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Arthritis Research & Therapy

Ausgabe 1/2015

Inhalt (384 Artikel)

A genetic study on C5-TRAF1 and progression of joint damage in rheumatoid arthritis

  • Open Access
  • Research article

Hanna W van Steenbergen, Luis Rodríguez-Rodríguez, Ewa Berglin, Alexandra Zhernakova, Rachel Knevel, Jose Ivorra-Cortés, Tom WJ Huizinga, Benjamin Fernández-Gutiérrez, Peter K Gregersen, Solbritt Rantapää-Dahlqvist, Annette HM van der Helm-van Mil

Increasing expression of substance P and calcitonin gene-related peptide in synovial tissue and fluid contribute to the progress of arthritis in developmental dysplasia of the hip

  • Open Access
  • Research article

Hui Wang, Xiang Zhang, Ji-Ye He, Xin-Feng Zheng, De Li, Zheng Li, Jun-Feng Zhu, Chao Shen, Gui-Quan Cai, Xiao-Dong Chen

Overexpression of cystatin C in synovium does not reduce synovitis or cartilage degradation in established osteoarthritis

  • Open Access
  • Research article

Sirkka Kyostio-Moore, Susan Piraino, Patricia Berthelette, Nance Moran, Joseph Serriello, Alison Bendele, Cathleen Sookdeo, Bindu Nambiar, Patty Ewing, Donna Armentano, Gloria L Matthews

CD55 deposited on synovial collagen fibers protects from immune complex-mediated arthritis

  • Open Access
  • Research article

Olga N Karpus, Hans P Kiener, Birgit Niederreiter, A Seda Yilmaz-Elis, Jos van der Kaa, Valeria Ramaglia, Ramon Arens, Josef S Smolen, Marina Botto, Paul P Tak, J Sjef Verbeek, Jörg Hamann

A comparison of the predictive accuracy of three screening models for pulmonary arterial hypertension in systemic sclerosis

  • Open Access
  • Research article

Yanjie Hao, Vivek Thakkar, Wendy Stevens, Kathleen Morrisroe, David Prior, Candice Rabusa, Peter Youssef, Eli Gabbay, Janet Roddy, Jennifer Walker, Jane Zochling, Joanne Sahhar, Peter Nash, Susan Lester, Maureen Rischmueller, Susanna M Proudman, Mandana Nikpour

Anti-type II collagen immune complex-induced granulocyte reactivity is associated with joint erosions in RA patients with anti-collagen antibodies

  • Open Access
  • Research article

Vivek Anand Manivel, Azita Sohrabian, Marius C Wick, Mohammed Mullazehi, Lena Douhan Håkansson, Johan Rönnelid

Expression of citrulline and homocitrulline residues in the lungs of non-smokers and smokers: implications for autoimmunity in rheumatoid arthritis

  • Open Access
  • Research article

Elena B Lugli, Raquel ESM Correia, Roman Fischer, Karin Lundberg, Ken R Bracke, Anna B Montgomery, Benedikt M Kessler, Guy G Brusselle, Patrick J Venables

A cross-sectional study of pain sensitivity, disease-activity assessment, mental health, and fibromyalgia status in rheumatoid arthritis

  • Open Access
  • Research article

Nalinie Joharatnam, Daniel F McWilliams, Deborah Wilson, Maggie Wheeler, Ira Pande, David A Walsh

Deficiency of fibroblast activation protein alpha ameliorates cartilage destruction in inflammatory destructive arthritis

  • Open Access
  • Research article

Stefan Wäldele, Christina Koers-Wunrau, Denise Beckmann, Adelheid Korb-Pap, Corinna Wehmeyer, Thomas Pap, Berno Dankbar

Epidemiology and management of gout in Taiwan: a nationwide population study

  • Open Access
  • Research article

Chang-Fu Kuo, Matthew J Grainge, Lai-Chu See, Kuang-Hui Yu, Shue-Fen Luo, Weiya Zhang, Michael Doherty

Golimumab in patients with active rheumatoid arthritis after treatment with tumor necrosis factor α inhibitors: findings with up to five years of treatment in the multicenter, randomized, double-blind, placebo-controlled, phase 3 GO-AFTER study

  • Open Access
  • Research article

Josef S Smolen, Jonathan Kay, Mittie Doyle, Robert Landewé, Eric L Matteson, Norman Gaylis, Jürgen Wollenhaupt, Frederick T Murphy, Stephen Xu, Yiying Zhou, Elizabeth C Hsia

Non-canonical NF-κB signaling in rheumatoid arthritis: Dr Jekyll and Mr Hyde?

  • Open Access
  • Review

Ae R Noort, Paul P Tak, Sander W Tas

Parietal and intravascular innate mechanisms of vascular inflammation

  • Open Access
  • Review

Giuseppe A Ramirez, Patrizia Rovere-Querini, Maria Grazia Sabbadini, Angelo A Manfredi

Proteasome inhibitors as experimental therapeutics of autoimmune diseases

  • Open Access
  • Review

Sue Ellen Verbrugge, Rik J Scheper, Willem F Lems, Tanja D de Gruijl, Gerrit Jansen

Occupational risk factors for hip osteoarthritis are associated with early hip structural abnormalities: a 3.0 T magnetic resonance imaging study of community-based adults

  • Open Access
  • Research article

Andrew J Teichtahl, Sam Smith, Yuanyuan Wang, Anita E Wluka, Richard O’Sullivan, Graham G Giles, Flavia M Cicuttini

Full-thickness cartilage defects are repaired via a microfracture technique and intraarticular injection of the small-molecule compound kartogenin

  • Open Access
  • Research article

Xingquan Xu, Dongquan Shi, Yeshuai Shen, Zhihong Xu, Jin Dai, Dongyang Chen, Huajian Teng, Qing Jiang

Beer and wine consumption and risk of knee or hip osteoarthritis: a case control study

  • Open Access
  • Research article

Stella G Muthuri, Weiya Zhang, Rose A Maciewicz, Kenneth Muir, Michael Doherty

Loss of sclerostin promotes osteoarthritis in mice via β-catenin-dependent and -independent Wnt pathways

  • Open Access
  • Research article

Wafa Bouaziz, Thomas Funck-Brentano, Hilène Lin, Caroline Marty, Hang-Korng Ea, Eric Hay, Martine Cohen-Solal

Anti-carbamylated protein antibodies in the pre-symptomatic phase of rheumatoid arthritis, their relationship with multiple anti-citrulline peptide antibodies and association with radiological damage

  • Open Access
  • Research article

Mikael Brink, Marije K Verheul, Johan Rönnelid, Ewa Berglin, Rikard Holmdahl, Rene EM Toes, Lars Klareskog, Leendert A Trouw, Solbritt Rantapää-Dahlqvist

IgG anti-apolipoprotein A-1 antibodies in patients with systemic lupus erythematosus are associated with disease activity and corticosteroid therapy: an observational study

  • Open Access
  • Research article

Sara Croca, Paul Bassett, Sharon Chambers, Maria Davari, Karim Fouad Alber, Oliver Leach, Yiannis Ioannou, Ian Giles, David Isenberg, Anisur Rahman

Serum progranulin levels are elevated in dermatomyositis patients with acute interstitial lung disease, predicting prognosis

  • Open Access
  • Research article

Atsushi Tanaka, Hiroshi Tsukamoto, Hiroki Mitoma, Chikako Kiyohara, Naoyasu Ueda, Masahiro Ayano, Shun-ichiro Ohta, Yasutaka Kimoto, Mitsuteru Akahoshi, Yojiro Arinobu, Hiroaki Niiro, Yoshifumi Tada, Takahiko Horiuchi, Koichi Akashi

Thyroid hormones enhance the biomechanical functionality of scaffold-free neocartilage

  • Open Access
  • Research article

Jennifer K Lee, Courtney A Gegg, Jerry C Hu, A Hari Reddi, Kyriacos A Athanasiou

T-cell metabolism in autoimmune disease

  • Open Access
  • Review

Zhen Yang, Eric L Matteson, Jörg J Goronzy, Cornelia M Weyand

Effect of alendronate on post-traumatic osteoarthritis induced by anterior cruciate ligament rupture in mice

  • Open Access
  • Research article

Mohammad S Khorasani, Sindi Diko, Allison W Hsia, Matthew J Anderson, Damian C Genetos, Dominik R Haudenschild, Blaine A Christiansen

Estrogen regulates T helper 17 phenotype and localization in experimental autoimmune arthritis

  • Open Access
  • Research article

Annica Andersson, Alexandra Stubelius, Merja Nurkkala Karlsson, Cecilia Engdahl, Malin Erlandsson, Louise Grahnemo, Marie K Lagerquist, Ulrika Islander

Transcriptome analysis of ageing in uninjured human Achilles tendon

  • Open Access
  • Research article

Mandy Jayne Peffers, Yongxiang Fang, Kathleen Cheung, Tim Koh Jia Wei, Peter David Clegg, Helen Lucy Birch

Regulatory T cell-deficient scurfy mice develop systemic autoimmune features resembling lupus-like disease

  • Open Access
  • Research article

Eva N Hadaschik, Xiaoying Wei, Harald Leiss, Britta Heckmann, Birgit Niederreiter, Günter Steiner, Walter Ulrich, Alexander H Enk, Josef S Smolen, Georg H Stummvoll

Takayasu arteritis in childhood: retrospective experience from a tertiary referral centre in the United Kingdom

  • Open Access
  • Research article

Despina Eleftheriou, Giulia Varnier, Pavla Dolezalova, Anne-Marie McMahon, Muthana Al-Obaidi, Paul A Brogan

Animal model of acute gout reproduces the inflammatory and ultrasonographic joint changes of human gout

  • Open Access
  • Research article

Carlos Pineda, Arturo J Fuentes-Gómez, Cristina Hernández-Díaz, Yessica Zamudio-Cuevas, Javier Fernández-Torres, Ambar López-Macay, Ismael Alba-Sánchez, Javier Camacho-Galindo, Lucio Ventura, Luis E Gómez-Quiróz, María Concepción Gutiérrez-Ruíz, Francisco García-Vázquez, Anthony M Reginato, Marwin Gutiérrez, Alberto López-Reyes

Increased 30-day and 1-year mortality rates and lower coronary revascularisation rates following acute myocardial infarction in patients with autoimmune rheumatic disease

  • Open Access
  • Research article

Sharon Van Doornum, Megan Bohensky, Mark A Tacey, Caroline A Brand, Vijaya Sundararajan, Ian P Wicks

Long-lived plasma cells are early and constantly generated in New Zealand Black/New Zealand White F1 mice and their therapeutic depletion requires a combined targeting of autoreactive plasma cells and their precursors

  • Open Access
  • Research article

Adriano Taddeo, Laleh Khodadadi, Caroline Voigt, Imtiaz M Mumtaz, Qingyu Cheng, Katrin Moser, Tobias Alexander, Rudolf A Manz, Andreas Radbruch, Falk Hiepe, Bimba F Hoyer

Physical activity and risk of rheumatoid arthritis in women: a population-based prospective study

  • Open Access
  • Research article

Daniela Di Giuseppe, Matteo Bottai, Johan Askling, Alicja Wolk

Role of C-reactive protein in osteoclastogenesis in rheumatoid arthritis

  • Open Access
  • Research article

Kyoung-Woon Kim, Bo-Mi Kim, Hee-Won Moon, Sang-Heon Lee, Hae-Rim Kim

MicroRNA-33a regulates cholesterol synthesis and cholesterol efflux-related genes in osteoarthritic chondrocytes

  • Open Access
  • Research article

Fotini Kostopoulou, Konstantinos N Malizos, Ioanna Papathanasiou, Aspasia Tsezou

Kinetics of gene expression and bone remodelling in the clinical phase of collagen-induced arthritis

  • Open Access
  • Research article

Katja CM Denninger, Thomas Litman, Troels Marstrand, Kristian Moller, Lars Svensson, Tord Labuda, Åsa Andersson

Haptoglobin-α1, -α2, vitamin D-binding protein and apolipoprotein C-III as predictors of etanercept drug response in rheumatoid arthritis

  • Open Access
  • Research article

Sabine Blaschke, Kathinka Rinke, Michael Maring, Thomas Flad, Susann Patschan, Olaf Jahn, Claudia A Mueller, Gerhard A Mueller, Hassan Dihazi

Polychromatic flow cytometry in evaluating rheumatic disease patients

  • Open Access
  • Review

Chungwen Wei, Scott Jenks, Iñaki Sanz

Anti-factor Xa antibodies in patients with antiphospholipid syndrome and their effects upon coagulation assays

  • Open Access
  • Research article

Bahar Artim-Esen, Charis Pericleous, Ian Mackie, Vera M Ripoll, David Latchman, David Isenberg, Anisur Rahman, Yiannis Ioannou, Ian Giles

Characterising deviation from treat-to-target strategies for early rheumatoid arthritis: the first three years

  • Open Access
  • Research article

Nasir Wabe, Michael J Sorich, Mihir D Wechalekar, Leslie G Cleland, Leah McWilliams, Anita Lee, Llewellyn Spargo, Robert G Metcalf, Cindy Hall, Susanna M Proudman, Michael D Wiese

Circulating miRNAs as potential biomarkers of therapy effectiveness in rheumatoid arthritis patients treated with anti-TNFα

  • Open Access
  • Research article

Carmen Castro-Villegas, Carlos Pérez-Sánchez, Alejandro Escudero, Ileana Filipescu, Miriam Verdu, Patricia Ruiz-Limón, Ma Angeles Aguirre, Yolanda Jiménez-Gomez, Pilar Font, Antonio Rodriguez-Ariza, Juan Ramon Peinado, Eduardo Collantes-Estévez, Rocío González-Conejero, Constantino Martinez, Nuria Barbarroja, Chary López-Pedrera

Comparison of two hyaluronic acid formulations for safety and efficacy (CHASE) study in knee osteoarthritis: a multicenter, randomized, double-blind, 26-week non-inferiority trial comparing Durolane to Artz

  • Open Access
  • Research article

Heng Zhang, Ke Zhang, Xianlong Zhang, Zhenan Zhu, Shigui Yan, Tiansheng Sun, Ai Guo, John Jones, R Grant Steen, Bin Shan, Jenny Zhang, Jianhao Lin

Significant effects of biologic therapy on lipid profiles and insulin resistance in patients with rheumatoid arthritis

  • Open Access
  • Research article

Der-Yuan Chen, Yi-Ming Chen, Tsu-Yi Hsieh, Chia-Wei Hsieh, Chi-Chen Lin, Joung-Liang Lan

Altered balance of interleukin-13/interferon-gamma contributes to lacrimal gland destruction and secretory dysfunction in CD25 knockout model of Sjögren’s syndrome

  • Open Access
  • Research article

Fang Bian, Flavia L Barbosa, Rosa M Corrales, Flavia SA Pelegrino, Eugene A Volpe, Stephen C Pflugfelder, Cintia S de Paiva

Mitochondrial respiration and redox coupling in articular chondrocytes

  • Open Access
  • Research article

Rachel S Lane, Yao Fu, Satoshi Matsuzaki, Michael Kinter, Kenneth M Humphries, Timothy M Griffin

