Patients with psoriasis are more likely to report poor sleep quality than those without psoriasis. Chronic sleep disturbance is a risk factor for the development of cardiovascular disease. |
This cross-sectional study evaluated the relationship between sleep quantity and myocardial infarction in patients with psoriasis. |
Multivariate logistic regression demonstrated a significant association between sleep quantity and myocardial infarction in patients with psoriasis, in which each hourly increase in average sleep quantity decreased the odds of a history of myocardial infarction. |
The association between sleep quantity and myocardial infarction was not significantly influenced by psoriasis severity or comorbid conditions including psoriatic arthritis, sleep apnea, or other traditional myocardial infarction risk factors. |
Introduction
Methods
Compliance with Ethics Guidelines
Results
Category | Demographic | Patient demographics, N (%) |
---|---|---|
Age (N = 1374) | < 35 years | 146 (10.6%) |
35–49 years | 330 (24.0%) | |
50–64 years | 545 (39.7%) | |
≥ 65 years | 353 (25.7%) | |
Race (N = 1388) | White/Caucasian | 1,203 (86.7%) |
Asian/Asian American | 58 (4.2%) | |
Black/African American | 43 (3.1%) | |
American Indian/Alaska Native | 15 (1.1%) | |
Native Hawaiian/Pacific Island | 4 (0.3%) | |
Other | 14 (1.0%) | |
Two or more races | 37 (2.7%) | |
Unsure | 14 (1.0%) | |
Gender (N = 1394) | Male | 634 (45.5%) |
Female | 760 (54.5%) | |
BMI (N = 1339) | Underweight (< 18.5) | 26 (1.9%) |
Normal weight (18.5–24.9) | 364 (27.2%) | |
Overweight (25–29.9) | 407 (30.4%) | |
Obese (≥ 30.0) | 542 (40.5%) | |
Annual household income (N = 1192) | < $75,000/year | 664 (55.7%) |
≥ $75,000/year | 528 (44.3%) | |
Psoriasis severity (N = 1319) | Mild psoriasis (< 3% BSA) | 690 (52.3%) |
Moderate psoriasis (3–10% BSA) | 385 (29.2%) | |
Severe psoriasis (> 10% BSA) | 244 (18.5%) | |
Mean BSA % (SD) | 7.27 (14.8) | |
Psoriatic arthritis (N = 1405) | Yes | 763 (54.3%) |
No | 642 (45.7%) | |
MI risk factorsa (N = 1495) | Yes | 799 (53.4%) |
No | 696 (46.6%) | |
History of MI (N = 1405) | Yes | 43 (3.1%) |
No | 1362 (96.9%) | |
Sleep apnea (N = 1405) | Yes | 280 (19.9%) |
No | 1125 (80.1%) | |
Sleep quantity (N = 1405) | Average hours sleep per night (SD) | 6.403 (1.399) |
Variable | Odds ratio | 95% CI | Standard error | z | P |
---|---|---|---|---|---|
Sleep quantity | 0.669 | 0.489–0.915 | 0.107 | – 2.52 | 0.012 |
MI risk factors | 2.00 | 0.643–6.230 | 1.15 | 1.20 | 0.231 |
Psoriasis severity | 1.010 | 0.988–1.033 | 0.011 | 0.88 | 0.381 |
Psoriatic arthritis | 1.064 | 0.475–2.384 | 0.438 | 0.15 | 0.881 |
Sleep apnea | 1.761 | 0.764–4.056 | 0.750 | 1.33 | 0.184 |
Obesity | 1.15 | 0.504–2.635 | 0.486 | 0.34 | 0.736 |
Age | 1.064 | 1.023–1.110 | 0.021 | 3.13 | 0.002 |
White race | 1.092 | 0.287–4.156 | 0.744 | 0.13 | 0.898 |
Male gender | 2.910 | 1.179–7.179 | 1.341 | 2.32 | 0.020 |
Household income | 1.001 | 0.441–2.278 | 0.420 | 0.00 | 0.997tab |