G, pre-eclampsia, immunity and vascular events. J Reprod Immunol 59:219–234PubMed Le Bouteiller P, Pizzato N, Barakonyi A, Solier C (2003) HLA-G, pre-eclampsia, immunity and vascular events. J Reprod Immunol 59:219–234PubMed
91.
Zurück zum Zitat Yie S-m, Li L-h, Li Y-m, Librach C (2004) HLA-G protein concentrations in maternal serum and placental tissue are decreased in preeclampsia. Am J Obstet Gynecol 191:525–529PubMed Yie S-m, Li L-h, Li Y-m, Librach C (2004) HLA-G protein concentrations in maternal serum and placental tissue are decreased in preeclampsia. Am J Obstet Gynecol 191:525–529PubMed
92.
Zurück zum Zitat Jones RL, Stoikos C, Findlay JK, Salamonsen LA (2006) TGF-{beta} superfamily expression and actions in the endometrium and placenta. Reproduction 132:217–232PubMed Jones RL, Stoikos C, Findlay JK, Salamonsen LA (2006) TGF-{beta} superfamily expression and actions in the endometrium and placenta. Reproduction 132:217–232PubMed
93.
Zurück zum Zitat Huppertz B, Kadyrov M, Kingdom JCP (2006) Apoptosis and its role in the trophoblast. Am J Obstet Gynecol 195:29–39PubMed Huppertz B, Kadyrov M, Kingdom JCP (2006) Apoptosis and its role in the trophoblast. Am J Obstet Gynecol 195:29–39PubMed
94.
Zurück zum Zitat Matthiesen L, Berg G, Ernerudh J, Ekerfelt C, Jonsson Y, Sharma S (2005) Immunology of preeclampsia. Chem Immunol Allergy 89:49–61PubMedCrossRef Matthiesen L, Berg G, Ernerudh J, Ekerfelt C, Jonsson Y, Sharma S (2005) Immunology of preeclampsia. Chem Immunol Allergy 89:49–61PubMedCrossRef
95.
Zurück zum Zitat Kadyrov M, Kingdom JCP, Huppertz B (2006) Divergent trophoblast invasion and apoptosis in placental bed spiral arteries from pregnancies complicated by maternal anemia and early-onset preeclampsia/intrauterine growth restriction. Am J Obstet Gynecol 194:557–563PubMed Kadyrov M, Kingdom JCP, Huppertz B (2006) Divergent trophoblast invasion and apoptosis in placental bed spiral arteries from pregnancies complicated by maternal anemia and early-onset preeclampsia/intrauterine growth restriction. Am J Obstet Gynecol 194:557–563PubMed
96.
Zurück zum Zitat Lash GE, Otun HA, Innes BA, Kirkley M, De Oliveira L, Searle RF, Robson SC, Bulmer JN (2006) Interferon-{gamma} inhibits extravillous trophoblast cell invasion by a mechanism that involves both changes in apoptosis and protease levels. FASEB J 20:2512–2518PubMed Lash GE, Otun HA, Innes BA, Kirkley M, De Oliveira L, Searle RF, Robson SC, Bulmer JN (2006) Interferon-{gamma} inhibits extravillous trophoblast cell invasion by a mechanism that involves both changes in apoptosis and protease levels. FASEB J 20:2512–2518PubMed
97.
Zurück zum Zitat Hu Y, Dutz JP, MacCalman CD, Yong P, Tan R, von Dadelszen P (2006) Decidual NK cells alter in vitro first trimester extravillous cytotrophoblast migration: a role for IFN–{gamma}. J Immunol 177:8522–8530PubMed Hu Y, Dutz JP, MacCalman CD, Yong P, Tan R, von Dadelszen P (2006) Decidual NK cells alter in vitro first trimester extravillous cytotrophoblast migration: a role for IFN–{gamma}. J Immunol 177:8522–8530PubMed
98.
Zurück zum Zitat Gammill HS, Lin C, Hubel CA (2007) Endothelial progenitor cells and preeclampsia. Front Biosci 12:2383–2394PubMed Gammill HS, Lin C, Hubel CA (2007) Endothelial progenitor cells and preeclampsia. Front Biosci 12:2383–2394PubMed
99.
Zurück zum Zitat Wei J, Satomi M, Negishi Y, Matsumura Y, Miura A, Nishi Y, Asakura H, Takeshita T (2006) Effect of sera on the adhesion of natural killer cells to the endothelium in severe pre-eclampsia. J Obstet Gynaecol Res 32:443–448PubMed Wei J, Satomi M, Negishi Y, Matsumura Y, Miura A, Nishi Y, Asakura H, Takeshita T (2006) Effect of sera on the adhesion of natural killer cells to the endothelium in severe pre-eclampsia. J Obstet Gynaecol Res 32:443–448PubMed
100.