Carotid artery plaque in women with rheumatoid arthritis and low estimated cardiovascular disease risk: a cross-sectional study

  • Open Access
  • Research article

Alfonso Corrales, Patrick H Dessein, Linda Tsang, Trinitario Pina, Ricardo Blanco, Carlos Gonzalez-Juanatey, Javier Llorca, Miguel A Gonzalez-Gay

CYB5A polymorphism increases androgens and reduces risk of rheumatoid arthritis in women

  • Open Access
  • Research article

Klaus Stark, Rainer H Straub, Jozef Rovenský, Stanislava Blažičková, Gabriele Eiselt, Martin Schmidt

Anti-PM/Scl antibodies are found in Japanese patients with various systemic autoimmune conditions besides myositis and scleroderma

  • Open Access
  • Research article

Yoshinao Muro, Yuji Hosono, Kazumitsu Sugiura, Yasushi Ogawa, Tsuneyo Mimori, Masashi Akiyama

Angiogenic gene expression and vascular density are reflected in ultrasonographic features of synovitis in early rheumatoid arthritis: an observational study

  • Open Access
  • Research article

Stephen Kelly, Michele Bombardieri, Frances Humby, Nora Ng, Alessandra Marrelli, Sudeh Riahi, Maria DiCicco, Arti Mahto, Lu Zou, Debasish Pyne, Rebecca E Hands, Costantino Pitzalis

Subjective and objective levels of physical activity and their association with cardiorespiratory fitness in rheumatoid arthritis patients

  • Open Access
  • Research article

Chen-an Yu, Peter C Rouse, Jet JCS Veldhuijzen Van Zanten, Nikos Ntoumanis, George D Kitas, Joan L Duda, George S Metsios

Effect of coculturing canine notochordal, nucleus pulposus and mesenchymal stromal cells for intervertebral disc regeneration

  • Open Access
  • Research article

Irene TM Arkesteijn, Lucas A Smolders, Sandra Spillekom, Frank M Riemers, Esther Potier, Björn P Meij, Keita Ito, Marianna A Tryfonidou

CD27-IgD- memory B cells are modulated by in vivo interleukin-6 receptor (IL-6R) blockade in rheumatoid arthritis

  • Open Access
  • Research article

Zafar Mahmood, Khalid Muhammad, Marc Schmalzing, Petra Roll, Thomas Dörner, Hans-Peter Tony

Thymic stromal lymphopoietin in hepatitis C virus-related cryoglobulinemic vasculitis: gene expression level and protein distribution

  • Open Access
  • Research article

Domenico Sansonno, Sabino Russi, Silvia Sansonno, Fabio Pavone, Franco Dammacco

Rheumatoid arthritis response to treatment across IgG1 allotype – anti-TNF incompatibility: a case-only study

  • Open Access
  • Research article

Ariana Montes, Eva Perez-Pampin, Federico Navarro-Sarabia, Virginia Moreira, Arturo Rodríguez de la Serna, Berta Magallares, Yiannis Vasilopoulos, Theologia Sarafidou, Antonio Fernández-Nebro, María del Carmen Ordóñez, Javier Narváez, Juan D Cañete, Ana Marquez, Dora Pascual-Salcedo, Beatriz Joven, Patricia Carreira, Manuel J Moreno-Ramos, Rafael Caliz, Miguel Angel Ferrer, Rosa Garcia-Portales, Francisco J Blanco, Cesar Magro, Enrique Raya, Lara Valor, Juan J Alegre-Sancho, Alejandro Balsa, Javier Martin, Darren Plant, John Isaacs, Ann W Morgan, Anne Barton, Anthony G Wilson, Juan J Gómez-Reino, Antonio Gonzalez

The metastatic tumor antigen 1-transglutaminase-2 pathway is involved in self-limitation of monosodium urate crystal-induced inflammation by upregulating TGF-β1

  • Open Access
  • Research article

Jia-Hau Yen, Ling-Chung Lin, Meng-Chi Chen, Zsolt Sarang, Pui-Ying Leong, I-Chang Chang, Jeng-Dong Hsu, Jiunn-Horng Chen, Yu-Fan Hsieh, Anna Pallai, Krisztina Köröskényi, Zsuzsa Szondy, Gregory J Tsay

Meta-analysis of two Chinese populations identifies an autoimmune disease risk allele in 22q11.21 as associated with systemic lupus erythematosus

  • Open Access
  • Research article

Yan Zhang, Yong-Fei Wang, Jing Yang, Jing Zhang, Liangdan Sun, Nattiya Hirankarn, Hai-Feng Pan, Chak Sing Lau, Tak Mao Chan, Tsz Leung Lee, Alexander Moon Ho Leung, Chi Chiu Mok, Lu Zhang, Jiangshan Jane Shen, Sik Nin Wong, Ka Wing Lee, Marco Hok Kung Ho, Pamela Pui Wah Lee, Brian Hon-Yin Chung, Chun Yin Chong, Raymond Woon Sing Wong, Mo Yin Mok, Wilfred Hing Sang Wong, Kwok Lung Tong, Niko Kei Chiu Tse, Xiang-Pei Li, Yingyos Avihingsanon, Pornpimol Rianthavorn, Thavatchai Deekajorndej, Kanya Suphapeetiporn, Vorasuk Shotelersuk, Shirley King Yee Ying, Samuel Ka Shun Fung, Wai Ming Lai, Chun-Ming Wong, Irene Oi Lin Ng, Maria-Merce Garcia-Barcelo, Stacey S Cherny, Paul Kwong-Hang Tam, Pak Chung Sham, Sen Yang, Dong Qing Ye, Yong Cui, Xue-Jun Zhang, Wanling Yang, Yu Lung Lau

Intracellular free radical production by peripheral blood T lymphocytes from patients with systemic sclerosis: role of NADPH oxidase and ERK1/2

  • Open Access
  • Research article

Donatella Amico, Tatiana Spadoni, Marina Rovinelli, Marta Serafini, Giovanna D’Amico, Nadia Campelli, Silvia Svegliati Baroni, Armando Gabrielli

Detecting cathepsin activity in human osteoarthritis via activity-based probes

  • Open Access
  • Research article

Louisa Ben-Aderet, Emmanuelle Merquiol, Duha Fahham, Ashok Kumar, Eli Reich, Yael Ben-Nun, Leonid Kandel, Amir Haze, Meir Liebergall, Marta K Kosińska, Juergen Steinmeyer, Boris Turk, Galia Blum, Mona Dvir-Ginzberg

Racial disparities in total ankle arthroplasty utilization and outcomes

  • Open Access
  • Research article

Jasvinder A Singh, Rekha Ramachandran

Identification of NF-κB and PLCL2 as new susceptibility genes and highlights on a potential role of IRF8 through interferon signature modulation in systemic sclerosis

  • Open Access
  • Research article

Maria Arismendi, Matthieu Giraud, Nadira Ruzehaji, Philippe Dieudé, Eugenie Koumakis, Barbara Ruiz, Paolo Airo, Daniele Cusi, Marco Matucci-Cerinic, Erika Salvi, Giovanna Cuomo, Eric Hachulla, Elisabeth Diot, Paola Caramaschi, Valeria Riccieri, Jérôme Avouac, Cristiane Kayser, Yannick Allanore

Local synthesis of interferon-alpha in lupus nephritis is associated with type I interferons signature and LMP7 induction in renal tubular epithelial cells

  • Open Access
  • Research article

Giuseppe Castellano, Cesira Cafiero, Chiara Divella, Fabio Sallustio, Margherita Gigante, Paola Pontrelli, Giuseppe De Palma, Michele Rossini, Giuseppe Grandaliano, Loreto Gesualdo

Multiplex cytokine analysis of dermal interstitial blister fluid defines local disease mechanisms in systemic sclerosis

  • Open Access
  • Research article

Kristina EN Clark, Henry Lopez, Bahja Ahmed Abdi, Sandra G Guerra, Xu Shiwen, Korsa Khan, Oseme Etomi, George R Martin, David J Abraham, Christopher P Denton, Richard J Stratton

Head-to-head comparison of the safety of tocilizumab and tumor necrosis factor inhibitors in rheumatoid arthritis patients (RA) in clinical practice: results from the registry of Japanese RA patients on biologics for long-term safety (REAL) registry

  • Open Access
  • Research article

Ryoko Sakai, Soo-Kyung Cho, Toshihiro Nanki, Kaori Watanabe, Hayato Yamazaki, Michi Tanaka, Ryuji Koike, Yoshiya Tanaka, Kazuyoshi Saito, Shintaro Hirata, Koichi Amano, Hayato Nagasawa, Takayuki Sumida, Taichi Hayashi, Takahiko Sugihara, Hiroaki Dobashi, Shinsuke Yasuda, Tetsuji Sawada, Kazuhiko Ezawa, Atsuhisa Ueda, Takao Fujii, Kiyoshi Migita, Nobuyuki Miyasaka, Masayoshi Harigai

Cumulative inflammatory burden is independently associated with increased arterial stiffness in patients with psoriatic arthritis: a prospective study

  • Open Access
  • Research article

Jiayun Shen, Qing Shang, Edmund K Li, Ying-Ying Leung, Emily W Kun, Lai-Wa Kwok, Martin Li, Tena K Li, Tracy Y Zhu, Cheuk-Man Yu, Lai-Shan Tam

CD4 T-cell transcriptome analysis reveals aberrant regulation of STAT3 and Wnt signaling pathways in rheumatoid arthritis: evidence from a case–control study

  • Open Access
  • Research article

Hua Ye, Jing Zhang, Jun Wang, Yanyan Gao, Yan Du, Chun Li, Minghua Deng, Jianping Guo, Zhanguo Li

Application of the 2013 ACR/EULAR classification criteria for systemic sclerosis to patients with Raynaud’s phenomenon

  • Open Access
  • Research article

Jin-Su Park, Min-Chan Park, Jason Jungsik Song, Yong-Beom Park, Soo-Kon Lee, Sang-Won Lee

Effect of prednisone on type I interferon signature in rheumatoid arthritis: consequences for response prediction to rituximab

  • Open Access
  • Research article

Tamarah D de Jong, Saskia Vosslamber, Marjolein Blits, Gertjan Wolbink, Mike T Nurmohamed, Conny J van der Laken, Gerrit Jansen, Alexandre E Voskuyl, Cornelis L Verweij

Visceral fat obesity is highly associated with primary gout in a metabolically obese but normal weighted population: a case control study

  • Open Access
  • Research article

Jennifer Lee, Ji-Yeon Lee, Jae-Ho Lee, Seung-Min Jung, Young Sun Suh, Jung-Hee Koh, Seung-Ki Kwok, Ji Hyeon Ju, Kyung-Su Park, Sung-Hwan Park

Characterization of the major histocompatibility complex locus association with Behçet’s disease in Iran

  • Open Access
  • Research article

Joana M Xavier, Fereydoun Davatchi, Olga Abade, Farhad Shahram, Vânia Francisco, Bahar Sadeghi Abdollahi, Hélder Trindade, Abdolhadi Nadji, Niloofar Mojarad Shafiee, Fahmida Ghaderibarmi, Dário Ligeiro, Sofia A Oliveira

Meniscal extrusion promotes knee osteoarthritis structural progression: protective effect of strontium ranelate treatment in a phase III clinical trial

  • Open Access
  • Research article

Camille Roubille, Johanne Martel-Pelletier, Jean-Pierre Raynauld, François Abram, Marc Dorais, Philippe Delorme, Jean-Pierre Pelletier

An external validation study reporting poor correlation between the claims-based index for rheumatoid arthritis severity and the disease activity score

  • Open Access
  • Research article

Rishi J Desai, Daniel H Solomon, Michael E Weinblatt, Nancy Shadick, Seoyoung C Kim

Bone mineral density and carotid atherosclerosis in systemic lupus erythematosus: a controlled cross-sectional study

  • Open Access
  • Research article

Sofia Ajeganova, Thomas Gustafsson, Tomas Jogestrand, Johan Frostegård, Ingiäld Hafström

Association analyses confirm five susceptibility loci for systemic lupus erythematosus in the Han Chinese population

  • Open Access
  • Research article

Yu-jun Sheng, Jian-hua Xu, Yong-gui Wu, Xian-bo Zuo, Jin-ping Gao, Yan Lin, Zheng-wei Zhu, Lei-lei Wen, Chao Yang, Lu Liu, Yu-yan Cheng, Yan Chang, Lu-lu Yang, Fu-sheng Zhou, Xian-fa Tang, Xiao-dong Zheng, Xian-yong Yin, Hua-yang Tang, Liang-dan Sun, Yong Cui, Sen Yang, Xue-jun Zhang

Body mass index and the risk of rheumatoid arthritis: a systematic review and dose-response meta-analysis

  • Open Access
  • Research article

Baodong Qin, Min Yang, Haitao Fu, Ning Ma, Tingting Wei, Qingqin Tang, Zhide Hu, Yan Liang, Zaixing Yang, Renqian Zhong

The interface between cholinergic pathways and the immune system and its relevance to arthritis

  • Open Access
  • Review

Robin M McAllen, Andrew D Cook, Hsu Wei Khiew, Davide Martelli, John A Hamilton

Are mesenchymal stromal cells immune cells?

  • Open Access
  • Review

Martin J Hoogduijn

Methotrexate: should it still be considered for chronic calcium pyrophosphate crystal disease?

