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Arthritis Research & Therapy

Ausgabe 1/2024

Inhalt (91 Artikel)

Open Access Research

Monocyte-derived transcriptomes explain the ineffectiveness of abatacept in rheumatoid arthritis

Takeshi Iwasaki, Ryu Watanabe, Hiromu Ito, Takayuki Fujii, Koichiro Ohmura, Hiroyuki Yoshitomi, Koichi Murata, Kosaku Murakami, Akira Onishi, Masao Tanaka, Shuichi Matsuda, Fumihiko Matsuda, Akio Morinobu, Motomu Hashimoto

Open Access Research

Exosome-mediated delivery of super-repressor IκBα alleviates inflammation and joint damages in rheumatoid arthritis

Hae-In Lee, Min-Joo Ahn, Jae-Kwang Yoo, So-Hee Ahn, Seon Young Park, Hyangmi Seo, Moon-Ju Kim, Yu Jeong Lee, Hyun Hee Jang, Seung Cheol Shim, Eun Jeong Won, Cheolhyoung Park, Chulhee Choi, Tae-Jong Kim

Open Access Research

Changes in type VI collagen degradation reflect clinical response to treatment in rheumatoid arthritis patients treated with tocilizumab

Christian S. Thudium, Peder Frederiksen, Morten A. Karsdal, Anne-Christine Bay-Jensen

Open Access Research

Nailfold videocapillaroscopy in antineutrophil cytoplasmic antibody–associated vasculitis

Megan M. Sullivan, Andy Abril, Nabeel Aslam, Colleen T. Ball, Florentina Berianu

Open Access Research

Causality between rheumatoid arthritis and the risk of cognitive impairment: a Mendelian randomization study

Lincheng Duan, Shiyin Li, Haoming Li, Yue Shi, Xiaolong Xie, Yue Feng

Open Access Research

Clinical characteristics of hypertrophic cranial pachymeningitis in granulomatosis with polyangiitis: a retrospective single-center study in China

Yiran Chen, Lijuan Gou, Li Wang, Min Qian, Qingjun Wu, Wenjie Zheng, Mengtao Li, Xiaofeng Zeng, Fengchun Zhang

Open Access Research

Decreased expression of NAT10 in peripheral blood mononuclear cells from new-onset ankylosing spondylitis and its clinical significance

Qing Luo, Juxiang Zhu, Shiqian Wang, Peng fu, Biqi Fu, Zikun Huang, Junming Li

Open Access Research

Proteomic profiling identifies SPP1 associated with rapidly progressive interstitial lung disease in anti-MDA5-positive dermatomyositis

Yulu Qiu, Xiaoke Feng, Chang Liu, Yumeng Shi, Lingxiao Xu, Hanxiao You, Lei Wang, Chengyin Lv, Fang Wang, Wenfeng Tan

Open Access Research

Inhibitory effects of Acanthopanax sessiliflorus Harms extract on the etiology of rheumatoid arthritis in a collagen-induced arthritis mouse model

Dahye Kim, Yunji Heo, Mangeun Kim, Godagama Gamaarachchige Dinesh Suminda, Umar Manzoor, Yunhui Min, Minhye Kim, Jiwon Yang, Youngjun Park, Yaping Zhao, Mrinmoy Ghosh, Young-Ok Son

Open Access Research

Transcriptional profiling of human cartilage endplate cells identifies novel genes and cell clusters underlying degenerated and non-degenerated phenotypes

Kyle Kuchynsky, Patrick Stevens, Amy Hite, William Xie, Khady Diop, Shirley Tang, Maciej Pietrzak, Safdar Khan, Benjamin Walter, Devina Purmessur

Open Access Research

Usefulness of 18F-FDG PET-CT for assessing large-vessel involvement in patients with suspected giant cell arteritis and negative temporal artery biopsy

Javier Narváez, Paula Estrada, Paola Vidal-Montal, Iván Sánchez-Rodríguez, Aida Sabaté-Llobera, Joan Miquel Nolla, Montserrat Cortés-Romera

Open Access Research

The effects of suppressing inflammation by tofacitinib may simultaneously improve glycaemic parameters and inflammatory markers in rheumatoid arthritis patients with comorbid type 2 diabetes: a proof-of-concept, open, prospective, clinical study

Claudia Di Muzio, Ilenia Di Cola, Azadeh Shariat Panahi, Francesco Ursini, Annamaria Iagnocco, Roberto Giacomelli, Paola Cipriani, Piero Ruscitti