Zurück zum Zitat Matsubara K, Nagamatsu T, Fujii T, Kozuma S, Taketani Y (2005) Lymphokine-activated killer cells induced from decidual lymphocytes reduce the angiogenic activity of trophoblasts by enhancing the release of soluble fms-like tyrosine kinase-1 from trophoblasts: an implication for the pathophysiology of preeclampsia. J Reprod Immunol 68:27–37PubMed Matsubara K, Nagamatsu T, Fujii T, Kozuma S, Taketani Y (2005) Lymphokine-activated killer cells induced from decidual lymphocytes reduce the angiogenic activity of trophoblasts by enhancing the release of soluble fms-like tyrosine kinase-1 from trophoblasts: an implication for the pathophysiology of preeclampsia. J Reprod Immunol 68:27–37PubMed
101.
Zurück zum Zitat Levine RJ, Maynard SE, Qian C, Lim K-H, England LJ, Yu KF, Schisterman EF, Thadhani R, Sachs BP, Epstein FH, Sibai BM, Sukhatme VP, Karumanchi SA (2004) Circulating Angiogenic Factors and the Risk of Preeclampsia. N Engl J Med 350:672–683PubMed Levine RJ, Maynard SE, Qian C, Lim K-H, England LJ, Yu KF, Schisterman EF, Thadhani R, Sachs BP, Epstein FH, Sibai BM, Sukhatme VP, Karumanchi SA (2004) Circulating Angiogenic Factors and the Risk of Preeclampsia. N Engl J Med 350:672–683PubMed
102.
Zurück zum Zitat Maynard SE, Min JY, Merchan J, Lim KH, Li J, Mondal S, Libermann TA, Morgan JP, Sellke FW, Stillman IE, Epstein FH, Sukhatme VP, Karumanchi SA (2003) Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest 111:649–658PubMed Maynard SE, Min JY, Merchan J, Lim KH, Li J, Mondal S, Libermann TA, Morgan JP, Sellke FW, Stillman IE, Epstein FH, Sukhatme VP, Karumanchi SA (2003) Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest 111:649–658PubMed
103.
Zurück zum Zitat Luttun A, Carmeliet P (2003) Soluble VEGF receptor Flt1: the elusive preeclampsia factor discovered? J Clin Invest 111:600–602PubMed Luttun A, Carmeliet P (2003) Soluble VEGF receptor Flt1: the elusive preeclampsia factor discovered? J Clin Invest 111:600–602PubMed
104.
Zurück zum Zitat Tjoa ML, Levine RJ, Karumanchi SA (2007) Angiogenic factors and preeclampsia. Front Biosci 12:2395–2402PubMed Tjoa ML, Levine RJ, Karumanchi SA (2007) Angiogenic factors and preeclampsia. Front Biosci 12:2395–2402PubMed
105.
Zurück zum Zitat Crocker IP, Wareing M, Ferris GR, Jones CJ, Cartwright JE, Baker PN, Aplin JD (2005) The effect of vascular origin, oxygen, and tumour necrosis factor alpha on trophoblast invasion of maternal arteries in vitro. J Pathol 206:476–485PubMed Crocker IP, Wareing M, Ferris GR, Jones CJ, Cartwright JE, Baker PN, Aplin JD (2005) The effect of vascular origin, oxygen, and tumour necrosis factor alpha on trophoblast invasion of maternal arteries in vitro. J Pathol 206:476–485PubMed
106.
Zurück zum Zitat Bryceson YT, March ME, Ljunggren H-G, Long EO (2006) Activation, coactivation, and costimulation of resting human natural killer cells. Immunol Rev 214:73–91PubMed Bryceson YT, March ME, Ljunggren H-G, Long EO (2006) Activation, coactivation, and costimulation of resting human natural killer cells. Immunol Rev 214:73–91PubMed
107.
Zurück zum Zitat Gasser S, Raulet DH (2006) Activation and self-tolerance of natural killer cells. Immunol Rev 214:130–142PubMed Gasser S, Raulet DH (2006) Activation and self-tolerance of natural killer cells. Immunol Rev 214:130–142PubMed
108.
Zurück zum Zitat Caucheteux SM, Kanellopoulos-Langevin C, Ojcius DM (2003) At the innate frontiers between mother and fetus: linking abortion with complement activation. Immunity 18:169–172PubMed Caucheteux SM, Kanellopoulos-Langevin C, Ojcius DM (2003) At the innate frontiers between mother and fetus: linking abortion with complement activation. Immunity 18:169–172PubMed
109.