  • Open Access
  • Editorial

Eliseo Pascual, Mariano Andrés, Francisca Sivera

Gout and risk of chronic kidney disease and nephrolithiasis: meta-analysis of observational studies

  • Open Access
  • Research article

Matthew J Roughley, John Belcher, Christian D Mallen, Edward Roddy

The involvement of follistatin-like protein 1 in osteoarthritis by elevating NF-κB-mediated inflammatory cytokines and enhancing fibroblast like synoviocyte proliferation

  • Open Access
  • Research article

Su Ni, Kaisong Miao, Xianju Zhou, Nanwei Xu, Chenkai Li, Ruixia Zhu, Rongbin Sun, Yuji Wang

Differential effects of cyclophosphamide and mycophenolate mofetil on cellular and serological parameters in patients with systemic lupus erythematosus

  • Open Access
  • Research article

Till Fassbinder, Ute Saunders, Eva Mickholz, Elisabeth Jung, Heidemarie Becker, Bernhard Schlüter, Annett Marita Jacobi

The novel S59P mutation in the TNFRSF1A gene identified in an adult onset TNF receptor associated periodic syndrome (TRAPS) constitutively activates NF-κB pathway

  • Open Access
  • Research article

Eliana Greco, Ada Aita, Paola Galozzi, Alessandra Gava, Paolo Sfriso, Ola H Negm, Patrick Tighe, Francesco Caso, Filippo Navaglia, Emanuela Dazzo, Marzia De Bortoli, Alessandra Rampazzo, Laura Obici, Simona Donadei, Giampaolo Merlini, Mario Plebani, Ian Todd, Daniela Basso, Leonardo Punzi

The cellular signature of urinary immune cells in Lupus nephritis: new insights into potential biomarkers

  • Open Access
  • Research article

Katharina Kopetschke, Jan Klocke, Anna-Sophie Grießbach, Jens Y Humrich, Robert Biesen, Duska Dragun, Gerd-Rüdiger Burmester, Philipp Enghard, Gabriela Riemekasten

Evaluation of the effect of tofacitinib on measured glomerular filtration rate in patients with active rheumatoid arthritis: results from a randomised controlled trial

  • Open Access
  • Research article

Joel M Kremer, Alan J Kivitz, Jesus A Simon-Campos, Evgeny L Nasonov, Hans-Peter Tony, Soo-Kon Lee, Bonnie Vlahos, Constance Hammond, Jack Bukowski, Huihua Li, Seth L Schulman, Susan Raber, Andrea Zuckerman, John D Isaacs

Response to ‘Increase of nerve growth factor levels in the human herniated intervertebral disc: can annular rupture trigger discogenic back pain?’ – authors’ reply

  • Open Access
  • Letter

Yasuchika Aoki, Arata Nakajima, Seiji Ohtori, Hiroshi Takahashi, Fusako Watanabe, Masato Sonobe, Fumiaki Terajima, Masahiko Saito, Kazuhisa Takahashi, Tomoaki Toyone, Atsuya Watanabe, Takayuki Nakajima, Makoto Takazawa, Koichi Nakagawa

Patients lacking classical poor prognostic markers might also benefit from a step-down glucocorticoid bridging scheme in early rheumatoid arthritis: week 16 results from the randomized multicenter CareRA trial

  • Open Access
  • Research article

Patrick Verschueren, Diederik De Cock, Luk Corluy, Rik Joos, Christine Langenaken, Veerle Taelman, Frank Raeman, Isabelle Ravelingien, Klaas Vandevyvere, Jan Lenaerts, Elke Geens, Piet Geusens, Johan Vanhoof, Anne Durnez, Jan Remans, Bert Vander Cruyssen, Els Van Essche, An Sileghem, Griet De Brabanter, Johan Joly, Kristien Van der Elst, Sabrina Meyfroidt, Rene Westhovens

Subclinical atherosclerosis and impaired bone health in patients with primary Sjogren’s syndrome: prevalence, clinical and laboratory associations

  • Open Access
  • Research article

Fotini Gravani, Ioanna Papadaki, Eleni Antypa, Andrianos Nezos, Kyriaki Masselou, Dimitrios Ioakeimidis, Michael Koutsilieris, Haralampos M Moutsopoulos, Clio P Mavragani

Glucose-6-phosphate isomerase promotes the proliferation and inhibits the apoptosis in fibroblast-like synoviocytes in rheumatoid arthritis

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Ming Zong, Tianbao Lu, Shasha Fan, Hui Zhang, Ruhan Gong, Lishan Sun, Zhiyan Fu, Lieying Fan

Fetal microchimerism in kidney biopsies of lupus nephritis patients may be associated with a beneficial effect

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Greiciane MS Florim, Heloisa C Caldas, Julio CR de Melo, Maria Alice SF Baptista, Ida MM Fernandes, Marcela Savoldi-Barbosa, Gustavo H Goldman, Mario Abbud-Filho

Association of HLA-B*41:02 with Henoch-Schönlein Purpura (IgA Vasculitis) in Spanish individuals irrespective of the HLA-DRB1 status

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Raquel López-Mejías, Fernanda Genre, Belén Sevilla Pérez, Santos Castañeda, Norberto Ortego-Centeno, Javier Llorca, Begoña Ubilla, Sara Remuzgo-Martínez, Verónica Mijares, Trinitario Pina, Vanesa Calvo-Río, Ana Márquez, José A Miranda-Filloy, Antonio Navas Parejo, Marta Conde-Jaldón, Lourdes Ortiz-Fernández, Diego Argila, Maximiliano Aragües, Esteban Rubio, Manuel León Luque, Juan María Blanco-Madrigal, Eva Galíndez-Aguirregoikoa, Francisca González Escribano, J Gonzalo Ocejo-Vinyals, Javier Martín, Ricardo Blanco, Miguel A González-Gay

Enhanced activation of dendritic cells by autologous apoptotic microvesicles in MRL/lpr mice

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Jürgen Dieker, Luuk Hilbrands, Astrid Thielen, Henry Dijkman, Jo H Berden, Johan van der Vlag

Anti-citrullinated peptide/protein antibody (ACPA)-negative RA shares a large proportion of susceptibility loci with ACPA-positive RA: a meta-analysis of genome-wide association study in a Japanese population

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Chikashi Terao, Koichiro Ohmura, Yuta Kochi, Katsunori Ikari, Yukinori Okada, Masakazu Shimizu, Naoshi Nishina, Akari Suzuki, Keiko Myouzen, Takahisa Kawaguchi, Meiko Takahashi, Kiyoshi Takasugi, Akira Murasawa, Shinichi Mizuki, Mitsuhiro Iwahashi, Keiko Funahashi, Masamitsu Natsumeda, Moritoshi Furu, Motomu Hashimoto, Hiromu Ito, Takao Fujii, Kazuhiko Ezawa, Tsukasa Matsubara, Tsutomu Takeuchi, Michiaki Kubo, Ryo Yamada, Atsuo Taniguchi, Hisashi Yamanaka, Shigeki Momohara, Kazuhiko Yamamoto, Tsuneyo Mimori, Fumihiko Matsuda

Involvement of RORγt-overexpressing T cells in the development of autoimmune arthritis in mice

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Yuya Kondo, Zhaojin Yao, Masahiro Tahara, Mana Iizuka, Masahiro Yokosawa, Shunta Kaneko, Seiji Segawa, Hiroto Tsuboi, Keigyou Yoh, Satoru Takahashi, Isao Matsumoto, Takayuki Sumida

Early cartilage abnormalities at the hip are associated with obesity and body composition measures – a 3.0T MRI community-based study

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Andrew J Teichtahl, Yuanyuan Wang, Sam Smith, Anita E Wluka, Donna Urquhart, Graham G Giles, Sultana Monira Hussain, Flavia M Cicuttini

Reappraisal of the diagnostic and prognostic value of morning stiffness in arthralgia and early arthritis: results from the Groningen EARC, Leiden EARC, ESPOIR, Leiden EAC and REACH

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Jessica AB van Nies, Celina Alves, Audrey LS Radix-Bloemen, Cécile Gaujoux-Viala, Tom WJ Huizinga, Johanna MW Hazes, Elisabeth Brouwer, Bruno Fautrel, Annette HM van der Helm-van Mil

Histological antiphospholipid-associated nephropathy versus lupus nephritis in patients with systemic lupus erythematosus: an observational cross-sectional study with longitudinal follow-up

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Jakob Gerhardsson, Birgitta Sundelin, Agneta Zickert, Leonid Padyukov, Elisabet Svenungsson, Iva Gunnarsson

Comparison and evaluation of lupus nephritis response criteria in lupus activity indices and clinical trials

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Kristin M Corapi, Mary Anne Dooley, William F Pendergraft III

Bone geometry of the hip is associated with obesity and early structural damage – a 3.0 T magnetic resonance imaging study of community-based adults

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Andrew J Teichtahl, Yuanyuan Wang, Sam Smith, Anita E Wluka, Michael Zhu, Donna Urquhart, Graham G Giles, Richard O’Sullivan, Flavia M Cicuttini

Physical inactivity is associated with narrower lumbar intervertebral discs, high fat content of paraspinal muscles and low back pain and disability

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Andrew J Teichtahl, Donna M Urquhart, Yuanyuan Wang, Anita E Wluka, Richard O’Sullivan, Graeme Jones, Flavia M Cicuttini

Concepts of pathogenesis in psoriatic arthritis: genotype determines clinical phenotype

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Oliver FitzGerald, Muhammad Haroon, Jon T Giles, Robert Winchester

Rheumatoid vasculitis: going, going, but not yet gone

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  • Editorial

David S Pisetsky

Utility of a novel inflammatory marker, GlycA, for assessment of rheumatoid arthritis disease activity and coronary atherosclerosis

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Michelle J. Ormseth, Cecilia P. Chung, Annette M. Oeser, Margery A. Connelly, Tuulikki Sokka, Paolo Raggi, Joseph F. Solus, James D. Otvos, C. Michael Stein

The prevalence of clinically diagnosed ankylosing spondylitis and its clinical manifestations: a nationwide register study

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Sofia Exarchou, Ulf Lindström, Johan Askling, Jonas K Eriksson, Helena Forsblad-d’Elia, Martin Neovius, Carl Turesson, Lars Erik Kristensen, Lennart TH Jacobsson

Differential glucocorticoid metabolism in patients with persistent versus resolving inflammatory arthritis

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Dominika E Nanus, Andrew D Filer, Lorraine Yeo, Dagmar Scheel-Toellner, Rowan Hardy, Gareth G Lavery, Paul M Stewart, Christopher D Buckley, Jeremy W Tomlinson, Mark S Cooper, Karim Raza

Pattern recognition receptors as potential therapeutic targets in inflammatory rheumatic disease

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Lisa M Mullen, Giselle Chamberlain, Sandra Sacre

The association between antibody levels before and after 7-valent pneumococcal conjugate vaccine immunization and subsequent pneumococcal infection in chronic arthritis patients

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Johanna Nagel, Pierre Geborek, Tore Saxne, Göran Jönsson, Martin Englund, Ingemar F Petersson, Jan-Åke Nilsson, Lennart Truedsson, Meliha C Kapetanovic

Associations of antibodies against citrullinated peptides with human leukocyte antigen-shared epitope and smoking prior to the development of rheumatoid arthritis

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Heidi Kokkonen, Mikael Brink, Monika Hansson, Ewa Lassen, Linda Mathsson-Alm, Rikard Holmdahl, Johan Rönnelid, Lars Klareskog, Solbritt Rantapää-Dahlqvist

Evidence for cadherin-11 cleavage in the synovium and partial characterization of its mechanism

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Erika H Noss, Gerald FM Watts, Davide Zocco, Tracy L Keller, Malcolm Whitman, Carl P Blobel, David M Lee, Michael B Brenner

Mass cytometry as a platform for the discovery of cellular biomarkers to guide effective rheumatic disease therapy

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Nitya Nair, Henrik E Mei, Shih-Yu Chen, Matthew Hale, Garry P Nolan, Holden T Maecker, Mark Genovese, C Garrison Fathman, Chan C Whiting

A candidate gene study reveals association between a variant of the Peroxisome Proliferator-Activated Receptor Gamma (PPAR-γ) gene and systemic sclerosis

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Roberta Goncalves Marangoni, Benjamin D Korman, Yannick Allanore, Philippe Dieude, Loren L Armstrong, Margarita Rzhetskaya, Monique Hinchcliff, Mary Carns, Sofia Podlusky, Sanjiv J Shah, Barbara Ruiz, Eric Hachulla, Kiet Tiev, Jean-Luc Cracowski, John Varga, M Geoffrey Hayes

Plasma complement factor H is associated with disease activity of patients with ANCA-associated vasculitis

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Su-Fang Chen, Feng-Mei Wang, Zhi-Ying Li, Feng Yu, Ming-Hui Zhao, Min Chen

Association of large intergenic noncoding RNA expression with disease activity and organ damage in systemic lupus erythematosus

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Yanfang Wu, Feifei Zhang, Jianyang Ma, Xiaoyan Zhang, Lingling Wu, Bo Qu, Shiwei Xia, Shunle Chen, Yuanjia Tang, Nan Shen

Longitudinal analysis of peripheral blood T cell receptor diversity in patients with systemic lupus erythematosus by next-generation sequencing

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Dharma R Thapa, Raffi Tonikian, Chao Sun, Mei Liu, Andrea Dearth, Michelle Petri, Francois Pepin, Ryan O Emerson, Ann Ranger

Existing joint erosions increase the risk of joint space narrowing independently of clinical synovitis in patients with early rheumatoid arthritis

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Robert Landewé, Josef S Smolen, Stefan Florentinus, Su Chen, Benoît Guérette, Désirée van der Heijde

Cost-effectiveness of abatacept, rituximab, and TNFi treatment after previous failure with TNFi treatment in rheumatoid arthritis: a pragmatic multi-centre randomised trial

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Sofie HM Manders, Wietske Kievit, Eddy Adang, Herman L Brus, Hein J Bernelot Moens, Andre Hartkamp, Lidy Hendriks, Elisabeth Brouwer, Henk Visser, Harald E Vonkeman, Jos Hendrikx, Tim L Jansen, Rene Westhovens, Mart AFJ van de Laar, Piet LCM van Riel

The preclinical pharmacology of the high affinity anti-IL-6R Nanobody® ALX-0061 supports its clinical development in rheumatoid arthritis

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Maarten Van Roy, Cedric Ververken, Els Beirnaert, Sven Hoefman, Joost Kolkman, Michel Vierboom, Elia Breedveld, Bert ‘t Hart, Sofie Poelmans, Lieselot Bontinck, Alex Hemeryck, Sandy Jacobs, Judith Baumeister, Hans Ulrichts

Safety of biologic and nonbiologic disease-modifying antirheumatic drug therapy in veterans with rheumatoid arthritis and hepatitis B virus infection: a retrospective cohort study

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Mary Jane Burton, Jeffrey R Curtis, Shuo Yang, Lang Chen, Jasvinder A Singh, Ted R Mikuls, Kevin L Winthrop, John W Baddley

Intradiscal application of rhBMP-7 does not induce regeneration in a canine model of spontaneous intervertebral disc degeneration

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Nicole Willems, Frances C Bach, Saskia G M Plomp, Mattie HP van Rijen, Jeannette Wolfswinkel, Guy CM Grinwis, Clemens Bos, Gustav J Strijkers, Wouter JA Dhert, Björn P Meij, Laura B Creemers, Marianna A Tryfonidou

Linking classification and therapeutic management of vasculitides

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Corisande Baldwin, Simon Carette, Christian Pagnoux

Gout and the risk of dementia: a nationwide population-based cohort study

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Jen-Yee Hong, Tzuo-Yun Lan, Gau-Jun Tang, Chao-Hsiun Tang, Tzeng-Ji Chen, Hsiao-Yi Lin

KIAA1199 as a potential diagnostic biomarker of rheumatoid arthritis related to angiogenesis

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Xinyu Yang, Pengcheng Qiu, Bingbing Chen, Yaoyao Lin, Zhonghao Zhou, Renshan Ge, Hai Zou, Jianmin Wang, Jianguang Wang

Early biomarkers of joint damage in rheumatoid and psoriatic arthritis

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Angela Mc Ardle, Brian Flatley, Stephen R. Pennington, Oliver FitzGerald

Approaches for estimating minimal clinically important differences in systemic lupus erythematosus

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Sharan K Rai, Jinoos Yazdany, Paul R Fortin, J Antonio Aviña-Zubieta

Laminin-rich blood vessels display activated growth factor signaling and act as the proliferation centers in Dupuytren’s contracture

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Janeli Viil, Katre Maasalu, Kristina Mäemets-Allas, Liis Tamming, Kadi Lõhmussaar, Mikk Tooming, Sulev Ingerpuu, Aare Märtson, Viljar Jaks

