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Erschienen in: CME 4/2017

04.04.2017 | Apoplex | CME Fortbildung

Könnte es ein Schlaganfall sein?

Frühsymptomatik, Diagnose und Therapie

verfasst von: Dr. Norbert Groß, Prof. Dr. Frank Erbguth

Erschienen in: CME | Ausgabe 4/2017

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Zusammenfassung

Der Schlaganfall ist einer der häufigsten medizinischen Notfälle und bedarf angesichts effektiver zeitkritischer Therapien einer raschen und korrekten Diagnose. Neben dem „klassischen“ plötzlich auftretenden sensomotorischen Hemisyndrom gibt es auch andere Symptom-Präsentationen mit Ausfällen von Hirnstamm- und Kleinhirnfunktionen, was sich beispielsweise als Schwindel und Okulomotorikstörung äußert. Der plötzliche Donnerschlag-Kopfschmerz ist das Leitsymptom der Subarachnoidalblutung. Die präklinische Versorgung von Schlaganfallpatienten besteht in einer Stabilisierung der Vitalparameter und umgehender stationärer Zuweisung möglichst in eine Stroke Unit. Die folgende Übersicht zeigt auf, wie die unterschiedlichen Präsentationen des Schlaganfalls am besten erkannt und differenzialdiagnostisch gegen andere Erkrankungen abgegrenzt werden können. Beschrieben werden auch die daraus resultierenden diagnostischen und therapeutischen Prioritäten.
Literatur
1.
Zurück zum Zitat Heuschmann PU, Busse O, Wagner M et al. (2010) Schlaganfallhäufigkeit und Versorgung von Schlaganfallpatienten in Deutschland, Akt Neurol 37: 333–340CrossRef Heuschmann PU, Busse O, Wagner M et al. (2010) Schlaganfallhäufigkeit und Versorgung von Schlaganfallpatienten in Deutschland, Akt Neurol 37: 333–340CrossRef
2.
Zurück zum Zitat Rothwell PM, Coull AJ, Silver LE et a. (2005) Population-based study of event-rate, incidence, case fatality, and mortality for all acute vascular events in all arterial territories (Oxford Vascular Study), Lancet. 366:1773–83CrossRefPubMed Rothwell PM, Coull AJ, Silver LE et a. (2005) Population-based study of event-rate, incidence, case fatality, and mortality for all acute vascular events in all arterial territories (Oxford Vascular Study), Lancet. 366:1773–83CrossRefPubMed
3.
Zurück zum Zitat Kunz A, Ebinger M, Geisler F et al. (2016) Functional outcomes of pre-hospital thrombolysis in a mobile stroke treatment unit compared with conventional care: an observational registry study. Lancet Neurol 15:1035–43.CrossRefPubMed Kunz A, Ebinger M, Geisler F et al. (2016) Functional outcomes of pre-hospital thrombolysis in a mobile stroke treatment unit compared with conventional care: an observational registry study. Lancet Neurol 15:1035–43.CrossRefPubMed
4.
Zurück zum Zitat Campbell BC, Christensen S, Levi CR et al. (2012) Comparison of computed tomography perfusion and magnetic resonance imaging perfusion-diffusion mismatch in ischemic stroke. Stroke 43:2648–53.CrossRefPubMed Campbell BC, Christensen S, Levi CR et al. (2012) Comparison of computed tomography perfusion and magnetic resonance imaging perfusion-diffusion mismatch in ischemic stroke. Stroke 43:2648–53.CrossRefPubMed
5.
Zurück zum Zitat Qureshi AI, Tuhrim S, Broderick JP et al. (2001) Spontaneous intracerebral hemorrhage. NEJM 344:1450–60.CrossRefPubMed Qureshi AI, Tuhrim S, Broderick JP et al. (2001) Spontaneous intracerebral hemorrhage. NEJM 344:1450–60.CrossRefPubMed
6.
Zurück zum Zitat Qureshi AI, Palesch YY, Barsan WG et al. (2016) Intensive Blood-Pressure Lowering in Patients with Acute Cerebral Hemorrhage. NEJM 375:1033–43.CrossRefPubMedPubMedCentral Qureshi AI, Palesch YY, Barsan WG et al. (2016) Intensive Blood-Pressure Lowering in Patients with Acute Cerebral Hemorrhage. NEJM 375:1033–43.CrossRefPubMedPubMedCentral
7.
Zurück zum Zitat van Gijn J, Rinkel GJ. (2001) Subarachnoid haemorrhage: diagnosis, causes and management. Brain 124:249–78CrossRefPubMed van Gijn J, Rinkel GJ. (2001) Subarachnoid haemorrhage: diagnosis, causes and management. Brain 124:249–78CrossRefPubMed
8.
Zurück zum Zitat Benninger F, Raphaeli G, Steiner I (2015) Subarachnoid hemorrhage mimicking myocardial infarction. J Clin Neurosci 22:1981–2.CrossRefPubMed Benninger F, Raphaeli G, Steiner I (2015) Subarachnoid hemorrhage mimicking myocardial infarction. J Clin Neurosci 22:1981–2.CrossRefPubMed
