Background
Methods
Study participants
Study design and intervention method
Routine chemotherapy nursing
Chemotherapy nursing based on CUSP model
Study CUSP
Build a multidisciplinary CUSP team
Look for defects
Effectiveness evaluation tool
Patient general demographic data questionnaire
MASCC Antiemesis Tool
Functional living index-Emesis (FLIE)
Hospital anxiety and Depression Scale (HADS)
Quality Control
Statistical analysis
Results
Comparison of general demographic data of patients
Variables | Categories | The intervention group (n = 45) | The control group (n = 45) | T /\({ \chi }^{2}\) |
P
|
---|---|---|---|---|---|
Age | 54.87 ± 10.51 | 55.93 ± 12.92 | -0.430 | 0.668 | |
Level of education | Primary or below | 31 | 33 | 2.196 | 0.533 |
Junior high | 9 | 9 | |||
Senior high / technical secondary | 4 | 1 | |||
Undergraduate / Junior college or above | 1 | 2 | |||
Place of residence | Rural | 33 | 36 | 0.559 | 0.455 |
Urban | 12 | 9 | |||
Employment | Employed | 12 | 8 | 1.029 | 0.310 |
Unemployed | 33 | 37 | |||
Vomiting of pregnancy | Yes | 34 | 33 | 0.058 | 0.809 |
No | 11 | 12 | |||
Pathological type | Epithelial carcinoma of the ovary | 43 | 40 | 1.442 | 0.486 |
Malignant germ cell tumor of ovary | 1 | 3 | |||
Malignant ovarian cord-stromal tumor | 1 | 2 | |||
Relapse | No | 31 | 34 | 0.498 | 0.480 |
Yes | 14 | 11 | |||
Chemotherapy regimens | TP regimensa | 24 | 23 | 1.807 | 0.613 |
EP regimensb | 2 | 5 | |||
DC regimensc | 5 | 3 | |||
Othersd | 14 | 14 | |||
The score of KPSe | 70–90 | 10 | 13 | 0.526 | 0.468 |
>90 | 35 | 32 |
Comparison of nausea degree and vomiting frequency in acute and delayed periods between the two groups before and after intervention
Variables | Intentional analysis | Per-protocol analysis* | ||||||
---|---|---|---|---|---|---|---|---|
The intervention group(n = 45) | The control group(n = 45) |
Z
|
P
| The intervention group(n = 41) | The control group(n = 41) |
Z
|
P
| |
Vomiting frequency (before intervention) | 1.0(1.0,2.0) | 1.0(1.0,2.0) | -0.540 | 0.589 | 1.0(1.0,2.0) | 1.0(1.0,2.0) | -0.231 | 0.817 |
Vomiting frequency (after intervention) | 1.0(0.0,1.0) | 1.0(0.5,1.0) | -2.770 | 0.006 | 1.0(0.0,1.0) | 1.0(0.0,1.0) | -2.075 | 0.038 |
Nausea degree (before intervention) | 2.0(1.0,3.0) | 2.0(1.0,2.5) | -1.587 | 0.113 | 2.0(1.0,2.5) | 1.0(1.0,2.5) | -1.525 | 0.127 |
Nausea degree (after intervention) | 1.0(0.0,1.0) | 1.0(1.0,2.0) | -3.400 | 0.001 | 1.0(0.0,1.5) | 1.0(1.0,2.0) | -2.375 | 0.018 |
Variables | Intentional analysis | Per-protocol analysis | ||||||
---|---|---|---|---|---|---|---|---|
The intervention group(n = 45) | The control group(n = 45) |
Z
|
P
| The intervention group(n = 41) | The control group(n = 41) |
Z
|
P
| |