RETRACTED ARTICLE: Combined effect of genetic background and gender in a mouse model of bleomycin-induced skin fibrosis

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Nadira Ruzehaji, Jerome Avouac, Muriel Elhai, Maxime Frechet, Camelia Frantz, Barbara Ruiz, Joerg H. Distler, Yannick Allanore

Salivary gland ultrasonography: a highly specific tool for the early diagnosis of primary Sjögren’s syndrome

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Chiara Baldini, Nicoletta Luciano, Gaia Tarantini, Rachele Pascale, Francesca Sernissi, Marta Mosca, Davide Caramella, Stefano Bombardieri

Yes-associated protein (YAP) is a negative regulator of chondrogenesis in mesenchymal stem cells

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Alexandra Karystinou, Anke J Roelofs, Anna Neve, Francesco P Cantatore, Henning Wackerhage, Cosimo De Bari

Pneumococcal polysaccharide vaccination in rheumatoid arthritis patients receiving tacrolimus

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Kiyoshi Migita, Yukihiro Akeda, Manabu Akazawa, Shigeto Tohma, Fuminori Hirano, Haruko Ideguchi, Ryutaro Matsumura, Eiichi Suematsu, Tomoya Miyamura, Shunsuke Mori, Takahiro Fukui, Yasumori Izumi, Nozomi Iwanaga, Hiroshi Tsutani, Kouichirou Saisyo, Takao Yamanaka, Shiro Ohshima, Takao Sugiyama, Yojiro Kawabe, Masao Katayama, Yasuo Suenaga, Akira Okamoto, Hisaji Ohshima, Yasumasa Okada, Kenji Ichikawa, Shigeru Yoshizawa, Kenji Kawakami, Toshihiro Matsui, Hiroshi Furukawa, Kazunori Oishi

Transvenous vagus nerve stimulation does not modulate the innate immune response during experimental human endotoxemia: a randomized controlled study

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Matthijs Kox, Lucas T. van Eijk, Tim Verhaak, Tim Frenzel, Harmke D. Kiers, Jelle Gerretsen, Johannes G. van der Hoeven, Lilian Kornet, Avram Scheiner, Peter Pickkers

Pneumococcal polysaccharide vaccination in adults undergoing immunosuppressive treatment for inflammatory diseases – a longitudinal study

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Lara Fischer, Patricia Francis Gerstel, Antoine Poncet, Claire-Anne Siegrist, Emmanuel Laffitte, Cem Gabay, Joerg Dieter Seebach, Camillo Ribi

Prognostic factors for progression of clinical osteoarthritis of the knee: a systematic review of observational studies

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Alex N. Bastick, Jos Runhaar, Janneke N. Belo, Sita M.A. Bierma-Zeinstra

Toll-like receptor 2 (TLR2) induces migration and invasive mechanisms in rheumatoid arthritis

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Trudy McGarry, Douglas J. Veale, Wei Gao, Carl Orr, Ursula Fearon, Mary Connolly

Overexpression of microRNA-155 increases IL-21 mediated STAT3 signaling and IL-21 production in systemic lupus erythematosus

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Tue Kruse Rasmussen, Thomas Andersen, Rasmus Otkjær Bak, Gloria Yiu, Christian Møller Sørensen, Kristian Stengaard-Pedersen, Jacob Giehm Mikkelsen, Paul Joseph Utz, Christian Kanstrup Holm, Bent Deleuran

Targeting of anti-citrullinated protein/peptide antibodies in rheumatoid arthritis using peptides mimicking endogenously citrullinated fibrinogen antigens

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Cátia Fernandes-Cerqueira, Elena Ossipova, Sunithi Gunasekera, Monika Hansson, Linda Mathsson, Anca I. Catrina, Yngve Sommarin, Lars Klareskog, Karin Lundberg, Johan Rönnelid, Ulf Göransson, Per-Johan Jakobsson

Comparison of two different folic acid doses with methotrexate – a randomized controlled trial (FOLVARI Study)

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Varun Dhir, Amit Sandhu, Jasbinder Kaur, Benzeeta Pinto, Phani Kumar, Prabhdeep Kaur, Nidhi Gupta, Ankita Sood, Aman Sharma, Shefali Sharma

High mobility group box 1 levels in large vessel vasculitis are not associated with disease activity but are influenced by age and statins

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Alexandre W. S. de Souza, Kornelis S. M. van der Geest, Elisabeth Brouwer, Frederico A. G. Pinheiro, Ana Cecília Diniz Oliveira, Emília Inoue Sato, Luis Eduardo C. Andrade, Marc Bijl, Johanna Westra, Cees G. M. Kallenberg

Gene expression changes reflect clinical response in a placebo-controlled randomized trial of abatacept in patients with diffuse cutaneous systemic sclerosis

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Eliza F. Chakravarty, Viktor Martyanov, David Fiorentino, Tammara A. Wood, David James Haddon, Justin Ansel Jarrell, Paul J. Utz, Mark C. Genovese, Michael L. Whitfield, Lorinda Chung

Resistance exercise improves muscle strength, health status and pain intensity in fibromyalgia—a randomized controlled trial

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Anette Larsson, Annie Palstam, Monika Löfgren, Malin Ernberg, Jan Bjersing, Indre Bileviciute-Ljungar, Björn Gerdle, Eva Kosek, Kaisa Mannerkorpi

Autoantigen microarrays reveal autoantibodies associated with proliferative nephritis and active disease in pediatric systemic lupus erythematosus

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D. James Haddon, Vivian K. Diep, Jordan V. Price, Cindy Limb, Paul J. Utz, Imelda Balboni

Complementary action of granulocyte macrophage colony-stimulating factor and interleukin-17A induces interleukin-23, receptor activator of nuclear factor-κB ligand, and matrix metalloproteinases and drives bone and cartilage pathology in experimental arthritis: rationale for combination therapy in rheumatoid arthritis

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Annemarie E. M. van Nieuwenhuijze, Fons A. van de Loo, Birgitte Walgreen, Miranda Bennink, Monique Helsen, Liduine van den Bersselaar, Ian P. Wicks, Wim B. van den Berg, Marije I. Koenders

Organisation of the motor cortex differs between people with and without knee osteoarthritis

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Camille J. Shanahan, Paul W. Hodges, Tim V. Wrigley, Kim L. Bennell, Michael J. Farrell

Stress Doppler echocardiography for early detection of systemic sclerosis-associated pulmonary arterial hypertension

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Christian Nagel, Philipp Henn, Nicola Ehlken, Antonello D’Andrea, Norbert Blank, Eduardo Bossone, Anke Böttger, Christoph Fiehn, Christine Fischer, Hanns-Martin Lorenz, Frank Stöckl, Ekkehard Grünig, Benjamin Egenlauf

Use of RNA sequencing to evaluate rheumatic disease patients

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Eugenia G Giannopoulou, Olivier Elemento, Lionel B Ivashkiv

Improved serological detection of rheumatoid arthritis: a highly antigenic mimotope of carbonic anhydrase III selected in a murine model by phage display

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Galber Rodrigues Araujo, Emília Rezende Vaz, Patricia Tiemi Fujimura, João Eurico Fonseca, Lucélia Maria de Lima, Helena Canhão, Gabriela Venturini, Karina Helena Morais Cardozo, Valdemir Melechco Carvalho, Marcelo Henrique Napimoga, Luiz Ricardo Goulart, João Gonçalves, Carlos Ueira-Vieira

Reactivity of rat bone marrow-derived macrophages to neurotransmitter stimulation in the context of collagen II-induced arthritis

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Dominique Muschter, Claudia Göttl, Mandy Vogel, Joachim Grifka, Rainer H. Straub, Susanne Grässel

Cartilage in facet joints of patients with ankylosing spondylitis (AS) shows signs of cartilage degeneration rather than chondrocyte hypertrophy: implications for joint remodeling in AS

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Janine Bleil, Joachim Sieper, Rene Maier, Uwe Schlichting, Axel Hempfing, Uta Syrbe, Heiner Appel

Ectopic lymphoid neogenesis is strongly associated with activation of the IL-23 pathway in rheumatoid synovitis

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Juan D. Cañete, Raquel Celis, Nataliya Yeremenko, Raimon Sanmartí, Leonie van Duivenvoorde, Julio Ramírez, Iris Blijdorp, Carmen M. García-Herrero, José L. Pablos, Dominique L. Baeten

Rheumatoid arthritis–associated autoantibodies in non–rheumatoid arthritis patients with mucosal inflammation: a case–control study

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Koen M J Janssen, Menke J de Smit, Elisabeth Brouwer, Fenne A C de Kok, Jan Kraan, Josje Altenburg, Marije K Verheul, Leendert A Trouw, Arie Jan van Winkelhoff, Arjan Vissink, Johanna Westra

Suppressed diversity of survivin splicing in active rheumatoid arthritis

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Minna Turkkila, Karin M.E. Andersson, Sylvie Amu, Mikael Brisslert, Malin C. Erlandsson, Sofia Silfverswärd, Maria I. Bokarewa

Differences in glutamate receptors and inflammatory cell numbers are associated with the resolution of pain in human rotator cuff tendinopathy

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Benjamin John Floyd Dean, Sarah J. B. Snelling, Stephanie G. Dakin, Richard J. Murphy, Muhammad Kassim Javaid, Andrew Jonathan Carr

The epidemiology of symptomatic midfoot osteoarthritis in community-dwelling older adults: cross-sectional findings from the Clinical Assessment Study of the Foot

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Martin J. Thomas, George Peat, Trishna Rathod, Michelle Marshall, Andrew Moore, Hylton B. Menz, Edward Roddy

In vivo pre-activation of monocytes in patients with axial spondyloarthritis

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Kristina Conrad, Peihua Wu, Joachim Sieper, Uta Syrbe

Increased carotid artery intima-media thickness and myeloperoxidase level in children with newly diagnosed juvenile idiopathic arthritis

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Jaanika Ilisson, Maksim Zagura, Kersti Zilmer, Erik Salum, Kaire Heilman, Anneli Piir, Vallo Tillmann, Jaak Kals, Mihkel Zilmer, Chris Pruunsild

Sustained biologic-free and drug-free remission in rheumatoid arthritis, where are we now?

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György Nagy, Ronald F van Vollenhoven

Pathophysiology of cutaneous lupus erythematosus

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Jordan C Achtman, Victoria P Werth

Association between arthritis score at the onset of the disease and long-term locomotor outcome in adjuvant-induced arthritis in rats

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Claude Mossiat, Davy Laroche, Clément Prati, Thierry Pozzo, Céline Demougeot, Christine Marie

Epratuzumab inhibits the production of the proinflammatory cytokines IL-6 and TNF-α, but not the regulatory cytokine IL-10, by B cells from healthy donors and SLE patients

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Vanessa Fleischer, Julia Sieber, Sarah J. Fleischer, Anthony Shock, Guido Heine, Capucine Daridon, Thomas Dörner

Clinicopathological characteristics of immunoglobulin G4-related sialadenitis

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Wei Li, Yan Chen, Zhi-Peng Sun, Zhi-Gang Cai, Tong-Tong Li, Lei Zhang, Min-Xian Huang, Hong Hua, Mei Li, Xia Hong, Jia-Zeng Su, Zhu-Yan Zhang, Yan-Ying Liu, Jing He, Zhan-Guo Li, Yan Gao, Guang-Yan Yu

The role of interleukin-1 beta in the pathophysiology of Schnitzler’s syndrome

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Heleen D. de Koning, Joost Schalkwijk, Monique Stoffels, Johanna Jongekrijg, Joannes F. M. Jacobs, Eugène Verwiel, Hans J. P. M. Koenen, Frank Preijers, Dirk Holzinger, Irma Joosten, Jos W. M. van der Meer, Anna Simon

A prospective evaluation of ultrasound as a diagnostic tool in acute microcrystalline arthritis

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Pascal Zufferey, Roxana Valcov, Isabelle Fabreguet, Alexandre Dumusc, Patrick Omoumi, Alexander So

Trabecular bone loss in collagen antibody-induced arthritis

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Louise Grahnemo, Annica Andersson, Merja Nurkkala-Karlsson, Alexandra Stubelius, Marie K. Lagerquist, Mattias N. D. Svensson, Claes Ohlsson, Hans Carlsten, Ulrika Islander

Autoregulatory function of interleukin-10-producing pre-naïve B cells is defective in systemic lupus erythematosus

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Ji Hyun Sim, Hang-Rae Kim, Soog-Hee Chang, In Je Kim, Peter E. Lipsky, Jisoo Lee

Blockade of bone morphogenetic protein signaling potentiates the pro-inflammatory phenotype induced by interleukin-17 and tumor necrosis factor-α combination in rheumatoid synoviocytes

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Alberto Varas, Jaris Valencia, Fabien Lavocat, Víctor G. Martínez, Ndiémé Ndongo Thiam, Laura Hidalgo, Lidia M. Fernández-Sevilla, Rosa Sacedón, Angeles Vicente, Pierre Miossec

Osteoprotegerin and tumor necrosis factor-related apoptosis-inducing ligand as prognostic factors in rheumatoid arthritis: results from the ESPOIR cohort

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Rachel Audo, Claire Daien, Laura Papon, Cédric Lukas, Olivier Vittecoq, Michael Hahne, Bernard Combe, Jacques Morel

Molecular characterization of systemic sclerosis esophageal pathology identifies inflammatory and proliferative signatures

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Jaclyn N. Taroni, Viktor Martyanov, Chiang-Ching Huang, J. Matthew Mahoney, Ikuo Hirano, Brandon Shetuni, Guang-Yu Yang, Darren Brenner, Barbara Jung, Tammara A. Wood, Swati Bhattacharyya, Orit Almagor, Jungwha Lee, Arlene Sirajuddin, John Varga, Rowland W. Chang, Michael L. Whitfield, Monique Hinchcliff

Association of HLA-DRB1 amino acid residues with giant cell arteritis: genetic association study, meta-analysis and geo-epidemiological investigation

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Sarah Louise Mackie, John C. Taylor, Lubna Haroon-Rashid, Stephen Martin, Bhaskar Dasgupta, Andrew Gough, Michael Green, Lesley Hordon, Stephen Jarrett, Colin T. Pease, Jennifer H. Barrett, Richard Watts, Ann W. Morgan

Transforming growth factor-β increases interleukin-13 synthesis via GATA-3 transcription factor in T-lymphocytes from patients with systemic sclerosis

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Julie Baraut, Dominique Farge, Francette Jean-Louis, Ingrid Masse, Elena Ivan Grigore, Lucas C. M. Arruda, Jérôme Lamartine, Franck Verrecchia, Laurence Michel

Early medication use in new-onset rheumatoid arthritis may delay joint replacement: results of a large population-based study

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Cristiano S. Moura, Michal Abrahamowicz, Marie-Eve Beauchamp, Diane Lacaille, Yishu Wang, Gilles Boire, Paul R. Fortin, Louis Bessette, Claire Bombardier, Jessica Widdifield, John G. Hanly, Debbie Feldman, Walter Maksymowych, Christine Peschken, Cheryl Barnabe, Steve Edworthy, Sasha Bernatsky

