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Erschienen in: Journal of Nuclear Cardiology 3/2015

01.06.2015 | Review Article

Assessment of atherosclerosis in large vessel walls: A comprehensive review of FDG-PET/CT image acquisition protocols and methods for uptake quantification

verfasst von: Saeid Gholami, MD, Ali Salavati, MD, MPH, Sina Houshmand, MD, Thomas J. Werner, MSE, Abass Alavi, MD, MD (Hon), PhD (Hon), DSc (Hon)

Erschienen in: Journal of Nuclear Cardiology | Ausgabe 3/2015

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Abstract

There is growing evidence showing the importance of fluorodeoxyglucose positron emission tomography (FDG-PET) in the evaluation of vessel wall inflammation and atherosclerosis. Although this imaging modality has been increasingly used, there are various methods for image acquisition and evaluating FDG uptake activity in the vessel walls and atherosclerotic lesions, including qualitative visual scaling, semi-quantitative, and quantitative evaluations. Using each of these image acquisition protocols and measurement methods may result in different findings. In this review, we are going to describe the various image acquisition methods and common measurement strategies reflected in the literature and discuss their advantages and flaws.
Literatur
1.
Zurück zum Zitat Tawakol A, Migrino RQ, Bashian GG, Bedri S, Vermylen D, Cury RC, et al. In vivo 18F-fluorodeoxyglucose positron emission tomography imaging provides a noninvasive measure of carotid plaque inflammation in patients. J Am Coll Cardiol 2006;48:1818-24.PubMed Tawakol A, Migrino RQ, Bashian GG, Bedri S, Vermylen D, Cury RC, et al. In vivo 18F-fluorodeoxyglucose positron emission tomography imaging provides a noninvasive measure of carotid plaque inflammation in patients. J Am Coll Cardiol 2006;48:1818-24.PubMed
2.
Zurück zum Zitat Chen W, Bural GG, Torigian DA, Rader DJ, Alavi A. Emerging role of FDG-PET/CT in assessing atherosclerosis in large arteries. Eur J Nucl Med Mol Imaging 2009;36:144-51.PubMed Chen W, Bural GG, Torigian DA, Rader DJ, Alavi A. Emerging role of FDG-PET/CT in assessing atherosclerosis in large arteries. Eur J Nucl Med Mol Imaging 2009;36:144-51.PubMed
3.
Zurück zum Zitat Yun M, Yeh D, Araujo LI, Jang S, Newberg A, Alavi A. F-18 FDG uptake in the large arteries: A new observation. Clin Nucl Med 2001;26:314-9.PubMed Yun M, Yeh D, Araujo LI, Jang S, Newberg A, Alavi A. F-18 FDG uptake in the large arteries: A new observation. Clin Nucl Med 2001;26:314-9.PubMed
4.
Zurück zum Zitat Bural GG, Torigian DA, Chamroonrat W, Houseni M, Chen W, Basu S, et al. FDG-PET is an effective imaging modality to detect and quantify age-related atherosclerosis in large arteries. Eur J Nucl Med Mol Imaging 2008;35:562-9.PubMed Bural GG, Torigian DA, Chamroonrat W, Houseni M, Chen W, Basu S, et al. FDG-PET is an effective imaging modality to detect and quantify age-related atherosclerosis in large arteries. Eur J Nucl Med Mol Imaging 2008;35:562-9.PubMed
5.
Zurück zum Zitat Noh TS, Moon SH, Cho YS, Hong SP, Lee EJ, Choi JY, et al. Relation of carotid artery 18F-FDG uptake to C-reactive protein and Framingham risk score in a large cohort of asymptomatic adults. J Nucl Med 2013;54:2070-6.PubMed Noh TS, Moon SH, Cho YS, Hong SP, Lee EJ, Choi JY, et al. Relation of carotid artery 18F-FDG uptake to C-reactive protein and Framingham risk score in a large cohort of asymptomatic adults. J Nucl Med 2013;54:2070-6.PubMed
6.
Zurück zum Zitat Hag AM, Pedersen SF, Christoffersen C, Binderup T, Jensen MM, Jorgensen JT, et al. (18) F-FDG PET imaging of murine atherosclerosis: Association with gene expression of key molecular markers. PLoS One 2012;7:e50908.PubMedCentralPubMed Hag AM, Pedersen SF, Christoffersen C, Binderup T, Jensen MM, Jorgensen JT, et al. (18) F-FDG PET imaging of murine atherosclerosis: Association with gene expression of key molecular markers. PLoS One 2012;7:e50908.PubMedCentralPubMed
7.
Zurück zum Zitat Zhao QM, Feng TT, Zhao X, Xu ZM, Liu Y, Li DP, et al. Imaging of atherosclerotic aorta of rabbit model by detection of plaque inflammation with fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography. Chin Med J (Engl) 2011;124:911-7. Zhao QM, Feng TT, Zhao X, Xu ZM, Liu Y, Li DP, et al. Imaging of atherosclerotic aorta of rabbit model by detection of plaque inflammation with fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography. Chin Med J (Engl) 2011;124:911-7.
8.
Zurück zum Zitat Zhao QM, Zhao X, Feng TT, Zhang MD, Zhuang XC, Zhao XC, et al. Monitoring of atherosclerosis evolution by detection of inflammatory states of aortae in a rabbit model using 18F-FDG-PET/CT. Q J Nucl Med Mol Imaging 2014;58:440-50.PubMed Zhao QM, Zhao X, Feng TT, Zhang MD, Zhuang XC, Zhao XC, et al. Monitoring of atherosclerosis evolution by detection of inflammatory states of aortae in a rabbit model using 18F-FDG-PET/CT. Q J Nucl Med Mol Imaging 2014;58:440-50.PubMed
9.
Zurück zum Zitat Worthley SG, Zhang ZY, Machac J, Helft G, Tang C, Liew GY, et al. In vivo non-invasive serial monitoring of FDG-PET progression and regression in a rabbit model of atherosclerosis. Int J Cardiovasc Imaging 2009;25:251-7.PubMed Worthley SG, Zhang ZY, Machac J, Helft G, Tang C, Liew GY, et al. In vivo non-invasive serial monitoring of FDG-PET progression and regression in a rabbit model of atherosclerosis. Int J Cardiovasc Imaging 2009;25:251-7.PubMed
10.
Zurück zum Zitat Wallis deVries BM, van Dam GM, Tio RA, Hillebrands JL, Slart RH, Zeebregts CJ. Current imaging modalities to visualize vulnerability within the atherosclerotic carotid plaque. J Vasc Surg 2008;48:1620-29 Wallis deVries BM, van Dam GM, Tio RA, Hillebrands JL, Slart RH, Zeebregts CJ. Current imaging modalities to visualize vulnerability within the atherosclerotic carotid plaque. J Vasc Surg 2008;48:1620-29
11.
Zurück zum Zitat Ogawa M, Magata Y, Kato T, Hatano K, Ishino S, Mukai T, et al. Application of 18F-FDG PET for monitoring the therapeutic effect of antiinflammatory drugs on stabilization of vulnerable atherosclerotic plaques. J Nucl Med 2006;47:1845-50.PubMed Ogawa M, Magata Y, Kato T, Hatano K, Ishino S, Mukai T, et al. Application of 18F-FDG PET for monitoring the therapeutic effect of antiinflammatory drugs on stabilization of vulnerable atherosclerotic plaques. J Nucl Med 2006;47:1845-50.PubMed
12.
Zurück zum Zitat Rudd JH, Myers KS, Bansilal S, Machac J, Rafique A, Farkouh M, et al. (18)Fluorodeoxyglucose positron emission tomography imaging of atherosclerotic plaque inflammation is highly reproducible: Implications for atherosclerosis therapy trials. J Am Coll Cardiol 2007;50:892-6.PubMed Rudd JH, Myers KS, Bansilal S, Machac J, Rafique A, Farkouh M, et al. (18)Fluorodeoxyglucose positron emission tomography imaging of atherosclerotic plaque inflammation is highly reproducible: Implications for atherosclerosis therapy trials. J Am Coll Cardiol 2007;50:892-6.PubMed
13.
