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Arthritis Research & Therapy

Ausgabe 1/2022

Inhalt (286 Artikel)

Open Access Research article

A new and spontaneous animal model for ankylosing spondylitis is found in cynomolgus monkeys

Huanhuan Jia, Meili Chen, Yanzhen Cai, Xiaoling Luo, Gang Hou, Yongfeng Li, Chunmei Cai, Jun Chen, Qingnan Li, Kai-Kei Miu, Sin-Hang Fung, Zhangting Wang, Ren Huang, Huiyong Shen, Li Lu

Open Access Research article

Validation of an algorithm to identify incident interstitial lung disease in patients with rheumatoid arthritis

M. Meehan, A. Shah, J. Lobo, J. Oates, C. Clinton, N. Annapureddy, F. Xie, J. Zhuo, M. I. Danila, B. R. England, J. R. Curtis

Open Access Research article

Salivary anti-nuclear antibody (ANA) mirrors serum ANA in systemic lupus erythematosus

Ting Zhang, Yong Du, Qingqing Wu, Hao Li, Thao Nguyen, Gabriel Gidley, Valeria Duran, Daniel Goldman, Michelle Petri, Chandra Mohan

Open Access Research article

Hematological malignancies in systemic lupus erythematosus: clinical characteristics, risk factors, and prognosis—a case-control study

Yuqi Zhang, Wei Li, Panpan Zhang, Jinyan Guo, Jinlei Sun, Jiameng Lu, Shengyun Liu

Open Access Research article

Hydroxychloroquine administration exacerbates acute kidney injury complicated by lupus nephritis

Ning An, Chen Yang, Hong-Luan Wu, Yun Guo, Xi-Jie Huang, Tong-Sheng Huang, Zhi-Hong Wu, Jing Xue, Rui-Hong Chen, Zhi-Hang Li, Qing-Jun Pan, Hua-Feng Liu

Open Access Research article

Latent class analysis of 216 patients with adult-onset Still’s disease

Takahiro Sugiyama, Shunsuke Furuta, Masaki Hiraguri, Kei Ikeda, Yosuke Inaba, Shin-ichiro Kagami, Yasuhiko Kita, Kei Kobayashi, Yoshihisa Kobayashi, Kazuhiro Kurasawa, Daiki Nakagomi, Yasushi Nawata, Yohei Kawasaki, Yuki Shiko, Takao Sugiyama, Hiroshi Nakajima

Open Access Research article

The presence of non-criteria manifestations negatively affects the prognosis of seronegative antiphospholipid syndrome patients: a multicenter study

Gilberto Pires da Rosa, Bernardo Sousa-Pinto, Ester Ferreira, Olga Araújo, Giuseppe Barilaro, Paulo Bettencourt, Ricard Cervera, Gerard Espinosa

Open Access Research article

Preterm birth is strongly affected by the glucocorticoid dose during pregnancy in women complicated by systemic lupus erythematosus

Hiromi Shimada, Risa Wakiya, Kenji Kanenishi, Nobuyuki Miyatake, Shusaku Nakashima, Mai Mahmoud Fahmy Mansour, Mikiya Kato, Taichi Miyagi, Koichi Sugihara, Yusuke Ushio, Rina Mino, Mao Mizusaki, Tomohiro Kameda, Norimitsu Kadowaki, Hiroaki Dobashi

Open Access Research article

The impact of filgotinib on patient-reported outcomes and health-related quality of life for patients with active rheumatoid arthritis: a post hoc analysis of Phase 3 studies

Clifton O. Bingham III, David Walker, Peter Nash, Susan J. Lee, Lei Ye, Hao Hu, Javaria Mona Khalid, Bernard Combe

Open Access Research article

Cannabinoid type 2 receptor (CB2R) distribution in dermatomyositis skin and peripheral blood mononuclear cells (PBMCs) and in vivo effects of LenabasumTM

Spandana Maddukuri, Jay Patel, De Anna Diaz, Kristen L. Chen, Maria Wysocka, Christina Bax, Yubin Li, Adarsh Ravishankar, Madison Grinnell, Majid Zeidi, Nithin Reddy, Josef Symon S. Concha, Muhammad M. Bashir, Joyce Okawa, Barbara White, Victoria P. Werth

Open Access Research article

Acazicolcept (ALPN-101), a dual ICOS/CD28 antagonist, demonstrates efficacy in systemic sclerosis preclinical mouse models

Cindy Orvain, Anne Cauvet, Alexis Prudent, Christophe Guignabert, Raphaël Thuillet, Mina Ottaviani, Ly Tu, Fanny Duhalde, Carole Nicco, Frédéric Batteux, Jérôme Avouac, NingXin Wang, Michelle A. Seaberg, Stacey R. Dillon, Yannick Allanore

Open Access Research article

The risk of malignancy in patients with IgG4-related disease: a systematic review and meta-analysis

Tingfeng Yu, Yaxian Wu, Jia Liu, Yanyan Zhuang, Xiaoyan Jin, Lingyun Wang

Open Access Research article

Integrative blood-derived epigenetic and transcriptomic analysis reveals the potential regulatory role of DNA methylation in ankylosing spondylitis

Min Xiao, Xuqi Zheng, Xiaomin Li, Xinyu Wu, Yefei Huang, Qiujing Wei, Shuangyan Cao, Jieruo Gu

Open Access Research article

The association between psoriatic arthritis and venous thromboembolism: a population-based cohort study

Tal Gazitt, Jacob Pesachov, Idit Lavi, Muna Elias, Amir Haddad, Ilan Feldhamer, Arnon Dov Cohen, Walid Saliba, Devy Zisman

Open Access Research article

The difference of lipid profiles between psoriasis with arthritis and psoriasis without arthritis and sex-specific downregulation of methotrexate on the apolipoprotein B/apolipoprotein A-1 ratio

Bing Wang, Hui Deng, Yao Hu, Ling Han, Qiong Huang, Xu Fang, Ke Yang, Siyuan Wu, Zhizhong Zheng, Nikhil Yawalkar, Zhenghua Zhang, Kexiang Yan

Open Access Research article

Hyaluronidase treatment of synovial fluid is required for accurate detection of inflammatory cells and soluble mediators

Hilde Brouwers, Johannes Hendrick von Hegedus, Enrike van der Linden, Rachid Mahdad, Margreet Kloppenburg, René Toes, Martin Giera, Andreea Ioan-Facsinay

Open Access Research article

Impact of lung function decline on time to hospitalisation events in systemic sclerosis-associated interstitial lung disease (SSc-ILD): a joint model analysis

Michael Kreuter, Francesco Del Galdo, Corinna Miede, Dinesh Khanna, Wim A. Wuyts, Laura K. Hummers, Margarida Alves, Nils Schoof, Christian Stock, Yannick Allanore

Open Access Correction

Correction to: Rapamycin-induced hyperglycemia is associated with exacerbated age-related osteoarthritis

Dennis M. Minton, Christian J. Elliehausen, Martin A. Javors, Kelly S. Santangelo, Adam R. Konopka

Open Access COVID-19 Research article

Low frequency of disease flare in patients with rheumatic musculoskeletal diseases who received SARS-CoV-2 mRNA vaccine

Francesca Romana Spinelli, Ennio Giulio Favalli, Cristina Garufi, Martina Cornalba, Serena Colafrancesco, Fabrizio Conti, Roberto Caporali

Open Access Research article

Sex-specific differences and how to handle them in early psoriatic arthritis

E. Passia, M. Vis, L. C. Coates, A. Soni, I. Tchetverikov, A. H. Gerards, M. R. Kok, P. A. J. M. Vos, L. Korswagen, F. Fodili, Y. P. M. Goekoop-Ruiterman, J. van der Kaap, M. van Oosterhout, J. J. Luime

Open Access Research article

Characterization and use of the ECV304 autoantigenic citrullinome to understand anti-citrullinated protein/peptide autoantibodies in rheumatoid arthritis

Natalia Regine de França, Henri André Ménard, Maximilien Lora, Zhijie Zhou, Joyce Rauch, Carol Hitchon, Luís Eduardo Coelho Andrade, Inés Colmegna

Open Access Research article

A role for neutrophils in early enthesitis in spondyloarthritis

Zheni Stavre, Charles Bridgewood, Qiao Zhou, Yukiko Maeda, Ting-ting Huang, Jozsef Karman, Almas Khan, Sami Giryes, Kassem Sharif, Dennis McGonagle, Ellen M. Gravallese

Open Access Research article

Fibrotic alterations in human annulus fibrosus correlate with progression of intervertebral disc herniation

A. L. Castro, C. Ribeiro-Machado, C. M. Oliveira, G. Q. Teixeira, C. Neidlinger-Wilke, P. Pereira, R. Vaz, M. A. Barbosa, R. M. Gonçalves

Open Access Research article

Prioritising referrals of individuals at-risk of RA: guidance based on results of a 10-year national primary care observational study

Leticia Garcia-Montoya, Jacqueline L. Nam, Laurence Duquenne, Catalina Villota-Eraso, Andrea Di Matteo, Collette Hartley, Kulveer Mankia, Paul Emery

Open Access Research article

Penfluridol targets acid sphingomyelinase to inhibit TNF signaling and is therapeutic against inflammatory autoimmune diseases

Yue-hong Chen, Rong-han Liu, Ya-zhou Cui, Aubryanna Hettinghouse, Wen-yu Fu, Lei Zhang, Chen Zhang, Chuan-ju Liu

Open Access Research article

Characterizing memory T helper cells in patients with psoriasis, subclinical, or early psoriatic arthritis using a machine learning algorithm

Hannah den Braanker, Wida Razawy, Kim Wervers, Anne-Marie C. Mus, Nadine Davelaar, Marc R. Kok, Erik Lubberts

Open Access Research article

Striking sex differences in magnetic resonance imaging findings in the sacroiliac joints in the population

J. Braun, X. Baraliakos, R. Bülow, C. O. Schmidt, A. Richter

Open Access Research article

Sustained low disease activity measured by ASDAS slow radiographic spinal progression in axial spondyloarthritis patients treated with TNF-inhibitors: data from REGISPONSERBIO

Maria Llop, Mireia Moreno, Victoria Navarro-Compán, Xavier Juanola, Eugenio de Miguel, Raquel Almodóvar, Eduardo Cuende Quintana, Jesús Sanz Sanz, Emma Beltrán, M. Dolores Ruiz Montesinos, Joan Calvet, Antoni Berenguer-Llergo, Jordi Gratacós, Pedro Zarco Montejo, Beatriz Joven, Miriam Almirall, Ma Cruz Fernandez Espartero, Enrique Batlle Gualda, Cristina Campos, Eduardo Collantes Estevez, Pilar Font, Teresa Clavaguera Poch, Luis F. Linares Ferrando, Carlos Rodríguez Lozano, Beatriz Yoldi

Open Access Research article

“The medications are the decision-makers…” Making reproductive and medication use decisions among female patients with rheumatoid arthritis: a constructivist grounded theory

Nevena Rebić, Sarah Munro, Ria Garg, Glen Hazlewood, Neda Amiri, Corisande Baldwin, Stephanie Ensworth, Laurie Proulx, Mary A. De Vera

Open Access Research article

Association of acidic urine pH with impaired renal function in primary gout patients: a Chinese population-based cross-sectional study

Yuwei He, Xiaomei Xue, Robert Terkeltaub, Nicola Dalbeth, Tony R. Merriman, David B. Mount, Zhe Feng, Xinde Li, Lingling Cui, Zhen Liu, Yan Xu, Ying Chen, Hailong Li, Aichang Ji, Xiaopeng Ji, Xuefeng Wang, Jie Lu, Changgui Li

Open Access Research article

Non-criteria manifestations in primary antiphospholipid syndrome: a French multicenter retrospective cohort study

Alexis F. Guédon, Jennifer Catano, Laure Ricard, Charlotte Laurent, Claire de Moreuil, Geoffrey Urbanski, Sophie Deriaz, Grigorios Gerotziafas, Ismail Elalamy, Alexandra Audemard, Francois Chasset, Sonia Alamowitch, Jérémie Sellam, François Maillot, Jean Jacques Boffa, Ariel Cohen, Noémie Abisror, Olivier Fain, Arsène Mekinian

Open Access Research article

Associations between the morphological parameters of proximal tibiofibular joint (PTFJ) and changes in tibiofemoral joint structures in patients with knee osteoarthritis

Jun Chang, Tianyu Chen, Yizhu Yan, Zhaohua Zhu, Weiyu Han, Yi Zhao, Benny Antony, Anita Wluka, Tania Winzenberg, Flavia Cicuttini, Changhai Ding

Open Access Review

Role of the S100 protein family in rheumatoid arthritis

Yuan-yuan Wu, Xiao-feng Li, Sha Wu, Xue-ni Niu, Su-qin Yin, Cheng Huang, Jun Li

Open Access Research article

Ultrasound-guided lymph node biopsy sampling to study the immunopathogenesis of rheumatoid arthritis: a well-tolerated valuable research tool