Peripheral blood derived mononuclear cells enhance osteoarthritic human chondrocyte migration

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Niina Hopper, Frances Henson, Roger Brooks, Erden Ali, Neil Rushton, John Wardale

MRP8/14 serum levels as a predictor of response to starting and stopping anti-TNF treatment in juvenile idiopathic arthritis

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Janneke Anink, Lisette W. A. Van Suijlekom-Smit, Marieke H. Otten, Femke H. M. Prince, Marion A. J. van Rossum, Koert M. Dolman, Esther P. A. H. Hoppenreijs, Rebecca ten Cate, Simona Ursu, Lucy R. Wedderburn, Gerd Horneff, Michael Frosch, Thomas Vogl, Faekah Gohar, Dirk Foell, Johannes Roth, Dirk Holzinger

Biomarkers of pulmonary hypertension in patients with scleroderma: a case–control study

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Zsuzsanna McMahan, Florian Schoenhoff, Jennifer E. Van Eyk, Fredrick M. Wigley, Laura K. Hummers

Physical function continues to improve when clinical remission is sustained in rheumatoid arthritis patients

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Helga Radner, Farideh Alasti, Josef S. Smolen, Daniel Aletaha

The effects of experimental knee pain on lower limb corticospinal and motor cortex excitability

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David Andrew Rice, Thomas Graven-Nielsen, Gwyn Nancy Lewis, Peter John McNair, Nicola Dalbeth

A subset of patients with systemic lupus erythematosus fails to degrade DNA from multiple clinically relevant sources

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Jonatan Leffler, Katarzyna Ciacma, Birgitta Gullstrand, Anders A. Bengtsson, Myriam Martin, Anna M. Blom

Restrictive IgG antibody response against mutated citrullinated vimentin predicts response to rituximab in patients with rheumatoid arthritis

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Luisa Lindenberg, Lydia Spengler, Holger Bang, Thomas Dorner, Aleksej L Maslyanskiy, Sergey V Lapin, Elena I Ilivanova, Lorena Martinez-Gamboa, Hans Bastian, Esther Wittenborn, Karl Egerer, Gerd-R Burmester, Eugen Feist

Wolff’s law in action: a mechanism for early knee osteoarthritis

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Andrew J. Teichtahl, Anita E. Wluka, Pushpika Wijethilake, Yuanyuan Wang, Ali Ghasem-Zadeh, Flavia M. Cicuttini

Interferon gamma-inducible protein 16 in primary Sjögren’s syndrome: a novel player in disease pathogenesis?

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Alessia Alunno, Valeria Caneparo, Francesco Carubbi, Onelia Bistoni, Sara Caterbi, Elena Bartoloni, Roberto Giacomelli, Marisa Gariglio, Santo Landolfo, Roberto Gerli

Anti-citrullinated protein antibodies contribute to platelet activation in rheumatoid arthritis

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Kim L.L. Habets, Leendert A. Trouw, E.W. Nivine Levarht, Suzanne J.A. Korporaal, Petra A.M. Habets, Philip de Groot, Tom W.J. Huizinga, René E.M. Toes

Protein kinase C delta null mice exhibit structural alterations in articular surface, intra-articular and subchondral compartments

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Xiaohong Yang, Dian Teguh, Jian-Ping Wu, Bo He, Thomas Brett Kirk, Shengnan Qin, Siming Li, Honghui Chen, Wei Xue, Benjamin Ng, Shek Man Chim, Jennifer Tickner, Jiake Xu

Vitamin D deficiency in chronic inflammatory rheumatic diseases: results of the cardiovascular in rheumatology [CARMA] study

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Ana Urruticoechea-Arana, María A. Martín-Martínez, Santos Castañeda, Carlos A. Sanchez Piedra, Carlos González-Juanatey, Javier Llorca, Federico Díaz-Gonzalez, Miguel A. González-Gay

Incidence of malignancy in adult patients with rheumatoid arthritis: a meta-analysis

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Teresa A. Simon, Adam Thompson, Kunal K. Gandhi, Marc C. Hochberg, Samy Suissa

Nilotinib (Tasigna™) in the treatment of early diffuse systemic sclerosis: an open-label, pilot clinical trial

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Jessica K. Gordon, Viktor Martyanov, Cynthia Magro, Horatio F. Wildman, Tammara A. Wood, Wei-Ti Huang, Mary K. Crow, Michael L. Whitfield, Robert F. Spiera

Biocompatibility and intradiscal application of a thermoreversible celecoxib-loaded poly-N-isopropylacrylamide MgFe-layered double hydroxide hydrogel in a canine model

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Nicole Willems, Hsiao-yin Yang, Marloes L. P. Langelaan, Anna R. Tellegen, Guy C. M. Grinwis, Hendrik-Jan C. Kranenburg, Frank M. Riemers, Saskia G. M. Plomp, Eric G. M. Craenmehr, Wouter J. A. Dhert, Nicole E. Papen-Botterhuis, Björn P. Meij, Laura B. Creemers, Marianna A. Tryfonidou

Treatment of systemic lupus erythematosus patients with the BAFF antagonist “peptibody” blisibimod (AMG 623/A-623): results from randomized, double-blind phase 1a and phase 1b trials

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William Stohl, Joan T. Merrill, R. John Looney, Jill Buyon, Daniel J. Wallace, Michael H. Weisman, Ellen M. Ginzler, Blaire Cooke, Donna Holloway, Arunan Kaliyaperumal, Kameswara Rao Kuchimanchi, Tsui Chern Cheah, Erik Rasmussen, John Ferbas, Shelley S. Belouski, Wayne Tsuji, Debra J. Zack

Investigation of the relationship between the onset of arthritis and uveitis in genetically predisposed SKG mice

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Ellen J. Lee, Emily E. Vance, Brieanna R. Brown, Paige S. Snow, Jenna S. Clowers, Shimon Sakaguchi, Holly L. Rosenzweig

Abatacept decreases disease activity in the absence of CD4+ T cells in a collagen-induced arthritis model

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Diahann TSL Jansen, Hanane el Bannoudi, Ramon Arens, Kim LL Habets, Marjolijn Hameetman, Tom WJ Huizinga, Jeroen N. Stoop, René EM Toes

Plexin-D1/Semaphorin 3E pathway may contribute to dysregulation of vascular tone control and defective angiogenesis in systemic sclerosis

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Celestina Mazzotta, Eloisa Romano, Cosimo Bruni, Mirko Manetti, Gemma Lepri, Silvia Bellando-Randone, Jelena Blagojevic, Lidia Ibba-Manneschi, Marco Matucci-Cerinic, Serena Guiducci

Studies on ageing and the severity of radiographic joint damage in rheumatoid arthritis

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Lukas Mangnus, Hanna W. van Steenbergen, Elisabet Lindqvist, Elisabeth Brouwer, Monique Reijnierse, Tom WJ Huizinga, Peter K. Gregersen, Ewa Berglin, Solbritt Rantapää-Dahlqvist, Désirée van der Heijde, Annette HM van der Helm-van Mil

Effectiveness of imaging modalities for screening IgG4-related dacryoadenitis and sialadenitis (Mikulicz’s disease) and for differentiating it from Sjögren’s syndrome (SS), with an emphasis on sonography

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Mayumi Shimizu, Kazutoshi Okamura, Yoshitaka Kise, Yohei Takeshita, Hiroko Furuhashi, Warangkana Weerawanich, Masafumi Moriyama, Yukiko Ohyama, Sachiko Furukawa, Seiji Nakamura, Kazunori Yoshiura

A randomized, double-blind, placebo-controlled phase III trial of duloxetine in Japanese fibromyalgia patients

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Masato Murakami, Kenichi Osada, Hiromichi Mizuno, Toshimitsu Ochiai, Levent Alev, Kusuki Nishioka

On the predictive utility of animal models of osteoarthritis

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Anne-Marie Malfait, Christopher B. Little

Expression of Semaphorin 4A and its potential role in rheumatoid arthritis

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Lin Wang, Guanhua Song, Yabing Zheng, Weiwei Tan, Jihong Pan, Yu Zhao, Xiaotian Chang

A systematic review of the relationship between subchondral bone features, pain and structural pathology in peripheral joint osteoarthritis

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Andrew J. Barr, T. Mark Campbell, Devan Hopkinson, Sarah R. Kingsbury, Mike A. Bowes, Philip G. Conaghan

Phosphatase and tensin homolog (PTEN) in antigen-presenting cells controls Th17-mediated autoimmune arthritis

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Stephan Blüml, Emine Sahin, Victoria Saferding, Eliana Goncalves-Alves, Eva Hainzl, Birgit Niederreiter, Anastasia Hladik, Tobias Lohmeyer, Julia S. Brunner, Michael Bonelli, Marije I. Koenders, Wim B. van den Berg, Giulio Superti-Furga, Josef S. Smolen, Gernot Schabbauer, Kurt Redlich

Associations between circulating endostatin levels and vascular organ damage in systemic sclerosis and mixed connective tissue disease: an observational study

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Silje Reiseter, Øyvind Molberg, Ragnar Gunnarsson, May Brit Lund, Trond Mogens Aalokken, Pål Aukrust, Thor Ueland, Torhild Garen, Cathrine Brunborg, Annika Michelsen, Aurelija Abraityte, Anna-Maria Hoffmann-Vold

Disease flares in rheumatoid arthritis are associated with joint damage progression and disability: 10-year results from the BeSt study

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Iris M. Markusse, Linda Dirven, Andreas H. Gerards, Johannes H L M van Groenendael, H. Karel Ronday, Pit J S M Kerstens, Willem F. Lems, Tom W J Huizinga, Cornelia F. Allaart

Assessment of global DNA methylation in peripheral blood cell subpopulations of early rheumatoid arthritis before and after methotrexate

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María C. de Andres, Eva Perez-Pampin, Manuel Calaza, Francisco J. Santaclara, Ignacio Ortea, Juan J. Gomez-Reino, Antonio Gonzalez

CDP7657, an anti-CD40L antibody lacking an Fc domain, inhibits CD40L-dependent immune responses without thrombotic complications: an in vivo study

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Anthony Shock, Linda Burkly, Ian Wakefield, Christopher Peters, Ellen Garber, Janine Ferrant, Frederick R. Taylor, Lihe Su, Yen-Ming Hsu, David Hutto, Ali Amirkhosravi, Todd Meyer, John Francis, Sarah Malcolm, Martyn Robinson, Derek Brown, Stevan Shaw, Roland Foulkes, Alastair Lawson, Olivier Harari, Timothy Bourne, Alison Maloney, Neil Weir

Joint production of IL-22 participates in the initial phase of antigen-induced arthritis through IL-1β production

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Larissa G. Pinto, Jhimmy Talbot, Raphael S. Peres, Rafael F. Franca, Sérgio H. Ferreira, Bernhard Ryffel, José Carlos F. Aves-Filho, Florêncio Figueiredo, Thiago M. Cunha, Fernando Q. Cunha

Neuropathic-like pain features and cross-sectional associations in rheumatoid arthritis

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Sanne M. W. Koop, Peter M. ten Klooster, Harald E. Vonkeman, Laura M. M. Steunebrink, Mart A. F. J. van de Laar

Chimeric cells of maternal origin do not appear to be pathogenic in the juvenile idiopathic inflammatory myopathies or muscular dystrophy

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Carol M. Artlett, Sihem Sassi-Gaha, Ronald C. Ramos, Frederick W. Miller, Lisa G. Rider

Serum RANKL levels associate with anti- citrullinated protein antibodies in early untreated rheumatoid arthritis and are modulated following methotrexate

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Aase Haj Hensvold, Vijay Joshua, Wanying Li, Michaela Larkin, Ferhan Qureshi, Lena Israelsson, Leonid Padyukov, Karin Lundberg, Nadine Defranoux, Saedis Saevarsdottir, Anca Irinel Catrina

The biological basis of degenerative disc disease: proteomic and biomechanical analysis of the canine intervertebral disc

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William Mark Erwin, Leroi DeSouza, Martha Funabashi, Greg Kawchuk, Muhammad Zia Karim, Sarah Kim, Stefanie Mӓdler, Ajay Matta, Xiaomei Wang, K. Arne Mehrkens

Low numbers of blood and salivary natural killer cells are associated with a better response to belimumab in primary Sjögren’s syndrome: results of the BELISS study

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Raphaèle Seror, Gaétane Nocturne, Thierry Lazure, Houria Hendel-Chavez, Frédéric Desmoulins, Rakiba Belkhir, Philippe Ravaud, Mohcine Benbijja, Vichnou Poirier-Colame, Yacine Taoufik, Xavier Mariette

Variation at interleukin-6 receptor gene is associated to joint damage in rheumatoid arthritis

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Maria Lopez-Lasanta, Antonio Julià, Joan Maymó, Benjamín Fernández-Gutierrez, Inmaculada Ureña-Garnica, Francisco J. Blanco, Juan D. Cañete, Mercedes Alperi-López, Alex Olivè, Héctor Corominas, Jesus Tornero, Alba Erra, Miriam Almirall, Nuria Palau, Ana Ortiz, Gabriela Avila, Luis Rodriguez-Rodriguez, Arnald Alonso, Raül Tortosa, Isidoro Gonzalez-Alvaro, Sara Marsal

Efficacy and safety of canakinumab in adolescents and adults with colchicine-resistant familial Mediterranean fever

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Ahmet Gül, Huri Ozdogan, Burak Erer, Serdal Ugurlu, Ozgur Kasapcopur, Nicole Davis, Serhan Sevgi

IL2RA is associated with persistence of rheumatoid arthritis

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H.W. van Steenbergen, J.A.B. van Nies, A. Ruyssen-Witrand, T.W.J. Huizinga, Al. Cantagrel, F. Berenbaum, A.H.M. van der Helm-van Mil

Certolizumab pegol plus methotrexate 5-year results from the rheumatoid arthritis prevention of structural damage (RAPID) 2 randomized controlled trial and long-term extension in rheumatoid arthritis patients

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Josef S. Smolen, Ronald van Vollenhoven, Arthur Kavanaugh, Vibeke Strand, Jiri Vencovsky, Michael Schiff, Robert Landewé, Boulos Haraoui, Catherine Arendt, Irina Mountian, David Carter, Désirée van der Heijde

Does evaluation of the ligamentous compartment enhance diagnostic utility of sacroiliac joint MRI in axial spondyloarthritis?