Zurück zum Zitat Tahara N, Kai H, Ishibashi M, Nakaura H, Kaida H, Baba K, et al. Simvastatin attenuates plaque inflammation: Evaluation by fluorodeoxyglucose positron emission tomography. J Am Coll Cardiol 2006;48:1825-31.PubMed Tahara N, Kai H, Ishibashi M, Nakaura H, Kaida H, Baba K, et al. Simvastatin attenuates plaque inflammation: Evaluation by fluorodeoxyglucose positron emission tomography. J Am Coll Cardiol 2006;48:1825-31.PubMed
14.
Zurück zum Zitat Tawakol A, Fayad ZA, Mogg R, Alon A, Klimas MT, Dansky H, et al. Intensification of statin therapy results in a rapid reduction in atherosclerotic inflammation: Results of a multicenter fluorodeoxyglucose-positron emission tomography/computed tomography feasibility study. J Am Coll Cardiol 2013;62:909-17.PubMed Tawakol A, Fayad ZA, Mogg R, Alon A, Klimas MT, Dansky H, et al. Intensification of statin therapy results in a rapid reduction in atherosclerotic inflammation: Results of a multicenter fluorodeoxyglucose-positron emission tomography/computed tomography feasibility study. J Am Coll Cardiol 2013;62:909-17.PubMed
15.
Zurück zum Zitat Kobayashi Y, Ishii K, Oda K, Nariai T, Tanaka Y, Ishiwata K, et al. Aortic wall inflammation due to Takayasu arteritis imaged with 18F-FDG PET coregistered with enhanced CT. J Nucl Med 2005;46:917-22.PubMed Kobayashi Y, Ishii K, Oda K, Nariai T, Tanaka Y, Ishiwata K, et al. Aortic wall inflammation due to Takayasu arteritis imaged with 18F-FDG PET coregistered with enhanced CT. J Nucl Med 2005;46:917-22.PubMed
16.
Zurück zum Zitat Rose S, Sheth NH, Baker JF, Ogdie A, Raper A, Saboury B, et al. A comparison of vascular inflammation in psoriasis, rheumatoid arthritis, and healthy subjects by FDG-PET/CT: A pilot study. Am J Cardiovasc Dis 2013;3:273-8.PubMedCentralPubMed Rose S, Sheth NH, Baker JF, Ogdie A, Raper A, Saboury B, et al. A comparison of vascular inflammation in psoriasis, rheumatoid arthritis, and healthy subjects by FDG-PET/CT: A pilot study. Am J Cardiovasc Dis 2013;3:273-8.PubMedCentralPubMed
17.
Zurück zum Zitat Rudd JH, Myers KS, Bansilal S, Machac J, Pinto CA, Tong C, et al. Atherosclerosis inflammation imaging with 18F-FDG PET: Carotid, iliac, and femoral uptake reproducibility, quantification methods, and recommendations. J Nucl Med 2008;49:871-8.PubMed Rudd JH, Myers KS, Bansilal S, Machac J, Pinto CA, Tong C, et al. Atherosclerosis inflammation imaging with 18F-FDG PET: Carotid, iliac, and femoral uptake reproducibility, quantification methods, and recommendations. J Nucl Med 2008;49:871-8.PubMed
18.
Zurück zum Zitat Bissonnette R, Tardif JC, Harel F, Pressacco J, Bolduc C, Guertin MC. Effects of the tumor necrosis factor-alpha antagonist adalimumab on arterial inflammation assessed by positron emission tomography in patients with psoriasis: Results of a randomized controlled trial. Circ Cardiovasc Imaging 2013;6:83-90.PubMed Bissonnette R, Tardif JC, Harel F, Pressacco J, Bolduc C, Guertin MC. Effects of the tumor necrosis factor-alpha antagonist adalimumab on arterial inflammation assessed by positron emission tomography in patients with psoriasis: Results of a randomized controlled trial. Circ Cardiovasc Imaging 2013;6:83-90.PubMed
19.
Zurück zum Zitat Blomberg BA, Thomassen A, Takx RA, Hildebrandt MG, Simonsen JA, Buch-Olsen KM, et al. Delayed (1)(8)F-fluorodeoxyglucose PET/CT imaging improves quantitation of atherosclerotic plaque inflammation: Results from the CAMONA study. J Nucl Cardiol 2014;21:588-97.PubMed Blomberg BA, Thomassen A, Takx RA, Hildebrandt MG, Simonsen JA, Buch-Olsen KM, et al. Delayed (1)(8)F-fluorodeoxyglucose PET/CT imaging improves quantitation of atherosclerotic plaque inflammation: Results from the CAMONA study. J Nucl Cardiol 2014;21:588-97.PubMed
20.
Zurück zum Zitat Bucerius J, Mani V, Moncrieff C, Machac J, Fuster V, Farkouh ME, et al. Optimizing 18F-FDG PET/CT imaging of vessel wall inflammation: The impact of 18F-FDG circulation time, injected dose, uptake parameters, and fasting blood glucose levels. Eur J Nucl Med Mol Imaging 2014;41:369-83.PubMedCentralPubMed Bucerius J, Mani V, Moncrieff C, Machac J, Fuster V, Farkouh ME, et al. Optimizing 18F-FDG PET/CT imaging of vessel wall inflammation: The impact of 18F-FDG circulation time, injected dose, uptake parameters, and fasting blood glucose levels. Eur J Nucl Med Mol Imaging 2014;41:369-83.PubMedCentralPubMed
21.
Zurück zum Zitat Kim EJ, Kim S, Kang DO, Seo HS. Metabolic activity of the spleen and bone marrow in patients with acute myocardial infarction evaluated by 18f-fluorodeoxyglucose positron emission tomograpic imaging. Circ Cardiovasc Imaging 2014;7:454-60.PubMed Kim EJ, Kim S, Kang DO, Seo HS. Metabolic activity of the spleen and bone marrow in patients with acute myocardial infarction evaluated by 18f-fluorodeoxyglucose positron emission tomograpic imaging. Circ Cardiovasc Imaging 2014;7:454-60.PubMed
22.
Zurück zum Zitat Wasselius JA, Larsson SA, Jacobsson H. FDG-accumulating atherosclerotic plaques identified with 18F-FDG-PET/CT in 141 patients. Mol Imaging Biol 2009;11:455-9.PubMed Wasselius JA, Larsson SA, Jacobsson H. FDG-accumulating atherosclerotic plaques identified with 18F-FDG-PET/CT in 141 patients. Mol Imaging Biol 2009;11:455-9.PubMed
23.
Zurück zum Zitat Duivenvoorden R, Mani V, Woodward M, Kallend D, Suchankova G, Fuster V, et al. Relationship of serum inflammatory biomarkers with plaque inflammation assessed by FDG PET/CT: The dal-PLAQUE study. JACC Cardiovasc Imaging 2013;6:1087-94.PubMed Duivenvoorden R, Mani V, Woodward M, Kallend D, Suchankova G, Fuster V, et al. Relationship of serum inflammatory biomarkers with plaque inflammation assessed by FDG PET/CT: The dal-PLAQUE study. JACC Cardiovasc Imaging 2013;6:1087-94.PubMed
24.
Zurück zum Zitat Davies JR, Rudd JH, Fryer TD, Graves MJ, Clark JC, Kirkpatrick PJ, et al. Identification of culprit lesions after transient ischemic attack by combined 18F fluorodeoxyglucose positron-emission tomography and high-resolution magnetic resonance imaging. Stroke 2005;36:2642-7.PubMed Davies JR, Rudd JH, Fryer TD, Graves MJ, Clark JC, Kirkpatrick PJ, et al. Identification of culprit lesions after transient ischemic attack by combined 18F fluorodeoxyglucose positron-emission tomography and high-resolution magnetic resonance imaging. Stroke 2005;36:2642-7.PubMed
25.