Vomiting frequency (before intervention) | 5.0(4.0,5.0) | 5.0(2.0,5.5) | -0.391 | 0.695 | 5.0(4.0,5.0) | 5.0(2.0,5.5) | -0.798 | 0.425 |
Vomiting frequency (after intervention) | 3.0(2.0,3.0) | 4.0(2.0,5.0) | -3.259 | 0.001 | 3.0(1.5,3.5) | 4.0(2.0,5.0) | -2.712 | 0.007 |
Nausea degree (before intervention) | 4.0(4.0,5.0) | 5.0(2.0,6.0) | -0.723 | 0.470 | 4.0(3.5,5.0) | 5.0(2.0,6.0) | -0.559 | 0.576 |
Nausea degree (after intervention) | 3.0(2.0,4.0) | 5.0(2.0,5.5) | -1.989 | 0.047 | 3.0(2.0,4.0) | 4.0(1.5,5.0) | -2.313 | 0.021 |
Comparison of functional living index scores between two groups before and after intervention
Variables | Intentional analysis | Per-protocol analysis | ||||||
---|---|---|---|---|---|---|---|---|
The intervention group(n = 45) | The control group(n = 45) |
t
|
P
| The intervention group(n = 41) | The control group(n = 41) |
t
|
P
| |
Nausea dimensions (before intervention) | 34.69 ± 7.95 | 36.33 ± 9.20 | -0.907 | 0.367 | 35.59 ± 7.74 | 36.83 ± 9.40 | -0.654 | 0.515 |
Nausea dimensions (after intervention) | 44.56 ± 7.83 | 36.93 ± 9.31 | 4.206 | 0.000 | 44.56 ± 8.21 | 37.49 ± 9.49 | 3.609 | 0.001 |
Vomiting dimensions (before intervention) | 34.29 ± 7.82 | 35.38 ± 9.64 | -0.588 | 0.558 | 35.22 ± 7.50 | 35.85 ± 9.89 | -0.327 | 0.744 |
Vomiting dimensions (after intervention) | 43.07 ± 7.03 | 35.82 ± 9.41 | 4.140 | 0.000 | 43.07 ± 7.37 | 36.24 ± 9.66 | 3.597 | 0.001 |
Total dimensions (before intervention) | 68.98 ± 15.42 | 71.71 ± 18.68 | -0.757 | 0.451 | 70.80 ± 14.84 | 72.68 ± 19.13 | -0.497 | 0.621 |
Total dimensions (after intervention) | 87.10 ± 14.86 | 72.76 ± 18.10 | 4.124 | 0.000 | 87.05 ± 15.58 | 73.73 ± 18.37 | 3.540 | 0.001 |
Comparison of anxiety and depression scores between two groups before and after intervention
Variables | Intentional analysis | Per-protocol analysis | ||||||
---|---|---|---|---|---|---|---|---|
The intervention group(n = 45) | The control group(n = 45) |
t
|
P
| The intervention group(n = 41) | The control group(n = 41) |
t
|
P
| |
anxiety dimensions (before intervention) | 12.69 ± 2.74 | 13.56 ± 3.10 | -0.907 | 0.367 | 12.59 ± 2.67 | 13.41 ± 3.17 | -0.654 | 0.515 |
anxiety dimensions (after intervention) | 7.02 ± 1.84 | 13.38 ± 3.36 | 4.206 | 0.000 | 7.02 ± 1.93 | 13.29 ± 3.44 | 3.609 | 0.001 |
depression dimensions (before intervention) | 12.53 ± 2.26 | 12.62 ± 2.81 | -0.588 | 0.558 | 12.41 ± 2.29 | 12.61 ± 2.90 | -0.327 | 0.744 |
depression dimensions (after intervention) | 7.07 ± 1.97 | 12.12 ± 3.54 | 4.140 | 0.000 | 7.07 ± 2.07 | 12.12 ± 3.72 | 3.597 | 0.001 |
Total dimensions (before intervention) | 25.22 ± 4.76 | 26.18 ± 5.54 | -0.757 | 0.451 | 25.00 ± 4.73 | 26.02 ± 5.72 | -0.497 | 0.621 |
Total dimensions (after intervention) | 14.10 ± 3.34 | 25.50 ± 6.17 | 4.124 | 0.000 | 14.10 ± 3.51 | 25.41 ± 6.43 | 3.540 | 0.001 |