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Ulrich Weber, Walter P. Maksymowych, Stanley M. Chan, Kaspar Rufibach, Susanne J. Pedersen, Zheng Zhao, Veronika Zubler, Mikkel Østergaard, Robert GW Lambert

Macitentan inhibits the transforming growth factor-β profibrotic action, blocking the signaling mediated by the ETR/TβRI complex in systemic sclerosis dermal fibroblasts

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Paola Cipriani, Paola Di Benedetto, Piero Ruscitti, Daniela Verzella, Mariafausta Fischietti, Francesca Zazzeroni, Vasiliki Liakouli, Francesco Carubbi, Onorina Berardicurti, Edoardo Alesse, Roberto Giacomelli

O-linked N-acetylglucosamine glycosylation of p65 aggravated the inflammation in both fibroblast-like synoviocytes stimulated by tumor necrosis factor-α and mice with collagen induced arthritis

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Han Byeol Kim, Sang Won Lee, Chin Hee Mun, Ji Young Yoon, Jaeyoung Pai, Injae Shin, Yong Beom Park, Soo Kon Lee, Jin Won Cho

Apremilast, a novel phosphodiesterase 4 (PDE4) inhibitor, regulates inflammation through multiple cAMP downstream effectors

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Miguel Perez-Aso, M. Carmen Montesinos, Aránzazu Mediero, Tuere Wilder, Peter H. Schafer, Bruce Cronstein

How hepatitis C virus modifies the immunological profile of Sjögren syndrome: analysis of 783 patients

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Pilar Brito-Zerón, Hoda Gheitasi, Soledad Retamozo, Albert Bové, María Londoño, Jose-Maria Sánchez-Tapias, Miguel Caballero, Belchin Kostov, Xavier Forns, Srini V. Kaveri, Manuel Ramos-Casals

The inhibitory effects of a RANKL-binding peptide on articular and periarticular bone loss in a murine model of collagen-induced arthritis: a bone histomorphometric study

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Genki Kato, Yasuhiro Shimizu, Yuki Arai, Natsuki Suzuki, Yasutaka Sugamori, Miki Maeda, Mariko Takahashi, Yukihiko Tamura, Noriyuki Wakabayashi, Ramachandran Murali, Takashi Ono, Keiichi Ohya, Setsuko Mise-Omata, Kazuhiro Aoki

Serum calprotectin (S100A8/9): an independent predictor of ultrasound synovitis in patients with rheumatoid arthritis

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Jana Hurnakova, Jakub Zavada, Petra Hanova, Hana Hulejova, Martin Klein, Herman Mann, Olga Sleglova, Marta Olejarova, Sarka Forejtova, Olga Ruzickova, Martin Komarc, Jiri Vencovsky, Karel Pavelka, Ladislav Senolt

Recombinant human SIRT1 protects against nutrient deprivation-induced mitochondrial apoptosis through autophagy induction in human intervertebral disc nucleus pulposus cells

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Shingo Miyazaki, Kenichiro Kakutani, Takashi Yurube, Koichiro Maeno, Toru Takada, Zhongying Zhang, Takuto Kurakawa, Yoshiki Terashima, Masaaki Ito, Takeshi Ueha, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka, Kotaro Nishida

Fatigue in chronic inflammation - a link to pain pathways

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Karine Louati, Francis Berenbaum

Erratum to: A prospective evaluation of ultrasound as a diagnostic tool in acute microcrystalline arthritis

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  • Erratum

Pascal Zufferey, Roxana Valcov, Isabelle Fabreguet, Alexandre Dumusc, Patrick Omoumi, Alexander So

Enhanced activity of NLRP3 inflammasome in peripheral blood cells of patients with active rheumatoid arthritis

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Christianna Choulaki, Garyfallia Papadaki, Argyro Repa, Eleni Kampouraki, Konstantinos Kambas, Konstantinos Ritis, George Bertsias, Dimitrios T. Boumpas, Prodromos Sidiropoulos

Experimental knee pain impairs submaximal force steadiness in isometric, eccentric, and concentric muscle actions

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David A. Rice, Peter J. McNair, Gwyn N. Lewis, Jamie Mannion

Association of CXCL10 and CXCL13 levels with disease activity and cutaneous manifestation in active adult-onset Still’s disease

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Jae Ho Han, Chang-Hee Suh, Ju-Yang Jung, Jin-Young Nam, Jee Eun Kwon, Hyunee Yim, Hyoun-Ah Kim

Significantly impaired shoulder function in the first years of rheumatoid arthritis: a controlled study

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Annelie Bilberg, Tomas Bremell, Istvan Balogh, Kaisa Mannerkorpi

Reanalysis of the Rituximab in ANCA-Associated Vasculitis trial identifies granulocyte subsets as a novel early marker of successful treatment

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Mazen Nasrallah, Yannick Pouliot, Bjoern Hartmann, Patrick Dunn, Elizabeth Thomson, Jeffrey Wiser, Atul J. Butte

Body mass index modulates the relationship of sugar-sweetened beverage intake with serum urate concentrations and gout

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Nicola Dalbeth, Amanda Phipps-Green, Meaghan E. House, Gregory D. Gamble, Anne Horne, Lisa K. Stamp, Tony R. Merriman

Overexpression of MMP13 in human osteoarthritic cartilage is associated with the SMAD-independent TGF-β signalling pathway

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Erfan Aref-Eshghi, Ming Liu, Patricia E. Harper, Jules Doré, Glynn Martin, Andrew Furey, Roger Green, Proton Rahman, Guangju Zhai

Sponyloarthritis features forecasting the presence of HLA-B27 or sacroiliitis on magnetic resonance imaging in patients with suspected axial spondyloarthritis: results from a cross-sectional study in the ESPeranza Cohort

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Victoria Navarro-Compán, Eugenio de Miguel, Désirée van der Heijde, Robert Landewé, Raquel Almodóvar, Carlos Montilla, Emma Beltrán, Pedro Zarco

Subclinical synovitis detected by macrophage PET, but not MRI, is related to short-term flare of clinical disease activity in early RA patients: an exploratory study

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Yoony Y. J. Gent, Marieke M. ter Wee, Alexandre E. Voskuyl, Debby den Uyl, Nazanin Ahmadi, Cristina Dowling, Cornelis van Kuijk, Otto S. Hoekstra, Maarten Boers, Willem F. Lems, Conny J. van der Laken

Effect of dexamethasone prodrug on inflamed temporomandibular joints in juvenile rats

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Mitchell Knudsen, Matthew Bury, Callie Holwegner, Adam L. Reinhardt, Fang Yuan, Yijia Zhang, Peter Giannini, David B. Marx, Dong Wang, Richard A. Reinhardt

Histone deacetylase inhibition activates Nrf2 and protects against osteoarthritis

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Dawei Cai, Shasha Yin, Jun Yang, Qing Jiang, Wangsen Cao

Bone marrow lesions can be subtyped into groups with different clinical outcomes using two magnetic resonance imaging (MRI) sequences

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Anita E. Wluka, Andrew J. Teichtahl, Rheza Maulana, Bonnie M. Liu, Yuanyuan Wang, Graham G. Giles, Richard O’Sullivan, David Findlay, Flavia M. Cicuttini

Preserved skeletal muscle protein anabolic response to acute exercise and protein intake in well-treated rheumatoid arthritis patients

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Ulla Ramer Mikkelsen, Kasper Dideriksen, Mads Bisgaard Andersen, Anders Boesen, Nikolai Mølkjær Malmgaard-Clausen, Inge Juul Sørensen, Peter Schjerling, Michael Kjær, Lars Holm

Effects of non-pharmacological interventions on inflammatory biomarker expression in patients with fibromyalgia: a systematic review

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Kenji Sanada, Marta Alda Díez, Montserrat Salas Valero, María Cruz Pérez-Yus, Marcelo M P Demarzo, Mauro García-Toro, Javier García-Campayo

Diagnostic performance of measuring antibodies to the glycopeptidolipid core antigen specific to Mycobacterium avium complex in patients with rheumatoid arthritis: results from a cross-sectional observational study

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Wataru Hirose, Takashi Uchiyama, Asuka Nemoto, Masayoshi Harigai, Kenji Itoh, Toshiaki Ishizuka, Mitsuyo Matsumoto, Kazue Yamaoka, Toshihiro Nanki

Systematic review and meta-analysis of the sero-epidemiological association between Epstein-Barr virus and rheumatoid arthritis

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Robert J. Ball, Alison Avenell, Lorna Aucott, Peter Hanlon, Mark A. Vickers

CD1a+ survivin+ dendritic cell infiltration in dermal lesions of systemic sclerosis

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Sho Mokuda, Tatsuhiko Miyazaki, Yoshifumi Ubara, Masamoto Kanno, Eiji Sugiyama, Kiyoshi Takasugi, Junya Masumoto

An investigation of the added value of an ACPA multiplex assay in an early rheumatoid arthritis setting

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Jurgen van Heemst, Leendert A. Trouw, Leonor Nogueira, Hanna W. van Steenbergen, Annette H. M. van der Helm-van Mil, Cornelia F. Allaart, Guy Serre, Rikard Holmdahl, Tom W. J. Huizinga, René E. M. Toes, Diane van der Woude

Early treatment with hydroxychloroquine prevents the development of endothelial dysfunction in a murine model of systemic lupus erythematosus

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Agostino Virdis, Chiara Tani, Emiliano Duranti, Sabrina Vagnani, Linda Carli, Anja A. Kühl, Anna Solini, Chiara Baldini, Rosaria Talarico, Stefano Bombardieri, Stefano Taddei, Marta Mosca

Low-intensity pulsed ultrasound rescues insufficient salivary secretion in autoimmune sialadenitis

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Minami Sato, Shingo Kuroda, Karima Qurnia Mansjur, Ganzorig Khaliunaa, Kumiko Nagata, Shinya Horiuchi, Toshihiro Inubushi, Yoshiko Yamamura, Masayuki Azuma, Eiji Tanaka

Rosuvastatin improves endothelial function in patients with inflammatory joint diseases, longitudinal associations with atherosclerosis and arteriosclerosis: results from the RORA-AS statin intervention study

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Eirik Ikdahl, Jonny Hisdal, Silvia Rollefstad, Inge C. Olsen, Tore K. Kvien, Terje R. Pedersen, Anne Grete Semb

Non-adherence to disease-modifying antirheumatic drugs is associated with higher disease activity in early arthritis patients in the first year of the disease

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Annelieke Pasma, Charlotte V. Schenk, Reinier Timman, Jan J. V. Busschbach, Bart J.F. van den Bemt, Esmeralda Molenaar, Willemijn H. van der Laan, Saskia Schrauwen, Adriaan van’t Spijker, Johanna M. W. Hazes

Safety, tolerability, pharmacokinetics, and efficacy of AMG 403, a human anti-nerve growth factor monoclonal antibody, in two phase I studies with healthy volunteers and knee osteoarthritis subjects

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Jason M. Gow, Wayne H. Tsuji, Gary J. Williams, Daniel Mytych, David Sciberras, Shawn L. Searle, Tim Mant, John P. Gibbs

Serum hyaluronic acid concentration predicts the progression of joint space narrowing in normal knees and established knee osteoarthritis – a five-year prospective cohort study

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Eiji Sasaki, Eiichi Tsuda, Yuji Yamamoto, Shugo Maeda, Ryo Inoue, Daisuke Chiba, Hiroshi Fujita, Ippei Takahashi, Takashi Umeda, Shigeyuki Nakaji, Yasuyuki Ishibashi

High serum cholesterol predicts rheumatoid arthritis in women, but not in men: a prospective study

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Carl Turesson, Ulf Bergström, Mitra Pikwer, Jan-Åke Nilsson, Lennart TH Jacobsson

Bach1 deficiency reduces severity of osteoarthritis through upregulation of heme oxygenase-1

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Tsuyoshi Takada, Shigeru Miyaki, Hiroyuki Ishitobi, Yuya Hirai, Tomoyuki Nakasa, Kazuhiko Igarashi, Martin K. Lotz, Mitsuo Ochi

Role of PTPN22 and CSK gene polymorphisms as predictors of susceptibility and clinical heterogeneity in patients with Henoch-Schönlein purpura (IgA vasculitis)

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Raquel López-Mejías, Fernanda Genre, Sara Remuzgo-Martínez, Belén Sevilla Pérez, Santos Castañeda, Javier Llorca, Norberto Ortego-Centeno, Begoña Ubilla, Verónica Mijares, Trinitario Pina, Vanesa Calvo-Río, Natalia Palmou, José A. Miranda-Filloy, Antonio Navas Parejo, Diego Argila, Javier Sánchez-Pérez, Esteban Rubio, Manuel León Luque, Juan María Blanco-Madrigal, Eva Galíndez-Aguirregoikoa, J. Gonzalo Ocejo-Vinyals, Javier Martín, Ricardo Blanco, Miguel A. González-Gay

Spatiotemporal gait compensations following medial collateral ligament and medial meniscus injury in the rat: correlating gait patterns to joint damage

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Heidi E. Kloefkorn, Brittany Y. Jacobs, Ayomiposi M. Loye, Kyle D. Allen

Multiplicative interaction of functional inflammasome genetic variants in determining the risk of gout

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Cushla McKinney, Lisa K. Stamp, Nicola Dalbeth, Ruth K. Topless, Richard O. Day, Diluk RW Kannangara, Kenneth M. Williams, Matthijs Janssen, Timothy L. Jansen, Leo A. Joosten, Timothy R. Radstake, Philip L. Riches, Anne-Kathrin Tausche, Frederic Lioté, Alexander So, Tony R. Merriman

Continuously elevated serum matrix metalloproteinase-3 for 3 ~ 6 months predict one-year radiographic progression in rheumatoid arthritis: a prospective cohort study

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Jian-Da Ma, Xiu-Ning Wei, Dong-Hui Zheng, Ying-Qian Mo, Le-Feng Chen, Xiang Zhang, Jin-Hua Li, Lie Dai

Celebrating the past, concentrating on the future: the next decade for AR&T

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  • Editorial

Christopher D. Buckley, Harris Perlman

Conditional deletion of caspase-8 in macrophages alters macrophage activation in a RIPK-dependent manner

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Carla M. Cuda, Alexander V. Misharin, Sonal Khare, Rana Saber, FuNien Tsai, Amy M. Archer, Philip J. Homan, G. Kenneth Haines III, Jack Hutcheson, Andrea Dorfleutner, G. R. Scott Budinger, Christian Stehlik, Harris Perlman

Impaired function of endothelial progenitor cells in children with primary systemic vasculitis

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Ying Hong, Despina Eleftheriou, Nigel J. Klein, Paul A. Brogan

Analyzing pathogenic (double-stranded (ds) DNA-specific) plasma cells via immunofluorescence microscopy

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Oliver Winter, Stephanie Musiol, Melissa Schablowsky, Qingyu Cheng, Laleh Khodadadi, Falk Hiepe

The prevalence of vertebral fractures in spondyloarthritis: relation to disease characteristics, bone mineral density, syndesmophytes and history of back pain and trauma

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Piet Geusens, Liesbeth De Winter, Dana Quaden, Johan Vanhoof, Debby Vosse, Joop van den Bergh, Veerle Somers

Methotrexate polyglutamates as a potential marker of adherence to long-term therapy in children with juvenile idiopathic arthritis and juvenile dermatomyositis: an observational, cross-sectional study

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Ahmed F. Hawwa, AbdelQader AlBawab, Madeleine Rooney, Lucy R. Wedderburn, Michael W. Beresford, James C. McElnay

Utility of untimed single urine protein/creatinine ratio as a substitute for 24-h proteinuria for assessment of proteinuria in systemic lupus erythematosus

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Jorge Medina-Rosas, Dafna D. Gladman, Jiandong Su, Arthy Sabapathy, Murray B. Urowitz, Zahi Touma

A Dose–response relationship between severity of disc degeneration and intervertebral disc height in the lumbosacral spine