Open Access Research

Management and treatment outcomes of rheumatoid arthritis in the era of biologic and targeted synthetic therapies: evaluation of 10-year data from the KURAMA cohort

Takayuki Fujii, Koichi Murata, Hideo Onizawa, Akira Onishi, Masao Tanaka, Kosaku Murakami, Kohei Nishitani, Moritoshi Furu, Ryu Watanabe, Motomu Hashimoto, Hiromu Ito, Takao Fujii, Tsuneyo Mimori, Akio Morinobu, Shuichi Matsuda

Open Access Research

Characteristics of the synovial microenvironment and synovial mesenchymal stem cells with hip osteoarthritis of different bone morphologies

Yang Yang, Hideyuki Koga, Yusuke Nakagawa, Tomomasa Nakamura, Hiroki Katagiri, Ryohei Takada, Mai Katakura, Kunikazu Tsuji, Ichiro Sekiya, Kazumasa Miyatake

Open Access Research

Synovial tissue features associated with poor prognosis in inflammatory arthritis

Ana Belén Azuaga, Andrea Cuervo, Raquel Celis, Beatriz Frade-Sosa, Juan C. Sarmiento-Monroy, Virginia Ruiz-Esquide, José A. Gómez-Puerta, Raimon Sanmartí, Julio Ramírez

Open Access Research

Specific-cytokine associations with outcomes in knee osteoarthritis subgroups: breaking down disease heterogeneity with phenotyping

Joan Calvet, Antoni Berenguer-Llergo, Cristóbal Orellana, María García-Manrique, Menna Rusiñol, Silvia Garcia-Cirera, Maria Llop, Marta Arévalo, Alba Garcia-Pinilla, Carlos Galisteo, Cristina Aymerich, Rafael Gómez, Alejandra Serrano, Anna Carreras, Jordi Gratacós

Open Access Research

ADAM8 silencing suppresses the migration and invasion of fibroblast-like synoviocytes via FSCN1/MAPK cascade in osteoarthritis

Kai Chen, Huaqiang Tao, Pengfei Zhu, Miao Chu, Xueyan Li, Yi Shi, Liyuan Zhang, Yaozeng Xu, Shujun Lv, Lixin Huang, Wei Huang, Dechun Geng

Open Access Research

Impaired immune tolerance mediated by reduced Tfr cells in rheumatoid arthritis linked to gut microbiota dysbiosis and altered metabolites

Ruihe Wu, Dongming Wang, Liyun Cheng, Rui Su, Baochen Li, Chunxue Fan, Chong Gao, Caihong Wang

Open Access Correction

Correction: NOD2 attenuates osteoarthritis via reprogramming the activation of synovial macrophages

Changchuan Li, Zhuji Ouyang, Yuhsi Huang, Sipeng Lin, Shixun Li, Jing Xu, Taihe Liu, Jionglin Wu, Peidong Guo, Zhong Chen, Haoyu Wu, Yue Ding

Open Access Research

Cartilage destruction in early rheumatoid arthritis patients correlates with CD21−/low double-negative B cells

Katrin Thorarinsdottir, Sarah McGrath, Kristina Forslind, Monica Leu Agelii, Anna-Karin Hultgård Ekwall, Lennart T. H. Jacobsson, Anna Rudin, Inga-Lill Mårtensson, Inger Gjertsson

Open Access Review

Molecular imaging for evaluation of synovitis associated with osteoarthritis: a narrative review

Kwanghoon Lee, Soheil Niku, Sonya J. Koo, Ernest Belezzuoli, Monica Guma

Open Access Research

CXCL9 may serve as a potential biomarker for primary Sjögren’s syndrome with extra-glandular manifestations

Jingwei Hong, Hui Cheng, Ping Wang, Yanzhi Wu, Saisai Lu, Yan Zhou, Xiao bing Wang, Xiaofang Zhu

Open Access Research

Safety and tolerability of intravenous immunoglobulin in patients with active dermatomyositis: results from the randomised, placebo-controlled ProDERM study

Rohit Aggarwal, Joachim Schessl, Christina Charles-Schoeman, Zsuzsanna Bata-Csörgő, Mazen M. Dimachkie, Zoltan Griger, Sergey Moiseev, Chester V. Oddis, Elena Schiopu, Jiri Vencovský, Irene Beckmann, Elisabeth Clodi, Todd Levine

Open Access Research

Children systemic lupus erythematosus-associated pancreatitis

Dan Zhang, Jianming Lai, Gaixiu Su, Jia Zhu, Min, Kang, Ming Li, Yingjie Xu, Li Meng

