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The Journal of Obstetrics and Gynecology of India

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31.08.2023 | Original Article

Aspiration with Diosmin Intake in Endometrial Cavity Fluid Accumulation in ART Cycles: A Randomized Controlled Trial

verfasst von: Ahmed Samy Saad, Khalid Abd Aziz Mohamed

Erschienen in: The Journal of Obstetrics and Gynecology of India | Ausgabe 4/2023

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Abstract

Background

This was a prospective randomized controlled trial in 200 cases presented with endometrial cavity fluid at the day of oocyte retrieval at a private fertility center from 2013 to 2021. The cases were randomized at day of ovum pickup into 2 groups: Group 1 (control group) (n = 100): conventional management with follow-up and reassessment by transvaginal ultrasound on day 5. Group 2 (interventional group) (n = 100): aspiration of the fluid was done and cases were given diosmin 500 mg 3 times per day till reassessment at embryo transfer day. In both groups, we proceeded with fresh embryo transfer if no fluid is present on day 5 or freeze-all policy if persistent fluid was detected.

Results

Endometrial fluid on the 5th day was significantly higher in the control group (28.0%) than in the interventional group (6.0%) (P < 0.001). Regarding pregnancy rate, although being higher in the interventional group (54.3% vs 50.0%), the difference was not statistically significant (P = 0.5). It was found that the intervention was associated with risk reduction of endometrial fluid (OR = 0.168, 95% CI = 0.065–0.429, P < 0.001.

Conclusion

Aspiration of endometrial cavity fluid with diosmin intake increased the likelihood of fresh embryo transfer and with a slightly better pregnancy rate compared to conservative management.

Clinical trial number: NCT02158000, Date of registration: 6/6/2014, Date of initial enrollment (first patient recruiting): 1/11/2014, URL: https://clinicaltrials.gov/ct2/show/NCT02158000.

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Titel: Aspiration with Diosmin Intake in Endometrial Cavity Fluid Accumulation in ART Cycles: A Randomized Controlled Trial
verfasst von: Ahmed Samy Saad
Khalid Abd Aziz Mohamed
Publikationsdatum: 31.08.2023
Verlag: Springer India
Erschienen in: The Journal of Obstetrics and Gynecology of India / Ausgabe 4/2023
Print ISSN: 0971-9202
Elektronische ISSN: 0975-6434
DOI: https://doi.org/10.1007/s13224-023-01791-7

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Springer Medizin

Aspiration with Diosmin Intake in Endometrial Cavity Fluid Accumulation in ART Cycles: A Randomized Controlled Trial

Abstract

Background

Results

Conclusion

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Abstract

Background

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