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Andrew J. Teichtahl, Donna M. Urquhart, Yuanyuan Wang, Anita E. Wluka, Stephane Heritier, Flavia M. Cicuttini

Association of physical activity and physical performance with tibial cartilage volume and bone area in young adults

  • Open Access
  • Research article

Benny Antony, Alison Venn, Flavia Cicuttini, Lyn March, Leigh Blizzard, Terence Dwyer, Marita Cross, Graeme Jones, Changhai Ding

Antigen-induced arthritis in rats is associated with increased growth-associated protein 43–positive intraepidermal nerve fibres remote from the joint

  • Open Access
  • Research article

Elisabeth Jochmann, Michael Karl Boettger, Praveen Anand, Hans-Georg Schaible

Direct effects of HP Acthar Gel® on human B lymphocyte activation in vitro

  • Open Access
  • Research article

Nancy J. Olsen, Dima A. Decker, Paul Higgins, Patrice M. Becker, Carl A. McAloose, Ann L. Benko, William J. Kovacs

Update on mesenchymal stem cell-based therapy in lupus and scleroderma

  • Open Access
  • Review

Audrey Cras, Dominique Farge, Thierry Carmoi, Jean-Jacques Lataillade, Dan Dan Wang, Lingyun Sun

Is urate crystal precipitation a predictor of cardiovascular risk in hyperuricemic patients? A Danish cohort study

  • Open Access
  • Research article

Kasper Søltoft Larsen, Anton Pottegård, Hanne Lindegaard, Jesper Hallas

Different responses to treatment across classified diseases and severities in Japanese patients with microscopic polyangiitis and granulomatosis with polyangiitis: a nationwide prospective inception cohort study

  • Open Access
  • Research article

Ken-ei Sada, Masahiro Yamamura, Masayoshi Harigai, Takao Fujii, Yoshinari Takasaki, Koichi Amano, Shouichi Fujimoto, Eri Muso, Yohko Murakawa, Yoshihiro Arimura, Hirofumi Makino

PTGER4 gene variant rs76523431 is a candidate risk factor for radiological joint damage in rheumatoid arthritis patients: a genetic study of six cohorts

  • Open Access
  • Research article

Luis Rodriguez-Rodriguez, Jose Ivorra-Cortes, F. David Carmona, Javier Martín, Alejandro Balsa, Hanna W. van Steenbergen, Annette H. M. van der Helm-van Mil, Isidoro González-Álvaro, Benjamín Fernandez-Gutiérrez

Effects of tofacitinib monotherapy on patient-reported outcomes in a randomized phase 3 study of patients with active rheumatoid arthritis and inadequate responses to DMARDs

  • Open Access
  • Research article

Vibeke Strand, Joel Kremer, Gene Wallenstein, Keith S. Kanik, Carol Connell, David Gruben, Samuel H. Zwillich, Roy Fleischmann

68Ga-DOTA-Siglec-9 – a new imaging tool to detect synovitis

  • Open Access
  • Research article

Helena Virtanen, Anu Autio, Riikka Siitonen, Heidi Liljenbäck, Tiina Saanijoki, Petteri Lankinen, Jussi Mäkilä, Meeri Käkelä, Jarmo Teuho, Nina Savisto, Kimmo Jaakkola, Sirpa Jalkanen, Anne Roivainen

A novel method to detect articular chondrocyte death during early stages of osteoarthritis using a non-invasive ApoPep-1 probe

  • Open Access
  • Research article

Xiangguo Che, Lianhua Chi, Clara Yongjoo Park, Gyoung-Ho Cho, Narae Park, Seong-Gon Kim, Byung-Heon Lee, Je-Yong Choi

Erratum to: Continuously elevated serum matrix metalloproteinase-3 for 3 ~ 6 months predict one-year radiographic progression in rheumatoid arthritis: a prospective cohort study

  • Open Access
  • Erratum

Jian-Da Ma, Xiu-Ning Wei, Dong-Hui Zheng, Ying-Qian Mo, Le-Feng Chen, Xiang Zhang, Jin-Hua Li, Lie Dai

Measuring the positive psychological well-being of people with rheumatoid arthritis: a cross-sectional validation of the subjective vitality scale

  • Open Access
  • Research article

Peter C. Rouse, Jet J. J. C. S. Veldhuijzen Van Zanten, Nikos Ntoumanis, George S. Metsios, Chen-an Yu, George D. Kitas, Joan L. Duda

p21 deficiency is susceptible to osteoarthritis through STAT3 phosphorylation

  • Open Access
  • Research article

Shinya Hayashi, Takaaki Fujishiro, Shingo Hashimoto, Noriyuki Kanzaki, Nobuaki Chinzei, Shinsuke Kihara, Koji Takayama, Tomoyuki Matsumoto, Kotaro Nishida, Masahiro Kurosaka, Ryosuke Kuroda

Effect of antiresorptive and anabolic bone therapy on development of osteoarthritis in a posttraumatic rat model of OA

  • Open Access
  • Research article

Cedo M. Bagi, Edwin Berryman, David E. Zakur, Dean Wilkie, Catharine J. Andresen

Excessive reactive oxygen species are therapeutic targets for intervertebral disc degeneration

  • Open Access
  • Research article

Satoshi Suzuki, Nobuyuki Fujita, Naobumi Hosogane, Kota Watanabe, Ken Ishii, Yoshiaki Toyama, Keiyo Takubo, Keisuke Horiuchi, Takeshi Miyamoto, Masaya Nakamura, Morio Matsumoto

Higher education is associated with a better rheumatoid arthritis outcome concerning for pain and function but not disease activity: results from the EIRA cohort and Swedish rheumatology register

  • Open Access
  • Research article

Xia Jiang, Maria E. C. Sandberg, Saedis Saevarsdottir, Lars Klareskog, Lars Alfredsson, Camilla Bengtsson

A large infrapatellar fat pad protects against knee pain and lateral tibial cartilage volume loss

  • Open Access
  • Research article

Andrew J. Teichtahl, Ema Wulidasari, Sharmayne R. E. Brady, Yuanyuan Wang, Anita E. Wluka, Changhai Ding, Graham G. Giles, Flavia M. Cicuttini

Incidence and complications of interstitial lung disease in users of tocilizumab, rituximab, abatacept and anti-tumor necrosis factor α agents, a retrospective cohort study

  • Open Access
  • Research article

Jeffrey R. Curtis, Khaled Sarsour, Pavel Napalkov, Laurie A. Costa, Kathy L. Schulman

Fibronectin fragment-induced expression of matrix metalloproteinases is mediated by MyD88-dependent TLR-2 signaling pathway in human chondrocytes

  • Open Access
  • Research article

Hyun Sook Hwang, Su Jin Park, Eun Jeong Cheon, Mi Hyun Lee, Hyun Ah Kim

Development of key performance indicators to evaluate centralized intake for patients with osteoarthritis and rheumatoid arthritis

  • Open Access
  • Research article

Claire E. Barber, Jatin N. Patel, Linda Woodhouse, Christopher Smith, Stephen Weiss, Joanne Homik, Sharon LeClercq, Dianne Mosher, Tanya Christiansen, Jane Squire Howden, Tracy Wasylak, James Greenwood-Lee, Andrea Emrick, Esther Suter, Barb Kathol, Dmitry Khodyakov, Sean Grant, Denise Campbell-Scherer, Leah Phillips, Jennifer Hendricks, Deborah A. Marshall

Gout, not hyperuricemia alone, impairs left ventricular diastolic function

  • Open Access
  • Research article

Jing-Chi Lin, Chun-Liang Lin, Mien-Cheng Chen, Pey-Jium Chang, Shih-Tai Chang, Chang-Min Chung, Kuo-Li Pan

A subset of CD163+ macrophages displays mixed polarizations in discoid lupus skin

  • Open Access
  • Research article

Benjamin F. Chong, Lin-chiang Tseng, Gregory A. Hosler, Noelle M. Teske, Song Zhang, David R. Karp, Nancy J. Olsen, Chandra Mohan

Twenty-eight-week results from the REALISTIC phase IIIb randomized trial: efficacy, safety and predictability of response to certolizumab pegol in a diverse rheumatoid arthritis population

  • Open Access
  • Research article

Michael E. Weinblatt, Roy Fleischmann, Ronald F. van Vollenhoven, Paul Emery, Tom WJ Huizinga, Maurizio Cutolo, Désirée van der Heijde, Benjamin Duncan, Owen Davies, Kristel Luijtens, Maxime Dougados

Cross-talk between bone morphogenetic proteins and inflammatory pathways

  • Open Access
  • Editorial

Peter M. van der Kraan, Esmeralda N. Blaney Davidson

Cartilage stem/progenitor cells are activated in osteoarthritis via interleukin-1β/nerve growth factor signaling

  • Open Access
  • Research article

Yangzi Jiang, Changchang Hu, Shuting Yu, Junwei Yan, Hsuan Peng, Hong Wei Ouyang, Rocky S. Tuan

Is RANKL inhibition both anti-resorptive and anabolic in rheumatoid arthritis?

  • Open Access
  • Editorial

Natalie A. Sims, Evange Romas

High frequency ultrasound of skin involvement in systemic sclerosis – a follow-up study

  • Open Access
  • Research article

Roger Hesselstrand, Johanna Carlestam, Marie Wildt, Gunnel Sandqvist, Kristofer Andréasson

Tumor necrosis factor-α blockade in recurrent and disabling chronic sciatica associated with post-operative peridural lumbar fibrosis: results of a double-blind, placebo randomized controlled study

  • Open Access
  • Research article

Christelle Nguyen, Clémence Palazzo, Sophie Grabar, Antoine Feydy, Katherine Sanchez, Nathalie Zee, Laurent Quinquis, Myriam Ben Boutieb, Michel Revel, Marie-Martine Lefèvre-Colau, Serge Poiraudeau, François Rannou

Citral alleviates an accelerated and severe lupus nephritis model by inhibiting the activation signal of NLRP3 inflammasome and enhancing Nrf2 activation

  • Open Access
  • Research article

Shuk-Man Ka, Jung-Chen Lin, Tsai-Jung Lin, Feng-Cheng Liu, Louis Kuoping Chao, Chen-Lung Ho, Li-Tzu Yeh, Huey-Kang Sytwu, Kuo-Feng Hua, Ann Chen

Inhibition of angiogenesis by platelets in systemic sclerosis patients

  • Open Access
  • Research article

Daniela Hirigoyen, Paula I. Burgos, Veronica Mezzano, Josefina Duran, Magaly Barrientos, Claudia G. Saez, Olga Panes, Diego Mezzano, Mirentxu Iruretagoyena

Association between environmental exposures and granulomatosis with polyangiitis in Canterbury, New Zealand

  • Open Access
  • Research article

Lisa K. Stamp, Peter T. Chapman, Janine Francis, Lutz Beckert, Christopher Frampton, Richard A. Watts, John L. O’Donnell

Interleukin-6-dependent influence of nociceptive sensory neurons on antigen-induced arthritis

  • Open Access
  • Research article

Matthias Ebbinghaus, Gisela Segond von Banchet, Julia Massier, Mieczyslaw Gajda, Rolf Bräuer, Michaela Kress, Hans-Georg Schaible

Serum leptin and serum leptin/serum leptin receptor ratio imbalance in obese rheumatoid arthritis patients positive for anti-cyclic citrullinated peptide antibodies

  • Open Access
  • Research article

Eduardo Gómez-Bañuelos, Rosa Elena Navarro-Hernández, Fernanda Corona-Meraz, Perla Monserrat Madrigal-Ruíz, Beatríz Teresita Martín-Marquez, Oscar Enrique Pizano-Martinez, Jorge Aguilar-Arreola, Paul Jacob Perez-Cruz, Hector Macias-Reyes, Laura Gonzalez-Lopez, Jorge Ivan Gamez-Nava, Mario Salazar-Páramo, Monica Vazquez-del Mercado

Probability and heritability estimates on primary osteoarthritis of the hip leading to total hip arthroplasty: a nationwide population based follow-up study in Danish twins

  • Open Access
  • Research article

Søren Glud Skousgaard, Jacob Hjelmborg, Axel Skytthe, Lars Peter Andreas Brandt, Sören Möller, Søren Overgaard

Peripheral blood natural killer cell percentages in granulomatosis with polyangiitis correlate with disease inactivity and stage

  • Open Access
  • Research article

Wolfgang Merkt, Prisca Sturm, Felix Lasitschka, Theresa Tretter, Carsten Watzl, Daniel Saure, Michael Hundemer, Vedat Schwenger, Norbert Blank, Hanns-Martin Lorenz, Adelheid Cerwenka

Antibodies against High Mobility Group Box protein-1 (HMGB1) versus other anti-nuclear antibody fine-specificities and disease activity in systemic lupus erythematosus

  • Open Access
  • Research article

Lina Wirestam, Hanna Schierbeck, Thomas Skogh, Iva Gunnarsson, Lars Ottosson, Helena Erlandsson-Harris, Jonas Wetterö, Christopher Sjöwall

The specificity of anti-carbamylated protein antibodies for rheumatoid arthritis in a setting of early arthritis

  • Open Access
  • Research article

Jing Shi, Hanna W. van Steenbergen, Jessica A. B. van Nies, E. W. Nivine Levarht, Tom W. J. Huizinga, Annette H. M. van der Helm-van Mil, René E. M. Toes, Leendert A. Trouw

Soluble PD-1 aggravates progression of collagen-induced arthritis through Th1 and Th17 pathways

  • Open Access
  • Research article

Cuiping Liu, Juean Jiang, Li Gao, Xiaoting Wang, Xiaohan Hu, Min Wu, Jian Wu, Ting Xu, Qin Shi, Xueguang Zhang

Serum tenascin-C discriminates patients with active SLE from inactive patients and healthy controls and predicts the need to escalate immunosuppressive therapy: a cohort study

  • Open Access
  • Research article

Jakub Závada, Michal Uher, Radka Svobodová, Marta Olejárová, Markéta Hušáková, Hana Ciferská, Hana Hulejová, Michal Tomčík, Ladislav Šenolt, Jiří Vencovský

An HLA-C amino-acid variant in addition to HLA-B*27 confers risk for ankylosing spondylitis in the Korean population

  • Open Access
  • Research article

Kwangwoo Kim, So-Young Bang, Seunghun Lee, Hye-Soon Lee, Seung-Cheol Shim, Young Mo Kang, Chang-Hee Suh, Celi Sun, Swapan K. Nath, Sang-Cheol Bae, Tae-Hwan Kim

Impact of certolizumab pegol on patient-reported outcomes in rheumatoid arthritis and correlation with clinical measures of disease activity

  • Open Access
  • Research article

Janet Pope, Clifton O. Bingham III, Roy M. Fleischmann, Maxime Dougados, Elena M. Massarotti, Jürgen Wollenhaupt, Benjamin Duncan, Geoffroy Coteur, Michael E. Weinblatt

CCR6+ Th cell populations distinguish ACPA positive from ACPA negative rheumatoid arthritis