Renée H. Fiechter, Janne W. Bolt, Marleen G. H. van de Sande, Caroline J. Aalbers, Robert B. M. Landewé, Mario Maas, Sander W. Tas, Lisa G. M. van Baarsen

Open Access Research article

N6-methyladenosine-dependent modification of circGARS acts as a new player that promotes SLE progression through the NF-κB/A20 axis

Xingwang Zhao, Rui Dong, Longlong Zhang, Junkai Guo, Ying Shi, Lan Ge, Juan Wang, Zhiqiang Song, Bing Ni, Yi You

Open Access Research article

Development of a convolutional neural network for the identification and the measurement of the median nerve on ultrasound images acquired at carpal tunnel level

Gianluca Smerilli, Edoardo Cipolletta, Gianmarco Sartini, Erica Moscioni, Mariachiara Di Cosmo, Maria Chiara Fiorentino, Sara Moccia, Emanuele Frontoni, Walter Grassi, Emilio Filippucci

Open Access Research article

Cytokine signatures differentiate systemic sclerosis patients at high versus low risk for pulmonary arterial hypertension

Kathleen D. Kolstad, Avani Khatri, Michele Donato, Sarah E. Chang, Shufeng Li, Virginia D. Steen, Paul J. Utz, Purvesh Khatri, Lorinda Chung

Open Access Research article

Time to response for clinical and patient-reported outcomes in patients with psoriatic arthritis treated with tofacitinib, adalimumab, or placebo

Dafna D. Gladman, Laura C. Coates, Joseph Wu, Lara Fallon, Elizabeth D. Bacci, Joseph C. Cappelleri, Andrew G. Bushmakin, Philip S. Helliwell

Open Access Research article

Secular trends in cryoglobulinemia mortality in the USA in the era of direct-acting antivirals

Qianyu Guo, Jinfang Gao, Jiaoniu Duan, Ruihong Hou, Tsung-Hsueh Lu, Liyun Zhang

Open Access Research article

Gut dysbiosis associated with worse disease activity and physical function in axial spondyloarthritis

Jonas Sagard, Tor Olofsson, Elisabeth Mogard, Jan Marsal, Kristofer Andréasson, Mats Geijer, Lars Erik Kristensen, Elisabet Lindqvist, Johan K. Wallman

Open Access Research article

Tumor necrosis factor alpha neutralization attenuates immune checkpoint inhibitor-induced activation of intermediate monocytes in synovial fluid mononuclear cells from patients with inflammatory arthritis

Anne Sofie Sørensen, Morten Nørgaard Andersen, Kristian Juul-Madsen, Amalie Dyrelund Broksø, Cæcilie Skejø, Henrik Schmidt, Thomas Vorup-Jensen, Tue Wenzel Kragstrup

Open Access Research article

Chondrocyte-derived exosomes promote cartilage calcification in temporomandibular joint osteoarthritis

Qian Liu, Ruoxin Wang, Shujie Hou, Feng He, Yuanjun Ma, Tao Ye, Shibin Yu, Hongwei Chen, Helin Wang, Mian Zhang

Open Access Research article

CD34+THY1+ synovial fibroblast subset in arthritic joints has high osteoblastic and chondrogenic potentials in vitro

Seiji Noda, Tadashi Hosoya, Yoji Komiya, Yasuhiro Tagawa, Kentaro Endo, Keiichiro Komori, Hideyuki Koga, Yasuhiro Takahara, Kazutaka Sugimoto, Ichiro Sekiya, Tetsuya Saito, Fumitaka Mizoguchi, Shinsuke Yasuda

Open Access Research article

The effect of 24-week belimumab treatment withdrawal followed by treatment restart in patients with SLE: an open-label, non-randomised 52-week study

Sang-Cheol Bae, Damon L. Bass, Myron Chu, Paula Curtis, Richard Dimelow, Laurence Harvey, Beulah Ji, Regina Kurrasch, Saima Muzaffar, Raj Punwaney, David A. Roth, Yeong-Wook Song, Wendy Xie, Fengchun Zhang

Open Access Research article

Prediction of flare following remission and treatment withdrawal in early rheumatoid arthritis: post hoc analysis of a phase IIIb trial with abatacept

Harris A. Ahmad, Joshua F. Baker, Philip G. Conaghan, Paul Emery, Thomas W. J. Huizinga, Yedid Elbez, Subhashis Banerjee, Mikkel Østergaard

Open Access Research article

Increased oxidative stress contributes to impaired peripheral CD56dimCD57+ NK cells from patients with systemic lupus erythematosus

Zhimin Lu, Yao Tian, Ziran Bai, Jiaqing Liu, Yan Zhang, Jingjing Qi, Minli Jin, Jie Zhu, Xia Li

Open Access Research article

A comprehensive profile of chemokines in the peripheral blood and vascular tissue of patients with Takayasu arteritis

Xiufang Kong, Sifan Wu, Xiaojuan Dai, Wensu Yu, Jinghua Wang, Ying Sun, Zongfei Ji, Lingying Ma, Xiaomin Dai, Huiyong Chen, Lili Ma, Lindi Jiang

Open Access Research article

Overexpression of OASL upregulates TET1 to induce aberrant activation of CD4+ T cells in systemic sclerosis via IRF1 signaling

Zhuotong Zeng, Yaoyao Wang, Yangfan Xiao, Jie Zheng, Ruizhen Liu, Xinglan He, Jiangfan Yu, Bingsi Tang, Xiangning Qiu, Rui Tang, Yaqian Shi, Rong Xiao

Open Access Research article

TLC599 in patients with osteoarthritis of the knee: a phase IIa, randomized, placebo-controlled, dose-finding study

David J. Hunter, Chi-Ching Chang, James Cheng-Chung Wei, Hsiao-Yi Lin, Carl Brown, Tien-Tzu Tai, Chih-Feng Wu, Wing Chia-Ming Chuang, Sheue-Fang Shih

Open Access Research article

Factors affecting patient satisfaction related to cost and treatment effectiveness in rheumatoid arthritis: results from the multicenter observational cohort study, FRANK Registry

Toshifumi Fujiwara, Masakazu Kondo, Hisakata Yamada, Akihisa Haraguchi, Kenjiro Fujimura, Koji Sakuraba, Satoshi Kamura, Jun-ichi Fukushi, Hisaaki Miyahara, Yasushi Inoue, Tomomi Tsuru, Toshihide Shuto, Seiji Yoshizawa, Eiichi Suematsu, Tomoya Miyamura, Masahiro Ayano, Hiroki Mitoma, Yojiro Arinobu, Hiroaki Niiro, Masanobu Ohishi, Akie Hirata, Shoji Tokunaga, Atsushi Takada, Daisuke Hara, Hidetoshi Tsushima, Yukio Akasaki, Satoshi Ikemura, Takuya Sueishi, Masakazu Toya, Takahide Sakuragi, Tomoko Tsutsui, Kazuhiro Kai, Shinkichi Arisumi, Yasuharu Nakashima

Open Access Research article

Analysis of the fecal and oral microbiota in chronic recurrent multifocal osteomyelitis

Philipp Rausch, Meike Hartmann, John F. Baines, Philipp von Bismarck

Open Access Review

Systematic review of quantitative preference studies of treatments for rheumatoid arthritis among patients and at-risk populations

Gwenda Simons, Joshua Caplan, Rachael L. DiSantostefano, Jorien Veldwijk, Matthias Englbrecht, Karin Schölin Bywall, Ulrik Kihlbom, Karim Raza, Marie Falahee

Open Access Research article

Rheumatoid arthritis, as a clinical disease, but not rheumatoid arthritis-associated autoimmunity, is linked to cardiovascular events

Hélène Gouze, Philippe Aegerter, Roula Said-Nahal, Marie Zins, Marcel Goldberg, Guillaume Morelle, Georg Schett, Maxime Breban, Maria Antonietta D’Agostino

Open Access Research article

Plasma interleukin-23 and circulating IL-17A+IFNγ+ ex-Th17 cells predict opposing outcomes of anti-TNF therapy in rheumatoid arthritis

Melanie J. Millier, Niamh C. Fanning, Christopher Frampton, Lisa K. Stamp, Paul A. Hessian

Open Access Research article

Clinical features of gout in adult patients with type Ia glycogen storage disease: a single-centre retrospective study and a review of literature

Na Xu, Xinxin Han, Yun Zhang, Xiaoming Huang, Weiguo Zhu, Min Shen, Wen Zhang, Chen Jialin, Min Wei, Zhengqing Qiu, Xuejun Zeng

Open Access Review

Senescent skeletal cells cross-talk with synovial cells plays a key role in the pathogenesis of osteoarthritis

Chong-Jie Wu, Ri-Xu Liu, Song-Wei Huan, Wang Tang, Yu-Kai Zeng, Jun-Cheng Zhang, Jie Yang, Zhen-Yan Li, Ying Zhou, Zhen-Gang Zha, Huan-Tian Zhang, Ning Liu

Open Access Research article

Preferable outcome of Janus kinase inhibitors for a group of difficult-to-treat rheumatoid arthritis patients: from the FIRST Registry

Sae Ochi, Koshiro Sonomoto, Shingo Nakayamada, Yoshiya Tanaka

Open Access Research article

Longitudinal assessment of reactivity and affinity profile of anti-Jo1 autoantibodies to distinct HisRS domains and a splice variant in a cohort of patients with myositis and anti-synthetase syndrome

Antonella Notarnicola, Charlotta Preger, Susanna L. Lundström, Nuria Renard, Edvard Wigren, Eveline Van Gompel, Angeles S. Galindo-Feria, Helena Persson, Maryam Fathi, Johan Grunewald, Per-Johan Jakobsson, Susanne Gräslund, Ingrid E. Lundberg, Cátia Fernandes-Cerqueira

Open Access Research article

Amniotic suspension allograft improves pain and function in a rat meniscal tear-induced osteoarthritis model

Kelly A. Kimmerling, Andreas H. Gomoll, Jack Farr, Katie C. Mowry

Open Access Research article

Single-cell transcriptomics of popliteal lymphatic vessels and peripheral veins reveals altered lymphatic muscle and immune cell populations in the TNF-Tg arthritis model

H. Mark Kenney, Chia-Lung Wu, Alayna E. Loiselle, Lianping Xing, Christopher T. Ritchlin, Edward M. Schwarz

Open Access Research

Angiopoietin-2/-1 ratios and MMP-3 levels as an early warning sign for the presence of giant cell arteritis in patients with polymyalgia rheumatica

Yannick van Sleen, Philip Therkildsen, Berit Dalsgaard Nielsen, Kornelis S. M. van der Geest, Ib Hansen, Peter Heeringa, Marcel D. Posthumus, Maria Sandovici, Erik J. M. Toonen, Jannik Zijlstra, Annemieke M. H. Boots, Ellen-Margrethe Hauge, Elisabeth Brouwer

Open Access Research article

Prediction of knee osteoarthritis progression using radiological descriptors obtained from bone texture analysis and Siamese neural networks: data from OAI and MOST cohorts

Ahmad Almhdie-Imjabbar, Khac-Lan Nguyen, Hechmi Toumi, Rachid Jennane, Eric Lespessailles

Open Access Research article

A machine learning-assisted model for renal urate underexcretion with genetic and clinical variables among Chinese men with gout

Mingshu Sun, Wenyan Sun, Xuetong Zhao, Zhiqiang Li, Nicola Dalbeth, Aichang Ji, Yuwei He, Hongzhu Qu, Guangmin Zheng, Lidan Ma, Jiayi Wang, Yongyong Shi, Xiangdong Fang, Haibing Chen, Tony R. Merriman, Changgui Li

Open Access Review

Computational pathology for musculoskeletal conditions using machine learning: advances, trends, and challenges

Maxwell A. Konnaris, Matthew Brendel, Mark Alan Fontana, Miguel Otero, Lionel B. Ivashkiv, Fei Wang, Richard D. Bell

Open Access Correction

Correction to: Cannabinoid type 2 receptor (CB2R) distribution in dermatomyositis skin and peripheral blood mononuclear cells (PBMCs) and in vivo efects of LenabasumTM

Spandana Maddukuri, Jay Patel, De Anna Diaz, Kristen L. Chen, Maria Wysocka, Christina Bax, Yubin Li, Adarsh Ravishankar, Madison Grinnell, Majid Zeidi, Nithin Reddy, Josef Symon S. Concha, Muhammad M. Bashir, Joyce Okawa, Barbara White, Victoria P. Werth

Open Access Research article

‘Not at target’: prevalence and consequences of inadequate disease control in systemic lupus erythematosus—a multinational observational cohort study

