Erschienen in:
26.10.2018 | ASO Author Reflections
ASO Author Reflections: The Role of Tumor Size in the Prognosis of Anal Squamous Cell Carcinoma: A Validation on the New American Joint Committee on Cancer Subclassification of Stage IIA and B
verfasst von:
Paolo Goffredo, MD, Imran Hassan, MD
Erschienen in:
Annals of Surgical Oncology
|
Sonderheft 3/2018
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Excerpt
Anal squamous cell carcinoma (ASCC) accounts for < 3% of gastrointestinal cancers in the US, however its incidence has been increasing over several decades. In 1998, the American Joint Committee on Cancer (AJCC) published the first staging system for ASCC in the 3rd edition of the AJCC manual.
1 Tumors between 2 and 5 cm were defined as T2, while tumors > 5 cm in size were classified as T3; both were categorized as stage II cancers. In a secondary analysis of the Gastrointestinal Radiation Therapy Oncology Group (RTOG) 98-11 trial, it was observed that T3 (> 5 cm) ASCCs had worse prognosis compared with T2 (2–5 cm) tumors.
2 As a result, in order to better prognosticate these cancers, the 8th edition of the AJCC manual stratified ASCC stage II into IIA (T2N0M0) and IIB (T3N0M0) subcategories based on the size of the primary tumor. This study was aimed at validating the new subclassification utilizing two nationally representative databases.
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