  • Open Access
  • Research article

Sandra M. J. Paulissen, Jan Piet van Hamburg, Nadine Davelaar, Heleen Vroman, Johanna M. W. Hazes, Pascal H. P. de Jong, Erik Lubberts

Statistical considerations for stopping systemic lupus erythematosus clinical trials earlier

  • Open Access
  • Review

Robert A. Lew, Matthew H. Liang, Gheorghe Doros

Aesthetic discomfort in hand osteoarthritis: results from the LIège Hand Osteoarthritis Cohort (LIHOC)

  • Open Access
  • Research article

Audrey Neuprez, Olivier Bruyère, Emmanuel Maheu, Nadia Dardenne, Nansa Burlet, Pieter D’Hooghe, Stéphan Distèche, Jean-Yves Reginster

BAFF inhibition does not significantly impair immunization responses in patients with rheumatoid arthritis

  • Open Access
  • Letter

Clifton O. Bingham III, Kevin L. Winthrop, Lili Yang, Chin Lee, Wendy J. Komocsar

Determinants of patient preferences for total knee replacement: African-Americans and whites

  • Open Access
  • Research article

C. Kent Kwoh, Ernest R. Vina, Yona K. Cloonan, Michael J. Hannon, Robert M. Boudreau, Said A. Ibrahim

Discovery of a novel genetic susceptibility locus on X chromosome for systemic lupus erythematosus

  • Open Access
  • Research article

Zhengwei Zhu, Zhuoyuan Liang, Herty Liany, Chao Yang, Leilei Wen, Zhiming Lin, Yujun Sheng, Yan Lin, Lei Ye, Yuyan Cheng, Yan Chang, Lu Liu, Lulu Yang, Yinjuan Shi, Changbing Shen, Fusheng Zhou, Xiaodong Zheng, Jun Zhu, Bo Liang, Yantao Ding, Yi Zhou, Xianyong Yin, Huayang Tang, Xianbo Zuo, Liangdan Sun, Jin-Xin Bei, Jianjun Liu, Sen Yang, Wanling Yang, Yong Cui, Xuejun Zhang

High level of interleukin-32 gamma in the joint of ankylosing spondylitis is associated with osteoblast differentiation

  • Open Access
  • Research article

Eun-Ju Lee, Eun-Jin Lee, Yeon-Ho Chung, Da-Hyun Song, Seokchan Hong, Chang-Keun Lee, Bin Yoo, Tae-Hwan Kim, Ye-Soo Park, Soo-Hyun Kim, Eun-Ju Chang, Yong-Gil Kim

Stratifying primary Sjögren’s syndrome: killers in the balance?

  • Open Access
  • Editorial

Simon J. Bowman, Benjamin A. Fisher

Triamcinolone acetonide activates an anti-inflammatory and folate receptor–positive macrophage that prevents osteophytosis in vivo

  • Open Access
  • Research article

Michiel Siebelt, Nicoline Korthagen, Wu Wei, Harald Groen, Yvonne Bastiaansen-Jenniskens, Christina Müller, Jan Hendrik Waarsing, Marion de Jong, Harrie Weinans

The interaction of lubricin/proteoglycan 4 (PRG4) with toll-like receptors 2 and 4: an anti-inflammatory role of PRG4 in synovial fluid

  • Open Access
  • Research article

Ali Alquraini, Steven Garguilo, Gerard D’Souza, Ling X. Zhang, Tannin A. Schmidt, Gregory D. Jay, Khaled A. Elsaid

Retraction Note: Mast cells are the main interleukin 17-positive cells in anticitrullinated protein antibody-positive and -negative rheumatoid arthritis and osteoarthritis synovium

  • Open Access
  • Retraction Note

Jolien Suurmond, Annemarie L. Dorjée, Mariëtte R. Boon, Edward F. Knol, Tom W. J. Huizinga, René E. M. Toes, Annemie J. M. Schuerwegh

A low cortisol response to stress is associated with musculoskeletal pain combined with increased pain sensitivity in young adults: a longitudinal cohort study

  • Open Access
  • Research article

Markus Paananen, Peter O’Sullivan, Leon Straker, Darren Beales, Pieter Coenen, Jaro Karppinen, Craig Pennell, Anne Smith

Simultaneous inhibition of JAK and SYK kinases ameliorates chronic and destructive arthritis in mice

  • Open Access
  • Research article

Alba Llop-Guevara, Mónica Porras, Carla Cendón, Irene Di Ceglie, Francesco Siracusa, Federica Madarena, Vagelis Rinotas, Lluís Gómez, Peter L. van Lent, Eleni Douni, Hyun Dong Chang, Thomas Kamradt, Juan Román

Effect of abatacept on the immunogenicity of 23-valent pneumococcal polysaccharide vaccination (PPSV23) in rheumatoid arthritis patients

  • Open Access
  • Research article

Kiyoshi Migita, Yukihiro Akeda, Manabu Akazawa, Shigeto Tohma, Fuminori Hirano, Haruko Ideguchi, Hideko Kozuru, Yuka Jiuchi, Ryutaro Matsumura, Eiichi Suematsu, Tomoya Miyamura, Shunsuke Mori, Takahiro Fukui, Yasumori Izumi, Nozomi Iwanaga, Hiroshi Tsutani, Kouichirou Saisyo, Takao Yamanaka, Shiro Ohshima, Naoya Mori, Akinori Matsumori, Koichiro Takahi, Shigeru Yoshizawa, Yojiro Kawabe, Yasuo Suenaga, Tetsuo Ozawa, Norikazu Hamada, Yasuhiro Komiya, Toshihiro Matsui, Hiroshi Furukawa, Kazunori Oishi

Parity influences the severity of ACPA-negative early rheumatoid arthritis: a cohort study based on the Swedish EIRA material

  • Open Access
  • Research article

Mitra Pikwer, Cecilia Orellana, Henrik Källberg, Andreas Pikwer, Carl Turesson, Lars Klareskog, Lars Alfredsson, Saedis Saevarsdottir, Camilla Bengtsson

Investigating CD11c expression as a potential genomic biomarker of response to TNF inhibitor biologics in whole blood rheumatoid arthritis samples

  • Open Access
  • Research article

Samantha Louise Smith, Stephen Eyre, Annie Yarwood, Kimme Hyrich, Ann W. Morgan, A. G. Wilson, John Isaacs, Darren Plant, Anne Barton

The effectiveness of low-level laser therapy for nonspecific chronic low back pain: a systematic review and meta-analysis

  • Open Access
  • Research article

ZeYu Huang, Jun Ma, Jing Chen, Bin Shen, FuXing Pei, Virginia Byers Kraus

Cytokine preconditioning of engineered cartilage provides protection against interleukin-1 insult

  • Open Access
  • Research article

Andrea R. Tan, Curtis D. VandenBerg, Mukundan Attur, Steven B. Abramson, Martin M Knight, J. Chloe Bulinski, Gerard A. Ateshian, James L Cook, Clark T. Hung

Systematic review and meta-analysis of serious infections with tofacitinib and biologic disease-modifying antirheumatic drug treatment in rheumatoid arthritis clinical trials

  • Open Access
  • Research article

Vibeke Strand, Sima Ahadieh, Jonathan French, Jamie Geier, Sriram Krishnaswami, Sujatha Menon, Tina Checchio, Thomas G. Tensfeldt, Elaine Hoffman, Richard Riese, Mary Boy, Juan J. Gómez-Reino

The HLA-B*35 allele modulates ER stress, inflammation and proliferation in PBMCs from Limited Cutaneous Systemic Sclerosis patients

  • Open Access
  • Research article

Stefania Lenna, Shervin Assassi, G. Alessandra Farina, Julio C. Mantero, Raffaella Scorza, Robert Lafyatis, Harrison W. Farber, Maria Trojanowska

Supplement of 5-hydroxytryptophan before induction suppresses inflammation and collagen-induced arthritis

  • Open Access
  • Research article

Tao-Hsiang Yang, Peng-Yang Hsu, Menghsiao Meng, Che-Chun Su

Serological epitope profile of anti-Ro52–positive patients with systemic autoimmune rheumatic diseases

  • Open Access
  • Research article

Maria Infantino, Francesca Meacci, Valentina Grossi, Maurizio Benucci, Gabriella Morozzi, Elio Tonutti, Marilina Tampoia, Antonina Ott, Wolfgang Meyer, Fabiola Atzeni, Piercarlo Sarzi-Puttini, Mariangela Manfredi, Nicola Bizzaro

Minorities with lupus nephritis and medications: a study of facilitators to medication decision-making

  • Open Access
  • Research article

Jasvinder A. Singh, Haiyan Qu, Jinoos Yazdany, Winn Chatham, Richard Shewchuk

IgG4-related sialadenitis: IgG4 is helpful, but biopsies are still crucial

  • Open Access
  • Editorial

Torsten Witte, Hendrik Schulze-Koops

Inflammatory but not apoptotic death of granulocytes citrullinates fibrinogen

  • Open Access
  • Research article

Nathalie E. Blachère, Salina Parveen, John Fak, Mayu O. Frank, Dana E. Orange

Nerves are more abundant than blood vessels in the degenerate human intervertebral disc

  • Open Access
  • Research article

Abbie L. A. Binch, Ashley A. Cole, Lee M. Breakwell, Antony L. R. Michael, Neil Chiverton, Laura B. Creemers, Alison K. Cross, Christine L. Le Maitre

Prognostic value of anti-CRP antibodies in lupus nephritis in long-term follow-up

  • Open Access
  • Research article

Satu Sinikka Pesickova, Romana Rysava, Martin Lenicek, Libor Vitek, Eliska Potlukova, Zdenka Hruskova, Eva Jancova, Eva Honsova, Jakub Zavada, Marten Trendelenburg, Vladimir Tesar

Predictors of lung function decline in scleroderma-related interstitial lung disease based on high-resolution computed tomography: implications for cohort enrichment in systemic sclerosis–associated interstitial lung disease trials

  • Open Access
  • Research article

Dinesh Khanna, Vivek Nagaraja, Chi-hong Tseng, Fereidoun Abtin, Robert Suh, Grace Kim, Athol Wells, Daniel E. Furst, Philip J. Clements, Michael D. Roth, Donald P. Tashkin, Jonathan Goldin

Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin-1β

  • Open Access
  • Research article

Clare L. Thompson, Riana Patel, Terri-Ann N. Kelly, Angus K. T. Wann, Clark T. Hung, J. Paul Chapple, Martin M. Knight

Half of UK patients with rheumatoid arthritis are prescribed oral glucocorticoid therapy in primary care: a retrospective drug utilisation study

  • Open Access
  • Research article

Rachel J. Black, Rebecca M. Joseph, Benjamin Brown, Mohammad Movahedi, Mark Lunt, William G. Dixon

In vivo optical imaging of early osteoarthritis using an antibody specific to damaged arthritic cartilage

  • Open Access
  • Research article

Ngee Han Lim, Tonia L. Vincent, Ahuva Nissim

Alterations of bone mineral density, bone microarchitecture and strength in patients with ankylosing spondylitis: a cross-sectional study using high-resolution peripheral quantitative computerized tomography and finite element analysis

  • Open Access
  • Research article

Nisha Nigil Haroon, Eva Szabo, Janet M. Raboud, Heather Mcdonald-Blumer, Lydia Fung, Robert G. Josse, Robert D. Inman, Angela M. Cheung

Soluble biglycan: a potential mediator of cartilage degradation in osteoarthritis

  • Open Access
  • Research article

Goncalo Barreto, Antti Soininen, Pekka Ylinen, Jerker Sandelin, Yrjö T. Konttinen, Dan C. Nordström, Kari K. Eklund

The beneficial effects of Tai Chi exercise on endothelial function and arterial stiffness in elderly women with rheumatoid arthritis

  • Open Access
  • Research article

Jeong-Hun Shin, Yonggu Lee, Soon Gil Kim, Bo Youl Choi, Hye-Soon Lee, So-Young Bang

Dysregulation of RasGRP1 in rheumatoid arthritis and modulation of RasGRP3 as a biomarker of TNFα inhibitors

  • Open Access
  • Research article

Marie-Laure Golinski, Thibault Vandhuick, Céline Derambure, Manuel Fréret, Matthieu Lecuyer, Clément Guillou, Martine Hiron, Olivier Boyer, Xavier Le Loët, Olivier Vittecoq, Thierry Lequerré

Usefulness of using laser-induced photoacoustic measurement and 3.0 Tesla MRI to assess knee cartilage damage: a comparison study

  • Open Access
  • Research article

Taku Ukai, Masato Sato, Miya Ishihara, Munetaka Yokoyama, Tomonori Takagaki, Genya Mitani, Yoshiki Tani, Tomohiro Yamashita, Yutaka Imai, Joji Mochida

Maintenance of autoantibody production in pristane-induced murine lupus

  • Open Access
  • Research article

Shuhong Han, Haoyang Zhuang, Yuan Xu, Pui Lee, Yi Li, Joseph C. Wilson, Osvaldo Vidal, Hong Seok Choi, Yu Sun, Li-Jun Yang, Westley H. Reeves

Kompaktes Leitlinien-Wissen Innere Medizin (Link öffnet in neuem Fenster)

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Leitlinien-Wissen kostenlos und immer griffbereit auf ihrem Desktop, Handy oder Tablet.

Neu im Fachgebiet Innere Medizin

Ohne Arztkittel nicht vertrauenswürdig?

Hausärztinnen und -ärzte werden immer noch am liebsten im traditionellen weißen Kittel gesehen, so das Ergebnis eines systematischen Reviews. Dabei scheinen vor allem männliche Patienten zunehmend auch ein saloppes Outfit zu billigen – allerdings nur beim Arzt, nicht bei der Ärztin.

Gemischte Ergebnisse für PROTAC-Östrogenrezeptor-Degrader

In der Phase-III-Studie VERITAC-2 schnitt Vepdegestant mit Blick auf das progressionsfreie Überleben nur in der Subgruppe der Patientinnen mit ESR1-mutierten rezidivierten Mammakarzinomen besser ab als Fulvestrant. Interessant sind die Ergebnisse im größeren Forschungskontext aber so oder so.

Bis zu 40% der Krebsüberlebenden leiden langfristig an Fatigue

Nach Resultaten einer deutschen Analyse klagt mehr als ein Drittel der Menschen nach einer überstandenen Brust-, Darm- oder Prostatakrebserkrankung über Fatigue. Bei den betroffenen Menschen ist auch die Sterberate zumindest kurzfristig erhöht.

Metformin bei metastasiertem Prostatakarzinom nicht lebensverlängernd

Die Hoffnung, durch Metformin die Überlebensaussichten bei hormonsensitivem metastasiertem Prostatakrebs zu verbessern, hat sich in der Phase-3-Studie STAMPEDE nicht erfüllt. Trotzdem liefert die Studie mögliche Argumente für eine ergänzende Behandlung mit dem Antidiabetikum.

EKG Essentials: EKG befunden mit System (Link öffnet in neuem Fenster)

In diesem CME-Kurs können Sie Ihr Wissen zur EKG-Befundung anhand von zwölf Video-Tutorials auffrischen und 10 CME-Punkte sammeln.
Praxisnah, relevant und mit vielen Tipps & Tricks vom Profi.

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