Zurück zum Zitat Figueroa AL, Subramanian SS, Cury RC, Truong QA, Gardecki JA, Tearney GJ, et al. Distribution of inflammation within carotid atherosclerotic plaques with high-risk morphological features: A comparison between positron emission tomography activity, plaque morphology, and histopathology. Circ Cardiovasc Imaging 2012;5:69-77.PubMed Figueroa AL, Subramanian SS, Cury RC, Truong QA, Gardecki JA, Tearney GJ, et al. Distribution of inflammation within carotid atherosclerotic plaques with high-risk morphological features: A comparison between positron emission tomography activity, plaque morphology, and histopathology. Circ Cardiovasc Imaging 2012;5:69-77.PubMed
26.
Zurück zum Zitat Fifer KM, Qadir S, Subramanian S, Vijayakumar J, Figueroa AL, Truong QA, et al. Positron emission tomography measurement of periodontal 18F-fluorodeoxyglucose uptake is associated with histologically determined carotid plaque inflammation. J Am Coll Cardiol 2011;57:971-6.PubMed Fifer KM, Qadir S, Subramanian S, Vijayakumar J, Figueroa AL, Truong QA, et al. Positron emission tomography measurement of periodontal 18F-fluorodeoxyglucose uptake is associated with histologically determined carotid plaque inflammation. J Am Coll Cardiol 2011;57:971-6.PubMed
27.
Zurück zum Zitat Font MA, Fernandez A, Carvajal A, Gamez C, Badimon L, Slevin M, et al. Imaging of early inflammation in low-to-moderate carotid stenosis by 18-FDG-PET. Front Biosci 2009;14:3352-60. Font MA, Fernandez A, Carvajal A, Gamez C, Badimon L, Slevin M, et al. Imaging of early inflammation in low-to-moderate carotid stenosis by 18-FDG-PET. Front Biosci 2009;14:3352-60.
28.
Zurück zum Zitat Yarasheski KE, Laciny E, Overton ET, Reeds DN, Harrod M, Baldwin S, et al. 18FDG PET-CT imaging detects arterial inflammation and early atherosclerosis in HIV-infected adults with cardiovascular disease risk factors. J Inflamm (Lond) 2012;9:26. Yarasheski KE, Laciny E, Overton ET, Reeds DN, Harrod M, Baldwin S, et al. 18FDG PET-CT imaging detects arterial inflammation and early atherosclerosis in HIV-infected adults with cardiovascular disease risk factors. J Inflamm (Lond) 2012;9:26.
29.
Zurück zum Zitat Menezes LJ, Kotze CW, Hutton BF, Endozo R, Dickson JC, Cullum I, et al. Vascular inflammation imaging with 18F-FDG PET/CT: When to image? J Nucl Med 2009;50:854-7.PubMed Menezes LJ, Kotze CW, Hutton BF, Endozo R, Dickson JC, Cullum I, et al. Vascular inflammation imaging with 18F-FDG PET/CT: When to image? J Nucl Med 2009;50:854-7.PubMed
30.
Zurück zum Zitat Rudd JH, Machac J, Fayad ZA. Simvastatin and plaque inflammation. J Am Coll Cardiol 2007;49:1991; author reply-2. Rudd JH, Machac J, Fayad ZA. Simvastatin and plaque inflammation. J Am Coll Cardiol 2007;49:1991; author reply-2.
31.
Zurück zum Zitat Wu YW, Kao HL, Chen MF, Lee BC, Tseng WY, Jeng JS, et al. Characterization of plaques using 18F-FDG PET/CT in patients with carotid atherosclerosis and correlation with matrix metalloproteinase-1. J Nucl Med 2007;48:227-33.PubMed Wu YW, Kao HL, Chen MF, Lee BC, Tseng WY, Jeng JS, et al. Characterization of plaques using 18F-FDG PET/CT in patients with carotid atherosclerosis and correlation with matrix metalloproteinase-1. J Nucl Med 2007;48:227-33.PubMed
32.
Zurück zum Zitat Graebe M, Borgwardt L, Hojgaard L, Sillesen H, Kjaer A. When to image carotid plaque inflammation with FDG PET/CT. Nucl Med Commun 2010;31:773-9.PubMed Graebe M, Borgwardt L, Hojgaard L, Sillesen H, Kjaer A. When to image carotid plaque inflammation with FDG PET/CT. Nucl Med Commun 2010;31:773-9.PubMed
33.
Zurück zum Zitat Rudd JH, Warburton EA, Fryer TD, Jones HA, Clark JC, Antoun N, et al. Imaging atherosclerotic plaque inflammation with [18F]-fluorodeoxyglucose positron emission tomography. Circulation 2002;105:2708-11.PubMed Rudd JH, Warburton EA, Fryer TD, Jones HA, Clark JC, Antoun N, et al. Imaging atherosclerotic plaque inflammation with [18F]-fluorodeoxyglucose positron emission tomography. Circulation 2002;105:2708-11.PubMed
34.
Zurück zum Zitat Rudd JH, Myers KS, Bansilal S, Machac J, Woodward M, Fuster V, et al. Relationships among regional arterial inflammation, calcification, risk factors, and biomarkers: A prospective fluorodeoxyglucose positron-emission tomography/computed tomography imaging study. Circ Cardiovasc Imaging 2009;2:107-15.PubMedCentralPubMed Rudd JH, Myers KS, Bansilal S, Machac J, Woodward M, Fuster V, et al. Relationships among regional arterial inflammation, calcification, risk factors, and biomarkers: A prospective fluorodeoxyglucose positron-emission tomography/computed tomography imaging study. Circ Cardiovasc Imaging 2009;2:107-15.PubMedCentralPubMed
35.
Zurück zum Zitat Yun M, Jang S, Cucchiara A, Newberg AB, Alavi A. 18F FDG uptake in the large arteries: A correlation study with the atherogenic risk factors. Semin Nucl Med 2002;32:70-6.PubMed Yun M, Jang S, Cucchiara A, Newberg AB, Alavi A. 18F FDG uptake in the large arteries: A correlation study with the atherogenic risk factors. Semin Nucl Med 2002;32:70-6.PubMed
36.
Zurück zum Zitat Ryu Y, Yoshida K, Suzuki Y, Nakadate M, Umehara I, Tomita M, et al. Long-term changes of aortic 18F-FDG uptake and calcification in health-screening subjects. Ann Nucl Med 2013;27:239-46.PubMed Ryu Y, Yoshida K, Suzuki Y, Nakadate M, Umehara I, Tomita M, et al. Long-term changes of aortic 18F-FDG uptake and calcification in health-screening subjects. Ann Nucl Med 2013;27:239-46.PubMed
37.
Zurück zum Zitat Figueroa AL, Abdelbaky A, Truong QA, Corsini E, MacNabb MH, Lavender ZR, et al. Measurement of arterial activity on routine FDG PET/CT images improves prediction of risk of future CV events. JACC Cardiovasc Imaging 2013;6:1250-9.PubMed Figueroa AL, Abdelbaky A, Truong QA, Corsini E, MacNabb MH, Lavender ZR, et al. Measurement of arterial activity on routine FDG PET/CT images improves prediction of risk of future CV events. JACC Cardiovasc Imaging 2013;6:1250-9.PubMed
38.
Zurück zum Zitat Paulmier B, Duet M, Khayat R, Pierquet-Ghazzar N, Laissy JP, Maunoury C, et al. Arterial wall uptake of fluorodeoxyglucose on PET imaging in stable cancer disease patients indicates higher risk for cardiovascular events. J Nucl Cardiol 2008;15:209-17.PubMed Paulmier B, Duet M, Khayat R, Pierquet-Ghazzar N, Laissy JP, Maunoury C, et al. Arterial wall uptake of fluorodeoxyglucose on PET imaging in stable cancer disease patients indicates higher risk for cardiovascular events. J Nucl Cardiol 2008;15:209-17.PubMed
39.
