Erschienen in:
19.01.2024 | ASO Author Reflections
ASO Author Reflections: Selected Multisite Metastatic Colorectal Cancer Patients May Benefit from Radical Multimodal Treatment
verfasst von:
Vahan Kepenekian, MD, PhD, Rémi Grange, MD, Guillaume Passot, MD, PhD, Olivier Glehen, MD, PhD, Pascal Rousset, MD, PhD
Erschienen in:
Annals of Surgical Oncology
|
Ausgabe 4/2024
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Excerpt
Half of colorectal cancer patients present at diagnosis with metastases.
1 Together with the progress of systemic and locoregional treatments, curative-intent strategies have been developed on the basis of a comprehensive approach combining systemic and locoregional chemotherapies and radical resection or destruction of all detectable metastases.
2 Elaboration of these strategies is demanding, as it requires the ability to identify all metastases, confirm chemosensitivity, and perform complete treatment with controlled post-interventional morbidity and mortality, guaranteeing correct quality of life.
2 As oncologic outcomes are encouraging, there is a trend to extend the boundaries of resectability to include a larger proportion of patients in such strategies.
3 Progressively, patients with several metastatic sites, in particular liver and peritoneum, are considered for these multimodal radical treatments.
4 These strategies are highly demanding for patients and for physicians. Thus, the most important pitfall is early recurrence, meaning treatment failure with no sufficient treatment-free interval for the patients. There is a need for accurate selection criteria to select the best candidates for such ambitious strategies. …