Zurück zum Zitat Varla-Leftherioti M, Spyropoulou-Vlachou M, Niokou D, Keramitsoglou T, Darlamitsou A, Tsekoura C, Papadimitropoulos M, Lepage V, Balafoutas C, Stavropoulos-Giokas C (2003) Natural killer (NK) cell receptors’ repertoire in couples with recurrent spontaneous abortions. Am J Reprod Immunol 49:183–191PubMed Varla-Leftherioti M, Spyropoulou-Vlachou M, Niokou D, Keramitsoglou T, Darlamitsou A, Tsekoura C, Papadimitropoulos M, Lepage V, Balafoutas C, Stavropoulos-Giokas C (2003) Natural killer (NK) cell receptors’ repertoire in couples with recurrent spontaneous abortions. Am J Reprod Immunol 49:183–191PubMed
110.
Zurück zum Zitat Dosiou C, Giudice LC (2005) Natural killer cells in pregnancy and recurrent pregnancy loss: endocrine and immunologic perspectives. Endocr Rev 26:44–62PubMed Dosiou C, Giudice LC (2005) Natural killer cells in pregnancy and recurrent pregnancy loss: endocrine and immunologic perspectives. Endocr Rev 26:44–62PubMed
111.
Zurück zum Zitat van den Heuvel MJ, Horrocks J, Bashar S, Taylor S, Burke S, Hatta K, Lewis JE, Croy BA (2005) Menstrual cycle hormones induce changes in functional interactions between lymphocytes and decidual vascular endothelial cells. J Clin Endocrinol Metab 90:2835–2842PubMed van den Heuvel MJ, Horrocks J, Bashar S, Taylor S, Burke S, Hatta K, Lewis JE, Croy BA (2005) Menstrual cycle hormones induce changes in functional interactions between lymphocytes and decidual vascular endothelial cells. J Clin Endocrinol Metab 90:2835–2842PubMed
112.
Zurück zum Zitat Chantakru S, Wang WC, van den Heuvel M, Bashar S, Simpson A, Chen Q, Croy BA, Evans SS (2003) Coordinate regulation of lymphocyte-endothelial interactions by pregnancy-associated hormones. J Immunol 171:4011–4019PubMed Chantakru S, Wang WC, van den Heuvel M, Bashar S, Simpson A, Chen Q, Croy BA, Evans SS (2003) Coordinate regulation of lymphocyte-endothelial interactions by pregnancy-associated hormones. J Immunol 171:4011–4019PubMed
113.
Zurück zum Zitat Huang ST, Vo KC, Lyell DJ, Faessen GH, Tulac S, Tibshirani R, Giaccia AJ, Giudice LC (2004) Developmental response to hypoxia. FASEB J 18:1348–1365PubMed Huang ST, Vo KC, Lyell DJ, Faessen GH, Tulac S, Tibshirani R, Giaccia AJ, Giudice LC (2004) Developmental response to hypoxia. FASEB J 18:1348–1365PubMed
114.
115.
Zurück zum Zitat Wagner LK (2004) Diagnosis and management of preeclampsia. Am Fam Physician 70:2317–2324PubMed Wagner LK (2004) Diagnosis and management of preeclampsia. Am Fam Physician 70:2317–2324PubMed
116.
Zurück zum Zitat Sibai BM (2005) Diagnosis, prevention, and management of eclampsia. Obstet Gynecol 105:402–410PubMed Sibai BM (2005) Diagnosis, prevention, and management of eclampsia. Obstet Gynecol 105:402–410PubMed
117.
Zurück zum Zitat Borzychowski AM, Croy BA, Chan WL, Redman CW, Sargent IL (2005) Changes in systemic type 1 and type 2 immunity in normal pregnancy and pre-eclampsia may be mediated by natural killer cells. Eur J Immunol 35:3054–3063PubMed Borzychowski AM, Croy BA, Chan WL, Redman CW, Sargent IL (2005) Changes in systemic type 1 and type 2 immunity in normal pregnancy and pre-eclampsia may be mediated by natural killer cells. Eur J Immunol 35:3054–3063PubMed
118.
Zurück zum Zitat Henderson TA, Saunders PT, Moffett-King A, Groome NP, Critchley HO (2003) Steroid receptor expression in uterine natural killer cells. J Clin Endocrinol Metab 88:440–449PubMed Henderson TA, Saunders PT, Moffett-King A, Groome NP, Critchley HO (2003) Steroid receptor expression in uterine natural killer cells. J Clin Endocrinol Metab 88:440–449PubMed
119.
Zurück zum Zitat Kim YM, Bujold E, Chaiworapongsa T, Gomez R, Yoon BH, Thaler HT, Rotmensch S, Romero R (2003) Failure of physiologic transformation of the spiral arteries in patients with preterm labor and intact membranes. Am J Obstet Gynecol 189:1063–1069PubMed Kim YM, Bujold E, Chaiworapongsa T, Gomez R, Yoon BH, Thaler HT, Rotmensch S, Romero R (2003) Failure of physiologic transformation of the spiral arteries in patients with preterm labor and intact membranes. Am J Obstet Gynecol 189:1063–1069PubMed
120.