Open Access Research

Protein profiling in systemic sclerosis patients with different pulmonary complications using proteomic antibody microarray

Jing Huang, Honglin Zhu, Sijia Liu, Mengtao Li, Yisha Li, Hui Luo, Xiaoxia Zuo

Open Access Research

Association of biochemical markers with bone marrow lesion changes on imaging—data from the Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium

Shirley P. Yu, Leticia A. Deveza, Virginia B. Kraus, Morten Karsdal, Anne-Christine Bay-Jensen, Jamie E. Collins, Ali Guermazi, Frank W. Roemer, Christoph Ladel, Venkatesha Bhagavath, David J. Hunter

Open Access Research

Potential role of RhoA GTPase regulation in type interferon signaling in systemic lupus erythematosus

Wei Fan, Bo Wei, Xuyan Chen, Yi Zhang, Pingping Xiao, Kaiyan Li, Yi qin Zhang, Jinmei Huang, Lin Leng, Richard Bucala

Open Access Research

PD-1 signaling uncovers a pathogenic subset of T cells in inflammatory arthritis

Johanna Straube, Shoiab Bukhari, Shalom Lerrer, Robert J. Winchester, Yevgeniya Gartshteyn, Brian S. Henick, Matthew A. Dragovich, Adam Mor

Open Access Research

Tetraspanin profiles of serum extracellular vesicles reflect functional limitations and pain perception in knee osteoarthritis

Anne-Mari Mustonen, Mari Palviainen, Laura Säisänen, Lauri Karttunen, Sylvain Tollis, Amir Esrafilian, Jusa Reijonen, Petro Julkunen, Pia R-M Siljander, Heikki Kröger, Jussi Mäki, Jari Arokoski, Petteri Nieminen

Open Access Correction

Correction: Iguratimod attenuated fbrosis in systemic sclerosis via targeting early growth response 1 expression

Lichong Shen, Hanlin Yin, Li Sun, Zhiliang Zhang, Yuyang Jin, Shan Cao, Qiong Fu, Chaofan Fan, Chunde Bao, Liangjing Lu, Yifan Zhan, Xiaojiang Xu, Xiaoxiang Chen, Qingran Yan

Open Access Research

Endoplasmic reticulum aminopeptidase 2 regulates CD4+ T cells pyroptosis in rheumatoid arthritis

Jianhua Zhang, Hao Cai, Weiwei Sun, Weijie Wu, Yunyi Nan, Yingchen Ni, Xinyuan Wu, Minhao Chen, Hua Xu, Youhua Wang

Open Access Research

Apolipoproteins and the risk of giant cell arteritis—a nested case–control study

Karin Wadström, Lennart T. H. Jacobsson, Aladdin J. Mohammad, Kenneth J. Warrington, Eric L. Matteson, Carl Turesson

Open Access Research

Interaction of 5-HTTLPR and SLE disease status on resting-state brain function

Lihua Ma, Yifan Yang, Shu Li, Bibhuti Upreti, Shuang Liu, Xiangyu Wang, Ru Bai, Yuqi Cheng, Jian Xu

Open Access Correction

Correction: CircPTPN22 modulates T‑cell activation by sponging miR‑4689 to regulate S1PR1 expression in patients with systemic lupus erythematosus

Zhuyan Jiang, Shifei Li, Yuying Jia, Qijun Wu, Xuemeng Chen, Mengjie Zhang, Qingqing Miao, Zhiting Zhong, Zhifang Zhai, Bing Ni, Jun Xiao, Jun Tang

Open Access Research

Induction of cervical disc degeneration and discogenic pain by low concentration Propionibacterium acnes infection: an in vivo animal study

Jie Li, Hui Li, Yilei Chen, Dikai Bei, Bao Huang, Kaifeng Gan, Peiming Sang, Junhui Liu, Zhi Shan, Jian Chen, Fengdong Zhao, Binhui Chen

Open Access Research

Patients with obesity have more inflamed joints and higher CRP levels during the disease course in ACPA-positive RA but not in ACPA-negative RA

N. K. den Hollander, A. M. P Boeren, A. H. M. van der Helm-van Mil, H. W. van Steenbergen

Open Access Review

Manifestations and management of Sjögren’s disease

Mehrnaz Maleki-Fischbach, Liudmila Kastsianok, Matthew Koslow, Edward D. Chan

Open Access Research

Prediction of ineffectiveness of biological drugs using machine learning and explainable AI methods: data from the Austrian Biological Registry BioReg