Rangi Kandane-Rathnayake, Worawit Louthrenoo, Alberta Hoi, Shue-Fen Luo, Yeong-Jian J. Wu, Yi-Hsing Chen, Jiacai Cho, Aisha Lateef, Laniyati Hamijoyo, Sandra V. Navarra, Leonid Zamora, Sargunan Sockalingam, Yuan An, Zhanguo Li, Yasuhiro Katsumata, Masayoshi Harigai, Yanjie Hao, Zhuoli Zhang, Jun Kikuchi, Tsutomu Takeuchi, B. M. D. B. Basnayake, Madelynn Chan, Kristine Pek Ling Ng, Nicola Tugnet, Sunil Kumar, Shereen Oon, Fiona Goldblatt, Sean O’Neill, Kathryn A. Gibson, Naoaki Ohkubo, Yoshiya Tanaka, Sang-Cheol Bae, Chak Sing Lau, Mandana Nikpour, Vera Golder, Eric F. Morand

Open Access Research article

The differential diagnosis of IgG4-related disease based on machine learning

Motohisa Yamamoto, Masanori Nojima, Ryuta Kamekura, Akiko Kuribara-Souta, Masaaki Uehara, Hiroki Yamazaki, Noritada Yoshikawa, Satsuki Aochi, Ichiro Mizushima, Takayuki Watanabe, Aya Nishiwaki, Toshihiko Komai, Hirofumi Shoda, Koji Kitagori, Hajime Yoshifuji, Hideaki Hamano, Mitsuhiro Kawano, Ken-ichi Takano, Keishi Fujio, Hirotoshi Tanaka

Open Access Research

Validation in the ESPOIR cohort of vitamin K-dependent protein S (PROS) as a potential biomarker capable of predicting response to the methotrexate/etanercept combination

Olivier Vittecoq, Clément Guillou, Julie Hardouin, Baptiste Gerard, Francis Berenbaum, Arnaud Constantin, Nathalie Rincheval, Bernard Combe, Thierry Lequerre, Pascal Cosette

Open Access Research article

Pooled safety results across phase 3 randomized trials of intravenous golimumab in rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis

M. Elaine Husni, Atul Deodhar, Sergio Schwartzman, Soumya D. Chakravarty, Elizabeth C. Hsia, Jocelyn H. Leu, Yiying Zhou, Kim H. Lo, Arthur Kavanaugh

Open Access Research article

Using real-world data to dynamically predict flares during tapering of biological DMARDs in rheumatoid arthritis: development, validation, and potential impact of prediction-aided decisions

Matthijs S. van der Leeuw, Marianne A. Messelink, Janneke Tekstra, Ojay Medina, Jaap M. van Laar, Saskia Haitjema, Floris Lafeber, Josien J. Veris-van Dieren, Marlies C. van der Goes, Alfons A. den Broeder, Paco M. J. Welsing

Open Access Research article

Differences in topographical location of sacroiliac joint MRI lesions in patients with early axial spondyloarthritis and mechanical back pain

Rosa Marie Kiil, Clara E. Mistegaard, Anne Gitte Loft, Anna Zejden, Oliver Hendricks, Anne Grethe Jurik

Open Access Research

Effect of resistance exercise on serum leptin levels in a prospective longitudinal study of women patients with rheumatoid arthritis

Young Bin Joo, Kyoung Bo Lee, Bomi Sul, Hye-Soon Lee, Seong Hoon Lim, Yune-Jung Park

Open Access Research article

Urinary galectin-3 binding protein (G3BP) as a biomarker for disease activity and renal pathology characteristics in lupus nephritis

Huihua Ding, Yiwei Shen, Cheng Lin, Ling Qin, Shijun He, Min Dai, Shinji L. Okitsu, Julie A. DeMartino, Qiang Guo, Nan Shen

Open Access Research article

Observed efficacy and clinically important improvements in participants with osteoarthritis treated with subcutaneous tanezumab: results from a 56-week randomized NSAID-controlled study

Tuhina Neogi, David J. Hunter, Melvin Churchill, Ivan Shirinsky, Alexander White, Ali Guermazi, Masanari Omata, Robert J. Fountaine, Glenn Pixton, Lars Viktrup, Mark T. Brown, Christine R. West, Kenneth M. Verburg

Open Access Research

Risk factor analysis of perioperative complications in patients with rheumatoid arthritis undergoing primary cervical spine surgery

Koji Sakuraba, Yuki Omori, Kazuhiro Kai, Kazumasa Terada, Nobuo Kobara, Satoshi Kamura, Kenjiro Fujimura, Hirofumi Bekki, Masanari Ohta, Hisa-aki Miyahara, Jun-ichi Fukushi

Open Access Research

Alemtuzumab for refractory primary systemic vasculitis—a randomised controlled dose ranging clinical trial of efficacy and safety (ALEVIATE)

Seerapani Gopaluni, Rona Smith, Donna Goymer, Hugh Cahill, Elizabeth Broadhurst, Elizabeth Wallin, Mark McClure, Afzal Chaudhry, David Jayne

Open Access Research article

The impact of tofacitinib on fatigue, sleep, and health-related quality of life in patients with rheumatoid arthritis: a post hoc analysis of data from Phase 3 trials

Susan J. Bartlett, Clifton O. Bingham, Ronald van Vollenhoven, Christopher Murray, David Gruben, David A. Gold, David Cella

Open Access Research

Using magnetic resonance imaging to map the hidden burden of muscle involvement in systemic sclerosis

Laura Ross, Anniina Lindqvist, Benedict Costello, Dylan Hansen, Zoe Brown, Jessica A. Day, Wendy Stevens, Andrew Burns, Warren Perera, Marcus Pianta, André La Gerche, Mandana Nikpour

Open Access Research

Association of tramadol with all-cause mortality, cardiovascular diseases, venous thromboembolism, and hip fractures among patients with osteoarthritis: a population-based study

Lingyi Li, Shelby Marozoff, Na Lu, Hui Xie, Jacek A. Kopec, Jolanda Cibere, John M. Esdaile, J. Antonio Aviña-Zubieta

Open Access Research

Impact of serum interleukin-22 as a biomarker for the differential use of molecular targeted drugs in psoriatic arthritis: a retrospective study

Ippei Miyagawa, Shingo Nakayamada, Masanobu Ueno, Yusuke Miyazaki, Shigeru Iwata, Satoshi Kubo, Koshiro Sonomoto, Junpei Anan, Naoaki Ohkubo, Yoshino Inoue, Yoshiya Tanaka

Open Access Research

Lupus nephritis correlates with B cell interferon-β, anti-Smith, and anti-DNA: a retrospective study

Fatima Alduraibi, Huma Fatima, Jennie A. Hamilton, W. Winn. Chatham, Hui-Chen Hsu, John D. Mountz

Open Access Research

One- and 2-year flare rates after treat-to-target and tight-control therapy of gout: results from the NOR-Gout study

Till Uhlig, Lars F. Karoliussen, Joe Sexton, Tore K. Kvien, Espen A. Haavardsholm, Fernando Perez-Ruiz, Hilde Berner Hammer

Open Access Comment

The role of interleukin (IL)-23 in regulating pain in arthritis

Kevin M.-C. Lee, Jonathan P. Sherlock, John A. Hamilton

Open Access Research

HLA-DRB1 haplotypes predict cardiovascular mortality in inflammatory polyarthritis independent of CRP and anti-CCP status

Seema Sharma, Darren Plant, John Bowes, Alex Macgregor, Suzanne Verstappen, Anne Barton, Sebastien Viatte

Open Access Research article

Systemic sclerosis and pregnancy outcomes: a retrospective study from a single center

Giuseppe Barilaro, Aleida Castellanos, Inês Gomez-Ferreira, Gema Maria Lledó, Carlo Della Rocca, Lorena Fernandez-Blanco, Ricard Cervera, Núria Baños, Francesc Figueras, Gerard Espinosa

Open Access Research article

Associated factors with poor treatment response to initial glucocorticoid therapy in patients with adult-onset Still’s disease

Fumiaki Kondo, Takahiko Sugihara, Natsuka Umezawa, Hisanori Hasegawa, Tadashi Hosoya, Naoki Kimura, Masaaki Mori, Shinsuke Yasuda

Open Access Research

Elevation of α-1,3 fucosylation promotes the binding ability of TNFR1 to TNF-α and contributes to osteoarthritic cartilage destruction and apoptosis

Hanjie Yu, Mingxiu Li, Xiaodong Wen, Jie Yang, Xiaojun Liang, Xia Li, Xiaojuan Bao, Jian Shu, Xiameng Ren, Wentian Chen, Zheng Li, Yi Li

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The compound LG283 inhibits bleomycin-induced skin fibrosis via antagonizing TGF-β signaling

Akira Utsunomiya, Takenao Chino, Hiroshi Kasamatsu, Takumi Hasegawa, Natsuko Utsunomiya, Vu Huy Luong, Takashi Matsushita, Yoko Sasaki, Dai Ogura, Shin-ichiro Niwa, Noritaka Oyama, Minoru Hasegawa

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Autologous hematopoietic stem cell transplantation promotes connective tissue remodeling in systemic sclerosis patients

Djúlio C. Zanin-Silva, Maynara Santana-Gonçalves, Marianna Y. Kawashima-Vasconcelos, João R. Lima-Júnior, Juliana B. E. Dias, Daniela A. Moraes, Dimas T. Covas, Kelen C. R. Malmegrim, Leandra Ramalho, Maria Carolina Oliveira

Open Access Research article

Effects of local cryotherapy on systemic endothelial activation, dysfunction, and vascular inflammation in adjuvant-induced arthritis (AIA) rats

C. Peyronnel, P. Totoson, V. Petitcolin, F. Bonnefoy, X. Guillot, P. Saas, F. Verhoeven, H. Martin, C. Demougeot

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Clinical heterogeneity of ocular Behçet’s syndrome versus intestinal Behçet’s syndrome: a cross-sectional study from Shanghai Behçet’s syndrome database

Cheng-cheng Hou, Dan Luo, Hua-fang Bao, Jing-fen Ye, Hai-fen Ma, Yan Shen, Jun Zou, Jian-long Guan

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The angiopoietin-like protein 4, apolipoprotein C3, and lipoprotein lipase axis is disrupted in patients with rheumatoid arthritis

Laura de Armas-Rillo, Juan Carlos Quevedo-Abeledo, Vanesa Hernández-Hernández, Antonia de Vera-González, Alejandra González-Delgado, José A. García-Dopico, Miguel Á. González-Gay, Iván Ferraz-Amaro

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Impact of type and dose of oral polyunsaturated fatty acid supplementation on disease activity in inflammatory rheumatic diseases: a systematic literature review and meta-analysis

Johanna Sigaux, Sylvain Mathieu, Yann Nguyen, Pauline Sanchez, Jean-Guillaume Letarouilly, Martin Soubrier, Sébastien Czernichow, René-Marc Flipo, Jérémie Sellam, Claire Daïen

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Impaired activation of STAT5 upon IL-2 stimulation in Tregs and elevated sIL-2R in Sjögren’s syndrome

Magdalena Keindl, Richard Davies, Brith Bergum, Johan G. Brun, Daniel Hammenfors, Roland Jonsson, Valeriya Lyssenko, Silke Appel

Open Access Research

Risk factors and surgical prognosis in patients with aortic valve involvement caused by Takayasu arteritis

Xuemei Shi, Juan Du, Taotao Li, Na Gao, Wei Fang, Suwei Chen, Zhiyu Qiao, Chengnan Li, Junming Zhu, Lili Pan

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Gastric antral vascular ectasia in systemic sclerosis: a study of its epidemiology, disease characteristics and impact on survival

Kathleen Morrisroe, Dylan Hansen, Wendy Stevens, Joanne Sahhar, Gene-Siew Ngian, Catherine Hill, Janet Roddy, Jennifer Walker, Susanna Proudman, Mandana Nikpour

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Apolipoprotein C-III in patients with systemic lupus erythematosus

Candelaria Martín-González, Carmen Ferrer-Moure, Juan Carlos Quevedo-Abeledo, Antonia de Vera-González, Alejandra González-Delgado, Julio Sánchez-Martín, Miguel Á. González-Gay, Iván Ferraz-Amaro

Open Access Review

Small molecules of herbal origin for osteoarthritis treatment: in vitro and in vivo evidence

Penghui Zhang, Kaihu Li, Amir Kamali, Reihane Ziadlou, Paras Ahmad, Xinluan Wang, R. Geoff Richards, Mauro Alini, Valentina Basoli, Zhen Li, Sibylle Grad

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Clinical and pathological predictors of relapse in IgG4-related disease

Ji Zongfei, Chen Lingli, Sun Ying, Ma Lingying, Zhang Lijuan, Liu Dongmei, Dai Xiaomin, Hou Yingyong, Chen Huiyong, Ma Lili, Jiang Lindi

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Assessing the diagnostic value of a potential screening tool for detecting early interstitial lung disease at the onset of inflammatory rheumatic diseases

Tobias Hoffmann, Peter Oelzner, Marcus Franz, Ulf Teichgräber, Diane Renz, Martin Förster, Joachim Böttcher, Claus Kroegel, P. Christian Schulze, Gunter Wolf, Alexander Pfeil

