Erschienen in:
25.05.2020 | ASO Author Reflections
ASO Author Reflections: Targeting the Immunosuppressive Tumor Microenvironment for Treating Peritoneal Carcinomatosis of Gastrointestinal and Pancreaticobiliary Cancer
verfasst von:
Carlos H. F. Chan, MD, PhD
Erschienen in:
Annals of Surgical Oncology
|
Sonderheft 3/2020
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Excerpt
Peritoneal carcinomatosis (PC) is a common and deadly metastatic spread from gastrointestinal and pancreaticobiliary cancers. In 2020, over 333,000 new cancer cases from the digestive system were estimated in the United States.
1 Between 2009 and 2015, metastatic disease was present in 18% of hepatobiliary, 21% of colorectal, and 52% of pancreatic cancer patients at the time of diagnosis.
1 Five-year survival of patients with metastatic disease remains poor with 2% in hepatobiliary cancers, 3% in pancreatic cancers and 14% in colorectal cancers.
1 While some patients can undergo aggressive surgery and systemic therapy, many are not candidates for any treatment and only have a few weeks to live. …