Dubravka Ukalovic, Burkhard F. Leeb, Bernhard Rintelen, Gabriela Eichbauer-Sturm, Peter Spellitz, Rudolf Puchner, Manfred Herold, Miriam Stetter, Vera Ferincz, Johannes Resch-Passini, Jochen Zwerina, Marcus Zimmermann-Rittereiser, Ruth Fritsch-Stork

Open Access Research

Interaction of genetic variation at ADH1B and MLXIPL with alcohol consumption for elevated serum urate level and gout among people of European ethnicity

Min H Chuah, Megan P Leask, Ruth K Topless, Gregory D Gamble, Nicholas A Sumpter, Lisa K Stamp, Tony R Merriman, Nicola Dalbeth

Open Access Research

Macrophage subpopulations in pediatric patients with lupus nephritis and other inflammatory diseases affecting the kidney

Mira Sandersfeld, Maike Büttner-Herold, Fulvia Ferrazzi, Kerstin Amann, Kerstin Benz, Christoph Daniel

Open Access Research

Large-scale integrative analysis of juvenile idiopathic arthritis for new insight into its pathogenesis

Daeun Kim, Jaeseung Song, Nicholas Mancuso, Serghei Mangul, Junghyun Jung, Wonhee Jang

Open Access Research

Evaluating the safety profile of calcineurin inhibitors: cancer risk in patients with systemic lupus erythematosus from the LUNA registry—a historical cohort study

Kunihiro Ichinose, Shuntaro Sato, Takashi Igawa, Momoko Okamoto, Ayuko Takatani, Yushiro Endo, Sosuke Tsuji, Toshimasa Shimizu, Remi Sumiyoshi, Tomohiro Koga, Shin-ya Kawashiri, Naoki Iwamoto, Mami Tamai, Hideki Nakamura, Tomoki Origuchi, Nobuyuki Yajima, Ken-Ei Sada, Yoshia Miyawaki, Ryusuke Yoshimi, Yasuhiro Shimojima, Shigeru Ohno, Hiroshi Kajiyama, Shuzo Sato, Michio Fujiwara, Atsushi Kawakami

Open Access Research

Long-term safety of Ixekizumab in adults with psoriasis, psoriatic arthritis, or axial spondyloarthritis: a post-hoc analysis of final safety data from 25 randomized clinical trials

Atul Deodhar, Andrew Blauvelt, Mark Lebwohl, Meghan Feely, Andris Kronbergs, Nadezhda Eberhart, Danting Zhu, Elsa Inman, Elsie Grace, Thorsten Holzkaemper, Proton Rahman, Helena Marzo-Ortega, Kim A. Papp, Joseph F. Merola, Alice B. Gottlieb, Sergio Schwartzman

Open Access Review

Improvement in work productivity among psoriatic arthritis patients treated with biologic or targeted synthetic drugs: a systematic literature review and meta-analysis

Laure Gossec, Brittany Humphries, Megan Rutherford, Vanessa Taieb, Damon Willems, William Tillett

Open Access Correspondence

Lipoxygenase-derived oxylipins are enriched in anti-citrullinated protein antibody (ACPA)-positive individuals at risk for developing rheumatoid arthritis

Liam J. O’Neil, Vidyanand Anaparti, Tanja Winter, Irene Smolik, Xiaobo Meng, Harold M. Aukema, Hani El-Gabalawy

Open Access Research

Regulatory T and B cells in pediatric Henoch–Schönlein purpura: friends or foes?

Anne Filleron, Renaud Cezar, Marc Fila, Nastassja Protsenko, Kathleen Van Den Hende, Eric Jeziorski, Bob Occean, Thierry Chevallier, Pierre Corbeau, Tu Anh Tran

Open Access Research

Targeting an inflammation-amplifying cell population can attenuate osteoarthritis-associated pain

Akshay Pandey, Mamta Singla, Ana Geller, Stuart B. Goodman, Nidhi Bhutani

Open Access Research

Longitudinal patterns and predictors of response to standard-of-care therapy in lupus nephritis: data from the Accelerating Medicines Partnership Lupus Network

