Erschienen in:
20.04.2020 | ASO Author Reflections
ASO Author Reflections: Intrahepatic Cholangiocarcinoma: Downstaging Strategies Open the Gate to Surgery and Cure
verfasst von:
Karim Boudjema, MD, PhD, Julien Edeline, MD, PhD
Erschienen in:
Annals of Surgical Oncology
|
Ausgabe 10/2020
Einloggen, um Zugang zu erhalten
Excerpt
Intrahepatic cholangiocarcinoma (ICC) was an uncommon primary liver cancer. Until 10 years ago, this tumor received little attention from surgeons. One of the reasons for this disinterest was that most patients were diagnosed at an advanced stage. Resection was reserved for the few patients in good general condition with tumors limited in size. Positive margins were frequent, and 5-year survival was dismal, only reaching 30% in the best series. Recurrences were frequent, and early and multiple lesions, positive nodes, or surgical margins were strong predictive factors of poor progression-free survival.
1 The results of chemotherapy in unresectable disease were limited with a low response rate (20–25%), and very few patients were downstaged to surgery, the only curative option.
2 …