Zurück zum Zitat Yagel S, Goldman-Wohl DS, Mandelboim O, Hanna Y, Hochner-Celnikier D (2005) Maternal adaptation to vasculogenesis and angiogenesis at the feto-maternal interface. Thromb Res 115(Suppl 1):97–99PubMed Yagel S, Goldman-Wohl DS, Mandelboim O, Hanna Y, Hochner-Celnikier D (2005) Maternal adaptation to vasculogenesis and angiogenesis at the feto-maternal interface. Thromb Res 115(Suppl 1):97–99PubMed
121.
Zurück zum Zitat Carmeliet P (2005) Angiogenesis in life, disease and medicine. Nature 438:932–936PubMed Carmeliet P (2005) Angiogenesis in life, disease and medicine. Nature 438:932–936PubMed
122.
Zurück zum Zitat Saftlas AF, Beydoun H, Triche E (2005) Immunogenetic determinants of preeclampsia and related pregnancy disorders: a systematic review. Obstet Gynecol 106:162–172PubMed Saftlas AF, Beydoun H, Triche E (2005) Immunogenetic determinants of preeclampsia and related pregnancy disorders: a systematic review. Obstet Gynecol 106:162–172PubMed
123.
Zurück zum Zitat Sargent IL, Borzychowski AM, Redman CW (2006) Immunoregulation in normal pregnancy and pre–eclampsia: an overview. Reprod Biomed Online 13:680–686PubMedCrossRef Sargent IL, Borzychowski AM, Redman CW (2006) Immunoregulation in normal pregnancy and pre–eclampsia: an overview. Reprod Biomed Online 13:680–686PubMedCrossRef
124.
Zurück zum Zitat Zhang C, Zhang J, Tian Z (2006) The regulatory effect of natural killer cells: do “NK-reg cells” exist? Cell Mol Immunol 3:241–254PubMed Zhang C, Zhang J, Tian Z (2006) The regulatory effect of natural killer cells: do “NK-reg cells” exist? Cell Mol Immunol 3:241–254PubMed
125.
Zurück zum Zitat Blouw B, Song H, Tihan T, Bosze J, Ferrara N, Gerber H-P, Johnson RS, Bergers G (2003) The hypoxic response of tumors is dependent on their microenvironment. Cancer Cell 4:133–146PubMed Blouw B, Song H, Tihan T, Bosze J, Ferrara N, Gerber H-P, Johnson RS, Bergers G (2003) The hypoxic response of tumors is dependent on their microenvironment. Cancer Cell 4:133–146PubMed
126.
Zurück zum Zitat Helige C, Hagendorfer G, Smolle J, Dohr G (2001) Uterine natural killer cells in a three–dimensional tissue culture model to study trophoblast invasion. Lab Invest 81:1153–1162PubMed Helige C, Hagendorfer G, Smolle J, Dohr G (2001) Uterine natural killer cells in a three–dimensional tissue culture model to study trophoblast invasion. Lab Invest 81:1153–1162PubMed
127.
Zurück zum Zitat Zenclussen AC, Fest S, Joachim R, Klapp BF, Arck PC (2004) Introducing a mouse model for pre-eclampsia: adoptive transfer of activated Th1 cells leads to pre-eclampsia-like symptoms exclusively in pregnant mice. Eur J Immunol 34:377–387PubMed Zenclussen AC, Fest S, Joachim R, Klapp BF, Arck PC (2004) Introducing a mouse model for pre-eclampsia: adoptive transfer of activated Th1 cells leads to pre-eclampsia-like symptoms exclusively in pregnant mice. Eur J Immunol 34:377–387PubMed
128.
Zurück zum Zitat Wulff C, Weigand M, Kreienberg R, Fraser HM (2003) Angiogenesis during primate placentation in health and disease. Reproduction 126:569–577PubMed Wulff C, Weigand M, Kreienberg R, Fraser HM (2003) Angiogenesis during primate placentation in health and disease. Reproduction 126:569–577PubMed
Metadaten
Titel
UNK cells: their role in tissue re-modelling and preeclampsia
verfasst von
Jianhong Zhang
Zhigang Tian
Publikationsdatum
01.06.2007
Verlag
Springer-Verlag
Erschienen in
Seminars in Immunopathology / Ausgabe 2/2007
Print ISSN: 1863-2297
Elektronische ISSN: 1863-2300
DOI
https://doi.org/10.1007/s00281-007-0068-1

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