Zurück zum Zitat Fayad ZA, Mani V, Woodward M, Kallend D, Bansilal S, Pozza J, et al. Rationale and design of dal-PLAQUE: A study assessing efficacy and safety of dalcetrapib on progression or regression of atherosclerosis using magnetic resonance imaging and 18F-fluorodeoxyglucose positron emission tomography/computed tomography. Am Heart J 2011;162:e2.PubMed Fayad ZA, Mani V, Woodward M, Kallend D, Bansilal S, Pozza J, et al. Rationale and design of dal-PLAQUE: A study assessing efficacy and safety of dalcetrapib on progression or regression of atherosclerosis using magnetic resonance imaging and 18F-fluorodeoxyglucose positron emission tomography/computed tomography. Am Heart J 2011;162:e2.PubMed
40.
Zurück zum Zitat Kim TN, Kim S, Yang SJ, Yoo HJ, Seo JA, Kim SG, et al. Vascular inflammation in patients with impaired glucose tolerance and type 2 diabetes: Analysis with 18F-fluorodeoxyglucose positron emission tomography. Circ Cardiovasc Imaging 2010;3:142-8.PubMed Kim TN, Kim S, Yang SJ, Yoo HJ, Seo JA, Kim SG, et al. Vascular inflammation in patients with impaired glucose tolerance and type 2 diabetes: Analysis with 18F-fluorodeoxyglucose positron emission tomography. Circ Cardiovasc Imaging 2010;3:142-8.PubMed
41.
Zurück zum Zitat Kwee RM, Teule GJ, van Oostenbrugge RJ, Mess WH, Prins MH, van der Geest RJ, et al. Multimodality imaging of carotid artery plaques: 18F-fluoro-2-deoxyglucose positron emission tomography, computed tomography, and magnetic resonance imaging. Stroke 2009;40:3718-24.PubMed Kwee RM, Teule GJ, van Oostenbrugge RJ, Mess WH, Prins MH, van der Geest RJ, et al. Multimodality imaging of carotid artery plaques: 18F-fluoro-2-deoxyglucose positron emission tomography, computed tomography, and magnetic resonance imaging. Stroke 2009;40:3718-24.PubMed
42.
Zurück zum Zitat Tawakol A, Singh P, Rudd JH, Soffer J, Cai G, Vucic E, et al. Effect of treatment for 12 weeks with rilapladib, a lipoprotein-associated phospholipase A2 inhibitor, on arterial inflammation as assessed with 18F-fluorodeoxyglucose-positron emission tomography imaging. J Am Coll Cardiol 2014;63:86-8.PubMed Tawakol A, Singh P, Rudd JH, Soffer J, Cai G, Vucic E, et al. Effect of treatment for 12 weeks with rilapladib, a lipoprotein-associated phospholipase A2 inhibitor, on arterial inflammation as assessed with 18F-fluorodeoxyglucose-positron emission tomography imaging. J Am Coll Cardiol 2014;63:86-8.PubMed
43.
Zurück zum Zitat Mehta NN, Torigian DA, Gelfand JM, Saboury B, Alavi A. Quantification of atherosclerotic plaque activity and vascular inflammation using [18-F] fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT). J Vis Exp 2012;63:e3777.PubMed Mehta NN, Torigian DA, Gelfand JM, Saboury B, Alavi A. Quantification of atherosclerotic plaque activity and vascular inflammation using [18-F] fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT). J Vis Exp 2012;63:e3777.PubMed
44.
Zurück zum Zitat Bural GG, Torigian DA, Chamroonrat W, Alkhawaldeh K, Houseni M, El-Haddad G, et al. Quantitative assessment of the atherosclerotic burden of the aorta by combined FDG-PET and CT image analysis: A new concept. Nucl Med Biol 2006;33:1037-43.PubMed Bural GG, Torigian DA, Chamroonrat W, Alkhawaldeh K, Houseni M, El-Haddad G, et al. Quantitative assessment of the atherosclerotic burden of the aorta by combined FDG-PET and CT image analysis: A new concept. Nucl Med Biol 2006;33:1037-43.PubMed
45.
Zurück zum Zitat Noh TS, Yoo J, Kim SW, Lee EJ, Choi JY, Kim BT, et al. Effects of coverage extent and slice skipping on mean and maximum arterial 18F-FDG uptake ratios in patients with carotid plaque. Ann Nucl Med 2012;26:715-22.PubMed Noh TS, Yoo J, Kim SW, Lee EJ, Choi JY, Kim BT, et al. Effects of coverage extent and slice skipping on mean and maximum arterial 18F-FDG uptake ratios in patients with carotid plaque. Ann Nucl Med 2012;26:715-22.PubMed
46.
Zurück zum Zitat Nitta Y, Tahara N, Tahara A, Honda A, Kodama N, Mizoguchi M, et al. Pioglitazone decreases coronary artery inflammation in impaired glucose tolerance and diabetes mellitus: Evaluation by FDG-PET/CT imaging. JACC Cardiovasc Imaging 2013;6:1172-82.PubMed Nitta Y, Tahara N, Tahara A, Honda A, Kodama N, Mizoguchi M, et al. Pioglitazone decreases coronary artery inflammation in impaired glucose tolerance and diabetes mellitus: Evaluation by FDG-PET/CT imaging. JACC Cardiovasc Imaging 2013;6:1172-82.PubMed
47.
Zurück zum Zitat Ogawa M, Ishino S, Mukai T, Asano D, Teramoto N, Watabe H, et al. (18)F-FDG accumulation in atherosclerotic plaques: Immunohistochemical and PET imaging study. J Nucl Med 2004;45:1245-50.PubMed Ogawa M, Ishino S, Mukai T, Asano D, Teramoto N, Watabe H, et al. (18)F-FDG accumulation in atherosclerotic plaques: Immunohistochemical and PET imaging study. J Nucl Med 2004;45:1245-50.PubMed
48.
Zurück zum Zitat Ishino S, Ogawa M, Mori I, Nishimura S, Ikeda S, Sugita T, et al. 18F-FDG PET and intravascular ultrasonography (IVUS) images compared with histology of atherosclerotic plaques: 18F-FDG accumulates in foamy macrophages. Eur J Nucl Med Mol Imaging 2014;41:624-33.PubMed Ishino S, Ogawa M, Mori I, Nishimura S, Ikeda S, Sugita T, et al. 18F-FDG PET and intravascular ultrasonography (IVUS) images compared with histology of atherosclerotic plaques: 18F-FDG accumulates in foamy macrophages. Eur J Nucl Med Mol Imaging 2014;41:624-33.PubMed
49.
Zurück zum Zitat Thie JA. Understanding the standardized uptake value, its methods, and implications for usage. J Nucl Med 2004;45:1431-4.PubMed Thie JA. Understanding the standardized uptake value, its methods, and implications for usage. J Nucl Med 2004;45:1431-4.PubMed
50.
Zurück zum Zitat Vucic E, Calcagno C, Dickson SD, Rudd JH, Hayashi K, Bucerius J, et al. Regression of inflammation in atherosclerosis by the LXR agonist R211945: A noninvasive assessment and comparison with atorvastatin. JACC Cardiovasc Imaging 2012;5:819-28.PubMedCentralPubMed Vucic E, Calcagno C, Dickson SD, Rudd JH, Hayashi K, Bucerius J, et al. Regression of inflammation in atherosclerosis by the LXR agonist R211945: A noninvasive assessment and comparison with atorvastatin. JACC Cardiovasc Imaging 2012;5:819-28.PubMedCentralPubMed
51.
Zurück zum Zitat Bucerius J, Mani V, Moncrieff C, Rudd JH, Machac J, Fuster V, et al. Impact of noninsulin-dependent type 2 diabetes on carotid wall 18F-fluorodeoxyglucose positron emission tomography uptake. J Am Coll Cardiol 2012;59:2080-8.PubMedCentralPubMed Bucerius J, Mani V, Moncrieff C, Rudd JH, Machac J, Fuster V, et al. Impact of noninsulin-dependent type 2 diabetes on carotid wall 18F-fluorodeoxyglucose positron emission tomography uptake. J Am Coll Cardiol 2012;59:2080-8.PubMedCentralPubMed
52.