Peter M. Izmirly, Mimi Y. Kim, Philip M. Carlucci, Katherine Preisinger, Brooke Z. Cohen, Kristina Deonaraine, Devyn Zaminski, Maria Dall’Era, Kenneth Kalunian, Andrea Fava, H. Michael Belmont, Ming Wu, Chaim Putterman, Jennifer Anolik, Jennifer L. Barnas, Betty Diamond, Anne Davidson, David Wofsy, Diane Kamen, Judith A. James, Joel M. Guthridge, William Apruzzese, Deepak A. Rao, Michael H. Weisman, Darren Tabechian, Ralf Thiele, Jennifer Hossler, Brendan Boyce, Nida Meednu, Javier Rangel-Moreno, Christopher Ritchlin, Vivian Bykerk, Laura Donlin, Susan Goodman, Lionel Ivashkiv, Alessandra Pernis, Ed DiCarlo, Dana Orange, John Carrino, Oganna Nwawka, Endo Yoshimi, Rahul Satija, Lionel Ivashkiv, Robert Darnell, Mark Figgie, Michael McNamara, Larry W. Moreland, Mandy J. McGeachy, Jay Kolls, Aaron Wise, Andrew Cordle, Peter Gregersen, Diane Horowitz, Andrew D. Filer, Jason Turner, Holly Adams, Costantino Pitzalis, Stephen Kelly, Rebecca Hands, Michael Brenner, Derrick Todd, Kevin Wei, Deepak Rao, Fumitaka Mizoguchi, V. Michael Holers, Kevin D. Deane, Jennifer A. Seifert, Nirmal K. Banda, Gary S. Firestein, David Boyle, Ami Ben-Artzi, Lindsy Forbess, Ellen Gravallese, Karen Salomon-Escoto, Harris Perlman, Arthur Mandelin, Emily Bacalao, Deborah Parks, John Atkinson, Joan Bathon, Eric Matteson, Louis Bridges, Laura B. Hughes, David Fox, Robert Ike, Chun-Hao Lee, Derek Fine, Manny Monroy-Trujillo, Jennifer Anolik, Ummara Shah, Michael Weisman, Mariko Ishimori, Jill P. Buyon, Robert M. Clancy, Peter Izmirly, Michael Belmont, Nicole Bornkamp, Evan Der, Beatrice Goilav, Nicole Jordan, Daniel Schwartz, James Pullman, Dawn Smilek, Patti Tosta, Matthias Kretzler, Celine C. Berthier, F. Steve Woodle, Dave Hildeman, Michael Brenner, Deepak Rao, William Robinson, Garry Nolan, Veronica Gonzales, Michael Brenner, Deepak Rao, Kevin Wei, Jim Lederer, Joshua Keegan, Adam Chicoine, Yanyan Liu, Gerald Watts, Nir Hacohen, Arnon Arazi, David Lieb, Thomas Eisenhaure, Thomas Tuschl, P. J. Utz, Mina Rohani-Pichavant, Rohit Gupta, Holden Maecker, Maria Sargent, Soumya Raychaudhuri, Yvonne Lee, Kamil Slowikowski, Chamith Fonseka, Fan Zhang, Maria Guitierrez-Arcelus, Justine Buschman, Jennifer Chi, Su-Yau Mao, Susana Serrate-Sztein, Yan Wang, Quan Chen, John Peyman, Ellen Goldmuntz, Patrick Dunn, Michelle Petri, Jill Buyon, Richard Furie

Open Access Research

Single-cell RNA sequencing of submandibular gland reveals collagen type XV-positive fibroblasts as a disease-characterizing cell population of IgG4-related disease

Shigeru Tanaka, Takuya Yamamoto, Arifumi Iwata, Masahiro Kiuchi, Kota Kokubo, Tomohisa Iinuma, Takahiro Sugiyama, Toyoyuki Hanazawa, Kiyoshi Hirahara, Kei Ikeda, Hiroshi Nakajima

Open Access Research

Impact of multimorbidity on the first ts/bDMARD effectiveness and retention rate after two years of follow-up in patients with rheumatoid arthritis from the BIOBADASER registry

Jerusalem Calvo-Gutiérrez, Clementina López-Medina, Lucía Otero-Varela, Alejandro Escudero-Contreras, Rafaela Ortega-Castro, Lourdes Ladehesa-Pineda, Cristina Campos, Pilar Bernabeu-Gonzalvez, Ana Pérez-Gómez, Alicia García-Dorta, Dolores Ruiz-Montesino, Manuel Pombo-Suarez, Inmaculada Ros-Vilamajo, Fernando Sánchez-Alonso, Isabel Castrejón

Open Access Research

Identifying functional dysregulation of NOD2 variant Q902K in patients with Yao syndrome

Jingyuan Zhang, Yi Luo, Bingxuan Wu, Xin Huang, Mengzhu Zhao, Na Wu, Junke Miao, Ji Li, Lei Zhu, Di Wu, Min Shen