9.
Zurück zum Zitat Steiner T, Juvela S, Unterberg A et al. (2013) European Stroke Organization guidelines for the management of intracranial aneurysms and subarachnoid haemorrhage. Cerebrovasc Dis 35:93–112.CrossRef Steiner T, Juvela S, Unterberg A et al. (2013) European Stroke Organization guidelines for the management of intracranial aneurysms and subarachnoid haemorrhage. Cerebrovasc Dis 35:93–112.CrossRef
10.
Zurück zum Zitat Mackey J, Khoury JC, Alwell K et al. (2016) Stable incidence but declining case-fatality rates of subarachnoid hemorrhage in a population, Neurology 87:2192-219 Mackey J, Khoury JC, Alwell K et al. (2016) Stable incidence but declining case-fatality rates of subarachnoid hemorrhage in a population, Neurology 87:2192-219
11.
Zurück zum Zitat Molyneux AJ, Birks J, Clarke A, Sneade M, Kerr RS (2015) The durability of endovascular coiling versus neurosurgical clipping of ruptured cerebral aneurysms: 18 year follow-up of the UK cohort of the International Subarachnoid Aneurysm Trial (ISAT)}. Lancet 385:691–697.CrossRefPubMedPubMedCentral Molyneux AJ, Birks J, Clarke A, Sneade M, Kerr RS (2015) The durability of endovascular coiling versus neurosurgical clipping of ruptured cerebral aneurysms: 18 year follow-up of the UK cohort of the International Subarachnoid Aneurysm Trial (ISAT)}. Lancet 385:691–697.CrossRefPubMedPubMedCentral
12.
Zurück zum Zitat Jonathan M. Coutinho, Susanna M et al. (2012) The Incidence of Cerebral Venous Thrombosis. Stroke 43:3375–3377. Jonathan M. Coutinho, Susanna M et al. (2012) The Incidence of Cerebral Venous Thrombosis. Stroke 43:3375–3377.
13.
Zurück zum Zitat Coutinho JM (2015) Cerebral venous thrombosis. J Thromb Haemost Suppl 1:S238–44.CrossRef Coutinho JM (2015) Cerebral venous thrombosis. J Thromb Haemost Suppl 1:S238–44.CrossRef
14.
Zurück zum Zitat Kamitani S, Nishimura K, Nakamura F et al. Consciousness level and off-hour admission affect discharge outcome of acute stroke patients: a J-ASPECT study. J Am Heart Assoc. 2014 Oct 21;3(5):e001059. doi: 10.1161/JAHA.114.001059. Kamitani S, Nishimura K, Nakamura F et al. Consciousness level and off-hour admission affect discharge outcome of acute stroke patients: a J-ASPECT study. J Am Heart Assoc. 2014 Oct 21;3(5):e001059. doi: 10.1161/JAHA.114.001059.
15.
Zurück zum Zitat Siket MS, Edlow J (2013) Transient ischemic attack: an evidence-based update. Emerg Med Pract 15:1–26.PubMed Siket MS, Edlow J (2013) Transient ischemic attack: an evidence-based update. Emerg Med Pract 15:1–26.PubMed
17.
Zurück zum Zitat Kerber A, Meurer WJ, Brown D et al. (2015) Stroke risk stratification in acute dizziness presentations - A prospective imaging-based study. Neurology 85:1869–1878CrossRefPubMedPubMedCentral Kerber A, Meurer WJ, Brown D et al. (2015) Stroke risk stratification in acute dizziness presentations - A prospective imaging-based study. Neurology 85:1869–1878CrossRefPubMedPubMedCentral
18.
Zurück zum Zitat Atzema CL, Grewal K, Lu H, et al. (2015) Outcomes Among Patients Discharged From des Emergency Department With a Diagnosis of Peripheral Vertigo. Ann Neurol 79:32–41.CrossRefPubMed Atzema CL, Grewal K, Lu H, et al. (2015) Outcomes Among Patients Discharged From des Emergency Department With a Diagnosis of Peripheral Vertigo. Ann Neurol 79:32–41.CrossRefPubMed
19.
Zurück zum Zitat Venhovens J, Meulstee J, Verhagen WI (2016) Acute vestibular syndrome: a critical review and diagnostic algorithm concerning the clinical differentiation of peripheral versus central aetiologies in the emergency department. J Neurol 263:2151–2157CrossRefPubMed Venhovens J, Meulstee J, Verhagen WI (2016) Acute vestibular syndrome: a critical review and diagnostic algorithm concerning the clinical differentiation of peripheral versus central aetiologies in the emergency department. J Neurol 263:2151–2157CrossRefPubMed
20.
Zurück zum Zitat Ferro JM, Massaro AR, Mas JL (2010) Aetiological diagnosis of isMit chaemic stroke in young adults. Lancet Neurol. 2010 Nov;} 9(11):1085–96.CrossRefPubMed Ferro JM, Massaro AR, Mas JL (2010) Aetiological diagnosis of isMit chaemic stroke in young adults. Lancet Neurol. 2010 Nov;} 9(11):1085–96.CrossRefPubMed