Zurück zum Zitat Millon A, Dickson SD, Klink A, Izquierdo-Garcia D, Bini J, Lancelot E, et al. Monitoring plaque inflammation in atherosclerotic rabbits with an iron oxide (P904) and (18)F-FDG using a combined PET/MR scanner. Atherosclerosis 2013;228:339-45.PubMedCentralPubMed Millon A, Dickson SD, Klink A, Izquierdo-Garcia D, Bini J, Lancelot E, et al. Monitoring plaque inflammation in atherosclerotic rabbits with an iron oxide (P904) and (18)F-FDG using a combined PET/MR scanner. Atherosclerosis 2013;228:339-45.PubMedCentralPubMed
53.
Zurück zum Zitat Bai B, Bading J, Conti PS. Tumor quantification in clinical positron emission tomography. Theranostics 2013;3:787-801.PubMedCentralPubMed Bai B, Bading J, Conti PS. Tumor quantification in clinical positron emission tomography. Theranostics 2013;3:787-801.PubMedCentralPubMed
54.
Zurück zum Zitat Calcagno C, Ramachandran S, Izquierdo-Garcia D, Mani V, Millon A, Rosenbaum D, et al. The complementary roles of dynamic contrast-enhanced MRI and 18F-fluorodeoxyglucose PET/CT for imaging of carotid atherosclerosis. Eur J Nucl Med Mol Imaging 2013;40:1884-93.PubMed Calcagno C, Ramachandran S, Izquierdo-Garcia D, Mani V, Millon A, Rosenbaum D, et al. The complementary roles of dynamic contrast-enhanced MRI and 18F-fluorodeoxyglucose PET/CT for imaging of carotid atherosclerosis. Eur J Nucl Med Mol Imaging 2013;40:1884-93.PubMed
55.
Zurück zum Zitat Jaipersad AS, Shantsila A, Lip GY, Shantsila E. Expression of monocyte subsets and angiogenic markers in relation to carotid plaque neovascularization in patients with pre-existing coronary artery disease and carotid stenosis. Ann Med 2014;46:530-8.PubMed Jaipersad AS, Shantsila A, Lip GY, Shantsila E. Expression of monocyte subsets and angiogenic markers in relation to carotid plaque neovascularization in patients with pre-existing coronary artery disease and carotid stenosis. Ann Med 2014;46:530-8.PubMed
56.
Zurück zum Zitat Menezes LJ, Kayani I, Ben-Haim S, Hutton B, Ell PJ, Groves AM. What is the natural history of 18F-FDG uptake in arterial atheroma on PET/CT? Implications for imaging the vulnerable plaque. Atherosclerosis 2010;211:136-40.PubMed Menezes LJ, Kayani I, Ben-Haim S, Hutton B, Ell PJ, Groves AM. What is the natural history of 18F-FDG uptake in arterial atheroma on PET/CT? Implications for imaging the vulnerable plaque. Atherosclerosis 2010;211:136-40.PubMed
57.
Zurück zum Zitat Rogers IS, Nasir K, Figueroa AL, Cury RC, Hoffmann U, Vermylen DA, et al. Feasibility of FDG imaging of the coronary arteries: Comparison between acute coronary syndrome and stable angina. JACC Cardiovasc Imaging 2010;3:388-97.PubMed Rogers IS, Nasir K, Figueroa AL, Cury RC, Hoffmann U, Vermylen DA, et al. Feasibility of FDG imaging of the coronary arteries: Comparison between acute coronary syndrome and stable angina. JACC Cardiovasc Imaging 2010;3:388-97.PubMed
58.
Zurück zum Zitat Wu YW, Kao HL, Huang CL, Chen MF, Lin LY, Wang YC, et al. The effects of 3-month atorvastatin therapy on arterial inflammation, calcification, abdominal adipose tissue and circulating biomarkers. Eur J Nucl Med Mol Imaging 2012;39:399-407.PubMed Wu YW, Kao HL, Huang CL, Chen MF, Lin LY, Wang YC, et al. The effects of 3-month atorvastatin therapy on arterial inflammation, calcification, abdominal adipose tissue and circulating biomarkers. Eur J Nucl Med Mol Imaging 2012;39:399-407.PubMed
59.
Zurück zum Zitat Elkhawad M, Rudd JH, Sarov-Blat L, Cai G, Wells R, Davies LC, et al. Effects of p38 mitogen-activated protein kinase inhibition on vascular and systemic inflammation in patients with atherosclerosis. JACC Cardiovasc Imaging 2012;5:911-22.PubMed Elkhawad M, Rudd JH, Sarov-Blat L, Cai G, Wells R, Davies LC, et al. Effects of p38 mitogen-activated protein kinase inhibition on vascular and systemic inflammation in patients with atherosclerosis. JACC Cardiovasc Imaging 2012;5:911-22.PubMed
60.
Zurück zum Zitat Bucerius J, Mani V, Wong S, Moncrieff C, Izquierdo-Garcia D, Machac J, et al. Arterial and fat tissue inflammation are highly correlated: A prospective 18F-FDG PET/CT study. Eur J Nucl Med Mol Imaging 2014;41:934-45.PubMedCentralPubMed Bucerius J, Mani V, Wong S, Moncrieff C, Izquierdo-Garcia D, Machac J, et al. Arterial and fat tissue inflammation are highly correlated: A prospective 18F-FDG PET/CT study. Eur J Nucl Med Mol Imaging 2014;41:934-45.PubMedCentralPubMed
61.
Zurück zum Zitat Subramanian S, Emami H, Vucic E, Singh P, Vijayakumar J, Fifer KM, et al. High-dose atorvastatin reduces periodontal inflammation: A novel pleiotropic effect of statins. J Am Coll Cardiol 2013;62:2382-91.PubMed Subramanian S, Emami H, Vucic E, Singh P, Vijayakumar J, Fifer KM, et al. High-dose atorvastatin reduces periodontal inflammation: A novel pleiotropic effect of statins. J Am Coll Cardiol 2013;62:2382-91.PubMed
62.
Zurück zum Zitat Emami H, Vijayakumar J, Subramanian S, Vucic E, Singh P, MacNabb MH, et al. Arterial 18F-FDG uptake in rheumatoid arthritis correlates with synovial activity. JACC Cardiovasc Imaging 2014;7:959-60.PubMed Emami H, Vijayakumar J, Subramanian S, Vucic E, Singh P, MacNabb MH, et al. Arterial 18F-FDG uptake in rheumatoid arthritis correlates with synovial activity. JACC Cardiovasc Imaging 2014;7:959-60.PubMed
63.
Zurück zum Zitat Zhang Z, Machac J, Helft G, Worthley SG, Tang C, Zaman AG, et al. Non-invasive imaging of atherosclerotic plaque macrophage in a rabbit model with F-18 FDG PET: A histopathological correlation. BMC Nucl Med 2006;6:3.PubMedCentralPubMed Zhang Z, Machac J, Helft G, Worthley SG, Tang C, Zaman AG, et al. Non-invasive imaging of atherosclerotic plaque macrophage in a rabbit model with F-18 FDG PET: A histopathological correlation. BMC Nucl Med 2006;6:3.PubMedCentralPubMed
65.
Zurück zum Zitat Fayad ZA, Mani V, Woodward M, Kallend D, Abt M, Burgess T, et al. Safety and efficacy of dalcetrapib on atherosclerotic disease using novel non-invasive multimodality imaging (dal-PLAQUE): A randomised clinical trial. Lancet 2011;378:1547-59.PubMedCentralPubMed Fayad ZA, Mani V, Woodward M, Kallend D, Abt M, Burgess T, et al. Safety and efficacy of dalcetrapib on atherosclerotic disease using novel non-invasive multimodality imaging (dal-PLAQUE): A randomised clinical trial. Lancet 2011;378:1547-59.PubMedCentralPubMed
66.