Open Access Research

Distinct uric acid trajectories are associated with incident cardiac conduction block

Na Li, Liufu Cui, Rong Shu, Haicheng Song, Jierui Wang, Shuohua Chen, Gary Tse, Nan Zhang, Xuemei Yang, Wenqi Xu, Shouling Wu, Tong Liu

Open Access Review

Vaccination and the risk of systemic lupus erythematosus: a meta-analysis of observational studies

Meijiao Wang, Huanpeng Gu, Yingqi Zhai, Xuanlin Li, Lin Huang, Haichang Li, Zhijun Xie, Chengping Wen

Open Access Research

Urinary prostanoids are elevated by anti-TNF and anti-IL6 receptor disease-modifying antirheumatic drugs but are not predictive of response to treatment in early rheumatoid arthritis

Jianyang Liu, Helena Idborg, Marina Korotkova, Kristina Lend, Ronald van Vollenhoven, Jon Lampa, Anna Rudin, Dan Nordström, Bjorn Gudbjornsson, Gerdur Gröndal, Till Uhlig, Kim Hørslev-Petersen, Merete Lund Hetland, Mikkel Østergaard, Michael Nurmohamed, Per-Johan Jakobsson

Open Access Research

B cell receptor repertoire analysis in primary Sjogren’s syndrome salivary glands identifies repertoire features associated with clinical activity

Ling Chang, Zihan Zheng, Yiwen Zhou, Kun Liu, Yinong Li, Bing Zhong, Zihua Zhao, Chengshun Chen, Can Qian, Qingshan Ni, Qinghua Zou, Yuzhang Wu, Jingyi Li, Liyun Zou

Open Access Research

Effect of remission, clinical remission with active serology, and glucocorticoid dosage on the pregnancy outcome of pregnant patients with systemic lupus erythematosus

Takehiro Nakai, Nanase Honda, Eri Soga, Sho Fukui, Ayako Kitada, Naoto Yokogawa, Masato Okada

Open Access Research

LATS2 degradation promoted fibrosis damage and rescued by vitamin K3 in lupus nephritis

Chen Cheng, Hao Yang, Chan Yang, Juan Xie, Jinshen Wang, Luping Cheng, Jianfu He, Honglian Li, Haoxing Yuan, Fangfang Guo, Minmin Li, Shuwen Liu

Open Access Research

Low CD4 + T cell count is related to specific anti-nuclear antibodies, IFNα protein positivity and disease activity in systemic lupus erythematosus pregnancy

Agnes Torell, Marit Stockfelt, Kaj Blennow, Henrik Zetterberg, Tansim Akhter, Dag Leonard, Lars Rönnblom, Sofia Pihl, Muna Saleh, Christopher Sjöwall, Helena Strevens, Andreas Jönsen, Anders A. Bengtsson, Estelle Trysberg, Maria Majczuk Sennström, Agneta Zickert, Elisabet Svenungsson, Iva Gunnarsson, Johan Bylund, Bo Jacobsson, Anna Rudin, Anna-Carin Lundell

Open Access Research

Streamlined, single-step non-viral CRISPR-Cas9 knockout strategy enhances gene editing efficiency in primary human chondrocyte populations

Simone Ponta, Angela Bonato, Philipp Neidenbach, Valentino F. Bruhin, Alexis Laurent, Lee Ann Applegate, Marcy Zenobi-Wong, Goncalo Barreto

Open Access Research

Antiphospholipid antibodies as potential predictors of disease severity and poor prognosis in systemic lupus erythematosus-associated thrombocytopenia: results from a real-world CSTAR cohort study

Jun Li, Liying Peng, Lijun Wu, Yufang Ding, Xinwang Duan, Jian Xu, Wei Wei, Zhen Chen, Cheng Zhao, Min Yang, Nan Jiang, Shangzhu Zhang, Qian Wang, Xinping Tian, Mengtao Li, Xiaofeng Zeng, Yan Zhao, Jiuliang Zhao

Open Access Research

Concomitant Sjögren’s disease as a biomarker for treatment effectiveness in rheumatoid arthritis - results from the Swiss clinical quality management cohort

Lisa Christ, Seraphina Kissling, Axel Finckh, Benjamin A. Fisher, Sabine Adler, Britta Maurer, Burkhard Möller, Florian Kollert

Open Access Research

Long-term follow-up of 109 children with juvenile idiopathic oligoarthritis after first intra-articular corticosteroid injection

