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Erschienen in:
01.03.2011 | Short Communication
Association between consanguineous marriages and risk of pre-eclampsia
Erschienen in: Archives of Gynecology and Obstetrics | Sonderheft 1/2011
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Purpose
The objective of this hospital-based case–control study was to assess the association between consanguinity and risk of pre-eclampsia in Shiraz (Fars Province, southern Iran) where the rate of consanguinity is relatively high.
Methods
A total of 171 healthy pregnant women and 140 pre-eclamptic women were included. The healthy control group was frequency matched with the age of the pre-eclamptic women. Control women had no history of pregnancies with pre-eclampsia.
Results
The prevalence of consanguinity was 42.8 and 30.9% in cases and controls, respectively. In univariate analysis, the mean inbreeding coefficient for cases (α = 0.0218) was higher than that of controls (α = 0.0174), denoting a significant difference (p = 0.02). When family history was entered as a covariate in multivariate analysis, adjusted odds ratios (OR) revealed that the first cousin once removed (OR = 4.11, 95% CI 1.32–12.7, p = 0.014) increased the risk of pre-eclampsia, in comparison with unrelated marriages.
Conclusions
Consanguinity in terms of first cousin once removed seems to be associated with pre-eclampsia after controlling for maternal age and family history of pre-eclampsia. Further investigations adjusting for other confounding factors are needed to confirm this information.