Zurück zum Zitat Hayashi K, Mani V, Nemade A, Aguiar S, Postley JE, Fuster V, et al. Variations in atherosclerosis and remodeling patterns in aorta and carotids. J Cardiovasc Magn Reson 2010;12:10.PubMedCentralPubMed Hayashi K, Mani V, Nemade A, Aguiar S, Postley JE, Fuster V, et al. Variations in atherosclerosis and remodeling patterns in aorta and carotids. J Cardiovasc Magn Reson 2010;12:10.PubMedCentralPubMed
67.
Zurück zum Zitat Rominger A, Saam T, Wolpers S, Cyran CC, Schmidt M, Foerster S, et al. 18F-FDG PET/CT identifies patients at risk for future vascular events in an otherwise asymptomatic cohort with neoplastic disease. J Nucl Med 2009;50:1611-20.PubMed Rominger A, Saam T, Wolpers S, Cyran CC, Schmidt M, Foerster S, et al. 18F-FDG PET/CT identifies patients at risk for future vascular events in an otherwise asymptomatic cohort with neoplastic disease. J Nucl Med 2009;50:1611-20.PubMed
68.
Zurück zum Zitat Lee JM, Wiesmann F, Shirodaria C, Leeson P, Petersen SE, Francis JM, et al. Early changes in arterial structure and function following statin initiation: Quantification by magnetic resonance imaging. Atherosclerosis 2008;197:951-8.PubMedCentralPubMed Lee JM, Wiesmann F, Shirodaria C, Leeson P, Petersen SE, Francis JM, et al. Early changes in arterial structure and function following statin initiation: Quantification by magnetic resonance imaging. Atherosclerosis 2008;197:951-8.PubMedCentralPubMed
69.
Zurück zum Zitat Arauz A, Hoyos L, Zenteno M, Mendoza R, Alexanderson E. Carotid plaque inflammation detected by 18F-fluorodeoxyglucose-positron emission tomography. Pilot study. Clin Neurol Neurosurg 2007;109:409-12.PubMed Arauz A, Hoyos L, Zenteno M, Mendoza R, Alexanderson E. Carotid plaque inflammation detected by 18F-fluorodeoxyglucose-positron emission tomography. Pilot study. Clin Neurol Neurosurg 2007;109:409-12.PubMed
70.
Zurück zum Zitat Kuehl H, Eggebrecht H, Boes T, Antoch G, Rosenbaum S, Ladd S, et al. Detection of inflammation in patients with acute aortic syndrome: Comparison of FDG-PET/CT imaging and serological markers of inflammation. Heart 2008;94:1472-7.PubMed Kuehl H, Eggebrecht H, Boes T, Antoch G, Rosenbaum S, Ladd S, et al. Detection of inflammation in patients with acute aortic syndrome: Comparison of FDG-PET/CT imaging and serological markers of inflammation. Heart 2008;94:1472-7.PubMed
71.
Zurück zum Zitat Arora S, Chien JD, Cheng SC, Chun KA, Wintermark M. Optimal carotid artery coverage for carotid plaque CT-imaging in predicting ischemic stroke. J Neuroradiol 2010;37:98-103.PubMed Arora S, Chien JD, Cheng SC, Chun KA, Wintermark M. Optimal carotid artery coverage for carotid plaque CT-imaging in predicting ischemic stroke. J Neuroradiol 2010;37:98-103.PubMed
72.
Zurück zum Zitat Tresoldi S, Di Leo G, Zoffoli E, Munari A, Primolevo A, Cornalba G, et al. Association of aortic wall thickness on contrast-enhanced chest CT with major cerebro-cardiac events. Acta Radiol 2013;55:1040-9.PubMed Tresoldi S, Di Leo G, Zoffoli E, Munari A, Primolevo A, Cornalba G, et al. Association of aortic wall thickness on contrast-enhanced chest CT with major cerebro-cardiac events. Acta Radiol 2013;55:1040-9.PubMed
73.
Zurück zum Zitat Crouse JR 3rd. Thematic review series: Patient-oriented research. Imaging atherosclerosis: State of the art. J Lipid Res 2006;47:1677-99.PubMed Crouse JR 3rd. Thematic review series: Patient-oriented research. Imaging atherosclerosis: State of the art. J Lipid Res 2006;47:1677-99.PubMed
74.
Zurück zum Zitat Glagov S, Weisenberg E, Zarins CK, Stankunavicius R, Kolettis GJ. Compensatory enlargement of human atherosclerotic coronary arteries. N Engl J Med. 1987;316:1371-5.PubMed Glagov S, Weisenberg E, Zarins CK, Stankunavicius R, Kolettis GJ. Compensatory enlargement of human atherosclerotic coronary arteries. N Engl J Med. 1987;316:1371-5.PubMed
75.
Zurück zum Zitat Schoenhagen P, Ziada KM, Kapadia SR, Crowe TD, Nissen SE, Tuzcu EM. Extent and direction of arterial remodeling in stable versus unstable coronary syndromes: An intravascular ultrasound study. Circulation 2000;101:598-603.PubMed Schoenhagen P, Ziada KM, Kapadia SR, Crowe TD, Nissen SE, Tuzcu EM. Extent and direction of arterial remodeling in stable versus unstable coronary syndromes: An intravascular ultrasound study. Circulation 2000;101:598-603.PubMed
76.
Zurück zum Zitat Tahara N, Kai H, Yamagishi S, Mizoguchi M, Nakaura H, Ishibashi M, et al. Vascular inflammation evaluated by [18F]-fluorodeoxyglucose positron emission tomography is associated with the metabolic syndrome. J Am Coll Cardiol 2007;49:1533-9.PubMed Tahara N, Kai H, Yamagishi S, Mizoguchi M, Nakaura H, Ishibashi M, et al. Vascular inflammation evaluated by [18F]-fluorodeoxyglucose positron emission tomography is associated with the metabolic syndrome. J Am Coll Cardiol 2007;49:1533-9.PubMed
77.
Zurück zum Zitat Silvera SS, Aidi HE, Rudd JH, Mani V, Yang L, Farkouh M, et al. Multimodality imaging of atherosclerotic plaque activity and composition using FDG-PET/CT and MRI in carotid and femoral arteries. Atherosclerosis 2009;207:139-43.PubMedCentralPubMed Silvera SS, Aidi HE, Rudd JH, Mani V, Yang L, Farkouh M, et al. Multimodality imaging of atherosclerotic plaque activity and composition using FDG-PET/CT and MRI in carotid and femoral arteries. Atherosclerosis 2009;207:139-43.PubMedCentralPubMed
78.
Zurück zum Zitat Bural GG, Torigian DA, Botvinick E, Houseni M, Basu S, Chen W, et al. A pilot study of changes in (18)F-FDG uptake, calcification and global metabolic activity of the aorta with aging. Hell J Nucl Med 2009;12:123-8.PubMed Bural GG, Torigian DA, Botvinick E, Houseni M, Basu S, Chen W, et al. A pilot study of changes in (18)F-FDG uptake, calcification and global metabolic activity of the aorta with aging. Hell J Nucl Med 2009;12:123-8.PubMed
79.
Zurück zum Zitat Strobl FF, Rominger A, Wolpers S, Rist C, Bamberg F, Thierfelder KM, et al. Impact of cardiovascular risk factors on vessel wall inflammation and calcified plaque burden differs across vascular beds: A PET-CT study. Int J Cardiovasc Imaging 2013;29:1899-908.PubMed Strobl FF, Rominger A, Wolpers S, Rist C, Bamberg F, Thierfelder KM, et al. Impact of cardiovascular risk factors on vessel wall inflammation and calcified plaque burden differs across vascular beds: A PET-CT study. Int J Cardiovasc Imaging 2013;29:1899-908.PubMed
80.