21.
Zurück zum Zitat Debette S, Compter A, Labeyrie MA et al. (2015) Epidemiology, pathophysiology, diagnosis, and management of intracranial artery dissection. Lancet Neurol 14:640–54.CrossRefPubMed Debette S, Compter A, Labeyrie MA et al. (2015) Epidemiology, pathophysiology, diagnosis, and management of intracranial artery dissection. Lancet Neurol 14:640–54.CrossRefPubMed
22.
Zurück zum Zitat Tsivgoulis G, Zand R, Katsanos AH et al. (2015) Safety of intravenous thrombolysis in stroke mimics; prospective 5-year study and comprehensive meta-analysis. Stroke 46:1281–1287.CrossRefPubMed Tsivgoulis G, Zand R, Katsanos AH et al. (2015) Safety of intravenous thrombolysis in stroke mimics; prospective 5-year study and comprehensive meta-analysis. Stroke 46:1281–1287.CrossRefPubMed
23.
Zurück zum Zitat Richoz B, Hugli O, Dami F et al. (2015) Acute stroke chameleons in a university hospital: Risk factors, circumstances, and outcomes. Neurology 85:505–11.CrossRefPubMed Richoz B, Hugli O, Dami F et al. (2015) Acute stroke chameleons in a university hospital: Risk factors, circumstances, and outcomes. Neurology 85:505–11.CrossRefPubMed
25.
Zurück zum Zitat Stroke Unit Trialists’ Collaboration (2013) Organised inpatient (stroke unit) care for stroke. Cochrane Database Syst Rev Sep 11;(9):CD000197. doi: 10.1002/14651858 Stroke Unit Trialists’ Collaboration (2013) Organised inpatient (stroke unit) care for stroke. Cochrane Database Syst Rev Sep 11;(9):CD000197. doi: 10.1002/14651858
26.
Zurück zum Zitat Emberson J, Lees KR, Lyden P et al. (2014) Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: A meta-analysis of individual patient data from randomised trials. Lancet 384:1929–1935.CrossRefPubMedPubMedCentral Emberson J, Lees KR, Lyden P et al. (2014) Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: A meta-analysis of individual patient data from randomised trials. Lancet 384:1929–1935.CrossRefPubMedPubMedCentral
27.
Zurück zum Zitat International Stroke Trial-3 collaborative group (2015) Association between brain imaging signs, early and late outcomes, and response to intravenous alteplase after acute ischaemic stroke in the third international stroke trial (ist-3): Secondary analysis of a randomised controlled trial. Lancet Neurol 14:485–496CrossRef International Stroke Trial-3 collaborative group (2015) Association between brain imaging signs, early and late outcomes, and response to intravenous alteplase after acute ischaemic stroke in the third international stroke trial (ist-3): Secondary analysis of a randomised controlled trial. Lancet Neurol 14:485–496CrossRef
28.
Zurück zum Zitat Goyal M, Menon BK, van Zwam WH et al. (2016) Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials. Lancet 387:1723–31CrossRefPubMed Goyal M, Menon BK, van Zwam WH et al. (2016) Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials. Lancet 387:1723–31CrossRefPubMed
29.
Zurück zum Zitat Saver JL, Goyal M, van der Lugt A et al. (2016) Time to Treatment With Endovascular Thrombectomy and Outcomes From Ischemic Stroke: A Meta-analysis. JAMA 316:1279–88.CrossRefPubMed Saver JL, Goyal M, van der Lugt A et al. (2016) Time to Treatment With Endovascular Thrombectomy and Outcomes From Ischemic Stroke: A Meta-analysis. JAMA 316:1279–88.CrossRefPubMed
30.
Zurück zum Zitat Rothwell PM, Algra A, Chen Z et al. (2016) Effects of aspirin on risk and severity of early recurrent stroke after transient ischaemic attack and ischaemic stroke: time-course analysis of randomised trials. Lancet 388:365–75.CrossRefPubMedPubMedCentral Rothwell PM, Algra A, Chen Z et al. (2016) Effects of aspirin on risk and severity of early recurrent stroke after transient ischaemic attack and ischaemic stroke: time-course analysis of randomised trials. Lancet 388:365–75.CrossRefPubMedPubMedCentral
Metadaten
Titel
Könnte es ein Schlaganfall sein?
Frühsymptomatik, Diagnose und Therapie
verfasst von
Dr. Norbert Groß
Prof. Dr. Frank Erbguth
Publikationsdatum
04.04.2017
Verlag
Springer Medizin
Erschienen in
CME / Ausgabe 4/2017
Print ISSN: 1614-371X
Elektronische ISSN: 1614-3744
DOI
https://doi.org/10.1007/s11298-017-5978-1

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