Open Access Review

The role of endothelin and RAS/ERK signaling in immunopathogenesis-related fibrosis in patients with systemic sclerosis: an updated review with therapeutic implications

Mohsen Rokni, Mina Sadeghi Shaker, Hoda Kavosi, Shahrzad Shokoofi, Mahdi Mahmoudi, Elham Farhadi

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Increased frequency of IgD-CD27hiCD38hi B cells and its association with the renal involvement in ANCA-associated vasculitis

Chen Wang, Zhi-Ying Li, Yan Gong, Ran You, Ming-Hui, Zhao, Min Chen

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Mobile health apps for systemic lupus erythematosus and lupus nephritis: a critical appraisal

Akshara Ramasamy, Poojitha Dugyala, Chandra Mohan

Open Access Research

Magnetic resonance imaging characteristics in patients with spondyloarthritis and clinical diagnosis of heel enthesitis: post hoc analysis from the phase 3 ACHILLES trial

X. Baraliakos, P. Sewerin, E. de Miguel, E. Pournara, C. Kleinmond, A. Shekhawat, C. Jentzsch, A. Wiedon, F. Behrens

Open Access Research

Baricitinib decreases anti-dsDNA in patients with systemic lupus erythematosus: results from a phase II double-blind, randomized, placebo-controlled trial

Thomas Dörner, Ronald F. van Vollenhoven, Andrea Doria, Bochao Jia, Jorge A. Ross Terres, Maria E. Silk, Stephanie de Bono, Peter Fischer, Daniel J. Wallace

Open Access Research article

Ketogenic diet ameliorates inflammation by inhibiting the NLRP3 inflammasome in osteoarthritis

Ganggang Kong, Jinyang Wang, Rong Li, Zhiping Huang, Le Wang

Open Access Correction

Correction: Association of tramadol with all-cause mortality, cardiovascular diseases, venous thromboembolism, and hip fractures among patients with osteoarthritis: a population-based study

Lingyi Li, Shelby Marozoff, Na Lu, Hui Xie, Jacek A. Kopec, Jolanda Cibere, John M. Esdaile, J. Antonio Avina-Zubieta

Open Access Research

Identification of biomarkers by machine learning classifiers to assist diagnose rheumatoid arthritis-associated interstitial lung disease

Yan Qin, Yanlin Wang, Fanxing Meng, Min Feng, Xiangcong Zhao, Chong Gao, Jing Luo

Open Access Research article

High risk of depression, anxiety, and an unfavorable complex comorbidity profile is associated with SLE: a nationwide patient-level study

Fruzsina Kósa, Péter Kunovszki, Judit Gimesi-Országh, Melinda Kedves, Melinda Szabó, Chetan S. Karyekar, György Nagy

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Monitoring of patients with rheumatoid arthritis by indocyanine green (ICG)-enhanced fluorescence optical imaging treated with anti-TNFα therapy

S. Hertrampf, J. Klotsche, Q. Schefer, A. M. Glimm, G. R. Burmester, P. Hoff, G. Schmittat, T. Häupl, S. Hermann, M. Backhaus, Sarah Ohrndorf

Open Access Correction

Correction: Serum biomarker for diagnostic evaluation of pulmonary arterial hypertension in systemic sclerosis

Lisa M. Rice, Julio C. Mantero, Eric A. Stratton, Rod Warburton, Kari Roberts, Nicholas Hill, Robert W. Simms, Robyn Domsic, Harrison W. Farber, Robert Lafyatis

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Mass spectrometry-based proteomics identify novel serum osteoarthritis biomarkers

Ginette Tardif, Frédéric Paré, Clarisse Gotti, Florence Roux-Dalvai, Arnaud Droit, Guangju Zhai, Guang Sun, Hassan Fahmi, Jean-Pierre Pelletier, Johanne Martel-Pelletier

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Circulating Th2 cell reduction and Th1/Th2 imbalance are correlated with primary Sjogren’s syndrome-associated interstitial lung disease

Lei Shi, Jia Wang, Hong-Xia Guo, Xiao-Lei Han, Yu-Ping Tang, Guang-Ying Liu

Open Access Research article

Accuracy and tolerability of self-sampling of capillary blood for analysis of inflammation and autoantibodies in rheumatoid arthritis patients—results from a randomized controlled trial

Johannes Knitza, Koray Tascilar, Nicolas Vuillerme, Ekaterina Eimer, Paul Matusewicz, Giulia Corte, Louis Schuster, Timothée Aubourg, Gerlinde Bendzuck, Marianne Korinth, Corinna Elling-Audersch, Arnd Kleyer, Sebastian Boeltz, Axel J. Hueber, Gerhard Krönke, Georg Schett, David Simon

Open Access Research article

Apolipoprotein C-III is linked to the insulin resistance and beta-cell dysfunction that are present in rheumatoid arthritis

Candelaria Martín-González, Tomás Martín-Folgueras, Juan Carlos Quevedo-Abeledo, Antonia de Vera-González, Alejandra González-Delgado, Laura de Armas-Rillo, Miguel Á. González-Gay, Iván Ferraz-Amaro

Open Access Research article

Risk factors for the recurrence of relapsing polychondritis

Tsuneyasu Yoshida, Hajime Yoshifuji, Mirei Shirakashi, Akiyoshi Nakakura, Kosaku Murakami, Koji Kitagori, Shuji Akizuki, Ran Nakashima, Koichiro Ohmura, Akio Morinobu

Open Access Research

The anterior cruciate ligament in murine post-traumatic osteoarthritis: markers and mechanics

Lorenzo Ramos-Mucci, Ahmed Elsheikh, Craig Keenan, Ashkan Eliasy, Kristiaan D’Aout, George Bou-Gharios, Eithne Comerford, Blandine Poulet

Open Access Research article

Comparative analysis of the gut microbiota composition between knee osteoarthritis and Kashin-Beck disease in Northwest China

Yujie Ning, Minhan Hu, Yi Gong, Ruitian Huang, Ke Xu, Sijie Chen, Feiyu Zhang, Yanli Liu, Feihong Chen, Yanhai Chang, Guanghui Zhao, Cheng Li, Rong Zhou, Mikko J. Lammi, Xiong Guo, Xi Wang

Open Access Comment

Zibotentan in systemic sclerosis-associated chronic kidney disease: a phase II randomised placebo-controlled trial

Edward P. Stern, Lauren V. Host, Ivy Wanjiku, K. Jane Escott, Peter S. Gilmour, Rachel Ochiel, Robert Unwin, Aine Burns, Voon H. Ong, Helen Cadiou, Aidan G. O’Keeffe, Christopher P. Denton

Open Access Research article

Clinical course of patients with rheumatoid arthritis who continue or discontinue biologic therapy after hospitalization for infection: a retrospective observational study

Yusuke Kashiwado, Chikako Kiyohara, Yasutaka Kimoto, Shuji Nagano, Takuya Sawabe, Kensuke Oryoji, Shinichi Mizuki, Hiroaki Nishizaka, Seiji Yoshizawa, Shigeru Yoshizawa, Tomomi Tsuru, Yasushi Inoue, Naoyasu Ueda, Shun-ichiro Ota, Yasuo Suenaga, Tomoya Miyamura, Yoshifumi Tada, Hiroaki Niiro, Koichi Akashi, Takahiko Horiuchi

Open Access Research article

Rheumatoid arthritis patients initiating rituximab with low number of previous bDMARDs failures may effectively reduce rituximab dose and experience fewer serious adverse events than patients on full dose: a 5-year cohort study

Antonios Bertsias, Nestor Avgoustidis, Ioannis Papalopoulos, Argyro Repa, Nikolaos Kougkas, Eleni Kalogiannaki, Georgios Bertsias, Irini Flouri, Prodromos Sidiropoulos

Open Access Research

Intravenous tocilizumab for the treatment of giant cell arteritis: a phase Ib dose-ranging pharmacokinetic bridging study

Christophe Schmitt, Laura Brockwell, Mylène Giraudon, Mauro Zucchetto, Lisa Christ, Bettina Bannert, Thomas Daikeler, Peter M. Villiger

Open Access Research

Semaphorin 3G exacerbates joint inflammation through the accumulation and proliferation of macrophages in the synovium

Jumpei Shoda, Shigeru Tanaka, Keishi Etori, Koto Hattori, Tadamichi Kasuya, Kei Ikeda, Yuko Maezawa, Akira Suto, Kotaro Suzuki, Junichi Nakamura, Yoshiro Maezawa, Minoru Takemoto, Christer Betsholtz, Koutaro Yokote, Seiji Ohtori, Hiroshi Nakajima

Open Access Research article

Efficacy and safety of HLX01 in patients with moderate-to-severe rheumatoid arthritis despite methotrexate therapy: a phase 3 study

Xiaofeng Zeng, Ju Liu, Xiumei Liu, Lijun Wu, Yi Liu, Xiangping Liao, Huaxiang Liu, Jiankang Hu, Xin Lu, Linjie Chen, Jian Xu, Zhenyu Jiang, Fu-ai Lu, Huaxiang Wu, Ying Li, Qingyu Wang, Jun Zhu, Lingyun Sun, Meimei Wang, Xiaoxia Yu, Pingting Yang, Qinghua Zou, Baijie Xu, Hua Zhang, Cibo Huang, Liqi Bi, Xiaoxia Li, Jianzhao Cheng, Hua Wei, Lan He, Hao Zhang, Hongsheng Sun, Zongwen Shuai, Jianhong Zhao, Yang Li, Rongbin Li, Fengju Li, Xiaomei Li, Zhuoli Zhang, Wufang Qi, Hongwei Du, Jingchun Jin, Jian Wu

Open Access Research

Tissue catabolism and donor-specific dexamethasone response in a human osteochondral model of post-traumatic osteoarthritis

Rebecca Mae Black, Lisa L. Flaman, Karin Lindblom, Susan Chubinskaya, Alan J. Grodzinsky, Patrik Önnerfjord

Open Access Research article

Global burden of rheumatic heart disease: trends from 1990 to 2019

Zejin Ou, Danfeng Yu, Yuanhao Liang, Jinhua Wu, Huan He, Yongzhi Li, Wenqiao He, Yuhan Gao, Fei Wu, Qing Chen

Open Access Research article

Associations of C-reactive protein isoforms with systemic lupus erythematosus phenotypes and disease activity

Jesper Karlsson, Jonas Wetterö, Maria Weiner, Johan Rönnelid, Rafael Fernandez-Botran, Christopher Sjöwall

Open Access Research

Clinical characteristics and prognosis of patients with antiphospholipid antibodies based on cluster analysis: an 8-year cohort study

Wanting Qi, Jiuliang Zhao, Can Huang, Nan Jiang, Jing Li, Chanyuan Wu, Shangzhu Zhang, Chaojun Hu, Dong Xu, Qian Wang, Mengtao Li, Xinping Tian, Yan Zhao, Xiaofeng Zeng

Open Access Research article

Systemic lupus erythematosus dysregulates the expression of long noncoding RNAs in placentas

Hui-hui Li, Lin-tao Sai, Yuan Liu, Colman I. Freel, Kai Wang, Chi Zhou, Jing Zheng, Qiang Shu, Ying-jie Zhao

Open Access Research

Peripheral blood CD4posCD25posFoxP3pos cells and inflammatory cytokines as biomarkers of response in rheumatoid arthritis patients treated with CTLA4-Ig

Elisa Gremese, Barbara Tolusso, Luca Petricca, Clara Di Mario, Maria Rita Gigante, Gianfranco Ferraccioli, Stefano Alivernini

Open Access Research article

Influence of initial glucocorticoid co-medication on mortality and hospitalization in early inflammatory arthritis: an investigation by record linkage of clinical and administrative databases

Garifallia Sakellariou, Carlo Alberto Scirè, Federica Rumi, Greta Carrara, Anna Zanetti, Carlo Cerra, Simona Migliazza, Serena Bugatti, Carlomaurizio Montecucco

Open Access Research article

Metabolomics with severity of radiographic knee osteoarthritis and early phase synovitis in middle-aged women from the Iwaki Health Promotion Project: a cross-sectional study

Eiji Sasaki, Hiroyuki Yamamoto, Toru Asari, Rira Matsuta, Seiya Ota, Yuka Kimura, Shizuka Sasaki, Kyota Ishibashi, Yuji Yamamoto, Kenjiro Kami, Masataka Ando, Eiichi Tsuda, Yasuyuki Ishibashi

Open Access Research

Defining minimal detectable difference in echocardiographic measures of right ventricular function in systemic sclerosis

Monica Mukherjee, Valentina Mercurio, Aparna Balasubramanian, Ami A. Shah, Steven Hsu, Catherine E. Simpson, Rachel Damico, Todd M. Kolb, Paul M. Hassoun, Stephen C. Mathai

Open Access Research article

The association between ambient UVB dose and ANCA-associated vasculitis relapse and onset