Zurück zum Zitat Okane K, Ibaraki M, Toyoshima H, Sugawara S, Takahashi K, Miura S, et al. 18F-FDG accumulation in atherosclerosis: Use of CT and MR co-registration of thoracic and carotid arteries. Eur J Nucl Med Mol Imaging 2006;33:589-94.PubMed Okane K, Ibaraki M, Toyoshima H, Sugawara S, Takahashi K, Miura S, et al. 18F-FDG accumulation in atherosclerosis: Use of CT and MR co-registration of thoracic and carotid arteries. Eur J Nucl Med Mol Imaging 2006;33:589-94.PubMed
81.
Zurück zum Zitat Mensel B, Quadrat A, Schneider T, Kuhn JP, Dorr M, Volzke H, et al. MRI-based determination of reference values of thoracic aortic wall thickness in a general population. Eur Radiol 2014;24:2038-44.PubMed Mensel B, Quadrat A, Schneider T, Kuhn JP, Dorr M, Volzke H, et al. MRI-based determination of reference values of thoracic aortic wall thickness in a general population. Eur Radiol 2014;24:2038-44.PubMed
82.
Zurück zum Zitat Shakeri A, Hafez Quran F, Javadrashid R, Abdekarimi MH, Ghojazadeh M, Abolghassemi Fakhree MB. Correlation between Aortic wall thickness and coronary artery disease by 64 slice multidetector computed tomography. J Cardiovasc Thorac Res 2013;5:91-5. Shakeri A, Hafez Quran F, Javadrashid R, Abdekarimi MH, Ghojazadeh M, Abolghassemi Fakhree MB. Correlation between Aortic wall thickness and coronary artery disease by 64 slice multidetector computed tomography. J Cardiovasc Thorac Res 2013;5:91-5.
83.
Zurück zum Zitat Burg S, Dupas A, Stute S, Dieudonne A, Huet P, Le Guludec D, et al. Partial volume effect estimation and correction in the aortic vascular wall in PET imaging. Phys Med Biol 2013;58:7527-42.PubMed Burg S, Dupas A, Stute S, Dieudonne A, Huet P, Le Guludec D, et al. Partial volume effect estimation and correction in the aortic vascular wall in PET imaging. Phys Med Biol 2013;58:7527-42.PubMed
84.
Zurück zum Zitat Izquierdo-Garcia D, Davies JR, Graves MJ, Rudd JH, Gillard JH, Weissberg PL, et al. Comparison of methods for magnetic resonance-guided [18-F]fluorodeoxyglucose positron emission tomography in human carotid arteries: Reproducibility, partial volume correction, and correlation between methods. Stroke 2009;40:86-93.PubMed Izquierdo-Garcia D, Davies JR, Graves MJ, Rudd JH, Gillard JH, Weissberg PL, et al. Comparison of methods for magnetic resonance-guided [18-F]fluorodeoxyglucose positron emission tomography in human carotid arteries: Reproducibility, partial volume correction, and correlation between methods. Stroke 2009;40:86-93.PubMed
85.
Zurück zum Zitat Houshmand S, Gholami S, Salavati A, Bashyam A, Ramachandran A, Werner T, et al. Accurate quantification of aortic wall inflammation using FDG-PET/CT: A method for partial volume effect correction based on contrast enhanced computed tomography. In: Annual congress of the european association of nuclear medicine, Gothenburg; 2014. Houshmand S, Gholami S, Salavati A, Bashyam A, Ramachandran A, Werner T, et al. Accurate quantification of aortic wall inflammation using FDG-PET/CT: A method for partial volume effect correction based on contrast enhanced computed tomography. In: Annual congress of the european association of nuclear medicine, Gothenburg; 2014.
86.
Zurück zum Zitat Nawaz A, Saboury B, Basu S, Zhuang H, Moghadam-Kia S, Werner T, et al. Relation between popliteal-tibial artery atherosclerosis and global glycolytic metabolism in the affected diabetic foot: A pilot study using quantitative FDG-PET. J Am Podiatr Med Assoc 2012;102:240-6.PubMed Nawaz A, Saboury B, Basu S, Zhuang H, Moghadam-Kia S, Werner T, et al. Relation between popliteal-tibial artery atherosclerosis and global glycolytic metabolism in the affected diabetic foot: A pilot study using quantitative FDG-PET. J Am Podiatr Med Assoc 2012;102:240-6.PubMed
87.
Zurück zum Zitat Basu S, Zhuang H, Alavi A. Imaging of lower extremity artery atherosclerosis in diabetic foot: FDG-PET imaging and histopathological correlates. Clin Nucl Med 2007;32:567-8.PubMed Basu S, Zhuang H, Alavi A. Imaging of lower extremity artery atherosclerosis in diabetic foot: FDG-PET imaging and histopathological correlates. Clin Nucl Med 2007;32:567-8.PubMed
88.
Zurück zum Zitat Strong JP, Malcom GT, McMahan CA, Tracy RE, Newman WP 3rd, Herderick EE, et al. Prevalence and extent of atherosclerosis in adolescents and young adults: Implications for prevention from the Pathobiological Determinants of Atherosclerosis in Youth Study. JAMA 1999;281:727-35.PubMed Strong JP, Malcom GT, McMahan CA, Tracy RE, Newman WP 3rd, Herderick EE, et al. Prevalence and extent of atherosclerosis in adolescents and young adults: Implications for prevention from the Pathobiological Determinants of Atherosclerosis in Youth Study. JAMA 1999;281:727-35.PubMed
89.
Zurück zum Zitat Morbelli S, Ghigliotti G, Spinella G, Marini C, Bossert I, Cimmino MA, et al. Systemic vascular inflammation in abdominal aortic aneurysm patients: A contrast-enhanced PET/CT study. Q J Nucl Med Mol Imaging 2014;58:299-309.PubMed Morbelli S, Ghigliotti G, Spinella G, Marini C, Bossert I, Cimmino MA, et al. Systemic vascular inflammation in abdominal aortic aneurysm patients: A contrast-enhanced PET/CT study. Q J Nucl Med Mol Imaging 2014;58:299-309.PubMed
90.
Zurück zum Zitat Orellana MR, Bentourkia M, Sarrhini O, Fulop T, Paquet N, Lavallee E, et al. Assessment of inflammation in large arteries with 18F-FDG-PET in elderly. Comput Med Imaging Graph 2013;37:459-65.PubMed Orellana MR, Bentourkia M, Sarrhini O, Fulop T, Paquet N, Lavallee E, et al. Assessment of inflammation in large arteries with 18F-FDG-PET in elderly. Comput Med Imaging Graph 2013;37:459-65.PubMed
91.
Zurück zum Zitat Roos CJ, Witkowska AJ, de Graaf MA, Veltman CE, Delgado V, de Grooth GJ, et al. Association of atherosclerosis in the descending thoracic aorta with coronary artery disease on multi detector row computed tomography coronary angiography in patients with suspected coronary artery disease. Int J Cardiovasc Imaging 2013;29:1829-37.PubMed Roos CJ, Witkowska AJ, de Graaf MA, Veltman CE, Delgado V, de Grooth GJ, et al. Association of atherosclerosis in the descending thoracic aorta with coronary artery disease on multi detector row computed tomography coronary angiography in patients with suspected coronary artery disease. Int J Cardiovasc Imaging 2013;29:1829-37.PubMed
92.
Zurück zum Zitat Thej MJ, Kalyani R, Kiran J. Atherosclerosis in coronary artery and aorta in a semi-urban population by applying modified American Heart Association classification of atherosclerosis: An autopsy study. J Cardiovasc Dis Res 2012;3:265-71.PubMedCentralPubMed Thej MJ, Kalyani R, Kiran J. Atherosclerosis in coronary artery and aorta in a semi-urban population by applying modified American Heart Association classification of atherosclerosis: An autopsy study. J Cardiovasc Dis Res 2012;3:265-71.PubMedCentralPubMed
93.
