Erschienen in:
23.03.2021 | ASO Author Reflections
ASO Author Reflections: Long-Term Impact of Pancreatoduodenectomy on Pancreas-Specific Quality of Life
verfasst von:
Zhi Ven Fong, MD, MPH, Cristina R. Ferrone, MD
Erschienen in:
Annals of Surgical Oncology
|
Ausgabe 8/2021
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Excerpt
The uptick in the use of cross-sectional imaging to identify intraductal papillary mucinous neoplasms (nonfunctional neuroendocrine tumors) and the advent of more effective neoadjuvant chemotherapeutics such as FOLFIRINOX has seen an increase in the number of long-term post-pancreatoduodenectomy (PD) survivors.
1 As such, the long-term impact of the operation on PD survivors’ quality of life (QoL) is of increasing importance to better inform shared decision-making for patients. In a previous analysis, the authors administered the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 questionnaire to patients who had undergone PD and were at least 5 years out from their operation. Surprisingly, the PD survivors demonstrated a better global QoL and better physical- and role-functioning scores than age- and sex-matched control subjects.
2 However, the instrument used was not organ-targeted for pancreatic cancer and may have missed important gastrointestinal (GI)-related disabilities. In the current study, the authors used the EORTC QLQ-PAN26 instrument, a pancreas cancer-targeted module, to compare functional outcomes and QoL in a large cohort of long-term PD survivors with published preoperative scores for patients with pancreatic cancer.
3 …