Jennifer Scott, Enock Havyarimana, Albert Navarro-Gallinad, Arthur White, Jason Wyse, Jos van Geffen, Michiel van Weele, Antonia Buettner, Tamara Wanigasekera, Cathal Walsh, Louis Aslett, John D. Kelleher, Julie Power, James Ng, Declan O’Sullivan, Lucy Hederman, Neil Basu, Mark A. Little, Lina Zgaga, Mark Little, Peter Lavin, Catherine Wall, George Mellotte, Jennifer Scott, Ted Fitzgerald, Hannah O’Keefe, Rachel Dilworth, Pamela O’Neill, Vicki Carr, Niall Conlon, Brenda Griffin, Donal Sexton, Caroline Kosgei, Yvonne O’Meara, Eoghan White, Stephen Mahony, Eamonn Molloy, John Holian, Matt Griffin, David Lappin, Conor Judge, Sarah Cormican, Blathnaid O’Connell, Michelle Clince, Liam Casserly, Michael Clarkson, Michelle O’Shaughnessy, Alyssa Verrelli, Sinead Stoeman, Fergus Daly, Laura Slattery, Aisling Murphy, Declan De Freitas, Peter Conlon, Mark Denton, Carol Treanor, Colm Magee, Conall O. Seaghdha, Paul O’Hara, Susan McGrath, Brona Moloney, Dean Moore, Dearbhla Kelly, Mary McCarthy, Tamara Wanigasekera, Ayanfeoluwa Obilana, Claire Kennedy, Dervla Connaughton, Mark Canney, Limy Wong, Sarah Moran

Open Access Research article

Myeloid cell-specific deletion of Capns1 prevents macrophage polarization toward the M1 phenotype and reduces interstitial lung disease in the bleomycin model of systemic sclerosis

Li Zhang, Dong Zheng, Yuemei Yan, Yong Yu, Ruizhen Chen, Zheng Li, Peter A. Greer, Tianqing Peng, Qiang Wang

Open Access Research article

High serum uric acid trajectories are associated with risk of myocardial infarction and all-cause mortality in general Chinese population

Xue Tian, Yingting Zuo, Shuohua Chen, Shouling Wu, Anxin Wang, Yanxia Luo

Open Access Research article

Association of clinic setting with quality indicator performance in systemic lupus erythematosus: a cross-sectional study

Sidha Sreedharan, Ning Li, Geoff Littlejohn, Russell Buchanan, Mandana Nikpour, Eric Morand, Alberta Hoi, Vera Golder

Open Access Research article

Long-term exposure to fine particulate matter and ozone and the onset of systemic autoimmune rheumatic diseases: an open cohort study in Quebec, Canada

Naizhuo Zhao, Audrey Smargiassi, Sonia Jean, Philippe Gamache, Elhadji-Anassour Laouan-Sidi, Hong Chen, Mark S. Goldberg, Sasha Bernatsky

Open Access Research

Extracellular matrix protein turnover markers are associated with axial spondyloarthritis—a comparison with postpartum women and other non-axial spondyloarthritis controls with or without back pain

Helena Port, Signe Holm Nielsen, Sofie Falkenløve Madsen, Anne-Christine Bay-Jensen, Morten Karsdal, Sengül Seven, Inge Juul Sørensen, Lone Morsel-Carlsen, Mikkel Østergaard, Susanne Juhl Pedersen

Open Access Research

Minimal disease activity (MDA) in patients with recent-onset psoriatic arthritis: predictive model based on machine learning

Rubén Queiro, Daniel Seoane-Mato, Ana Laiz, Eva Galíndez Agirregoikoa, Carlos Montilla, Hye-Sang Park, Jose A. Pinto-Tasende, Juan J. Bethencourt Baute, Beatriz Joven Ibáñez, Elide Toniolo, Julio Ramírez, Ana Serrano García, Juan D. Cañete, Xavier Juanola, Jordi Fiter, Jordi Gratacós, Jesús Rodriguez-Moreno, Jaime Notario Rosa, Andrés Lorenzo Martín, Anahy Brandy García, Pablo Coto Segura, Anna López Ferrer, Silvia Pérez Barrio, Andrés J. Plata Izquierdo, Sagrario Bustabad, Francisco J. Guimerá Martín-Neda, Eduardo Fonseca Capdevilla, Raquel Rivera Díaz, Andrea Cuervo, Mercè Alsina Gibert, Pilar Trenor Larraz, Isabel de la Morena Barrio, Laura Puchades Lanza, Diego Bedoya Sanchís, Catalina Meliá Mesquida, Claudia Murillo, Manuel J. Moreno Ramos, María D. Beteta, Paloma Sánchez-Pedreño Guillén, Leticia Lojo Oliveira, Teresa Navío Marco, Laura Cebrián, Pablo de la Cueva Dobao, Martina Steiner, Santiago Muñoz-Fernández, Ricardo Valverde Garrido, Manuel León, Esteban Rubio, Alejandro Muñoz Jiménez, Lourdes Rodríguez Fernández-Freire, Julio Medina Luezas, María D. Sánchez-González, Carolina Sanz Muñoz, José M. Senabre, José C. Rosas, Gregorio Santos Soler, Francisco J. Mataix Díaz, Juan C. Nieto-González, Carlos González, Juan G. Ovalles Bonilla, Ofelia Baniandrés Rodríguez, Fco Javier Nóvoa Medina, Dunia Luján, María D. Ruiz Montesino, Ana M. Carrizosa Esquivel, Cristina Fernández-Carballido, María P. Martínez-Vidal, Laura García Fernández, Vega Jovani, Rocío Caño Alameda, Silvia Gómez Sabater, Isabel Belinchón Romero, Ana Urruticoechea-Arana, Marta Serra Torres, Raquel Almodóvar, José L. López Estebaranz, María D. López Montilla, Antonio Vélez García-Nieto

Open Access Letter

Evidence for the presence of synovial sheaths surrounding the extensor tendons at the metacarpophalangeal joints: a microscopy study

Yousra J. Dakkak, Bastiaan T. van Dijk, Friso P. Jansen, Lambertus J. Wisse, Monique Reijnierse, Annette H. M. van der Helm-van Mil, Marco C. DeRuiter

Open Access Research article

Patient-reported outcomes of upadacitinib versus abatacept in patients with rheumatoid arthritis and an inadequate response to biologic disease-modifying antirheumatic drugs: 12- and 24-week results of a phase 3 trial

Martin Bergman, Namita Tundia, Naomi Martin, Jessica L. Suboticki, Jayeshkumar Patel, Debbie Goldschmidt, Yan Song, Grace C. Wright

Open Access Research

Improved skeletal muscle fatigue resistance in experimental autoimmune myositis mice following high-intensity interval training

Takashi Yamada, Yuki Ashida, Katsuyuki Tamai, Iori Kimura, Nao Yamauchi, Azuma Naito, Nao Tokuda, Håkan Westerblad, Daniel C. Andersson, Koichi Himori

Open Access Research

Dark-light cycle disrupts bone metabolism and suppresses joint deterioration in osteoarthritic rats

Xiaopeng Song, Mingchao Zhao, Jilang Tang, Tianwen Ma, Hui Bai, Xinyu Wang, Lin Liu, Ting Li, Xinyu Xu, Xuanbo Sheng, Binger Zhao, Yingying Wang, Tiantian Wang, Yingchao Guo, Xinmin Zhang, Li Gao

Open Access Research

Safety and effectiveness of mepolizumab therapy in remission induction therapy for eosinophilic granulomatosis with polyangiitis: a retrospective study

Masanobu Ueno, Ippei Miyagawa, Takafumi Aritomi, Koichi Kimura, Shigeru Iwata, Kentaro Hanami, Syunsuke Fukuyo, Satoshi Kubo, Yusuke Miyazaki, Shingo Nakayamada, Yoshiya Tanaka

Open Access Research

Neutrophil activation in patients with anti-neutrophil cytoplasmic autoantibody-associated vasculitis and large-vessel vasculitis

Despina Michailidou, Bhargavi Duvvuri, Runa Kuley, David Cuthbertson, Peter C. Grayson, Nader A. Khalidi, Curry L. Koening, Carol A. Langford, Carol A. McAlear, Larry W. Moreland, Christian Pagnoux, Philip Seo, Ulrich Specks, Antoine G. Sreih, Kenneth J. Warrington, Tomas Mustelin, Paul A. Monach, Peter A. Merkel, Christian Lood

Open Access Research

Efficacy and safety of the biosimilar denosumab candidate (Arylia) compared to the reference product (Prolia®) in postmenopausal osteoporosis: a phase III, randomized, two-armed, double-blind, parallel, active-controlled, and noninferiority clinical trial

Ahmadreza Jamshidi, Mahdi Vojdanian, Mohsen Soroush, Mahmoud Akbarian, Mehrdad Aghaei, Asghar Hajiabbasi, Zahra Mirfeizi, Alireza Khabbazi, Gholamhosein Alishiri, Anousheh Haghighi, Ahmad Salimzadeh, Hadi Karimzadeh, Fatemeh Shirani, Mohammad Reza Hatef Fard, MohammadAli Nazarinia, Soosan Soroosh, Nassim Anjidani, Farhad Gharibdoost

Open Access Research

Clinical predictors of response to methotrexate in patients with rheumatoid arthritis: a machine learning approach using clinical trial data

Stephanie Q. Duong, Cynthia S. Crowson, Arjun Athreya, Elizabeth J. Atkinson, John M. Davis III, Kenneth J. Warrington, Eric L. Matteson, Richard Weinshilboum, Liewei Wang, Elena Myasoedova

Open Access Research

Distinctive gut microbiomes of ankylosing spondylitis and inflammatory bowel disease patients suggest differing roles in pathogenesis and correlate with disease activity

P. R. Sternes, L. Brett, J. Phipps, F. Ciccia, T. Kenna, E. de Guzman, K. Zimmermann, M. Morrison, G. Holtmann, E. Klingberg, D. Mauro, C. McIvor, H. Forsblad-d’Elia, M. A. Brown

Open Access Research

The role of LCN2 and LCN2-MMP9 in spondylitis radiographic development: gender and HLA-B27 status differences

Florence W. L. Tsui, Aifeng Lin, Ismail Sari, Zhenbo Zhang, Kenneth P. H. Pritzker, Hing Wo Tsui, Robert D. Inman

Open Access Research article

Increased Wnt/β-catenin signaling contributes to autophagy inhibition resulting from a dietary magnesium deficiency in injury-induced osteoarthritis

Ruijun Bai, Michael Z. Miao, Hui Li, Yiqing Wang, Ruixue Hou, Ke He, Xuan Wu, Hongyu Jin, Chao Zeng, Yang Cui, Guanghua Lei

Open Access Research

Network analysis of synovial RNA sequencing identifies gene-gene interactions predictive of response in rheumatoid arthritis

Elisabetta Sciacca, Anna E. A. Surace, Salvatore Alaimo, Alfredo Pulvirenti, Felice Rivellese, Katriona Goldmann, Alfredo Ferro, Vito Latora, Costantino Pitzalis, Myles J. Lewis

Open Access Research

Cryoglobulinemia in systemic lupus erythematosus: a retrospective study of 213 patients

Yoann Roubertou, Sabine Mainbourg, Arnaud Hot, Denis Fouque, Cyrille Confavreux, Roland Chapurlat, Sébastien Debarbieux, Denis Jullien, Pascal Sève, Laurent Juillard, Marie-Nathalie Kolopp-Sarda, Jean-Christophe Lega

Open Access Research

Selective block of sensory neuronal T-type/Cav3.2 activity mitigates neuropathic pain behavior in a rat model of osteoarthritis pain

Brandon Itson-Zoske, Seung Min Shin, Hao Xu, Chensheng Qiu, Fan Fan, Quinn H. Hogan, Hongwei Yu

Open Access Research article

Modulation of B cell activation by extracellular vesicles and potential alteration of this pathway in patients with rheumatoid arthritis

Héctor Rincón-Arévalo, Catalina Burbano, Laura Atehortúa, Mauricio Rojas, Adriana Vanegas-García, Gloria Vásquez, Diana Castaño

Open Access Research

The potential roles of type I interferon activated neutrophils and neutrophil extracellular traps (NETs) in the pathogenesis of primary Sjögren’s syndrome

Yu Peng, Xunyao Wu, Shulan Zhang, Chuiwen Deng, Lidan Zhao, Mu Wang, Qingjun Wu, Huaxia Yang, Jiaxin Zhou, Linyi Peng, Xuan Luo, Yingying Chen, Anqi Wang, Qiufeng Xiao, Wen Zhang, Yan Zhao, Xiaofeng Zeng, Yunyun Fei

Open Access Review

The effect of disease-modifying anti-rheumatic drugs on skeletal muscle mass in rheumatoid arthritis patients: a systematic review with meta-analysis

Thales R. Hein, Leonardo Peterson, Barbara J. Bartikoski, Juliana Portes, Rafaela C. Espírito Santo, Ricardo M. Xavier

Open Access Research

Prognostic meaning of right ventricular function and output reserve in patients with systemic sclerosis

