Background
Methods
Study populations
Data collection and laboratory measurements
Statistical analysis
Results
Characteristics of the study population based on platelet levels
Lower platelet count (< 21.4 × 104/μL) | Higher platelet count (≥ 21.4 × 104/μL) |
p
| |
---|---|---|---|
No. at risk | 171 | 171 | |
Age, years | 74.2 ± 7.6 | 71.1 ± 7.1 | < 0.001 |
Systolic blood pressure, mmHg | 154 ± 15 | 154 ± 14 | 0.729 |
Diastolic blood pressure, mmHg | 86 ± 12 | 90 ± 10 | 0.003 |
Antihypertensive medication use, % | 57.9 | 50.9 | 0.194 |
Body mass index, kg/m2 | 24.3 ± 2.9 | 23.9 ± 2.9 | 0.208 |
Current drinker, % | 52.6 | 53.2 | 0.914 |
Current smoker, % | 15.8 | 18.7 | 0.476 |
Serum triglycerides (TG), mg/dL | 101 ± 52 | 117 ± 71 | 0.018 |
Serum HDL-cholesterol (HDL), mg/dL | 54 ± 14 | 57 ± 14 | 0.111 |
Antilipidemic medication use, % | 16.4 | 20.5 | 0.333 |
Serum HbA1c, % | 5.8 ± 0.9 | 5.9 ± 0.6 | 0.599 |
Serum creatinine, mg/dL | 0.88 ± 0.18 | 0.92 ± 0.58 | 0.452 |
Estimated glomerular filtration rate (eGFR), mL/min/1.73m2 | 67.8 ± 15.4 | 70.1 ± 16.4 | 0.179 |
Maximum carotid intima-media thickness (CIMT), mm | 1.05 ± 0.25 | 0.99 ± 0.22 | 0.021 |
Platelets, × 104/μL | 17.4 ± 2.8 | 25.7 ± 4.6 | < 0.001 |
Tongue pressure tertiles |
p
| |||
---|---|---|---|---|
T1 (low) | T2 | T3 (high) | ||
Lower platelet count | ||||
No. at risk | 55 | 64 | 52 | |
Age, years | 77.3 ± 6.9 | 73.7 ± 7.2 | 71.6 ± 7.7 | < 0.001 |
Systolic blood pressure, mmHg | 155 ± 14 | 153 ± 16 | 153 ± 14 | 0.801 |
Diastolic blood pressure, mmHg | 85 ± 11 | 86 ± 14 | 87 ± 9 | 0.718 |
Antihypertensive medication use, % | 50.9 | 50.0 | 57.7 | 0.908 |
Body mass index, kg/m2 | 22.9 ± 2.3 | 25.2 ± 2.9 | 24.7 ± 3.1 | < 0.001 |
Current drinker, % | 50.9 | 50.0 | 57.7 | 0.682 |
Current smoker, % | 14.5 | 14.0 | 19.2 | 0.719 |
Serum triglycerides (TG), mg/dL | 98 ± 54 | 106 ± 54 | 97 ± 49 | 0.585 |
Serum HDL-cholesterol (HDL), mg/dL | 56 ± 15 | 53 ± 13 | 55 ± 13 | 0.400 |
Antilipidemic medication use, % | 14.5 | 17.2 | 17.3 | 0.907 |
Serum HbA1c, % | 5.9 ± 1.1 | 5.7 ± 0.5 | 5.9 ± 0.6 | 0.357 |
Serum creatinine, mg/dL | 0.91 ± 0.17 | 0.89 ± 0.20 | 0.85 ± 0.17 | 0.222 |
Estimated glomerular filtration rate (eGFR), mL/min/1.73m2 | 64.6 ± 13.2 | 67.4 ± 16.6 | 71.5 ± 15.6 | 0.694 |
Maximum carotid intima-media thickness (CIMT), mm | 1.07 ± 0.23 | 1.08 ± 0.30 | 1.00 ± 0.19 | 0.218 |
Higher platelet count | ||||
No. at risk | 58 | 51 | 62 | |
Age, years | 74.7 ± 7.2 | 71.6 ± 7.0 | 67.5 ± 5.1 | < 0.001 |
Systolic blood pressure, mmHg | 154 ± 12 | 155 ± 15 | 153 ± 15 | 0.736 |
