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01.04.2016 | Gynecologic Oncology

Association of −463G/A MPO gene polymorphism and risk of cervical intraepithelial neoplasia

verfasst von: Camilla Natter, Stephan Polterauer, Sophie Pils, Dan Cacsire Castillo-Tong, Robert Zeilinger, Georg Heinze, Lukas Hefler, Christoph Grimm

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 4/2016

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Abstract

Purpose

The MPO system plays an important role in the control of infections and the deletion of malignant cells. Nevertheless, alternations in the MPO system can lead to DNA damage and carcinogenesis. Polymorphisms in the MPO Gene have been associated with an increased expression of MPO and a higher risk for development of cancer. This study evaluates the association between −463G/A MPO gene polymorphism and the risk for CIN.

Methods

The MPO gene polymorphism (−463G/A) was investigated in 616 women with cervical intraepithelial neoplasia and in 206 healthy women. Association between MPO gene polymorphism and risk of cervical intraepithelial neoplasia were analyzed by univariate and multivariable models.

Results

No significant difference in genotype distribution of the MPO gene polymorphism was observed in women with CIN and controls (p = 0.4; OR 1.2, 95 % CI 0.8–1.6). A subgroup analysis only including women with CIN did not show an association between −463G/A MPO gene polymorphism and risk for high-grade CIN (CIN 2/3) (p = 0.09; OR 1.5, 95 % CI 0.9–2.3).

Conclusions

The investigated MPO gene polymorphism is not associated with risk for the development of cervical intraepithelial neoplasia.

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Titel: Association of −463G/A MPO gene polymorphism and risk of cervical intraepithelial neoplasia
verfasst von: Camilla Natter
Stephan Polterauer
Sophie Pils
Dan Cacsire Castillo-Tong
Robert Zeilinger
Georg Heinze
Lukas Hefler
Christoph Grimm
Publikationsdatum: 01.04.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Archives of Gynecology and Obstetrics / Ausgabe 4/2016
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-015-3869-9

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