Panagiota Xanthouli, Julia Miazgowski, Nicola Benjamin, Ojan Gordjani, Benjamin Egenlauf, Satenik Harutyunova, Rebekka Seeger, Alberto M. Marra, Norbert Blank, Hanns-Martin Lorenz, Ekkehard Grünig, Christina A. Eichstaedt

Open Access Review

Senescence in osteoarthritis: from mechanism to potential treatment

Yikai Liu, Zian Zhang, Tao Li, Hao Xu, Haining Zhang

Open Access Research article

Xanthine oxidase inhibitor urate-lowering therapy titration to target decreases serum free fatty acids in gout and suppresses lipolysis by adipocytes

Monica Guma, Benyamin Dadpey, Roxana Coras, Ted R. Mikuls, Bartlett Hamilton, Oswald Quehenberger, Hilda Thorisdottir, David Bittleman, Kimberly Lauro, Shannon M. Reilly, Ru Liu-Bryan, Robert Terkeltaub

Open Access Research

Oral dextran sulfate sodium administration induces peripheral spondyloarthritis features in SKG mice accompanied by intestinal bacterial translocation and systemic Th1 and Th17 cell activation

Yuya Tabuchi, Masao Katsushima, Yuri Nishida, Mirei Shirakashi, Hideaki Tsuji, Hideo Onizawa, Koji Kitagori, Shuji Akizuki, Ran Nakashima, Kosaku Murakami, Koichi Murata, Hajime Yoshifuji, Masao Tanaka, Akio Morinobu, Motomu Hashimoto

Open Access Correction

Correction: Peripheral blood CD4posCD25posFoxP3pos cells and inflammatory cytokines as biomarkers of response in rheumatoid arthritis patients treated with CTLA4-Ig

Elisa Gremese, Barbara Tolusso, Luca Petricca, Clara Di Mario, Maria Rita Gigante, Gianfranco Ferraccioli, Stefano Alivernini

Open Access Research

Investigation of the association between coffee and risk of RA—results from the Swedish EIRA study

Helga Westerlind, Justine Dukuzimana, Xiaomin Lu, Lars Alfredsson, Lars Klareskog, Daniela Di Giuseppe

Open Access Research article

Association of low-dose glucocorticoid use and infection occurrence in systemic lupus erythematosus patients: a prospective cohort study

Kazuya Abe, Yuichi Ishikawa, Yasuhiko Kita, Nobuyuki Yajima, Eisuke Inoue, Ken-ei Sada, Yoshia Miyawaki, Ryusuke Yoshimi, Yasuhiro Shimojima, Shigeru Ohno, Hiroshi Kajiyama, Kunihiro Ichinose, Shuzo Sato, Michio Fujiwara

Open Access Research article

Incident and recurrent herpes zoster for first-line bDMARD and tsDMARD users in seropositive rheumatoid arthritis patients: a nationwide cohort study

Seogsong Jeong, Seulggie Choi, Sang Min Park, Jinseok Kim, Byeongzu Ghang, Eun Young Lee

Open Access Research

Targeting clock-controlled gene Nrf2 ameliorates inflammation-induced intervertebral disc degeneration

Pandi Peng, Dong Wang, Xiaolong Xu, Di Wang, Bo Gao, Han Wang, Haoruo Jia, Qiliang Shang, Chao Zheng, Chu Gao, Jianxin Mao, Zhuojing Luo, Liu Yang, Xueyu Hu

Open Access Correction

Correction: Genome-wide DNA methylation profile analysis identifies differentially methylated loci associated with ankylosis spondylitis

Jingcan Hao, Yang Liu, Jiawen Xu, Wenyu Wang, Yan Wen, Awen He, Qianrui Fan, Xiong Guo, Feng Zhang

Open Access Research

The MCP2 and the wrist plus two extensor compartments are the most affected and responsive joints/tendons out of the US7 score in patients with rheumatoid arthritis-an observational study

A. F. Podewski, A. M. Glimm, I. Fischer, G. A. W. Bruyn, P. Hanova, H. B. Hammer, A. B. Aga, E. A. Haavardsholm, S. Ramiro, G. R. Burmester, M. Backhaus, S. Ohrndorf

Open Access Research

Prospective changes in diastolic function in patients with rheumatoid arthritis

Elizabeth Park, Kazato Ito, Rabia Iqbal, Isabelle Amigues, Sabahat Bokhari, Jennifer Van Eyk, Christopher Depender, Jon T. Giles, Joan Bathon

Open Access Research

Does persistence to methotrexate treatment in early rheumatoid arthritis have a familial component?

Anton Öberg Sysojev, Thomas Frisell, Bénédicte Delcoigne, Saedis Saevarsdottir, Johan Askling, Helga Westerlind

Open Access Research

Transcriptome analysis of immune cells from Behçet’s syndrome patients: the importance of IL-17-producing cells and antigen-presenting cells in the pathogenesis of Behçet’s syndrome

Mai Okubo, Shuji Sumitomo, Yumi Tsuchida, Yasuo Nagafuchi, Yusuke Takeshima, Haruyuki Yanaoka, Harumi Shirai, Satomi Kobayashi, Yusuke Sugimori, Junko Maeda, Hiroaki Hatano, Yukiko Iwasaki, Hirofumi Shoda, Tomohisa Okamura, Kazuhiko Yamamoto, Mineto Ota, Keishi Fujio

Open Access Research

A randomized, double-blind, placebo-controlled 12-week trial of infliximab in patients with juvenile-onset spondyloarthritis

Rubén Burgos-Vargas, Adalberto Loyola-Sanchez, Sofia Ramiro, Arturo Reding-Bernal, Everardo Alvarez-Hernandez, Desirée van der Heijde, Janitzia Vázquez-Mellado

Open Access Research

Identification of TMEM129, encoding a ubiquitin-protein ligase, as an effector gene of osteoarthritis genetic risk

Abby Brumwell, Guillaume Aubourg, Juhel Hussain, Eleanor Parker, David J. Deehan, Sarah J. Rice, John Loughlin

Open Access Research

Treatment of rheumatoid arthritis and its outcomes in an aging society: a single-center cohort study in Japan from 2011 to 2020

Wataru Fukuda, Masatoshi Kadoya, Atsushi Omoto, Takuya Yanagida, Yu Isoda, Atsuhiko Sunaga, Hiroaki Kusuoka, Kentaro Ueno, Satoshi Morita, Masataka Kohno, Yutaka Kawahito

Open Access Research article

The risk of newly diagnosed cancer in patients with rheumatoid arthritis by TNF inhibitor use: a nationwide cohort study

Boyoon Choi, Hyun Jin Park, Yun-Kyoung Song, Yoon-Jeong Oh, In-Wha Kim, Jung Mi Oh

Open Access Research

Cytomegalovirus infection is a risk factor for venous thromboembolism in ANCA-associated vasculitis

C. King, R. Patel, C. Mendoza, J. K. Walker, E. Y. Wu, P. Moss, M. D. Morgan, D. O’Dell Bunch, L. Harper, D. Chanouzas

Open Access Research

Early persistence on therapy impacts drug-free remission: a case-control study in a cohort of Hispanic patients with recent-onset rheumatoid arthritis

Irazú Contreras-Yáñez, Guillermo Arturo Guaracha-Basáñez, Maximiliano Cuevas-Montoya, José de Jesús Hernández-Bautista, Virginia Pascual-Ramos

Open Access Research

Serum granulocyte-macrophage colony-stimulating factor (GM-CSF) is increased in patients with active radiographic axial spondyloarthritis and persists despite anti-TNF treatment

Charalampos Papagoras, Styliani Tsiami, Akrivi Chrysanthopoulou, Ioannis Mitroulis, Xenofon Baraliakos

Open Access Review

Role of NLRP3 inflammasome in systemic sclerosis

Cong Lin, Zhixing Jiang, Ling Cao, Hejian Zou, Xiaoxia Zhu

Open Access Research

Gingko biloba-inspired lactone prevents osteoarthritis by activating the AMPK-SIRT1 signaling pathway

Zhijian Zhao, Yang Liu, Yingjie Lu, Mingzhuang Hou, Xu Shen, Huilin Yang, Qin Shi, Yijian Zhang, Fan He, Xuesong Zhu

Open Access Research

Inflammatory cytokines and mechanical injury induce post-traumatic osteoarthritis-like changes in a human cartilage-bone-synovium microphysiological system

Garima Dwivedi, Lisa Flaman, Begum Alaybeyoglu, André Struglics, Eliot H. Frank, Susan Chubinskya, Stephen B. Trippel, Vicki Rosen, Murat Cirit, Alan J. Grodzinsky

Open Access Research

CC-99677, a novel, oral, selective covalent MK2 inhibitor, sustainably reduces pro-inflammatory cytokine production

Rajula Gaur, Kofi A. Mensah, Jason Stricker, Mary Adams, Anastasia Parton, Dorota Cedzik, Jamie Connarn, Michael Thomas, Gerald Horan, Peter Schafer, Stuart Mair, Maria Palmisano, Francisco Ramírez-Valle

Open Access Research

Calprotectin (S100A8/S100A9) detects inflammatory activity in rheumatoid arthritis patients receiving tocilizumab therapy

Michael Gernert, Marc Schmalzing, Hans-Peter Tony, Patrick-Pascal Strunz, Eva Christina Schwaneck, Matthias Fröhlich

Open Access Research

Cluster analysis of patients with granulomatosis with polyangiitis (GPA) based on clinical presentation symptoms: a UK population-based cohort study

Rasiah Thayakaran, Ruchika Goel, Nicola J. Adderley, Joht Singh Chandan, Dawit Zemedikun, Krishnarajah Nirantharakumar, Lorraine Harper

Open Access Research article

Comparing cardiovascular risk of patients with rheumatoid arthritis within the Social Security Disability Insurance with those commercially insured

Iris Navarro-Millán, Fenglong Xie, Cynthia S. Crowson, Monika M. Safford, Mangala Rajan, Sebastian E. Sattui, Jeffrey R. Curtis

Open Access Research

Neither low social support nor low decision latitude at work is associated with disease remission among patients with rheumatoid arthritis: results from the Swedish EIRA study

Louise Hedenstierna, Anna Karin Hedström, Lars Klareskog, Daniela Di Giuseppe, Lars Alfredsson, Johan Askling, Sofia Ernestam, Saedis Saevarsdottir, Lotta Ljung

Open Access Research

Hypertrophic pachymeningitis in ANCA-associated vasculitis: a cross-sectional and multi-institutional study in Japan (J-CANVAS)

Yasuhiro Shimojima, Dai Kishida, Takanori Ichikawa, Takashi Kida, Nobuyuki Yajima, Satoshi Omura, Daiki Nakagomi, Yoshiyuki Abe, Masatoshi Kadoya, Naoho Takizawa, Atsushi Nomura, Yuji Kukida, Naoya Kondo, Yasuhiko Yamano, Takuya Yanagida, Koji Endo, Shintaro Hirata, Kiyoshi Matsui, Tohru Takeuchi, Kunihiro Ichinose, Masaru Kato, Ryo Yanai, Yusuke Matsuo, Ryo Nishioka, Ryota Okazaki, Tomoaki Takata, Takafumi Ito, Mayuko Moriyama, Ayuko Takatani, Yoshia Miyawaki, Toshiko Ito-Ihara, Takashi Kawaguchi, Yutaka Kawahito, Yoshiki Sekijima

Open Access Review

Characteristics and mechanisms of resorption in lumbar disc herniation

Pengfei Yu, Feng Mao, Jingyun Chen, Xiaoying Ma, Yuxiang Dai, Guanhong Liu, Feng Dai, Jingtao Liu

Open Access Research

Baseline IgG-Fc N-glycosylation profile is associated with long-term outcome in a cohort of early inflammatory arthritis patients

Thomas Sénard, Irini Flouri, Frano Vučković, Garyfalia Papadaki, Panagiota Goutakoli, Aggelos Banos, Maja Pučić-Baković, Marija Pezer, George Bertsias, Gordan Lauc, Prodromos Sidiropoulos

Open Access Research

Association between low hemoglobin, clinical measures, and patient-reported outcomes in patients with rheumatoid arthritis: results from post hoc analyses of three phase III trials of sarilumab

Andrea Rubbert-Roth, Daniel E. Furst, Stefano Fiore, Amy Praestgaard, Vivian Bykerk, Clifton O. Bingham, Christina Charles-Schoeman, Gerd Burmester

Open Access Research

A multicentre, efficacy and safety study of methotrexate to increase response rates in patients with uncontrolled gout receiving pegloticase (MIRROR): 12-month efficacy, safety, immunogenicity, and pharmacokinetic findings during long-term extension of an open-label study

John K. Botson, John R. P. Tesser, Ralph Bennett, Howard M. Kenney, Paul M. Peloso, Katie Obermeyer, Yang Song, Brian LaMoreaux, Lin Zhao, Yan Xin, Jason Chamberlain, Srini Ramanathan, Michael E. Weinblatt, Jeff Peterson