Diastolic blood pressure, mmHg | 88 ± 11 | 89 ± 10 | 92 ± 9 | 0.088 |
Antihypertensive medication use, % | 48.3 | 52.9 | 51.6 | 0.881 |
Body mass index, kg/m2 | 23.8 ± 2.9 | 23.6 ± 2.5 | 24.2 ± 3.13 | 0.490 |
Current drinker, % | 46.6 | 50.9 | 61.3 | 0.255 |
Current smoker, % | 8.6 | 21.6 | 25.8 | 0.045 |
Serum triglycerides (TG), mg/dL | 104 ± 51 | 119 ± 73 | 127 ± 83 | 0.188 |
Serum HDL-cholesterol (HDL), mg/dL | 57 ± 15 | 56 ± 14 | 57 ± 14 | 0.822 |
Antilipidemic medication use, % | 19.0 | 17.6 | 24.2 | 0.655 |
Serum HbA1c, % | 5.8 ± 0.7 | 6.0 ± 0.7 | 5.9 ± 0.6 | 0.657 |
Serum creatinine, mg/dL | 0.96 ± 0.82 | 0.94 ± 0.54 | 0.86 ± 0.25 | 0.633 |
Estimated glomerular filtration rate (eGFR), mL/min/1.73m2 | 68.8 ± 16.8 | 68.8 ± 16.8 | 72.3 ± 15.8 | 0.400 |
Maximum carotid intima-media thickness (CIMT), mm | 1.03 ± 0.23 | 0.98 ± 0.22 | 0.96 ± 0.21 | 0.217 |
Association between tongue pressure and subclinical carotid atherosclerosis in total subjects
Tongue pressure | p for trend | 1 SD increment in tongue pressure | ||||
---|---|---|---|---|---|---|
T1 (low) | T2 | T3 (high) | ||||
Total subjects | ||||||
No. at risk | 113 | 115 | 114 | |||
No. of cases (percentage) | 42 (37.2) | 33 (28.7) | 24 (21.1) | |||
Crude ORs | 1 | 0.68 (0.39, 1.19) | 0.45 (0.25, 0.81) | 0.008 | 0.78 (0.61, 0.98) | |
Age-adjusted ORs | 1 | 0.78 (0.44, 1.38) | 0.60 (0.32, 1.13) | 0.110 | 0.88 (0.68, 1.13) | |
Multivariable ORs | 1 | 0.71 (0.39, 1.30) | 0.57 (0.30, 1.11) | 0.095 | 0.86 (0.65, 1.12) |
Association between tongue pressure and subclinical carotid atherosclerosis in relation to platelet levels
Tongue pressure | p for trend | 1 SD increment in tongue pressure | |||
---|---|---|---|---|---|
T1 (low) | T2 | T3 (high) | |||
Lower platelet count | |||||
No. at risk | 55 | 64 | 52 | ||
No. of cases (percentage) | 24 (43.6) | 19 (29.7) | 10 (19.2) | ||
Crude ORs | 1 | 0.55 (0.26, 1.16) | 0.31 (0.13, 0.74) | 0.007 | 0.55 (0.38, 0.81) |
Age-adjusted ORs | 1 | 0.60 (0.28, 1.29) | 0.35 (0.14, 0.87) | 0.023 | 0.59 (0.39, 0.87) |
Multivariable ORs | 1 | 0.61 (0.26, 1.44) | 0.35 (0.13, 0.91) | 0.031 | 0.54 (0.35, 0.85) |
Higher platelet count | |||||
No. at risk | 58 | 51 | 62 | ||
No. of cases (percentage) | 18 (31.0) | 14 (27.5) | 14 (22.6) | ||
Crude ORs | 1 | 0.84 (0.37, 1.93) | 0.65 (0.29, 1.46) | 0.297 | 0.99 (0.72, 1.35) |
Age-adjusted ORs | 1 | 1.05 (0.44, 2.51) | 1.10 (0.44, 2.79) | 0.834 | 1.27 (0.88, 1.83) |
Multivariable ORs | 1 | 0.92 (0.37, 2.30) | 1.11 (0.42, 2.29) | 0.846 | 1.31 (0.87, 1.96) |