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Erschienen in:

01.11.2012

Association between B-group vitamins and venous thrombosis: systematic review and meta-analysis of epidemiological studies

verfasst von: Kuangguo Zhou, Ruizhi Zhao, Zhe Geng, Lijun Jiang, Yang Cao, Danmei Xu, Yin Liu, Liang Huang, Jianfeng Zhou

Erschienen in: Journal of Thrombosis and Thrombolysis | Ausgabe 4/2012

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Abstract

A homocysteine-independent role for B-group vitamins on venous thrombosis (VT) development has been reported. However, related research findings remain inconsistent. PUBMED, EMBASE, and COCHRANE databases were searched to collect information on all eligible studies to make a meta-analysis about the relationship between B-group vitamins and VT. Literature search results did not suggest a correlation between thiamin, pantothenic acid, niacin, or riboflavin with VT. Based on their correlations in the literature, folic acid, vitamin B12, B6 were considered in the meta-analysis and systematic review. Significant standardized mean differences were obtained for plasma folic acid (−0.55; 95 % CI, −0.75 to −0.36) and vitamin B12 (−0.34; 95 % CI, −0.55 to −0.13). Reduced levels of folic acid and vitamin B12 may be independent risk factors of VT. Moreover, a qualitative systematic review indicated that low level of vitamin B6 was an independent risk factor of VT. Randomized clinical studies of B-group vitamins supplementation showed varying results on VT prevention. Multivitamin supplementation for VT prevention, regardless of homocysteine level, would be of interest. Further prospective clinical studies are needed to provide additional evidence on the clinical benefits of B-group vitamin supplementation for VT.

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Titel: Association between B-group vitamins and venous thrombosis: systematic review and meta-analysis of epidemiological studies
verfasst von: Kuangguo Zhou
Ruizhi Zhao
Zhe Geng
Lijun Jiang
Yang Cao
Danmei Xu
Yin Liu
Liang Huang
Jianfeng Zhou
Publikationsdatum: 01.11.2012
Verlag: Springer US
Erschienen in: Journal of Thrombosis and Thrombolysis / Ausgabe 4/2012
Print ISSN: 0929-5305
Elektronische ISSN: 1573-742X
DOI: https://doi.org/10.1007/s11239-012-0759-x

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Association between B-group vitamins and venous thrombosis: systematic review and meta-analysis of epidemiological studies

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