Mojca Zajc Avramovič, Nataša Toplak, Gašper Markelj, Nina Emeršič, Tadej Avčin

Open Access Research

Sensitive B-cell receptor repertoire analysis shows repopulation correlates with clinical response to rituximab in rheumatoid arthritis

Sabrina Pollastro, Anne Musters, Giulia Balzaretti, Ilse Niewold, Barbera van Schaik, Signe Hässler, Catharina M. Verhoef, Marc Pallardy, Antoine van Kampen, Xavier Mariette, Niek de Vries, Natacha Szely, Aude Gleizes, Salima Hacein-Bey Abina, Christophe Richez, Martin Soubrier, Jérome Avouac, Olivier Brocq, Jérémie Sellam, Tom Huizinga, Elizabeth Jury, Jessica Manson, Claudia Mauri, Andrea Matucci

Open Access Research

TfR1 mediated iron metabolism dysfunction as a potential therapeutic target for osteoarthritis

Wenchao Wang, Zhenkai Ma, Xuemin Feng, Jiabin Ren, Shengyao Sun, Yuandong Shao, Weimin Zhang, Xiaoxia Yang, Jiaming Zhang, Xingzhi Jing

Open Access Research

The prevalence of sarcopenia in spondyloarthritis patients: a meta-analysis

Jiawen Hu, Yiwen Wang, Xiaojian Ji, Yinan Zhang, Kunpeng Li, Feng Huang

Open Access Research

Targeting STAT6-mediated synovial macrophage activation improves pain in experimental knee osteoarthritis

Garth Blackler, Yue Lai-Zhao, Joseph Klapak, Holly T. Philpott, Kyle K. Pitchers, Andrew R. Maher, Benoit Fiset, Logan A. Walsh, Elizabeth R. Gillies, C. Thomas Appleton

Open Access Research

Nintedanib downregulates the profibrotic M2 phenotype in cultured monocyte-derived macrophages obtained from systemic sclerosis patients affected by interstitial lung disease

Stefano Soldano, Vanessa Smith, Paola Montagna, Emanuele Gotelli, Rosanna Campitiello, Carmen Pizzorni, Sabrina Paolino, Alberto Sulli, Andrea Cere, Maurizio Cutolo

Open Access Research

Patients with systemic sclerosis and low CD4 numbers after autologous stem cell transplantation have a favorable outcome

Ann-Christin Pecher, Reinhild Klein, Ina Koetter, Marieke Wagner, Wichard Vogel, Stefan Wirths, Claudia Lengerke, Joerg Christoph Henes

Open Access Research

Deficiency of peripheral CLA+ Tregs and clinical relevance in Behcet’s syndrome

Jiachen Li, Feng Sun, Danxue Zhu, Yuke Hou, Gong Cheng, Ping Wang, Xu Jin, Wenyan Zhou, Xiaolin Sun, Zhanguo Li, Tian Liu

Open Access Research

Peptidoglycan in osteoarthritis synovial tissue is associated with joint inflammation

Meaghan N Holub, Amanda Wahhab, Joseph R Rouse, Rebecca Danner, Lauren G Hackner, Christine B Duris, Mecaila E McClune, Jules M Dressler, Klemen Strle, Brandon L Jutras, Adam I Edelstein, Robert B Lochhead

Open Access Research

Specific isoforms of the ubiquitin ligase gene WWP2 are targets of osteoarthritis genetic risk via a differentially methylated DNA sequence

Jack B. Roberts, Olivia L.G. Boldvig, Guillaume Aubourg, S. Tanishq Kanchenapally, David J. Deehan, Sarah J. Rice, John Loughlin

Open Access Research

Effectiveness and safety of mycophenolate mofetil and rituximab combination therapy for immune idiopathic myopathies

Corrado Campochiaro, Nicola Farina, Giacomo De Luca, Veronica Batani, Giorgia Trignani, Davide Vignale, Anna Palmisano, Marco Matucci-Cerinic, Lorenzo Dagna

Open Access Research

Canakinumab treatment real world evidence in 3 monogenic periodic fever syndromes in 2009–2022: an interim analysis using the French JIR cohort database

Isabelle Koné-Paut, Sophie Georgin-Lavialle, Alexandre Belot, Magali Jover, Mathilde Pouriel, Laure Lacoin, Pascal Pillet, Véronique Hentgen

Open Access Correction

Correction: Nintedanib downregulates the profibrotic M2 phenotype in cultured monocyte-derived macrophages obtained from systemic sclerosis patients affected by interstitial lung disease