Zurück zum Zitat Agmon Y, Khandheria BK, Meissner I, Schwartz GL, Petterson TM, O’Fallon WM, et al. Relation of coronary artery disease and cerebrovascular disease with atherosclerosis of the thoracic aorta in the general population. Am J Cardiol 2002;89:262-7.PubMed Agmon Y, Khandheria BK, Meissner I, Schwartz GL, Petterson TM, O’Fallon WM, et al. Relation of coronary artery disease and cerebrovascular disease with atherosclerosis of the thoracic aorta in the general population. Am J Cardiol 2002;89:262-7.PubMed
94.
Zurück zum Zitat McGill HC Jr, McMahan CA, Herderick EE, Tracy RE, Malcom GT, Zieske AW, et al. Effects of coronary heart disease risk factors on atherosclerosis of selected regions of the aorta and right coronary artery. PDAY Research Group. Pathobiological Determinants of Atherosclerosis in Youth. Arterioscler Thromb Vasc Biol 2000;20:836-45.PubMed McGill HC Jr, McMahan CA, Herderick EE, Tracy RE, Malcom GT, Zieske AW, et al. Effects of coronary heart disease risk factors on atherosclerosis of selected regions of the aorta and right coronary artery. PDAY Research Group. Pathobiological Determinants of Atherosclerosis in Youth. Arterioscler Thromb Vasc Biol 2000;20:836-45.PubMed
95.
Zurück zum Zitat Rohani M, Jogestrand T, Ekberg M, van der Linden J, Kallner G, Jussila R, et al. Interrelation between the extent of atherosclerosis in the thoracic aorta, carotid intima-media thickness and the extent of coronary artery disease. Atherosclerosis 2005;179:311-6.PubMed Rohani M, Jogestrand T, Ekberg M, van der Linden J, Kallner G, Jussila R, et al. Interrelation between the extent of atherosclerosis in the thoracic aorta, carotid intima-media thickness and the extent of coronary artery disease. Atherosclerosis 2005;179:311-6.PubMed
96.
Zurück zum Zitat Alexanderson E, Slomka P, Cheng V, Meave A, Saldana Y, Garcia-Rojas L, et al. Fusion of positron emission tomography and coronary computed tomographic angiography identifies fluorine 18 fluorodeoxyglucose uptake in the left main coronary artery soft plaque. J Nucl Cardiol 2008;15:841-3.PubMed Alexanderson E, Slomka P, Cheng V, Meave A, Saldana Y, Garcia-Rojas L, et al. Fusion of positron emission tomography and coronary computed tomographic angiography identifies fluorine 18 fluorodeoxyglucose uptake in the left main coronary artery soft plaque. J Nucl Cardiol 2008;15:841-3.PubMed
97.
Zurück zum Zitat Saam T, Rominger A, Wolpers S, Nikolaou K, Rist C, Greif M, et al. Association of inflammation of the left anterior descending coronary artery with cardiovascular risk factors, plaque burden and pericardial fat volume: A PET/CT study. Eur J Nucl Med Mol Imaging 2010;37:1203-12.PubMed Saam T, Rominger A, Wolpers S, Nikolaou K, Rist C, Greif M, et al. Association of inflammation of the left anterior descending coronary artery with cardiovascular risk factors, plaque burden and pericardial fat volume: A PET/CT study. Eur J Nucl Med Mol Imaging 2010;37:1203-12.PubMed
98.
Zurück zum Zitat Wykrzykowska J, Lehman S, Williams G, Parker JA, Palmer MR, Varkey S, et al. Imaging of inflamed and vulnerable plaque in coronary arteries with 18F-FDG PET/CT in patients with suppression of myocardial uptake using a low-carbohydrate, high-fat preparation. J Nucl Med 2009;50:563-8.PubMed Wykrzykowska J, Lehman S, Williams G, Parker JA, Palmer MR, Varkey S, et al. Imaging of inflamed and vulnerable plaque in coronary arteries with 18F-FDG PET/CT in patients with suppression of myocardial uptake using a low-carbohydrate, high-fat preparation. J Nucl Med 2009;50:563-8.PubMed
99.
Zurück zum Zitat Tarkin JM, Joshi FR, Rudd JH. PET imaging of inflammation in atherosclerosis. Nat Rev Cardiol 2014;11:443-57.PubMed Tarkin JM, Joshi FR, Rudd JH. PET imaging of inflammation in atherosclerosis. Nat Rev Cardiol 2014;11:443-57.PubMed
100.
Zurück zum Zitat Hucker WJ, Jaffer FA. F-FDG PET imaging of atherosclerosis—A new approach to detect inflamed, high-risk coronary plaques? Curr Cardiovasc Imaging Rep 2011;4:1-3.PubMedCentralPubMed Hucker WJ, Jaffer FA. F-FDG PET imaging of atherosclerosis—A new approach to detect inflamed, high-risk coronary plaques? Curr Cardiovasc Imaging Rep 2011;4:1-3.PubMedCentralPubMed
101.
Zurück zum Zitat Leuschner F, Nahrendorf M. Molecular imaging of coronary atherosclerosis and myocardial infarction: Considerations for the bench and perspectives for the clinic. Circ Res 2011;108:593-606.PubMedCentralPubMed Leuschner F, Nahrendorf M. Molecular imaging of coronary atherosclerosis and myocardial infarction: Considerations for the bench and perspectives for the clinic. Circ Res 2011;108:593-606.PubMedCentralPubMed
102.
Zurück zum Zitat Kumar P, Patel CD, Singla S, Malhotra A. Effect of duration of fasting and diet on the myocardial uptake of F-18-2-fluoro-2-deoxyglucose (F-18 FDG) at rest. Indian J Nucl Med 2014;29:140-5.PubMedCentralPubMed Kumar P, Patel CD, Singla S, Malhotra A. Effect of duration of fasting and diet on the myocardial uptake of F-18-2-fluoro-2-deoxyglucose (F-18 FDG) at rest. Indian J Nucl Med 2014;29:140-5.PubMedCentralPubMed
103.
Zurück zum Zitat Buther F, Dawood M, Stegger L, Wubbeling F, Schafers M, Schober O, et al. List mode-driven cardiac and respiratory gating in PET. J Nucl Med 2009;50:674-81.PubMed Buther F, Dawood M, Stegger L, Wubbeling F, Schafers M, Schober O, et al. List mode-driven cardiac and respiratory gating in PET. J Nucl Med 2009;50:674-81.PubMed
104.
Zurück zum Zitat Chen W, Dilsizian V. (18)F-fluorodeoxyglucose PET imaging of coronary atherosclerosis and plaque inflammation. Curr Cardiol Rep 2010;12:179-84.PubMed Chen W, Dilsizian V. (18)F-fluorodeoxyglucose PET imaging of coronary atherosclerosis and plaque inflammation. Curr Cardiol Rep 2010;12:179-84.PubMed
105.
Zurück zum Zitat Fayad HJ, Lamare F, Le Rest CC, Bettinardi V, Visvikis D. Generation of 4-dimensional CT images based on 4-dimensional PET-derived motion fields. J Nucl Med 2013;54:631-8.PubMed Fayad HJ, Lamare F, Le Rest CC, Bettinardi V, Visvikis D. Generation of 4-dimensional CT images based on 4-dimensional PET-derived motion fields. J Nucl Med 2013;54:631-8.PubMed
Metadaten
Titel
Assessment of atherosclerosis in large vessel walls: A comprehensive review of FDG-PET/CT image acquisition protocols and methods for uptake quantification
verfasst von
Saeid Gholami, MD
Ali Salavati, MD, MPH
Sina Houshmand, MD
Thomas J. Werner, MSE
Abass Alavi, MD, MD (Hon), PhD (Hon), DSc (Hon)
Publikationsdatum
01.06.2015
Verlag
Springer US
Erschienen in
Journal of Nuclear Cardiology / Ausgabe 3/2015
Print ISSN: 1071-3581
Elektronische ISSN: 1532-6551
DOI
https://doi.org/10.1007/s12350-015-0069-8

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