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Erschienen in:
11.04.2016 | Originalien
Association between BLK polymorphisms and susceptibility to SLE
A meta-analysis
Erschienen in: Zeitschrift für Rheumatologie | Ausgabe 2/2017
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Objective
This study aimed to explore whether B‑cell lymphocyte kinase (BLK) polymorphisms are associated with susceptibility to systemic lupus erythematosus (SLE) in ethnically diverse populations.
Methods
We conducted a meta-analysis of the association between the BLK rs13277113 A/G, rs2736340 T/C, rs2248932 T/C, and rs2618476 G/A polymorphisms and SLE.
Results
Seventeen studies with 22,701 patients and 36,365 controls were included in the meta-analysis. The meta-analysis revealed a significant association between SLE and the BLK rs13277113 A allele (OR = 1.359, 95 % CI = 1.292–1.429, p < 1.0 × 10−8), and stratification by ethnicity indicated an association between this allele and SLE in Caucasians, Asians, and Africans (OR = 1.315, 95 % CI = 1.252–1.380, p < 1.0 × 10−8; OR = 1.415, 95 % CI = 1.287–1.555, p < 1.0 × 10−8; OR = 1.361, 95 % CI = 1.194–1.550, p = 3.6 × 10−6). A significant association between SLE and the rs2736340 T allele (OR = 1.354, 95 % CI = 1.286–1.426, p < 1.0 × 10−8) was also observed, and stratification by ethnicity indicated an association between the risk allele and SLE in Caucasians and Asians (OR = 1.333, 95 % CI = 1.259–1.412, p < 1.0 × 10−8; OR = 1.525, 95 % CI = 1.339–1.736, p < 1.0 × 10−8). Meta-analysis also revealed a significant association between SLE and the BLK alleles rs2248932 T and rs2618476 G (OR = 1.285 95 % CI = 1.228–1.345, p < 1.0 × 10−8; OR = 1.374, 95 % CI = 1.294–1.468, p < 1.0 × 10−8), and stratification by ethnicity indicated an association between these alleles and SLE in Caucasians and Asians.
Conclusions
This meta-analysis confirms that polymorphisms in the BLK alleles rs13277113 A/G, rs2736340 T/C, and rs2248932 T/C are associated with susceptibility to SLE in Caucasian and Asian populations.