Stefano Soldano, Vanessa Smith, Paola Montagna, Emanuele Gotelli, Rosanna Campitiello, Carmen Pizzorni, Sabrina Paolino, Alberto Sulli, Andrea Cere, Maurizio Cutolo

Open Access Research

Anxiety and depression symptoms in adolescents and young adults with juvenile idiopathic arthritis: results of an outpatient screening

Florian Milatz, Jens Klotsche, Martina Niewerth, Claudia Sengler, Daniel Windschall, Tilmann Kallinich, Frank Dressler, Ralf Trauzeddel, Reinhard W. Holl, Ivan Foeldvari, Normi Brück, Svenja Temming, Toni Hospach, Petra Warschburger, Rainer Berendes, Gabriele Erbis, Jasmin B. Kuemmerle-Deschner, Frank Weller-Heinemann, Johannes-Peter Haas, Annabel S. Müller-Stierlin, Agnes Mutter, Thomas Meissner, Harald Baumeister, Kirsten Minden

Open Access Research

Integrative analysis of single-cell and bulk transcriptome data reveal the significant role of macrophages in lupus nephritis

Shuping Wei, Haiyun Shen, Yidan Zhang, Chunrui Liu, Shoushan Li, Jing Yao, Zhibin Jin, Hongliang Yu

Open Access Research

Deregulation in adult IgA vasculitis skin as the basis for the discovery of novel serum biomarkers

Matija Bajželj, Matjaž Hladnik, Rok Blagus, Vesna Jurčić, Ana Markež, Tanya Deniz Toluay, Snežna Sodin-Šemrl, Alojzija Hočevar, Katja Lakota

Open Access Research

Urate-lowering therapy, serum urate, inflammatory biomarkers, and renal function in patients with gout following pegloticase discontinuation

Emily E. Holladay, Amy S. Mudano, Fenglong Xie, Jingyi Zhang, Ted R. Mikuls, Brian LaMoreaux, Lissa Padnick-Silver, Jeffrey R. Curtis

Open Access Research

Long-term effects of abatacept on atherosclerosis and arthritis in older vs. younger patients with rheumatoid arthritis: 3-year results of a prospective, multicenter, observational study

Zento Yamada, Sei Muraoka, Mai Kawazoe, Wataru Hirose, Hajime Kono, Shinsuke Yasuda, Takahiko Sugihara, Toshihiro Nanki

Open Access Research

Osteoarthritis and hypertension: observational and Mendelian randomization analyses

Zhi-Jie Yang, Yuan Liu, Yan-Li Liu, Bin Qi, Xin Yuan, Wan-Xin Shi, Liu Miao

Open Access Retraction Note

Retraction Note: Reduced immunomodulation potential of bone marrow-derived mesenchymal stem cells induced CCR4+CCR6+ Th/Treg cell subset imbalance in ankylosing spondylitis

Yanfeng Wu, Mingliang Ren, Rui Yang, Xinjun Liang, Yuanchen Ma, Yong Tang, Lin Huang, Jichao Ye, Keng Chen, Peng Wang, Huiyong Shen

Open Access Research

Thyroid hormone induces ossification and terminal maturation in a preserved OA cartilage biomimetic model

N. M. Korthagen, E. Houtman, I. Boone, R. Coutinho de Almeida, K. Sivasubramaniyan, R. Mahdad, R. G. H. H Nelissen, Y. F. M. Ramos, M. A Tessari, I. Meulenbelt

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Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Notfall-TEP der Hüfte ist auch bei 90-Jährigen machbar

26.04.2024 Hüft-TEP Nachrichten

Ob bei einer Notfalloperation nach Schenkelhalsfraktur eine Hemiarthroplastik oder eine totale Endoprothese (TEP) eingebaut wird, sollte nicht allein vom Alter der Patientinnen und Patienten abhängen. Auch über 90-Jährige können von der TEP profitieren.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

Insektenstiche sind bei Erwachsenen die häufigsten Auslöser einer Anaphylaxie. Einen wirksamen Schutz vor schweren anaphylaktischen Reaktionen bietet die allergenspezifische Immuntherapie. Jedoch kommt sie noch viel zu selten zum Einsatz.

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

25.04.2024 Hypertonie Nachrichten

Beginnen ältere Männer im Pflegeheim eine Antihypertensiva-Therapie, dann ist die Frakturrate in den folgenden 30 Tagen mehr als verdoppelt. Besonders häufig stürzen Demenzkranke und Männer, die erstmals Blutdrucksenker nehmen. Dafür spricht eine Analyse unter US-Veteranen.

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