Open Access Research

Both T and B cells are indispensable for the development of a PBMC transfer-induced humanized mouse model for SSc

Yaqing Shu, Xiaoyang Yue, Jacqueline Wax, Brigitte Kasper, Junping Yin, Xiaoqing Wang, Liang Zhang, Marjan Ahmadi, Harald Heidecke, Antje Müller, Peter Lamprecht, Xinhua Yu, Gabriela Riemekasten, Frank Petersen

Open Access Research

Dersimelagon, a novel oral melanocortin 1 receptor agonist, demonstrates disease-modifying effects in preclinical models of systemic sclerosis

Masahiro Kondo, Tsuyoshi Suzuki, Yuko Kawano, Shinji Kojima, Masahiko Miyashiro, Atsuhiro Matsumoto, Gabriela Kania, Przemysław Błyszczuk, Rebecca L. Ross, Panji Mulipa, Francesco Del Galdo, Yun Zhang, Jörg H. W. Distler

Open Access Research

Utilization of preventive services in a systemic lupus erythematosus population-based cohort: a Lupus Midwest Network (LUMEN) study

Baptiste Chevet, Gabriel Figueroa-Parra, Jeffrey X. Yang, Mehmet Hocaoglu, Shirley-Ann Osei-Onomah, Cassondra A. Hulshizer, Tina M. Gunderson, Divi Cornec, Kamil E. Barbour, Kurt J. Greenlund, Cynthia S. Crowson, Alí Duarte-García

Open Access Research

Factors secreted by monosodium urate crystal-stimulated macrophages promote a proinflammatory state in osteoblasts: a potential indirect mechanism of bone erosion in gout

Dorit Naot, Bregina Pool, Ashika Chhana, Ryan Gao, Jacob T. Munro, Jillian Cornish, Nicola Dalbeth

Open Access Research

Prognostic factors for the development of systemic lupus erythematosus in patients with immune thrombocytopenia

Soo Min Ahn, Eun-Ji Choi, Ji Seon Oh, Yong-Gil Kim, Chang-Keun Lee, Bin Yoo, Seokchan Hong

Open Access Research

Circ0007042 alleviates intervertebral disc degeneration by adsorbing miR-369 to upregulate BMP2 and activate the PI3K/AKt pathway

Zhenyu Wang, Yuguang Zhao, Yi Liu, Zhigang Qu, Xinming Zhuang, Qingxu Song, Haoyu Li, Jiali Leng

Open Access Research

Osteophytes mediate the associations between cartilage morphology and changes in knee symptoms in patients with knee osteoarthritis

Tianxiang Fan, Shibo Chen, Muhui Zeng, Jia Li, Xiaoshuai Wang, Guangfeng Ruan, Peihua Cao, Yan Zhang, Tianyu Chen, Qianhua Ou, Qianyi Wang, Anita E. Wluka, Flavia Cicuttini, Changhai Ding, Zhaohua Zhu

Open Access Research

Subclinical systolic and diastolic myocardial dysfunction in polyphasic polymyositis/dermatomyositis: a 2-year longitudinal study

Andrea Péter, Ágnes Balogh, Zoltán Csanádi, Katalin Dankó, Zoltan Griger

Open Access Research

Autologous Protein Solution processing alters lymphoid and myeloid cell populations and modulates gene expression dependent on cell type

Alexis N. Peña, Sven D. Sommerfeld, Amy E. Anderson, Jin Han, David R. Maestas Jr, Joscelyn C. Mejias, Jennifer Woodell-May, William King, Sudipto Ganguly, Jennifer H. Elisseeff

Open Access Research

Role of DNA dioxygenase Ten-Eleven translocation 3 (TET3) in rheumatoid arthritis progression

Akio Kawabe, Kaoru Yamagata, Shigeaki Kato, Kazuhisa Nakano, Kei Sakata, Yu-ichi Tsukada, Koichiro Ohmura, Shingo Nakayamada, Yoshiya Tanaka

Open Access Research

Association between radiographic hand osteoarthritis and bone microarchitecture in a population-based sample

Canchen Ma, Dawn Aitken, Feitong Wu, Kathryn Squibb, Flavia Cicuttini, Graeme Jones

Open Access Correction

Correction: CD34+THY1+ synovial fibroblast subset in arthritic joints has high osteoblastic and chondrogenic potentials in vitro

Seiji Noda, Tadashi Hosoya, Yoji Komiya, Yasuhiro Tagawa, Kentaro Endo, Keiichiro Komori, Hideyuki Koga, Yasuhiro Takahara, Kazutaka Sugimoto, Ichiro Sekiya, Tetsuya Saito, Fumitaka Mizoguchi, Shinsuke Yasuda

Open Access Research

Dorso-ventral osteophytes of interphalangeal joints correlate with cartilage damage and synovial inflammation in hand osteoarthritis: a histological/radiographical study

Ilse-Gerlinde Sunk, Love Amoyo-Minar, Birgit Niederreiter, Afschin Soleiman, Franz Kainberger, Josef S. Smolen, Daniel Aletaha, Klaus Bobacz

Open Access Research

Deep learning-based automatic-bone-destruction-evaluation system using contextual information from other joints

Kazuki Miyama, Ryoma Bise, Satoshi Ikemura, Kazuhiro Kai, Masaya Kanahori, Shinkichi Arisumi, Taisuke Uchida, Yasuharu Nakashima, Seiichi Uchida

Open Access Research

Polygenic risk score trend and new variants on chromosome 1 are associated with male gout in genome-wide association study

Ya-Sian Chang, Chien-Yu Lin, Ting-Yuan Liu, Chung-Ming Huang, Chin-Chun Chung, Yu-Chia Chen, Fuu-Jen Tsai, Jan-Gowth Chang, Shun-Jen Chang

Open Access Correspondence

Absence of Epstein-Barr virus DNA in anti-citrullinated protein antibody-expressing B cells of patients with rheumatoid arthritis

Sanne Kroos, Arieke S. B. Kampstra, René E. M. Toes, Linda M. Slot, Hans U. Scherer

Open Access Research

Comorbidity phenotypes and risk of mortality in patients with osteoarthritis in the UK: a latent class analysis

Dawit T. Zemedikun, Helena Lee, Krishnarajah Nirantharakumar, Karim Raza, Joht Singh Chandan, Janet M. Lord, Thomas A. Jackson

Open Access Research

Impact of cardiovascular risk on the diagnostic accuracy of the ultrasound Halo Score for giant cell arteritis

Juan Molina-Collada, Katerine López Gloria, Isabel Castrejón, Juan Carlos Nieto-González, Julia Martínez-Barrio, Ana M. Anzola Alfaro, Javier Rivera, José María Álvaro-Gracia

Open Access Research

Differences in trajectory of disease activity according to biologic and targeted synthetic disease-modifying anti-rheumatic drug treatment in patients with rheumatoid arthritis

Bon San Koo, Seongho Eun, Kichul Shin, Seokchan Hong, Yong-Gil Kim, Chang-Keun Lee, Bin Yoo, Ji Seon Oh

Open Access Research

Cationic amino acid transporter-1 (CAT-1) promotes fibroblast-like synoviocyte proliferation and cytokine secretion by taking up L-arginine in rheumatoid arthritis

Ying Lu, Chongbo Hao, Shanshan Yu, Zuan Ma, Xuelian Fu, Mingqing Qin, Menglei Ding, Zengguang Xu, Lieying Fan

Open Access Research

Senescence-accelerated mice prone 8 (SAMP8) in male as a spontaneous osteoarthritis model

Yohei Sanada, Yasunari Ikuta, Chenyang Ding, Masahiro Shinohara, Dilimulati Yimiti, Hiroyuki Ishitobi, Keita Nagira, Minjung Lee, Takayuki Akimoto, Sachi Shibata, Masakazu Ishikawa, Tomoyuki Nakasa, Kiminori Matsubara, Martin K. Lotz, Nobuo Adachi, Shigeru Miyaki

Open Access Research

Methotrexate improves endothelial function in early rheumatoid arthritis patients after 3 months of treatment

Giacomo Cafaro, Eleonora Petito, Onelia Bistoni, Emanuela Falcinelli, Sabrina Cipriani, Maria Chiara Borghi, Angelo F. Bonifacio, Elisa Giglio, Alessia Alunno, Carlo Perricone, Roberto Gerli, Paolo Gresele, Elena Bartoloni

Open Access Correction

Correction: The risk of newly diagnosed cancer in patients with rheumatoid arthritis by TNF inhibitor use: a nationwide cohort study

Boyoon Choi, Hyun Jin Park, Yun-Kyoung Song, Yoon-Jeong Oh, In-Wha Kim, Jung Mi Oh

Open Access Research

Efficacy and safety of guselkumab and adalimumab for pustulotic arthro-osteitis and their impact on peripheral blood immunophenotypes

Masanobu Ueno, Ippei Miyagawa, Yusuke Miyazaki, Kentaro Hanami, Shunsuke Fukuyo, Satoshi Kubo, Shingo Nakayamada, Yoshiya Tanaka

Open Access Research

Differentiating tracheobronchial involvement in granulomatosis with polyangiitis and relapsing polychondritis on chest CT: a cohort study

Carole Jalaber, Xavier Puéchal, Ines Saab, Emma Canniff, Benjamin Terrier, Luc Mouthon, Eglantine Cabanne, Sandra Mghaieth, Marie-Pierre Revel, Guillaume Chassagnon

Open Access Commentary

Clusters in Behçet’s syndrome

Ufuk İlgen

Open Access Research

Assessing the causal relationships between gout and hypertension: a bidirectional Mendelian randomisation study with coarsened exposures

Benjamin Lai, Huang-Ping Yu, Yu-Jing Chang, Liang-Chin Wang, Che-Kai Chen, Weiya Zhang, Michael Doherty, Shang-Hung Chang, Jun-Te Hsu, Kuang-Hui Yu, Chang-Fu Kuo

Open Access Correction

Correction: Expression of ADAM15 in rheumatoid synovium: up-regulation by vascular endothelial growth factor and possible implications for angiogenesis

Koichiro Komiya, Hiroyuki Enomoto, Isao Inoki, Satoko Okazaki, Yoshinari Fujita, Eiji Ikeda, Eiko Ohuchi, Hideo Matsumoto, Yoshiaki Toyama, Yasunori Okada

Open Access Letter

Response to Comment on “The effect of disease-modifying anti-rheumatic drugs on skeletal muscle mass in rheumatoid arthritis patients: a systematic review with meta-analysis”

Thales R. Hein, Leonardo Peterson, Barbara J. Bartikoski, Juliana Portes, Rafaela C. Espirito Santo, Ricardo M. Xavier

Open Access Research

PSTPIP2 regulates synovial macrophages polarization and dynamics via ERβ in the joint microenvironment

Yao Yao, Xiaoyu Cai, Meng Zhang, Xiao Zhang, Fujia Ren, Yan Zheng, Weidong Fei, Mengdan Zhao, Caihong Zheng

Open Access Correction

Correction: Patient-reported outcomes of upadacitinib versus abatacept in patients with rheumatoid arthritis and an inadequate response to biologic disease-modifying antirheumatic drugs: 12- and 24-week results of a phase 3 trial

Martin Bergman, Namita Tundia, Naomi Martin, Jessica L. Suboticki, Jayeshkumar Patel, Debbie Goldschmidt, Yan Song, Grace C. Wright

Open Access Research

Macrophage polarization toward M1 phenotype through NF-κB signaling in patients with Behçet’s disease

Xiuhua Wu, Zhimian Wang, Jing Shi, Xin Yu, Chaoran Li, Jinjing Liu, Fengchun Zhang, Hua Chen, Wenjie Zheng

Open Access Retraction Note

Retraction Note: MicroRNA-15b shuttled by bone marrow mesenchymal stem cell-derived extracellular vesicles binds to WWP1 and promotes osteogenic differentiation

Yanhong Li, Jing Wang, Yanchao Ma, Wenjia Du, Haijun Feng, Kai Feng, Guangjie Li, Shuanke Wang

Open Access Research

Periostin overexpression in scleroderma cardiac tissue and its utility as a marker for disease complications

Fatima El-Adili, Justin K. Lui, Mortada Najem, Giuseppina Farina, Maria Trojanowska, Flora Sam, Andreea M. Bujor

Open Access Research

Distinctive alterations in the functional anatomy of the cerebral cortex in pain-sensitized osteoarthritis and fibromyalgia patients

Jesus Pujol, Laura Blanco-Hinojo, Andrea Doreste, Fabiola Ojeda, Gerard Martínez-Vilavella, Víctor Pérez-Sola, Joan Deus, Jordi Monfort

Open Access Research

Accrual of organ damage in Behçet’s syndrome: trajectory, associated factors, and impact on patients’ quality of life over a 2-year prospective follow-up study

