Erschienen in:
08.04.2016 | Original Article
APOC3 rs2070666 Is Associated with the Hepatic Steatosis Independently of PNPLA3 rs738409 in Chinese Han Patients with Nonalcoholic Fatty Liver Diseases
verfasst von:
Rui-Nan Zhang, Rui-Dan Zheng, Yu-Qiang Mi, Da Zhou, Feng Shen, Guang-Yu Chen, Chan-Yan Zhu, Qin Pan, Jian-Gao Fan
Erschienen in:
Digestive Diseases and Sciences
|
Ausgabe 8/2016
Einloggen, um Zugang zu erhalten
Abstract
Background and Aim
The association between nonalcoholic fatty liver disease (NAFLD) and apolipoprotein C3 gene (APOC3) promoter region single-nucleotide polymorphisms (SNPs) rs2854117 and rs2854116 is controversial.
The aim of this study was to investigate the relationship between other polymorphisms of APOC3 and NAFLD in Chinese.
Methods
Fifty-nine liver biopsy-proven NAFLD patients and 72 healthy control subjects were recruited to a cohort representing Chinese Han population. The polymorphisms in the exons and flanking regions of APOC3 and patatin-like phospholipase domain-containing protein 3 (PNPLA3) rs738409 polymorphisms were genotyped.
Results
Among the five SNPs (rs4225, rs4520, rs5128, rs2070666, and rs2070667) in APOC3, only rs2070666 (c.179 + 62 T/A) was significantly different in genotype and allele frequency (both p < 0.01) between groups of NAFLD and control. After adjusting for sex, age, serum triglycerides, total cholesterol, body mass index, and the PNPLA3 rs738409 polymorphism, the APOC3 rs2070666 A allele was an independent risk factor for NAFLD with an odds ratio (OR) of 3.683 and 95 % confidence interval (CI) of 1.037–13.084. The APOC3 rs2070666 A allele was linked to the fourth quartile of the controlled attenuation parameter values (OR 2.769, 95 % CI 1.002–7.651) in 131 subjects, and also linked to the significant histological steatosis (OR 4.986, 95 % CI 1.020–24.371), but neither to liver stiffness measurement values nor to hepatic histological activity and fibrosis in NAFLD patients.
Conclusions
The APOC3 rs2070666 A allele is a risk factor for NAFLD independent of obesity, dyslipidemia, and PNPLA3 rs738409, and it might contribute to increased liver fat content in Chinese Han population.