Alberto Floris, Matteo Piga, Riccardo Laconi, Gerard Espinosa, Giuseppe Lopalco, Luisa Serpa Pinto, Nikolaos Kougkas, Jurgen Sota, Andrea Lo Monaco, Marcello Govoni, Luca Cantarini, George Bertsias, João Correia, Florenzo Iannone, Ricard Cervera, Carlos Vasconcelos, Alessandro Mathieu, Alberto Cauli

Open Access Research

EC-18 prevents autoimmune arthritis by suppressing inflammatory cytokines and osteoclastogenesis

Jin-Sil Park, Seung Cheon Yang, Ha Yeon Jeong, Seon-Young Lee, Jun-Geol Ryu, Jeong Won Choi, Hye Yeon Kang, Sung-Min Kim, Sun-Hee Hwang, Mi-La Cho, Sung-Hwan Park

Open Access Research

The biological activity of serum bacterial lipopolysaccharides associates with disease activity and likelihood of achieving remission in patients with rheumatoid arthritis

J. Parantainen, G. Barreto, R. Koivuniemi, H. Kautiainen, D. Nordström, E. Moilanen, M. Hämäläinen, M. Leirisalo-Repo, K. Nurmi, K. K. Eklund

Open Access Research

Rheumatoid arthritis sera antibodies to citrullinated collagen type II bind to joint cartilage

Qixing Li, Yanpeng Li, Bibo Liang, Rui Xu, Bingze Xu, Erik Lönnblom, Hui Feng, Jing’an Bai, Roma Stawikowska, Changrong Ge, Aiping Lu, Gregg B. Fields, Lianbo Xiao, Rikard Holmdahl

Open Access Research

Autologous hematopoietic stem cell transplantation improves long-term survival—data from a national registry

Norbert Blank, Marc Schmalzing, Pia Moinzadeh, Max Oberste, Elise Siegert, Ulf Müller-Ladner, Gabriela Riemekasten, Claudia Günther, Ina Kötter, Gabriele Zeidler, Christiane Pfeiffer, Aaron Juche, Ilona Jandova, Jan Ehrchen, Laura Susok, Tim Schmeiser, Cord Sunderkötter, Jörg H. W. Distler, Margitta Worm, Alexander Kreuter, Gernot Keyßer, Hanns-Martin Lorenz, Thomas Krieg, Nicolas Hunzelmann, Jörg Henes

Open Access Research

Abnormal cortical thickness and structural covariance networks in systemic lupus erythematosus patients without major neuropsychiatric manifestations

Shu Li, Ru Bai, Yifan Yang, Ruotong Zhao, Bibhuti Upreti, Xiangyu Wang, Shuang Liu, Yuqi Cheng, Jian Xu

Open Access Research

Epigenetic modification of miR-217 promotes intervertebral disc degeneration by targeting the FBXO21-ERK signalling pathway

Zhonghui Chen, Jianghua Ming, Yajing Liu, Geliang Hu, Qi Liao

Open Access Research

Four emerging immune cellular blood phenotypes associated with disease duration and activity established in Psoriatic Arthritis

Marie Skougaard, Sisse B. Ditlev, Zara R. Stisen, Laura C. Coates, Karen Ellegaard, Lars Erik Kristensen

Open Access Research

Expression of CFTR, a hallmark gene of ionocytes, is downregulated in salivary glands of Sjögren’s syndrome patients

Qi Zhang, Xiuying Lv, Ying Wang, Bin Wang, Yan He, Chubing Chen, Guixiu Shi, Yan Li

Open Access Research

Inhibition of bone erosion, determined by high-resolution peripheral quantitative computed tomography (HR-pQCT), in rheumatoid arthritis patients receiving a conventional synthetic disease-modifying anti-rheumatic drug (csDMARD) plus denosumab vs csDMARD therapy alone: an open-label, randomized, parallel-group study

Naoki Iwamoto, Ko Chiba, Shuntaro Sato, Kazuteru Shiraishi, Kounosuke Watanabe, Nozomi Oki, Akitomo Okada, Tomohiro Koga, Shin-ya Kawashiri, Mami Tamai, Naoki Hosogaya, Masako Furuyama, Makiko Kobayashi, Kengo Saito, Naoki Okubo, Masataka Uetani, Makoto Osaki, Atsushi Kawakami

Open Access Research

Novel alendronate-CGS21680 conjugate reduces bone resorption and induces new bone formation in post-menopausal osteoporosis and inflammatory osteolysis mouse models

Ane Larrañaga-Vera, Kiran S. Toti, James S. Flatow, Alexandra J. Haraczy, Eugene Warnick, Harsha Rao, Zhan-Guo Gao, Sarah M. Sussman, Aranzazu Mediero, Philipp Leucht, Kenneth A. Jacobson, Bruce N. Cronstein

Open Access Research

HSPB5 suppresses renal inflammation and protects lupus-prone NZB/W F1 mice from severe renal damage

Justin Knapp, Marsela Braunstein, Spencer Iner Thomas Berg, Cody Shirriff

Open Access Review

Artificial intelligence and the future of radiographic scoring in rheumatoid arthritis: a viewpoint

Alix Bird, Lauren Oakden-Rayner, Christopher McMaster, Luke A. Smith, Minyan Zeng, Mihir D. Wechalekar, Shonket Ray, Susanna Proudman, Lyle J. Palmer

Open Access Research

Higher fasting blood glucose worsens knee symptoms in patients with radiographic knee osteoarthritis and comorbid central sensitization: an Iwaki cohort study

Daisuke Chiba, Tetsushi Ohyama, Eiji Sasaki, Makoto Daimon, Shigeyuki Nakaji, Yasuyuki Ishibashi

Open Access Research

Rheumatoid arthritis and risk of site-specific cancers: Mendelian randomization study in European and East Asian populations

Shuai Yuan, Jie Chen, Xixian Ruan, Mathew Vithayathil, Siddhartha Kar, Xue Li, Amy M. Mason, Stephen Burgess, Susanna C. Larsson

Open Access Research

Outcome of adult patients with JIA treated with the biosimilar Benepali®: results of the biologic register JuMBO

Kristina Vollbach, Klaus Tenbrock, Nobert Wagner, Gerd Horneff, Ariane Klein, Ivan Foeldvari, Johannes-Peter Haas, Peer Aries, Georg Gauler, Frank Striesow, Paula Hoff, Christine Scholz, Stefanie Tatsis, Eva Seipelt, Jens Klotsche, Kirsten Minden

Open Access Retraction Note

Retraction Note: Propylthiouracil prevents cutaneous and pulmonary fibrosis in the reactive oxygen species murine model of systemic sclerosis

Gianluca Bagnato, Alessandra Bitto, Natasha Irrera, Gabriele Pizzino, Donatella Sangari, Maurizio Cinquegrani, William Neal Roberts, Marco Atteritano, Domenica Altavilla, Francesco Squadrito, Gianfilippo Bagnato, Antonino Saitta

Open Access Research

Low disease activity of microscopic polyangiitis in patients with anti-myosin light chain 6 antibody that disrupts actin rearrangement necessary for neutrophil extracellular trap formation

Miku Yoshinari, Yuka Nishibata, Sakiko Masuda, Daigo Nakazawa, Utano Tomaru, Yoshihiro Arimura, Koichi Amano, Yukio Yuzawa, Ken-Ei Sada, Tatsuya Atsumi, Hiroaki Dobashi, Hitoshi Hasegawa, Masayoshi Harigai, Seiichi Matsuo, Hirofumi Makino, Akihiro Ishizu

Open Access Correction

Correction: Macrophage polarization toward M1 phenotype through NF-κB signaling in patients with Behcet’s disease

Xiuhua Wu, Zhimian Wang, Jing Shi, Xin Yu, Chaoran Li, Jinjing Liu, Fengchun Zhang, Hua Chen, Wenjie Zheng

Open Access Research

The effect of targeted rheumatoid arthritis therapeutics on systemic inflammation and anemia: analysis of data from the CorEvitas RA registry

Anthony S. Padula, Dimitrios A. Pappas, Stefano Fiore, Taylor S. Blachley, Kerri Ford, Kelechi Emeanuru, Joel M. Kremer

Open Access Research

Neuronal CRMP2 phosphorylation inhibition by the flavonoid, naringenin, contributes to the reversal of spinal sensitization and arthritic pain improvement

Yue-Peng Jiang, Song Wang, Wei-Dong Lai, Xue-Qing Wu, Yan Jin, Zheng-Hao Xu, Aubin Moutal, Rajesh Khanna, Ki Duk Park, Zhi-Ming Shan, Cheng-Ping Wen, Jie Yu

Open Access Research

Multiparametric autoantibody analysis: a new paradigm for the diagnosis of connective tissue diseases

Nicola Bizzaro, Danilo Villalta, Vittorio Bini, Paola Migliorini, Franco Franceschini, Silvia Piantoni, Emirena Garrafa, Valeria Riccieri, Antonella Fioravanti, Francesca Bellisai, Marilina Tampoia, Marco Fornaro, Florenzo Iannone, Anna Ghirardello, Margherita Zen, Boaz Palterer, Paola Parronchi, Maria Infantino, Maurizio Benucci, Amelia Rigon, Luisa Arcarese, Stefania Del Rosso, Valentina Canti, Elena Bartoloni, Roberto Gerli, Onelia Bistoni, Giacomo Cafaro, Carlo Perricone, Fabiana Topini, Ilaria Cavazzana, Micaela Fredi, Stefania Masneri, Sara Cheleschi, Maria-Romana Bacarelli, Daniele Cammelli, Mariangela Manfredi, Roberto Giacomelli, Patrizia Rovere Querini

Open Access Research

Levels of extracellular matrix metabolites are associated with changes in Ankylosing Spondylitis Disease Activity Score and MRI inflammation scores in patients with axial spondyloarthritis during TNF inhibitor therapy

Signe Holm Nielsen, Shu Sun, Anne C. Bay-Jensen, Morten Karsdal, Inge Juul Sørensen, Ulrich Weber, Anne Gitte Loft, Gina Kollerup, Gorm Thamsborg, Ole Rintek Madsen, Jakob Møller, Mikkel Østergaard, Susanne Juhl Pedersen

Open Access Research

IL-22 inhibits bleomycin-induced pulmonary fibrosis in association with inhibition of IL-17A in mice

Ziye Qu, Wencan Dou, Kexin Zhang, Lili Duan, Dongmei Zhou, Songlou Yin

Open Access Research

Early removal of the infrapatellar fat pad/synovium complex beneficially alters the pathogenesis of moderate stage idiopathic knee osteoarthritis in male Dunkin Hartley guinea pigs

Maryam F. Afzali, Lauren B. Radakovich, Madeline M. Sykes, Margaret A. Campbell, Kayley M. Patton, Joseph L. Sanford, Nicole Vigon, Ryan Ek, Gerardo E. Narez, Angela J. Marolf, Katie J. Sikes, Tammy L. Haut Donahue, Kelly S. Santangelo

Open Access Research

Quantification of pre-existing radiographic damage and its relationship with joint activity and long-term clinical outcomes with secukinumab therapy in patients with psoriatic arthritis

Philip Mease, Désirée van der Heijde, Bruce Kirkham, Georg Schett, Ana-Maria Orbai, Christopher Ritchlin, Joseph F. Merola, Luminita Pricop, David A. James, Xuan Zhu, Gregory Ligozio

Open Access Research

Axl regulated survival/proliferation network and its therapeutic intervention in mouse models of glomerulonephritis

Yuxuan Zhen, Yan Ren, Mario Medvedovic, David E. Adams, Diping Wang, Wen-Hai Shao

Open Access Correspondence

Response letter to “Latent class analysis of 216 patients with adult-onset Still’s disease” by Sugiyama et al.

Marion Delplanque, Arsène Mekinian, Sophie Georgin-Lavialle

Open Access Review

The role of the sirtuin family in cartilage and osteoarthritis: molecular mechanisms and therapeutic targets

Kaibo Sun, Yuangang Wu, Yi Zeng, Jiawen Xu, Limin Wu, Mingyang Li, Bin Shen

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Notfall-TEP der Hüfte ist auch bei 90-Jährigen machbar

26.04.2024 Hüft-TEP Nachrichten

Ob bei einer Notfalloperation nach Schenkelhalsfraktur eine Hemiarthroplastik oder eine totale Endoprothese (TEP) eingebaut wird, sollte nicht allein vom Alter der Patientinnen und Patienten abhängen. Auch über 90-Jährige können von der TEP profitieren.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

Insektenstiche sind bei Erwachsenen die häufigsten Auslöser einer Anaphylaxie. Einen wirksamen Schutz vor schweren anaphylaktischen Reaktionen bietet die allergenspezifische Immuntherapie. Jedoch kommt sie noch viel zu selten zum Einsatz.

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

25.04.2024 Hypertonie Nachrichten

Beginnen ältere Männer im Pflegeheim eine Antihypertensiva-Therapie, dann ist die Frakturrate in den folgenden 30 Tagen mehr als verdoppelt. Besonders häufig stürzen Demenzkranke und Männer, die erstmals Blutdrucksenker nehmen. Dafür spricht eine Analyse unter US-Veteranen.

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